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Enantioselective Synthesis of Indanone Spiro-Isochromanone Derivatives via Dinuclear Zinc-Catalyzed Michael/Transesterification Tandem Reaction

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00541J, Paper
Xiao-Chao Yang, Meng Xu, Jin-Bao Wang, Meng-Meng Liu, Francois Mathey, Yuan-Zhao Hua, Mincan Wang
An enantioselective Michael/transesterification tandem reaction of α-hydroxy indanones with ortho-ester chalcones was realized by dinuclear zinc catalysts. A series of enantiomerically pure spiro[indanone-2,3’-isochromane-1-one] derivatives were obtained in good yields with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

Org. Biomol. Chem., 2020, 18,3229-3233
DOI: 10.1039/D0OB00265H, Communication
Ying Han, Yifan Da, Mingjia Yu, Yaping Cheng, Xin Wang, Jiale Xiong, Guoying Guo, Yan Li, Xianxing Jiang, Xiaoqing Cai
An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors

Org. Biomol. Chem., 2020, 18,3288-3296
DOI: 10.1039/C9OB02682G, Paper
Matthew B. Minus, Haopei Wang, Jaime O. Munoz, Alexandra M. Stevens, Alicia E. Mangubat-Medina, Michael J. Krueger, Wei Liu, Moses M. Kasembeli, Julian C. Cooper, Mikhail I. Kolosov, David J. Tweardy, Michele S. Redell, Zachary T. Ball
Recurrence and drug resistance are major challenges in the treatment of acute myeloid leukemia (AML) that spur efforts to identify new clinical targets and active agents.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of phenanthridines by I2-mediated sp3 C–H amination

Org. Biomol. Chem., 2020, 18,3312-3323
DOI: 10.1039/D0OB00433B, Paper
Benyao Fang, Jiao Hou, Jinyue Tian, Wenquan Yu, Junbiao Chang
An I2-mediated transition-metal-free sp3 C–H amination reaction is established for phenanthridine synthesis in an efficient and scalable manner.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pak politicians want to resolve Kashmir — military won't allow this: Arif Jamal

Arif Jamal is a Pakistani journalist and South Asia expert based in America.




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A strong and vibrant India is important for peace and stability in Asia: K Shanmugam, Singapore's foreign minister

Singapore is one of India's closest partners in Asia. In his first visit to meet PM Narendra Modi after the formation of the NDA government, K Shanmugam, Singapore's foreign minister, tells Indrani Bagchi they would build some of India's new smart cities and involve themselves in skill development programmes in India.




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Yogi launches app to collect data of migrants




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UP: 63 flee quarantine centre, all traced




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Delhi govt says it will pay train fare of migrants

Delhi government on Friday said it would bear the cost of train travel of migrant workers if their home states didn’t respond on the issue.




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Google and Apple partner up to defeat COVID-19 outbreak, tech giants to jointly develop technology for contact tracing

The multinational companies, which hold the largest market shares in the sphere of technology, have decided to put their joint efforts in developing technology that will help world governments to cut the spread of the virus and save lives




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COVID-19 gene detected in air pollutants: Study

The study was led by led by Leonardo Setti of the University of Bologna in Italy.




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'Laughter is so important these days'

'Comedy comes naturally to me.'




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What Akshay Kumar wants to tell ALL heroes!

'In our textbooks, we never had chapters where a woman does something. We had one Rani Laxmibai chapter, the rest only the men did. We have been trained like that but, now, things have to change.'





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'I don't do films that just want to make money'

Nithya Menen's fiery interview.




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'People think those who are empowered aren't romantic'

'It's up to the audience to decide if I am the lead or not. I want to stay away from these conversations because it demotivates the actors, when they get stuck in this game of lead, second lead or supporting cast.'




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'I am so nervous, I want to lock myself in a room!'

'I did not have a quintessential debut even though my father is a well known actor in the industry. That's why I never felt like an industry kid.'




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'I always wanted to sound sexy in my films'

'I don't watch my films more than once, otherwise I will fall in love with myself.'






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'Self-love is the most important thing'

'You can be fat, you can be thin, you can be fair, or not, you are whatever you are.''It is about being happy about yourself.'




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'I want to do films that my daughter can watch'

'If you don't get married, it's not a crime. If you do, it's not an achievement either.'





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'I don't want to waste time on Kangana'

'Both Kangana and Rangoli really love me and that's because they give me so much of time and attention from their lives.'







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'Irrfan doesn't want your pity. He wants your love'

'He's got such incredible resilience, such an incredible spirit that we were feeding off his strength rather than him feeding off ours.''Sometimes I look back and cannot figure out how the f*** we made this movie.'





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'People want to see me on screen'

'It is very difficult for anybody to say no to the fame and fancies that come along.''But I was courageous and had the strength to say no.'






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'I want to run out and scream'

'I meet him recently.''He was his usual cheerful, boisterous, self.''You didn't even get an iota of feeling about what he had gone through or may be going through internally.'




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Folklife News & Events: 2019 NEA National Heritage Fellows: Las Tesoros de San Antonio

Please Join us for our next Homegrown Concert:

2019 NEA National Heritage Fellows: Las Tesoros de San Antonio: Tejano Singers from San Antonio, TX

Beatriz "La Paloma del Norte" Llamas
Blanquita "Blanca Rosa" Rodríguez

Wednesday, September 18, 2019
Coolidge Auditorium, Ground Floor
Thomas Jefferson Building
The Library of Congress

A conversation with two NEA fellows, accompanied by music from Mariachi Esperanza: Henry Gomez (Director), virhuela, Moises Perez, trumpet, Jose Luis Vaca, violin, and Rafael Aguirre, guitarron

Las Tesoros de San Antonio are a group of elder women performers who teamed up to preserve Mexican and bicultural musical expressions through their singing and storytelling. Janet “Perla Tapatia” Cortez, Beatriz “La Paloma del Norte” Llamas, Blanquita “Blanca Rosa” Rodríguez, and Rita “La Calandria” Vidaurri each had impressive singing careers that soared both locally and internationally from the 1940s to the1960s before tapering off in later years. Through the Esperanza Peace & Justice Center in San Antonio, these women reemerged and teamed up as the group Las Tesoros in the 2000s. Although Janet “Perla Tapatia” Cortez and Rita “La Calandria” Vidaurri passed away in recent years, Llamas and Rodríguez continue to perform and maintain the legacy of the group.

All four women grew up in the West Side of San Antonio, Texas. Each singer, with her personal style and grace, forms part of this unique ensemble that represents the important sound of the Mexico/Texas border. They were all inspired by and connected to many other important Tejana singers, including the great Lydia Mendoza (1982 NEA National Heritage Fellow) and the internationally renowned Eva Garza.

Request ADA accommodations five days in advance at 202-707-6362 or ADA@loc.gov

More information is at this link!




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The economics, performance, and sustainability of internally cured concrete: held at the ACI Fall 2011 [i.e. 2012] Convention, Toronto, Ontario, Canada 21-25 October 2011 [i.e. 2012] / editors, Anton K. Schindler, Jiri G. Grygar, W. Jason Weiss

Barker Library - TA440.E358 2012




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Practices for unbound aggregate pavement layers / consultant, Erol Tutumluer

Barker Library - TA441.T88 2013




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Composites with inorganic matrix for repair of concrete and masonry structures: held at the ACI Spring 2017 Convention, Detroit, Michigan, USA, 26-30 March 2017 / editors, Gianmarco de Felice, Lesley H. Sneed, Antonio Nanni

Barker Library - TA439.A57 2017




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Quantum Vibe for Friday, Apr 10, 2020

Straight to Snake-Eyes




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Quantum Vibe for Monday, Apr 13, 2020

Tough-guy lawman




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Quantum Vibe for Wednesday, Apr 15, 2020

Not exactly born yesterday




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Quantum Vibe for Friday, Apr 17, 2020

Not that entire group of satrapies.




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Quantum Vibe for Monday, Apr 20, 2020

An all-hands-on-deck situation




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Quantum Vibe for Wednesday, Apr 22, 2020

Keeping up with the news.




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Quantum Vibe for Friday, Apr 24, 2020

Nebula of foreboding




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Quantum Vibe for Monday, Apr 27, 2020

Not everyone is a pessimist




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Quantum Vibe for Wednesday, Apr 29, 2020

A gang of non-conformists




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Quantum Vibe for Friday, May 01, 2020

Venus 23 in sum




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Quantum Vibe for Monday, May 04, 2020

Cracking open a Cold One




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Quantum Vibe for Wednesday, May 06, 2020

Ork Report




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Quantum Vibe for Friday, May 08, 2020

Cost-benefit analysis