A 10-year-old boy writes to Queensland's Environment Minister pleading with authorities not to remove a giant crocodile that has been sunning itself on a creek bank.

Howard the crocodile is being targeted for removal after a resident complained the four-metre reptile had been spotted basking near properties north of Cairns. But locals are angry and want him to stay.

Four crocodiles one nicknamed Pugly by locals are killed in abandoned fishing nets in Queensland's Cape York, infuriating locals.

As the wet season approaches, saltwater crocodiles are getting ready to lay their eggs and at croc farms across the north hay is an essential ingredient for good breeding.

The woman, 32, and man, 24, were reported missing in the Cairns area yesterday after they both failed to show up for work.

While one in six Gold Coast properties could become 'uninsurable' due to natural disasters, its council has not had a climate change strategy since 2014.

A Queensland crocodile farmer has found a surgical plate "complete with six stainless steel screws" inside a dead crocodile, months after the sick animal stopped eating.

An orthopaedic surgeon has identified the plate found in the corpse of 4.7-metre crocodile 'MJ' as a bone plate used to heal fractures in humans.

Researchers at Australia's first 'body farm' have observed that dead bodies move significantly when they decompose and believe it could be important in investigations.

Brendan Russell's body modification work includes tongue splitting and scarification, but court documents allege he used a branding iron to burn a woman's genitals, who later complained to police.

A man is charged over the death of a woman after he allegedly implanted a plastic snowflake under her skin at a NSW Central Coast tattoo shop.

Thousands of homes are still without power this morning as a series of severe thunderstorms dumped heavy rain across parts of Sydney, the central coast and Wollongong last night.

Caroline Harte is mostly confined to her bed after a fall at work. While her insurer completes modifications to her home she sleeps next to a portable toilet and shower.

"The Hot Zone" author Richard Preston gets candid about a failed 1990s movie adaptation that was once set to star A-listers Robert Redford and Jodie Foster before falling apart.

(United States Third Circuit) - In plaintiff's suit for interference with contract, unfair competition, and misappropriation of trade secrets, in connection with a technology for manufacturing a critical intermediate chemical used in manufacturing nylon, district court's denial of defendant's motion to either dismiss or stay the litigation in favor of arbitration is affirmed where: 1) the Tribunal's holding that it does not have jurisdiction over defendant moots this appeal, and given the Tribunal's ruling, it is clear that the district court could not have enforced the arbitration clause as defendant had urged; and 2) because defendant's appeal from the denial of its motion to dismiss under section 3 of the FAA is moot and must be dismissed, its appeal from the district court's denial of its discretionary motion to stay must also be dismissed for lack of pendent appellate jurisdiction.

Sectoren die nu nog offline only acteren komen meer en meer onder druk te staan. Na het verdwijnen van hele winkelketens en het op de schop nemen van volledige branches is de digitale revolutie op weg om ook de wereld van zakelijke events en B2B-beurzen te ‘disrupten’. Het stevige podium dat de beursvloer biedt is […]

(California Court of Appeal) - Held that Apple Inc. was not liable for a five-year-old girl's death and injuries to her family members that occurred when a driver using the FaceTime application on his iPhone crashed into her parents' car on a Texas highway. Affirmed dismissal of the complaint, concluding that Apple did not owe a duty of care and that the iPhone's design was not a proximate cause.

Since 2016, Well of Night have been restlessly building their sound into a rare blend of riff-heavy, energetic and melodic...

The post WELL OF NIGHT Offer Seering, Melodic Black Metal Song "Doctrine of Futility and Human Extinction" appeared first on Metal Injection.

Album Produced By Steve Evetts (The Dillinger Escape Plan, Suicide Silence, Poison The Well), And Mixed By Jamie King (Between The Buried And Me, The Contortionist)

The couple tied the knot in December.

Date: April 27, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating 50 years of Kids Coding!

Help stop the spread of COVID-19 by following these steps.
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

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Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface–expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cells against these targets using 2 different approaches. The first achieves pHLA recognition via affinity-enhanced versions of natural TCRs (e.g., immune-mobilizing monoclonal T cell receptors against cancer [ImmTAC] molecules), whereas the second harnesses an antibody-based format (TCR-mimic antibodies). For both classes of reagent, target specificity is vital, considering the vast universe of potential pHLA molecules that can be presented on healthy cells. Here, we made use of structural, biochemical, and computational approaches to investigate the molecular rules underpinning the reactivity patterns of pHLA-targeting bispecifics. We demonstrate that affinity-enhanced TCRs engage pHLA using a comparatively broad and balanced energetic footprint, with interactions distributed over several HLA and peptide side chains. As ImmTAC molecules, these TCRs also retained a greater degree of pHLA selectivity, with less off-target activity in cellular assays. Conversely, TCR-mimic antibodies tended to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater degree of crossreactivity. Our findings extend our understanding of the basic principles that underpin pHLA selectivity and exemplify a number of molecular approaches that can be used to probe the specificity of pHLA-targeting molecules, aiding the development of future reagents.

BACKGROUND Preclinical experiments have shown that donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression against the allogeneic donor.METHODS In this phase I trial, patients received either 1.5 × 106 MICs per kg BW on day –2 (n = 3, group A), or 1.5 × 108 MICs per kg BW on day –2 (n = 3, group B) or day –7 (n = 4, group C) before living donor kidney transplantation in addition to post-transplantation immunosuppression. The primary outcome measure was the frequency of adverse events (AEs) until day 30 (study phase) with follow-up out to day 360.RESULTS MIC infusions were extremely well tolerated. During the study phase, 10 treated patients experienced a total of 69 AEs that were unlikely to be related or not related to MIC infusion. No donor-specific human leukocyte antigen Abs or rejection episodes were noted, even though the patients received up to 1.3 × 1010 donor mononuclear cells before transplantation. Group C patients with low immunosuppression during follow-up showed no in vitro reactivity against stimulatory donor blood cells on day 360, whereas reactivity against third-party cells was still preserved. Frequencies of CD19+CD24hiCD38hi transitional B lymphocytes (Bregs) increased from a median of 6% before MIC infusion to 20% on day 180, which was 19- and 68-fold higher, respectively, than in 2 independent cohorts of transplanted controls. The majority of Bregs produced the immunosuppressive cytokine IL-10. MIC-treated patients showed the Immune Tolerance Network operational tolerance signature.CONCLUSION MIC administration was safe and could be a future tool for the targeted induction of tolerogenic Bregs.TRIAL REGISTRATION EudraCT number: 2014-002086-30; ClinicalTrials.gov identifier: NCT02560220FUNDING Federal Ministry for Economic Affairs and Technology, Berlin, Germany, and TolerogenixX GmbH, Heidelberg, Germany.

"And you know, we have to stop looking beyond this election cycle and see that this corporate driven ideology, you know, this commodification of the culture, this constant extracting of blood from us as citizens to pay what in essence were private debts of the banks which engaged in casino capitalism, has political consequences. History has taught us that. And Hillary Clinton is only going to further that process." Continue reading →

Daily Photo – Happy monks in Cambodia Most of the monks I saw in Cambodia were not really doing monk-like things. I expected to see lots of meditating or chanting or something. Most of the time, they were just goofing, playing games, smoking, and just acting like pretty much everyone else! Happy monks in Cambodia […]

In contrast to previous notes, in this set of notes we shall focus exclusively on Fourier analysis in the one-dimensional setting for simplicity of notation, although all of the results here have natural extensions to higher dimensions. Depending on the physical context, one can view the physical domain as representing either space or time; we […]

Česká rodinná firma SSI Group vznikla v době, kdy jsme ještě neznali mobilní telefony a podnikatelské prostředí 90. let bylo poměrně divoké. Přesto se ji Václavu Vodrážkovi společně se synem Janem a dalšími členy rodiny dařilo každý rok posouvat o něco dál. Letos tak na trhu významná bezpečnostní agentura oslaví 30 let svého působení na trhu.

musicisart magazine 2017 Best Music: Slenderbodies

Los Angeles-based duo Slenderbodies create music that feels like your watching the ocean. Slenderbodies recently released their brand new project fabulist out now via Majestic Casual Records. The five-track collection is full of whispers of sensuality found within falsetto vocals accompanied with vibrations of soft guitars melted into funky and soulful bass-lines that collide together […]

The post 2017 Best Music: Slenderbodies appeared first on musicisart magazine.

Recently Donald Trump tweeted the word "TREASON?" in light of the New York Times op ed that was published on Wednesday. The article was supposedly written by someone within the Trump Administration, calling themselves part of the "resistance." 

After Trump's "treason" tweet, people on Twitter began making their own amusing parodies, which you can read below!

A person who decides whether or not they're full of shit by the reactions of those around them.

"That guy who posted ____ but said he was just trolling when no one agreed with him is totally a Schrodingers Asshole"

Me: I’m back from my work trip. Do you still need those modifications to your logo files? 

Client: Hey! I was actually able to talk with my IT guy and he taught me how to use gimp to do all of that. But I will definitely let you know if I need anything else done.

Me: (WRITHING IN SYMPATHETIC PAIN FOR USING GIMP)