To provide high-quality medical care to its population — around 30% of whom are 65 or older — Japan is pursuing sovereign AI initiatives supporting nearly every aspect of healthcare. AI tools trained on country-specific data and local compute infrastructure are supercharging the abilities of Japan’s clinicians and researchers so they can care for patients, Read Article

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

One of the most important things that you need to do while you are at university is turn your assignments in on time. Your professor will give you a syllabus and it will tell you the plan for the semester. You will know when you have to do reading, when you have papers due, and when you have exams. Some weeks, you may have more than you can do. You can either plan ahead or get some help from essay writing services or a friend. The key is to make sure that you turn your work in on time. Continue […]

President Joe Biden and Indonesian President Prabowo Subianto met Tuesday at the White House to strengthen U.S.–Indonesia ties. The meeting came days after Jakarta signed a maritime agreement with Beijing that critics say could lend credibility to China’s “nine-dash line” that reflects its expansive claims in the South China Sea. White House Bureau Chief Patsy Widakuswara has this report

LONDON — The head of the Church of England, spiritual leader of the global Anglican Communion, is under pressure to resign after an investigation found that he failed to inform police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it. Some members of the General Synod, the church's national assembly, have started a petition calling on Archbishop of Canterbury Justin Welby to step down, saying he had "lost the confidence of his clergy." The petition had garnered more than 1,800 signatures on Change.org by late morning London time on Monday. Compounding the pressure, a senior cleric added her voice to those who believe he should resign. Helen-Ann Hartley, the bishop of Newcastle, told the BBC that Welby's position is "untenable.'' Calls for Welby's resignation have grown since Thursday, when the church released the results of an independent review into John Smyth, who sexually, psychologically and physically abused about 30 boys and young men in the United Kingdom and 85 in Africa over five decades. The 251-page report concluded that Welby failed to report Smyth to authorities when he was informed of the abuse in August 2013, soon after he became Archbishop of Canterbury. Welby last week took responsibility for not ensuring that the allegations were pursued as "energetically" as they should have been after he learned of the abuse but said he had decided not to resign. On Monday, his office issued a statement reiterating Welby's "horror at the scale of John Smyth's egregious abuse." "As he has said, he had no awareness or suspicion of the allegations before he was told in 2013 — and therefore, having reflected, he does not intend to resign," the statement said. "He hopes the Makin Review supports the ongoing work of building a safer church here and around the world." Church officials were first made aware of the abuse in 1982, when they received the results of an internal investigation into Smyth. The recipients of that report "participated in an active cover-up" to prevent its findings from coming to light, the Makin Review found. Between 1984 and 2001, Smyth moved to Zimbabwe and subsequently relocated to South Africa. He continued to abuse boys and young men in Zimbabwe and there is evidence that the abuse continued in South Africa until he died in August 2018. Smyth's abuse wasn't made public until a 2017 investigation by Britain's Channel 4 television, which led Hampshire Police to start an investigation. Police were planning to question Smyth at the time of his death and had been preparing to extradite him. The Makin Review found that if Smyth had been reported to police in 2013, it could have helped to uncover the truth, prevented further abuse and led to a possible criminal conviction. "In effect, three and a half years was lost, a time within which John Smyth could have been brought to justice and any abuse he was committing in South Africa discovered and stopped," the review found. The Archbishop of Canterbury is the head of the Church of England and is seen as the spiritual leader of the Anglican Communion, which has more than 85 million members in 165 countries. He is considered first among equals with respect to the communion's other primates.

London — Archbishop of Canterbury Justin Welby, head of the Church of England and spiritual leader of the global Anglican Communion, resigned Tuesday after an investigation found that he failed to tell police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it.  Pressure on Welby had been building since Thursday, when release of the inquiry's findings kindled anger about a lack of accountability at the highest reaches of the church. Helen-Ann Hartley, the bishop of Newcastle, said Monday that his position was "untenable" after some members of the church's national assembly started a petition calling on Welby to step down because he had "lost the confidence of his clergy."  "I believe that stepping aside is in the best interests of the Church of England, which I dearly love and which I have been honored to serve," Welby said in a statement.  The strongest outcry came from the victims of John Smyth, a prominent attorney who abused teenage boys and young men at Christian summer camps in Britain, Zimbabwe and South Africa over five decades. Andrew Morse, who was repeatedly beaten by Smyth over a period of five years, said that resigning was a chance for Welby to start repairing the damage caused by the church's handling of historical abuse cases more broadly.  "I believe that now is an opportunity for him to resign,'' Morse told the BBC before Welby stepped down. "I say opportunity in the sense that this would be an opportunity for him to stand with the victims of the Smyth abuse and all victims that have not been treated properly by the Church of England in their own abuse cases."  Welby's resignation comes against the backdrop of widespread historical sexual abuse in the Church of England. A 2022 report by the Independent Inquiry Child Sexual Abuse found that deference to the authority of priests, taboos surrounding the discussion of sexuality and a culture that gave more support to alleged perpetrators than their victims helped make the Church of England Church of England "a place where abusers could hide." 

[Addis Standard] Addis Abeba -- The Committee to Protect Journalists (CPJ) presented to the UN's Human Rights Council a five-year review of press freedom in Ethiopia ahead of the United Nations Universal Periodic Review (UPR) of Ethiopia at the 47th Session taking place today by the UN's Human Rights Council.

This event is expected to draw around 25,000 attendees, leading to significant delays on key routes across the island

Government is scoping the market for potential interest in the design and construction of a new Gozo hospital, a process abandoned when the Steward Health Care concession was terminated

[Shabelle] Mogadishu -- In a significant political development, two ministers from Somalia's federal government resigned on Sunday, November 3, 2024, citing what they described as the government's plans to exacerbate tensions with regional administrations, particularly Jubbaland and Puntland.

[Shabelle] Mogadishu -- In a move signaling deepening political discord, Somalia's Deputy Minister of Ports and Maritime Transport, MP Saddam Mohamud Abdi, resigned on Tuesday, accusing the federal government of constitutional violations and politicizing development projects in his home region of Puntland.

Thousands of Serbians demand prime minister's resignation following deadly roof collapse

Church of England head Justin Welby resigns over handling of sex abuse scandal

The decision of Israel’s parliament, the Knesset, to adopt two laws that would severely limit or outright ban UNRWA has the potential to set a dangerous precedent, where countries can simply implement their own justification to ban the activity of the United Nations, even if it violates their obligations under international humanitarian law. Even with […]

The town planning department on Tuesday signed a contract for the demolition of two apartment buildings in the government housing settlement of Platy in Aglandja, Nicosia, as part of the government’s Ktizo plan, which aims atimproving living conditions in refugee estates. According to a statement released by the interior ministry, the agreed cost for the […]

ADB sought to understand what improving transport meant for the community. Prior to project design, consultations were conducted with residents in Ulaanbaatar’s ger areas. Design decisions were tested back to ensure that mobility pain points were addressed.

Hansen was comfortably reelected to the state Senate last week, winning 84% of the vote.

Georgiev looks like a different goaltender in early November than he did last month.

to design cars like a pro

Captive dolphins are more likely to make an open-mouthed expression when their playmate can see them and they often reciprocate, hinting that it is a form of visual communication

New research into the moments between wakefulness and sleep could bring hope for insomniacs and even make us more creative problem-solvers

Two types of fusion reactor called tokamaks and stellarators both have drawbacks – but a new design combining parts from both could offer the best of both worlds

Title: Biden to Sign Bill That Helps Veterans Exposed to Toxic Burn Pits
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/11/2022 12:00:00 AM

Title: Thyroid Disorders Symptoms and Signs
Category: Diseases and Conditions
Created: 7/26/2018 12:00:00 AM
Last Editorial Review: 5/20/2022 12:00:00 AM

Title: Health Tip: When Hip Pain Signals Bursitis
Category: Health News
Created: 8/26/2010 10:10:00 AM
Last Editorial Review: 8/27/2010 12:00:00 AM

Title: Teen Smokers Show Early Signs of Heart Disease
Category: Health News
Created: 8/29/2012 11:00:00 AM
Last Editorial Review: 8/29/2012 12:00:00 AM

Title: In Diabetes, Any Protein in Urine May Signal Heart Risk
Category: Health News
Created: 8/30/2012 6:06:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Polyp Removal Doesn't Always Signal Raised Colon Cancer Risk, Study Says
Category: Health News
Created: 8/27/2014 5:36:00 PM
Last Editorial Review: 8/28/2014 12:00:00 AM

Title: Gene Research Yields Insights Into Ebola Virus
Category: Health News
Created: 8/28/2014 2:36:00 PM
Last Editorial Review: 8/29/2014 12:00:00 AM

Title: Health Tip: Mental Illness Warning Signs
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: Spotting the Signs of Deadly Melanoma Skin Cancers
Category: Health News
Created: 8/22/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM

Title: Bioengineered Pig Skin Is Turned Into Corneas, Restoring Patients' Sight
Category: Health News
Created: 8/11/2022 12:00:00 AM
Last Editorial Review: 8/12/2022 12:00:00 AM

Title: Rapid Loss of Smell May Be an Early Sign of Alzheimer's
Category: Health News
Created: 7/29/2022 12:00:00 AM
Last Editorial Review: 7/29/2022 12:00:00 AM

Title: Scientists Design Skin Patch That Takes Ultrasound Images
Category: Health News
Created: 7/29/2022 12:00:00 AM
Last Editorial Review: 7/29/2022 12:00:00 AM

Title: What Are the 5 Warning Signs of Bladder Cancer?
Category: Diseases and Conditions
Created: 4/22/2021 12:00:00 AM
Last Editorial Review: 6/8/2022 12:00:00 AM

Title: Is It Parkinson's? These 10 Signs Could Tell
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

The poly(A) signal, together with auxiliary elements, directs cleavage of a pre-mRNA and thus determines the 3' end of the mature transcript. In many species, including humans, the poly(A) signal is an AAUAAA hexamer, but we recently found that the deeply branching eukaryote Giardia lamblia uses a distinct hexamer (AGURAA) and lacks any known auxiliary elements. Our discovery prompted us to explore the evolutionary dynamics of poly(A) signals and auxiliary elements in the eukaryotic kingdom. We use direct RNA sequencing to determine poly(A) signals for four protists within the Metamonada clade (which also contains G. lamblia) and two outgroup protists. These experiments reveal that the AAUAAA hexamer serves as the poly(A) signal in at least four different eukaryotic clades, indicating that it is likely the ancestral signal, whereas the unusual Giardia version is derived. We find that the use and relative strengths of auxiliary elements are also plastic; in fact, within Metamonada, species like G. lamblia make use of a previously unrecognized auxiliary element where nucleotides flanking the poly(A) signal itself specify genuine cleavage sites. Thus, despite the fundamental nature of pre-mRNA cleavage for the expression of all protein-coding genes, the motifs controlling this process are dynamic on evolutionary timescales, providing motivation for future biochemical and structural studies as well as new therapeutic angles to target eukaryotic pathogens.

Understanding the evolution of chromatin conformation among species is fundamental to elucidate the architecture and plasticity of genomes. Nonrandom interactions of linearly distant loci regulate gene function in species-specific patterns, affecting genome function, evolution, and, ultimately, speciation. Yet, data from nonmodel organisms are scarce. To capture the macroevolutionary diversity of vertebrate chromatin conformation, here we generate de novo genome assemblies for two cryptodiran (hidden-neck) turtles via Illumina sequencing, chromosome conformation capture, and RNA-seq: Apalone spinifera (ZZ/ZW, 2n = 66) and Staurotypus triporcatus (XX/XY, 2n = 54). We detected differences in the three-dimensional (3D) chromatin structure in turtles compared to other amniotes beyond the fusion/fission events detected in the linear genomes. Namely, whole-genome comparisons revealed distinct trends of chromosome rearrangements in turtles: (1) a low rate of genome reshuffling in Apalone (Trionychidae) whose karyotype is highly conserved when compared to chicken (likely ancestral for turtles), and (2) a moderate rate of fusions/fissions in Staurotypus (Kinosternidae) and Trachemys scripta (Emydidae). Furthermore, we identified a chromosome folding pattern that enables "centromere–telomere interactions" previously undetected in turtles. The combined turtle pattern of "centromere–telomere interactions" (discovered here) plus "centromere clustering" (previously reported in sauropsids) is novel for amniotes and it counters previous hypotheses about amniote 3D chromatin structure. We hypothesize that the divergent pattern found in turtles originated from an amniote ancestral state defined by a nuclear configuration with extensive associations among microchromosomes that were preserved upon the reshuffling of the linear genome.