ia Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00555D, Research ArticleShenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong LiuThe continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Advances in antibacterial agents for Mycobacterium fortuitum By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00508B, Review ArticleCarlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando FumagalliThis review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00623B, Research ArticleOjaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi YaddanapudiA series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00670D, Research ArticleYuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen ZhouIn the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00373J, Research ArticleYongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian ZhangThe mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00663A, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin KrátkýLinking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00601A, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza GainaNew meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00558A, Research ArticleLaura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva JúniorThis article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00597J, Research ArticleAlbert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken WittSomatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00722K, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice MangiatordiDeveloping sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00724G, Research ArticleZhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei MaoA series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Adjuvant strategies to tackle mcr-mediated polymyxin resistance By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00654B, Review ArticleMadison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. LeungThe emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory By www.thehindu.com Published On :: Tue, 05 Nov 2024 12:48:36 +0530 Full Article U.S. Elections
ia Data crucial for building climate resilience, says ISRO scientist By www.thehindu.com Published On :: Tue, 05 Nov 2024 19:40:51 +0530 Full Article Tiruchirapalli
ia Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:10:58 +0530 About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive Full Article Tiruchirapalli
ia EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:25:59 +0530 Full Article Tiruchirapalli
ia Students and agriculture officials grapple with logistical, technical issues during digital crop survey By www.thehindu.com Published On :: Sat, 09 Nov 2024 20:32:48 +0530 Full Article Tiruchirapalli
ia Association holds protest against delay in Anna University’s staff absorption, promotions By www.thehindu.com Published On :: Sat, 09 Nov 2024 22:02:50 +0530 Full Article Tiruchirapalli
ia AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami By www.thehindu.com Published On :: Mon, 11 Nov 2024 00:39:42 +0530 Full Article Tiruchirapalli
ia 554: Jamstack Thoughts with Brian Rinaldi By shoptalkshow.com Published On :: Mon, 27 Feb 2023 20:50:01 +0000 Brian Rinaldi joins us to talk about the state of Jamstack in 2023, acronym confusion, SPA confusion, developing common tools of understanding, why Netlify bought Gatsby, and the state of developer conferences. Full Article All Episodes jamstack
ia 559: Fidget Apps, Coding with AI, Dialog Element Navs, Getting Rid of CSS By shoptalkshow.com Published On :: Mon, 03 Apr 2023 07:14:35 +0000 Is there still any value in specializing in front-of-the-frontend dev? Would you ever use the dialog element for a mobile navigation? Why did CodePen decide to use Go for its GraphQL server? Full Article All Episodes chatgpt dialog Go
ia 581: DevRel, Musical Mics, Social Sharing, and 100 Years of WordPress By shoptalkshow.com Published On :: Mon, 04 Sep 2023 08:25:38 +0000 Dave calls a quick Luro branding meeting, some thoughts on DevRel, Chris tries to figure out musical instrument mics, follow up on WordPress from a previous episode, Chris' journey through the social graph options, 100 year hosting with WordPress, and the introduction of a new segment: Happy Project Share Time. Full Article All Episodes guitar happy project share time Luro social graph Wordpress
ia 591: Cascade Layers, CSS Functions, and more CSS with Miriam Suzanne By shoptalkshow.com Published On :: Mon, 13 Nov 2023 10:11:50 +0000 Miriam Suzanne stops by to talk about CSS updates and news on container queries, rolling out cascade layers, !important things to remember, custom properties, exit animations, CSS functions, state queries, and more. Full Article All Episodes cascade layers CSS css functions exit animations
ia 595: MedTalk Show, Plagiarism and Code Grifting, and How We’re Testing Code By shoptalkshow.com Published On :: Mon, 11 Dec 2023 09:03:30 +0000 Blood pressure, stress, and COVID highlight the MedTalk Show portion of this episode, a new "Did You Know" segment about dev tools in Chrome, 4 hour video on plagiarism and code grifters, typography, breaking out of CSS Grid, the oldest things Chris and Dave worked on, and what the testing process is like at Luro or CodePen. Full Article All Episodes css grid plagirism Testing Typography
ia 634: Fabian Kägy on WordPress, Blocks, and Enterprise Dev By shoptalkshow.com Published On :: Mon, 23 Sep 2024 08:36:23 +0000 Fabian Kägy helps us understand the modern WordPress development process, Gutenberg vs Block editor vs full site editing, building with blocks or pages, what's coming in the Twenty Twenty-Five Theme, and whether the theme authoring process has been made too difficult in 2024? Full Article All Episodes Block Gutenberg Themes Wordpress
ia 637: Approachable Open Source with Brian Muenzenmeyer By shoptalkshow.com Published On :: Mon, 14 Oct 2024 08:28:34 +0000 Brian Muenzenmeyer joins the show to talk about his book, Approachable Open Source, ways we can make open source easier to get in, important conversations around funding and supporting open source, and whether money helps maintainers deal with burnout or not? Full Article All Episodes books Money Open Source
ia Are freeways viable? By www.thehindu.com Published On :: Fri, 20 Mar 2015 15:01:41 +0530 Barring very few functionally useful ones, many elevated concrete structures with suboptimal utility have ripped the city apart, defiled and marred it. Full Article Property Plus
ia It’s all in the material By www.thehindu.com Published On :: Fri, 05 Jun 2015 15:33:29 +0530 Materials have a major say in construction, as their manufacture has to be environment-friendly, making them energy-efficient, says green homes builder Chandrashekar Hariharan. By Ranjani Govind Full Article Green Living
ia Green power, officially By www.thehindu.com Published On :: Fri, 18 Mar 2016 15:31:36 +0530 The cumulative effects of changing the way government builds can have a lasting impact on the country’s carbon footprint Full Article Property Plus
ia F1: Piastri on pole as McLaren in front By www.rediff.com Published On :: McLaren are leading the constructor's championship but are only 29 points ahead of Ferrari, with Leclerc an obvious threat and team mate Carlos Sainz qualifying fifth and Mercedes' George Russell sixth. Full Article
ia Could Maini be India's next F1 driver? By www.rediff.com Published On :: India could finally have a driver on the F1 grid after 13 long years. Full Article
ia A sporty knock from India Inc By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 20:53:00 +0530 A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too Full Article Corporate File
ia Unlocking renewable energy from industrial waste: Biogas production from spent wash By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 15:51:29 +0530 It is a sustainable solution for industrial waste management and renewable energy generation Full Article Agri Business
ia From agri waste to industrial raw material By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 altM is developing alternatives to mined materials and petrochemicals Full Article Clean Tech
ia As India’s installed solar capacity crosses 90GW, a look at the journey By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 Sun-sational growth: In September, India’s installed solar power capacity reached 90,762 MW. Given the current rate of monthly capacity additions, there is little doubt that installed capacity will exceed 100 GW in 2024-25. Full Article Clean Tech
ia Investing in companies with ‘indicorn’ potential By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:01:00 +0530 Titan Capital backs seed-stage companies with potential to reach ₹100 crore revenue within five years Full Article Emerging Entrepreneurs
ia Diamonds are a UV photodetector’s best friend By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:34:55 +0530 How lab-grown rocks from Surat are set to power the development of high-performance electronics Full Article Science and Technology
ia Catalysing Indian IP creation By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:48:42 +0530 How policy support and monetisation can rev up India’s innovation ecosystem Full Article Science and Technology
ia ‘Our goal is beauty for each,’ says L’Oréal India chief By www.thehindubusinessline.com Published On :: Sat, 26 Oct 2024 13:11:01 +0530 Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey Full Article Corporate File
ia How Jio is powering Reliance’s media, entertainment biz By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:46:07 +0530 Despite a late entry into telecom, digital services, and media, Reliance has raced to the top Full Article Corporate File
ia India seeks $70 million from Climate Investment Funds By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 18:22:57 +0530 India looks to accelerate proposed ‘renewable energy integration programme’ Full Article Clean Tech
ia Toxic air chokes urban India By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 18:59:29 +0530 Residents grapple with respiratory, cardiac, and other ailments as the air thickens Full Article Pulse
ia Why more NRIs are buying health insurance in India By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 19:13:28 +0530 The number of NRIs buying health insurance from India has increased steadily over the past three years Full Article Pulse
ia Corporates look to tread the India Way By www.thehindubusinessline.com Published On :: Fri, 08 Nov 2024 10:33:04 +0530 Business leaders are realising that longevity may be a better marker for growth than shareholder value maximisation Full Article Corporate File
ia Nvidia: The lynchpin of the AI revolution By www.thehindubusinessline.com Published On :: Sat, 09 Nov 2024 18:18:47 +0530 The meteoric rise of the Santa Clara-headquartered chipmaker is powered by bold innovation Full Article Corporate File
ia IAF Mig-29 fighter crashes near Agra, pilot ejects to safety By www.thehindu.com Published On :: Mon, 04 Nov 2024 17:26:14 +0530 An enquiry has been ordered by the IAF, to ascertain the cause of the accident Full Article India
ia Jamiat cautions NDA partners, says ‘crutches’ cannot escape responsibility for Waqf Bill By www.thehindu.com Published On :: Mon, 04 Nov 2024 21:07:19 +0530 The Jamiat Ulama-i-Hind urged NDA partners TDP and JD(U) to heed Muslim sentiments on the contentious issue surrounding the Waqf (Amendment) Bill, 2024 Full Article India
ia AAP MLA ‘assaults’ MCD official, case registered By www.thehindu.com Published On :: Thu, 07 Nov 2024 01:10:03 +0530 Full Article Delhi
ia CBSE disaffiliates 21 schools over ‘dummy admissions’ By www.thehindu.com Published On :: Thu, 07 Nov 2024 01:12:30 +0530 Full Article Delhi
