z Sport24.co.za | Pitso fears for townships if PSL restarts By www.sport24.co.za Published On :: Sat, 09 May 2020 18:42:14 +0200 Sundowns coach Pitso Mosimane says the premature return of football, even behind closed doors, poses a number of potential problems. Full Article
z Sport24.co.za | All Blacks could play in December as NZR explores all options By www.sport24.co.za Published On :: Sat, 09 May 2020 18:44:39 +0200 NZ Rugby CEO Mark Robinson says there is still no clarity on the prospects for Test rugby in 2020, but said they will explore every avenue. Full Article
z The Simplest Hack to Be Your Most Organized Self By feedproxy.google.com Published On :: Wed, 06 May 2020 12:30:19 +0000 Finding a good system to be organized can be intimidating. There are so many options! Useful tips on how to get your life together are all over the internet. From minimalist planners to detailed systems, something is bound to draw you in. Choosing the best system to use will be the biggest decision you’ll have […] The post The Simplest Hack to Be Your Most Organized Self appeared first on Dumb Little Man. Full Article Lifehacks Productivity
z Dear Amazon, We’re Breaking Up. It’s Not Me. It’s You. By feedproxy.google.com Published On :: Tue, 21 Apr 2020 10:00:00 +0000 Hi, Amazon. We’ve had a long history, ever since I ordered those first books and DVDs to be delivered to my college mailbox. You indulged my whims, from paleo cooking to crocheting, and you deposited a solid amount of cash in my bank account at the end of every month. Not to mention that fat … Dear Amazon, We’re Breaking Up. It’s Not Me. It’s You. Read More » The post Dear Amazon, We’re Breaking Up. It’s Not Me. It’s You. appeared first on Adventurous Kate. Full Article Blog Travel Blogging
z EIT Elsewhere | “Time Out: San José” in Delta Sky Magazine By everintransit.com Published On :: Thu, 03 Oct 2019 00:10:06 +0000 I was excited to finally get the word that an article I wrote sharing my love for my hometown – San Jose, California – is out in Delta Sky Magazine this month! Time Out: San José (Are you flying Delta this month? If so, pick up a copy for me! I’d love to see it […] The article EIT Elsewhere | “Time Out: San José” in Delta Sky Magazine originated at EverInTransit.com Full Article California EIT Elsewhere San Francisco Bay Area San Jose
z Working remotely builds organizational resiliency By feedproxy.google.com Published On :: Fri, 27 Mar 2020 14:37:37 +0000 For many, moving from everyone’s-working-from-the-office to everyone’s-working-at-home isn’t so much a transition as it is a scramble. A very how the fuck? moment. That’s natural. And people need time to figure it out. So if you’re in a leadership position, bake in time. You can’t expect people to hit the ground running when everything’s different.… keep reading Full Article Uncategorized
z Take Prof Regan's food quiz By www.bbc.co.uk Published On :: 2008-02-26T16:20:00 Part of the Food for thought promo for the BBC UK Homepage Full Article
z A Sandwich, A Wallet, and Elizabeth Taylor's Cousin By feedproxy.google.com Published On :: Thu, 04 Nov 2010 22:31:36 +0000 Being a Parable for the Edification of Independents Seeking Independence THE PARABLE THE OSTENSIBLE CUSTOMER enters a deli and saunters up to the counter. The deli is tended by its rakishly handsome owner, THE SANDWICH GUY. "Hi," says The Sandwich Guy. "What looks good to you today?" "Slow down," says The Ostensible Customer, as THE LUNCH RUSH starts trickling in. "Lots of delis want my business, so, first I need to really understand what you can do for me." "Well," says The Sandwich Guy, "I guess I can try to do what I do for everybody here and make you a customized version of any of the 15 awesome sandwiches you see on my menu. What're you hungry for?" "Easy, easy, Ricky Roma! Before I make any decisions here I'm going to need to know a lot more about my options. Why are you so obsessed with 'what I want?'" "Okay, sorry," says The Sandwich Guy, uneasily eyeing the growing queue of The Lunch Rush now piling up behind The Ostensible Customer. "What else can I do to help here?" "That's better," says The Ostensible Customer. "Let's start by sitting down for a couple hours and going over all the ingredients you have back there." The Sandwich Guy laughs congenially and hands The Ostensible Customer a menu. "Friend, I can make you whatever you want, but, if it helps, the 15 sandwiches listed here show all the ingredients--right there between the name and the price..." "Whoa, whoa, whoa! The price?!? Already you're reaching for my wallet? Jeez, I barely just arrived." The Lunch Rush is getting restless and grumbling audibly. "Well. You know. I do sell sandwiches for a living," says The Sandwich Guy. "Did you have a certain budget in mind for your lunch?" "Oh, God, no. I'm nowhere near that point yet. I still need to learn a lot more about how you work, and so, obviously, I have no idea what I want to pay. Obviously." "Okay," says The Sandwich Guy, "but...I can't do much for you here without knowing either what you want to eat or how much money you want to spend. You get that, right?" The Ostensible Customer is miffed. "Listen, here. What I 'get,' so-called Sandwich Guy, is that you're not going to rush me into some tricky lifetime sandwich commitment until I understand precisely who I'm working with. And, so far, I do not like what I see. Still. I intend to find out more. So, meet me in Canada tomorrow to talk about this for an hour." The Lunch Rush begins waving their wallets as they lob their completed order forms at The Sandwich Guy's face. "Sorry," says The Sandwich Guy. "I can't do that. How about I just make you a Reuben. It's really good, it's our most popular sandwich, and it only costs eight bucks." "WHAT! EIGHT DOLLARS! 'Dollars' with a 'd?' That's way too much!" "I thought you didn't have a budget," says The Sandwich Guy. "Well, I don't. And, besides, I don't really 'need' a sandwich at all. Now, kindly fly to Canada." "That's not going to happen, sir." "Also," says The Ostensible Customer, "if I do decide to get a sandwich from you--and it's looking increasingly less likely that I will--I'll absolutely expect your deeply discounted price to reflect the fact that I'm not particularly hungry right now." The Lunch Rush begins lighting torches and chanting a guttural chant, not unlike the haunting overtone singing of Tuvan herdsmen. "Look," sighs The Sandwich Guy, "it sounds like you need a little more time. Here's a free Coke and a complimentary bowl of pickles. Please have a seat, take all the time you need, then just come on up whenever you're ready to order, okay?" "‘READY?!?’ TO...‘ORDER?!?’ Are you out of your mind?" "Mmmm...apparently." Presently, The Ostensible Customer turns beet-red. "This is an outrage! I can't even imagine how you stay in business when you treat your customers like this." The Lunch Rush grows silent as The Sandwich Guy slowly leans over the counter and smiles--his nose one slice of corned beef from The Ostensible Customer's nose. "Sir. First off: you aren't my customer yet. Right now, you're just some dude holding a bowl of free pickles." "Buh?" fumbled The Ostensible Customer. "And, second, the way I 'stay in business' is by making great sandwiches and having as few conversations like the one we're having as possible," The Sandwich Guy coos. "Because, the truth is, my real customers are actually all those nice people standing behind you. They're the people who buy my sandwiches with real money over and over again. I really like them, and so I give them almost all of my attention." The Sandwich Guy waves at The Lunch Rush. The Lunch Rush waves back. The Ostensible Customer looks stunned. "Sir," says The Sandwich Guy "enjoy your Coke and your pickles with my compliments. But, please step aside. Because right now, there's a whole bunch of hungry people trying to buy sandwiches that won't require me flying to Canada. Next, please!" The Lunch Rush roars approval. The Ostensible Customer is still stunned. Which is unfortunate. Because, several men from the back of the line spontaneously rush forward to drag The Ostensible Customer, screaming and grasping, onto the busy sidewalk outside, where they proceed to devour his flesh like those street urchins who eat Elizabeth Taylor's cousin in Suddenly, Last Summer. Meanwhile, The Sandwich Guy goes back to making sandwiches. And, The Lunch Rush goes back to eating them. THE MORAL(S)? The Sandwich Guy can't do much for you until you're hungry enough to really want a sandwich. Once you're hungry enough, you still have to pay money for the sandwich. This won't not come up. Few people become "a good customer" without understanding both 1 and 2. Few companies become "a smart business" without understanding 1, 2, and 3. Basing his business on an understanding of 1, 2, 3, 4, and 5 doesn't make The Sandwich Guy a dick; it makes him a smart business. If you vacation with Elizabeth Taylor? Seriously. Avoid provoking the cannibalistic rent boys. THE HOPE Me? I just very much hope it takes you far less than 15 years to see and accept these sorts of things. Both as a customer and as a business. Guys, avoid working for anyone who's not hungry enough to compensate you for your sandwich. It literally doesn't pay. THE RESERVE READING Bloodhounding Budgets - Cognition: The blog of web design & development firm Happy Cog Tell them nicely that your price is a sucky $200K. The key here is to do so candidly, like you’re sitting on their side of the table and have to approve the budget with them. Admit that you’re way over the mark, and essentially apologize for it. I’ve said, “If you want to tell us to get lost, we understand”. Basement.org: Negotiation And Speculation: The Risk Of Selling Low All those variables can change except your worth. That can’t change. It’s an undeniable fact beyond subjectivity and beyond the reality-bending rhetoric of your client-to-be. You are worth what you are worth and unless you’re feeling charitable something else has to give. Project Budgets and Secrets (thedesigncubicle.com) Within the first few minutes of contact — in my effort to be as open and detailed on how I work as possible — the client counteracted by lying about not having a budget to clearly having a budget. Mule Design Studio’s Blog: Presenting Design Like You Get Paid For It Unspoken expectations unmet lead to seething unspoken frustration which ultimately bursts forth in an ugly mess when you’ve run out of budget. Don’t Be Afraid of the S-Word :: Tips :: The 99 Percent Remember that client who said that we were “pretty expensive” for them? A qualifying question in the first phone call could have saved us many hours of working on this deal. If you decide that the deal is unqualified, you just save it under another bucket: the unqualified deals bucket. ”A Sandwich, A Wallet, and Elizabeth Taylor's Cousin” was written by Merlin Mann for 43Folders.com and was originally posted on November 04, 2010. Except as noted, it's ©2010 Merlin Mann and licensed for reuse under CC BY-NC-ND 3.0. "Why a footer?" Full Article Business Freelancers Independence Money S
z VIDEO: AG Barr criticizes Mueller’s handling of Steele dossier By dennismichaellynch.com Published On :: Sat, 09 May 2020 15:50:00 +0000 The DML News App offers the best in news reporting. The post VIDEO: AG Barr criticizes Mueller’s handling of Steele dossier appeared first on Dennis Michael Lynch. Full Article News Feed Powered by DMLNewsApp.com
z REPORT: Governor criticized over highest nursing home death toll By dennismichaellynch.com Published On :: Sat, 09 May 2020 16:34:32 +0000 The DML News App offers the best in news reporting. The post REPORT: Governor criticized over highest nursing home death toll appeared first on Dennis Michael Lynch. Full Article News Feed Powered by DMLNewsApp.com
z BREAKING: FDA issues emergency authorization for first coronavirus antigen test By dennismichaellynch.com Published On :: Sat, 09 May 2020 17:05:45 +0000 The DML News App offers the best in news reporting. The post BREAKING: FDA issues emergency authorization for first coronavirus antigen test appeared first on Dennis Michael Lynch. Full Article News Feed Powered by DMLNewsApp.com
z BREAKING: CBS News Allegedly Staged Fake COVID19 Testing In MI…Makes Dem Gov Whitmer Look Like She’s Doing More To Help Citizens Than Fed Government [VIDEO] By 100percentfedup.com Published On :: Wed, 06 May 2020 15:57:46 +0000 The following article, BREAKING: CBS News Allegedly Staged Fake COVID19 Testing In MI…Makes Dem Gov Whitmer Look Like She’s Doing More To Help Citizens Than Fed Government [VIDEO], was first published on 100PercentFedUp.com. Project Veritas founder James O’Keefe has done it again. He’s uncovered yet another deceitful piece of coverage on the Wuhan coronavirus pandemic in America by CBS News. O’Keefe begins his interview with a man whose identity is being hidden, “You’re telling me—you’re 100% certain, that CBS News, CBS News Corporation national—staged a fake event. They […] Continue reading: BREAKING: CBS News Allegedly Staged Fake COVID19 Testing In MI…Makes Dem Gov Whitmer Look Like She’s Doing More To Help Citizens Than Fed Government [VIDEO] ... Full Article Featured Left News Political Correctness Politics
z BREAKING: Sen Marsha Blackburn Introduces Stop COVID Act…Allowing US Citizens To Sue Communist China For Damage They’ve Inflicted On Our Nation By 100percentfedup.com Published On :: Wed, 06 May 2020 16:56:18 +0000 The following article, BREAKING: Sen Marsha Blackburn Introduces Stop COVID Act…Allowing US Citizens To Sue Communist China For Damage They’ve Inflicted On Our Nation, was first published on 100PercentFedUp.com. Yesterday, Senator Marsha Blackburn (R-TN), along with Senator Martha McSally (R-AZ) introduced the Stop COVID Act, giving Americans the ability to sue Communist China for the damage they’ve inflicted on our nation. Senator Blackburn appeared on Fox News with host Judge Jeanine where she explained the act to Jeanine Pirro. Blackburn told the Fox News […] Continue reading: BREAKING: Sen Marsha Blackburn Introduces Stop COVID Act…Allowing US Citizens To Sue Communist China For Damage They’ve Inflicted On Our Nation ... Full Article Featured Politics
z Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters By 100percentfedup.com Published On :: Wed, 06 May 2020 22:43:02 +0000 The following article, Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters, was first published on 100PercentFedUp.com. The media and even some governors are trying to paint the Americans who are protesting to open businesses up as racists and even Nazis. The Governor of Michigan recently made a derogatory statement about the protesters implying they are racists. Painting a negative picture of the people who want their freedom and businesses demonizes our […] Continue reading: Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters ... Full Article Featured Left News Political Correctness Politics
z Busted! Late-Night Hack Comedian, Jimmy Kimmel Is Forced To Apologize For Sharing Highly Edited Video Of VP Pence To Make Him Look Bad By 100percentfedup.com Published On :: Sat, 09 May 2020 01:45:58 +0000 The following article, Busted! Late-Night Hack Comedian, Jimmy Kimmel Is Forced To Apologize For Sharing Highly Edited Video Of VP Pence To Make Him Look Bad, was first published on 100PercentFedUp.com. Last night, Jimmy Kimmel, host of the low-rated, late-night Jimmy Kimmel Show, shared a deceptively edited video clip of Vice President Pence delivering PPE to a nursing home. Today, liberal activist Matt McDermott tweeted the videotaped segment on VP Pence that was edited to make the vice president look like he was faking a delivery […] Continue reading: Busted! Late-Night Hack Comedian, Jimmy Kimmel Is Forced To Apologize For Sharing Highly Edited Video Of VP Pence To Make Him Look Bad ... Full Article Featured Politics
z Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut By 100percentfedup.com Published On :: Sat, 09 May 2020 13:19:16 +0000 The following article, Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut, was first published on 100PercentFedUp.com. When Dallas, Texas salon owner Shelley Luther opened her salon in defiance of the lockdown order in Texas, she was visited numerous times by the local police and then sentenced to 7 days in jail with a fine of $7,000. After public outrage at her punishment, the Texas Supreme Court stepped in to demand her […] Continue reading: Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut ... Full Article Breaking Featured Government News Politics
z 'Quaranscream': Wine spritzer company opens Mother's Day venting hotline By www.ctvnews.ca Published On :: Sat, 9 May 2020 08:12:00 -0600 A beverage company in the U.S. is inviting moms to let out a ‘quaranscream’ this Mother’s Day on a designated ‘zero-judgement venting hotline’ for a chance to win its wine spritzers. Full Article
z The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3 [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC. Full Article
z Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Prostate cancer (PCa) cells heavily rely on an active androgen receptor (AR) pathway for their survival. Enzalutamide (MDV3100) is a second-generation antiandrogenic drug that was approved by the Food and Drug Administration in 2012 to treat patients with castration-resistant prostate cancer (CRPC). However, emergence of resistance against this drug is inevitable, and it has been a major challenge to develop interventions that help manage enzalutamide-resistant CRPC. Erythropoietin-producing human hepatocellular (Eph) receptors are targeted by ephrin protein ligands and have a broad range of functions. Increasing evidence indicates that this signaling pathway plays an important role in tumorigenesis. Overexpression of EPH receptor B4 (EPHB4) has been observed in multiple types of cancer, being closely associated with proliferation, invasion, and metastasis of tumors. Here, using RNA-Seq analyses of clinical and preclinical samples, along with several biochemical and molecular methods, we report that enzalutamide-resistant PCa requires an active EPHB4 pathway that supports drug resistance of this tumor type. Using a small kinase inhibitor and RNAi-based gene silencing to disrupt EPHB4 activity, we found that these disruptions re-sensitize enzalutamide-resistant PCa to the drug both in vitro and in vivo. Mechanistically, we found that EPHB4 stimulates the AR by inducing proto-oncogene c-Myc (c-Myc) expression. Taken together, these results provide critical insight into the mechanism of enzalutamide resistance in PCa, potentially offering a therapeutic avenue for enhancing the efficacy of enzalutamide to better manage this common malignancy. Full Article
z Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3 [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies. Full Article
z Zinc promotes liquid-liquid phase separation of tau protein [Protein Structure and Folding] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Tau is a microtubule-associated protein that plays a major role in Alzheimer's disease (AD) and other tauopathies. Recent reports indicate that, in the presence of crowding agents, tau can undergo liquid–liquid phase separation (LLPS), forming highly dynamic liquid droplets. Here, using recombinantly expressed proteins, turbidimetry, fluorescence microscopy imaging, and fluorescence recovery after photobleaching (FRAP) assays, we show that the divalent transition metal zinc strongly promotes this process, shifting the equilibrium phase boundary to lower protein or crowding agent concentrations. We observed no tau LLPS-promoting effect for any other divalent transition metal ions tested, including Mn2+, Fe2+, Co2+, Ni2+, and Cu2+. We also demonstrate that multiple zinc-binding sites on tau are involved in the LLPS-promoting effect and provide insights into the mechanism of this process. Zinc concentration is highly elevated in AD brains, and this metal ion is believed to be an important player in the pathogenesis of this disease. Thus, the present findings bring a new dimension to understanding the relationship between zinc homeostasis and the pathogenic process in AD and related neurodegenerative disorders. Full Article
z Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid [Microbiology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Interferon-regulated myxovirus resistance protein B (MxB) is an interferon-induced GTPase belonging to the dynamin superfamily. It inhibits infection with a wide range of different viruses, including HIV-1, by impairing viral DNA entry into the nucleus. Unlike the related antiviral GTPase MxA, MxB possesses an N-terminal region that contains a nuclear localization signal and is crucial for inhibiting HIV-1. Because MxB previously has been shown to reside in both the nuclear envelope and the cytoplasm, here we used bioinformatics and biochemical approaches to identify a nuclear export signal (NES) responsible for MxB's cytoplasmic location. Using the online computational tool LocNES (Locating Nuclear Export Signals or NESs), we identified five putative NES candidates in MxB and investigated whether their deletion caused nuclear localization of MxB. Our results revealed that none of the five deletion variants relocates to the nucleus, suggesting that these five predicted NES sequences do not confer NES activity. Interestingly, deletion of one sequence, encompassing amino acids 505–527, abrogated the anti-HIV-1 activity of MxB. Further mutation experiments disclosed that amino acids 515–519, and Pro-515 in particular, regulate MxB oligomerization and its binding to HIV-1 capsid, thereby playing an important role in MxB-mediated restriction of HIV-1 infection. In summary, our results indicate that none of the five predicted NES sequences in MxB appears to be required for its nuclear export. Our findings also reveal several residues in MxB, including Pro-515, critical for its oligomerization and anti-HIV-1 function. Full Article
z Reactive dicarbonyl compounds cause Calcitonin Gene-Related Peptide release and synergize with inflammatory conditions in mouse skin and peritoneum [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease. Full Article
z Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC. Full Article
z Webinar: Federalism in a Fragmented State: Rethinking Decentralization in Yemen By feedproxy.google.com Published On :: Tue, 07 Apr 2020 11:40:01 +0000 Research Event 15 April 2020 - 1:00pm to 2:00pm Event participants Osamah Al Rawhani, Deputy Director, Sana’a Center for Strategic StudiesModerator: Nadim Houry, Executive Director, Arab Reform Initiative Yemen suffered from the excessive control of the central government prior to the current conflict. Federalism has been put forward by many Yemeni political parties since the National Dialogue Conference (NDC) as the supposed magic cure for this significant problem. Today, Yemen is more fragmented than ever, its state central institutions have been scattered and lack leadership and the state has lost most of its sovereignty. The prevailing narrative that decentralization through federalism is Yemen’s inevitable path post-conflict often fails to acknowledge that there are prerequisites for effective local governance, beyond political will. In a recent article, Osamah Al Rawhani addressed how the weakness of central state institutions is the key challenge to proceeding with federalism in Yemen and highlighted prerequisites and contextual factors that need to be addressed before reforming the structure of the state. He argued that the viability of decentralization relies on the presence of a functioning, representative central government that is capable of devolving power but also able to keep the state from further fragmentation. In this webinar, part of the Chatham House project on The Future of the State in the Middle East and North Africa, the article’s author will discuss recent developments in Yemen, where shifting frontlines and regional divisions are fragmenting the country in new ways. The speaker will explore alternative approaches to pursue the path of federalism that recognize the current realities and the critical need for strong central institutions. He will also survey the internal and external factors that must be considered to rebuild a stable state in Yemen.You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page. Department/project Middle East and North Africa Programme, The Future of the State in the Middle East Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
z COVID-19 Crisis – Business as Usual for Gaza? By feedproxy.google.com Published On :: Wed, 06 May 2020 14:48:14 +0000 6 May 2020 Mohammed Abdalfatah Asfari Foundation Academy Fellow @mhalabi258 LinkedIn The COVID-19 pandemic has brought unprecedented challenges, economic collapse and strict lockdowns in many parts of the world. For the people of Gaza, this reality is nothing new. 2020-05-06-covid-19-gaza.jpg Palestinians light fireworks above the rubble during the Muslim holy month of Ramadan amid concerns about the spread of the coronavirus disease (COVID-19), in Gaza City , 30 April 2020. Photo by Majdi Fathi/NurPhoto via Getty Images. In August 2012, when the UN released its report Gaza in 2020: A liveable place?, they could not have imagined what the world would look like in 2020: cities under lockdown, restrictions on movement, border closures, widespread unemployment, economic collapse, fear and anxiety and, above all, uncertainty about what the future holds.For Gaza’s population of 2 million people this reality is nothing new. The conditions that the rest of the world are currently experiencing as a result of the COVID-19 pandemic is similar to the tight blockade Gaza has been living under ever since Hamas took over in 2007. Israel has imposed severe restrictions on the movement of people and goods, youth unemployment has reached 60 per cent, and over 80 per cent of Gaza’s population are now dependent on international aid.The people of Gaza are having to face the COVID-19 crisis already at a disadvantage, with poor infrastructure, limited resources and a shortage of the most basic services, such as water and power supply. It also has a fragile health system, with hospitals lacking essential medical supplies and equipment, as well as the capacity to deal with the outbreak as there are only 84 ICU beds and ventilators available. Meanwhile, intra-Palestinian divisions have persisted and were evident in the initial reaction to the pandemic. When President Mahmoud Abbas announced a state of emergency, it took two days for the Hamas-led government in Gaza to follow suit and shut down schools and universities. They later made a separate emergency appeal to address the crisis and prepare for a COVID-19 response in Gaza. This lack of coordination is typical of the way the Palestinian Authority and Hamas approach crisis situations.After the initial uncoordinated response, Hamas, as the de-facto ruler of Gaza, has asserted its ability to control Gaza’s borders by putting in place quarantine measures for everyone who enters the strip, whether through the Erez checkpoint with Israel or the Rafah border with Egypt. They have also assigned 21 hospitals, hotels, and schools as compulsory quarantine centres for all arrivals from abroad, who have to stay in quarantine for 21 days. In comparison, there are 20 quarantine centres in the West Bank. These strict measures have prevented the spread of the virus in the community and confined it to the quarantine centres, with only 20 confirmed cases of COVID-19 as of 6 May. Gaza’s de-facto authorities have also been able to monitor markets and prices to ensure the availability of essential goods.Faced with a major crisis, Al-Qassam Brigades – the armed wing of Hamas – have tried to play the role of a national army by participating in efforts to fight the pandemic. They have relatively good logistical capacity and have contributed to the construction of two quarantine facilities with a total capacity of 1,000 units to prepare for more arrivals into Gaza. At the local level, municipalities have been disinfecting public spaces and facilities in addition to disseminating information about the virus and related preventative and protective measures. Other precautionary measures put in place include closing the weekly open markets, and restricting social gatherings like weddings and funerals.Despite COVID-19, it’s business as usual when it comes to international dealings with Gaza. The key parties in the conflict – Israel, Hamas and the Palestinian Authority – along with the main external actors – Egypt, the United Nations and Qatar – have continued to stick to their policies aimed at keeping the security situation under control and preventing further escalation. Although Israel has allowed entry of pharmaceutical supplies and medical equipment into Gaza during the pandemic, it has kept its restrictions on the movement of goods and people in place, while keeping a close eye on the development of the COVID-19 outbreak in Gaza – a major outbreak here would be a nightmare scenario for Israel.Meanwhile, Qatar has continued to address the humanitarian and economic needs of Gaza in an attempt to ease the pressure and prevent further escalation. It has pledged $150 million over the next six months to help families in Gaza from poorer backgrounds. Gaza has also been discussed by the Middle East Quartet, as Nickolay Mladenov, the UN special coordinator for the Middle East Peace Process, expressed his concern about the risk of a disease outbreak in Gaza during a call with the members of the Quartet.Amid the pandemic, threats are still being exchanged between Israel and Hamas. The Israeli defence minister, Naftali Bennett, requested that in return for providing humanitarian aid to Gaza, Hamas agrees to return the remains of two Israeli soldiers killed in the 2014 war. While openly rejecting Bennett's statement, the leader of Hamas in Gaza, Yahya Sinwar, has offered to move forward with a prisoner swap deal if Israel agrees to release elderly prisoners and detainees in addition to detained women and children. Though dealing with its own COVID-19 outbreak, Egypt has started to mediate between the two parties in an attempt to stabilize the situation and reach a prisoner swap deal.In the wake of this pandemic, lessons should be learned and policies should be examined, by all parties. Firstly, Israel should re-evaluate its security measures towards Gaza by easing restrictions on movement and trade which would have a positive impact on living conditions for Gaza’s population. The current measures have proven to be unsustainable and have contributed to the endless cycle of violence. Secondly, the intra-Palestinian division should end, to save Palestinians from contradictory policies and insufficient capacity on both sides. In fact, all previous attempts have failed to end this self-destructive division and this is due to the absence of political will on both sides. Elections seem to be the only viable path towards unity. Finally, efforts by the international community should go beyond stabilizing the security situation and ongoing crisis inside Gaza, where disruption of normal life is the norm.While the world has reacted to this pandemic with a whole host of new policies and emergency measures, it has remained business as usual when dealing with Gaza. Should COVID-19 spread in Gaza, its people – who have already paid the price of a continuous blockade and intra-Palestinian division for 13 years – will pay a heavy price yet again. However, this time it is not a crisis that they alone will have to face. Full Article
z Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase [Metabolism] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications. Full Article
z Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid [Microbiology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Interferon-regulated myxovirus resistance protein B (MxB) is an interferon-induced GTPase belonging to the dynamin superfamily. It inhibits infection with a wide range of different viruses, including HIV-1, by impairing viral DNA entry into the nucleus. Unlike the related antiviral GTPase MxA, MxB possesses an N-terminal region that contains a nuclear localization signal and is crucial for inhibiting HIV-1. Because MxB previously has been shown to reside in both the nuclear envelope and the cytoplasm, here we used bioinformatics and biochemical approaches to identify a nuclear export signal (NES) responsible for MxB's cytoplasmic location. Using the online computational tool LocNES (Locating Nuclear Export Signals or NESs), we identified five putative NES candidates in MxB and investigated whether their deletion caused nuclear localization of MxB. Our results revealed that none of the five deletion variants relocates to the nucleus, suggesting that these five predicted NES sequences do not confer NES activity. Interestingly, deletion of one sequence, encompassing amino acids 505–527, abrogated the anti-HIV-1 activity of MxB. Further mutation experiments disclosed that amino acids 515–519, and Pro-515 in particular, regulate MxB oligomerization and its binding to HIV-1 capsid, thereby playing an important role in MxB-mediated restriction of HIV-1 infection. In summary, our results indicate that none of the five predicted NES sequences in MxB appears to be required for its nuclear export. Our findings also reveal several residues in MxB, including Pro-515, critical for its oligomerization and anti-HIV-1 function. Full Article
z Chatham House Prize 2015 Nominees Announced By feedproxy.google.com Published On :: Wed, 15 Apr 2015 15:03:27 +0000 20 March 2015 Chatham House is pleased to announce the nominees for the 2015 Chatham House Prize. The nominees are: Mahamadou Issoufou, President of the Republic of NigerMédecins Sans FrontièresAngela Merkel, Chancellor of the Federal Republic of GermanyJuan Manuel Santos, President of the Republic of Colombia The Chatham House Prize is awarded to the person or organization deemed to have made the most significant contribution to the improvement of international relations in the previous year. The winner will be announced later this year and an award ceremony will take place in the autumn. More about the 2015 nominees About the Chatham House Prize The selection proceed for the nominees draws on the expertise of Chatham House's research teams and three presidents - Lord Ashdown, Sir John Major and Baroness Scotland. Our members are then invited to vote for the winner in a ballot. The winner will be announced later this year. The winner will receive a crystal award and a scroll signed by our Patron, Her Majesty the Queen. An award ceremony will take place in London with keynote speeches by leading figures in international affairs. Previous winners include: Melinda Gates (2014); Hillary Rodham Clinton, former US Secretary of State (2013); Sheikh Rached Ghannouchi, Head of the Ennahdha movement, Tunisia and Dr Moncef Marzouki, President of Tunisia (2012); Aung San Suu Kyi, Burmese democracy campaigner (2011); HE Abdullah Gül, President of Turkey (2010), HE President Luiz Inácio Lula da Silva of Brazil (2009), President John Kufuor of Ghana (2008), HH Sheikha Mozah, Chairperson, Qatar Foundation (2007), HE Joaquim Chissano, former President of Mozambique (2006) and HE President Victor Yushchenko of Ukraine (2005). More about the Prize and previous winners Full Article
z Médecins Sans Frontières (MSF) Awarded 2015 Chatham House Prize By feedproxy.google.com Published On :: Mon, 22 Jun 2015 09:04:35 +0000 13 October 2015 Médecins Sans Frontières, the medical humanitarian organization, has been awarded the Chatham House Prize 2015 for its life-saving work in combating the outbreak of Ebola in West Africa. CHP15MSF.jpg Médecins Sans Frontières (MSF) has been awarded the Chatham House Prize 2015.The Chatham House Prize is presented annually to the person or organization deemed by members of the Royal Institute of International Affairs to have made the most significant contribution to the improvement of international relations in the previous year.This year, members voted for MSF in recognition of its work in combating the 2014 Ebola outbreak in West Africa. MSF was among the first groups to respond to the epidemic in March of that year and remained engaged on the ground throughout the crisis, caring for the majority of patients in Liberia, Guinea and Sierra Leone. MSF leaders and staff were persistent and forceful in their action to halt the spread of the epidemic and, as a result, were instrumental in saving thousands of lives. Dr Joanne Liu, MSF’s international president, will represent MSF at the Chatham House Prize award ceremony in London where she will be presented with a crystal award and a scroll, signed by Her Majesty The Queen, patron of the institute. Previous recipients of the Prize include former president Lula of Brazil, Burmese democracy campaigner Aung San Suu Kyi, former US secretary of state Hillary Clinton, and Melinda Gates, co-founder of the Bill and Melinda Gates Foundation.Dr Robin Niblett CMG, director of Chatham House, said: 'I warmly congratulate Médecins Sans Frontières on being voted the recipient of this year's Chatham House Prize. This is the first time an organization has been awarded the Prize and I am delighted that their vital work has been recognized in this way. MSF led the fight against Ebola by sounding an early alarm on its dangers. It put into place a highly effective operation that saved thousands of lives, and helped prevent a more wide-spread catastrophe, risking and, in some cases, losing the lives of its own staff.'Dr Joanne Liu, international president of MSF said:'I am honoured that MSF will be the recipient of this year’s Chatham House Prize and I look forward to accepting this award on behalf of the thousands of people who worked in the Ebola outbreak. This includes the doctors, nurses and logisticians who volunteered from around the world, and the thousands more national staff in Guinea, Liberia, Mali, Nigeria and Sierra Leone who made our work possible. Knowing that they did this while coping with the fear of Ebola in their communities and in the face of incredible stigma makes their contribution even more remarkable. While we continue to work on the ground, our focus is also trying to ensure that next time there is an outbreak, that patients get the care and treatment they need, on time, before it spreads and turns into a killer epidemic. But we all still have a long way to go and it is important that we work together to respond to these challenges and opportunities.'Members EventChatham House Prize 2015: In Conversation with Dr Joanne Liu of Médecins Sans Frontières13 October 2015 - 17:00 - 18:00SponsorsChatham House gratefully acknowledges the support of our lead sponsor Royal Dutch Shell, and other sponsors AIG, BHP Billiton, Chevron and DTCC.NomineesThere were three other nominees for the Chatham House Prize 2015:Mahamadou Issoufou, President, Republic of Niger (2011-) Juan Manuel Santos, President, Republic of Colombia (2010-)Angela Merkel, Chancellor, Federal Republic of Germany (2005-)About the Chatham House PrizeThe annual Chatham House Prize, launched in 2005, is awarded to the person or organization that is deemed by Chatham House members to have made the most significant contribution to the improvement of international relations in the previous year.The selection process draws on the expertise of Chatham House's research teams and three presidents, who nominate candidates. Our members are then invited to vote for the winner in a ballot.Further information about the Chatham House Prize Related pages Chatham House Prize Full Article
z Eliza Manningham-Buller Appointed as Co-President of Chatham House By feedproxy.google.com Published On :: Tue, 21 Jul 2015 13:10:28 +0000 22 July 2015 Manningham-BullerElizahz1.jpg Eliza Manningham-Buller is confirmed as a president of Chatham House replacing Paddy Ashdown who steps down after 10 years.The appointment of Baroness Manningham-Buller as a president of Chatham House was confirmed at the institute’s annual general meeting on Tuesday 21 July. Baroness Manningham-Buller joins Sir John Major and Baroness Scotland of Asthal as a co-president and succeeds Lord Ashdown of Norton-sub-Hamdon who has stepped down from the role after two terms.Eliza Manningham-Buller was director-general of the UK Security Service (MI5) between 2002 and 2007 and became an independent life peer in 2008. She served as Chairman of Imperial College London from 2011 to 2015. She brings to Chatham House an extensive knowledge of and experience in international security as well as a deep interest in medical research and global health, having served as a member of the Board of Governors of the Wellcome Trust since 2008. In October 2015, Baroness Mannigham-Buller will become Chairman of the Trust’s Board of Governors.Paddy Ashdown steps down after serving as a president for 10 years alongside Sir John Major, Patricia Scotland and their predecessors Lord Hurd of Westwell and Lord Robertson of Port Ellen, respectively. Over that period, the institute benefitted enormously from his extensive experience in international politics and conflict resolution, including as High Representative for Bosnia and Herzegovina from 2002 to 2006.Dr Robin Niblett, director of Chatham House, said:'I am delighted to welcome Elizabeth Manningham-Buller as a president of Chatham House. Throughout her career, she has brought deep knowledge, careful analysis and sound judgement to bear upon some of the most difficult dimensions of public policy. The institute will benefit greatly from these qualities as it draws on her engagement with Chatham House over the coming years.I would like to pay tribute to Paddy Ashdown for his long-standing support of Chatham House. His contributions to our substantive debates, both internally and externally, have been invaluable on numerous occasions, and we look forward to his continued involvement with the institute as a member of our Panel of Senior Advisers.'Baroness Manningham-Buller said:“I am delighted to be elected as a Chatham House president at this important time in the institute’s history, as it grapples with a complex and inter-connected agenda of policy challenges. I look forward to working with John Major and Patricia Scotland in supporting Chatham House and its valuable and necessary work. Editor's notes A president’s term at Chatham House is for five years, renewable once. There are no governance responsibilities, which reside solely with the institute’s Council.Chatham House’s three presidents underpin the institute’s independent, non-partisan voice on international affairs. The presidents confirm, through their experiences at the highest levels of government and diplomacy, the connection between Chatham House and policy-makers. Full Article
z Chatham House Prize 2016 Nominees Announced By feedproxy.google.com Published On :: Tue, 05 Apr 2016 15:36:14 +0000 5 April 2016 Chatham House is pleased to announce the nominees for the 2016 Chatham House Prize. CHP13-0644.jpg The nominees are:Laurent Fabius & Christiana Figueres: nominated for their pivotal role in delivering a global climate agreement at the COP 21 meeting in Paris in December 2015.Attahiru Muhammadu Jega: nominated for his professionalism, determination and integrity as chairman of Nigeria’s electoral commission, which, in 2015, ensured the conduct of Nigeria’s most credible election since the country’s return to civilian rule in 1999.John Kerry & Mohammad Javad Zarif: nominated for their crucial roles, throughout 2015, in successfully negotiating the historic nuclear deal between Iran and the P5+1.The Chatham House Prize is awarded to the person, persons or organization deemed to have made the most significant contribution to the improvement of international relations in the previous year.The winner will be announced later this year and an award ceremony will take place in the autumn.More about the 2016 nomineesMore about the Prize and previous winners Full Article
z John Kerry and Mohammad Javad Zarif named winners of the Chatham House Prize 2016 By feedproxy.google.com Published On :: Mon, 24 Oct 2016 12:40:51 +0000 24 October 2016 US Secretary of State John Kerry and Iranian Minister of Foreign Affairs Dr Mohammad Javad Zarif have been voted as the winners of this year’s Chatham House Prize. 2016-CHPrize-Kerry-ZarifA.jpg The Chatham House Prize is presented annually to the person, persons or organization deemed by members of the Royal Institute of International Affairs to have made the most significant contribution to the improvement of international relations in the previous year.This year, members voted for John Kerry and Mohammad Javad Zarif in recognition of their crucial roles, throughout 2015, in successfully negotiating the historic nuclear deal between Iran and the P5+1 – considered to be one of the most intractable diplomatic stand-offs in international affairs in the 21st century.The deal was one that many thought impossible. Overcoming enormous technical complexity, entrenched domestic opposition in the United States and Iran and three decades of intense hostility between their two countries, Kerry and Zarif’s leadership and commitment, in particular, were imperative to sustaining and driving the negotiations to their successful conclusion. With the vital participation of officials from other permanent members of the UN Security Council, Germany and the EU, they secured a deal, endorsed by the UN Security Council and more than 90 countries, which was a victory for diplomacy as well as against nuclear proliferation.EventsJohn Kerry at Chatham House: Chatham House Prize Presentation31 October 2016Mohammad Javad Zarif at Chatham House: Overcoming Regional Challenges in the Middle East4 February 2016NomineesThe nominees for the Chatham House Prize 2016 were:Laurent Fabius, Minister of Foreign Affairs, France (2012–16) and Christiana Figueres, Executive Secretary, UN Framework Convention Attahiru Muhammadu Jega, Chairman, Independent National Electoral Commission, Nigeria (2010–15)John Kerry, US Secretary of State and Dr Mohammad Javad Zarif, Iran’s Minister of Foreign AffairsAbout the Chatham House PrizeThe Chatham House Prize is presented to the person, persons or organization deemed by members of Chatham House to have made the most significant contribution to the improvement of international relations in the previous year.The selection process is independent, democratic and draws on the deep knowledge of Chatham House's research teams, making the Prize a distinctive and unique award in the field of international affairs.A short-list of nominees is selected by the institute's three presidents from a longer list submitted by the research programmes and departments in their areas of expertise. The recipient is then determined by Chatham House's broad membership base on a one-member, one-vote basis. The award is presented on behalf of the institute's patron, Her Majesty the Queen, representing the non-partisan and authoritative character of the Prize.The Chatham House Prize was launched in 2005. Previous recipients of the Prize include Burmese democracy campaigner Aung San Suu Kyi, Médecins Sans Frontières, former US Secretary of State Hillary Clinton, and Melinda Gates, co-founder of the Bill and Melinda Gates Foundation.For more information, please contact: Jenny Williams, Media Relations ManagerEmail: jwilliams@chathamhouse.orgPhone: +44 (0) 7921 867 626 Full Article
z Chatham House awarded Prospect magazine’s Think-Tank of the Year By feedproxy.google.com Published On :: Tue, 29 Nov 2016 10:11:18 +0000 29 November 2016 Chatham House named think-tank of the year at Prospect magazine’s annual think-tank awards. landscape Robin award.jpg Chatham House named Think-Tank of the Year. Photo: Visual Eye. Chatham House has been named Prospect magazine’s Think-Tank of the Year at a ceremony in the Houses of Parliament. The institute was also the winner in the UK categories for International Affairs and Energy and Environment. The quality, credibility and impact of Chatham House’s research was acknowledged for helping to create better understanding of key global phenomena at this critical time in world affairs. The judges commented that the institute’s work is ‘reliably excellent’ and a ‘gold standard of knowledge and professionalism’. Specifically, the US and the Americas and Asia programmes’ joint report Asia-Pacific Power Balance: Beyond the US-China Narrative, by Xenia Wickett, John Nilsson-Wright and Tim Summers, was singled out for being an important resource to help explain the developing geopolitical relationship between the United States and China.The Energy, Environment and Resources department’s livestock project was a major factor in their award in the Energy & Environment UK category, including the report Changing Climate, Changing Diets: Pathways to Lower Meat Consumption by Laura Wellesley, Antony Froggatt and Catherine Happer, which developed recommendations for how dietary change can be effected in different national and cultural contexts.Dr Robin Niblett, director of Chatham House said ‘The integrity and authority of Chatham House’s research is needed more than ever and I am extremely proud of our staff and their work particularly during this difficult and challenging year in world affairs’. Full Article
z Chatham House Prize 2017 Nominees Announced By feedproxy.google.com Published On :: Fri, 31 Mar 2017 10:35:44 +0000 3 April 2017 Chatham House is pleased to announce the nominees for the 2017 Chatham House Prize. CHP2017Nominees.jpg The Chatham House Prize is awarded to the person, persons or organization deemed to have made the most significant contribution to the improvement of international relations in the previous year.The nominees are:Charlotte Osei, Chairperson of the Electoral Commission of Ghana: nominated for ensuring a peaceful and transparent electoral process in Ghana in December 2016, further consolidating Ghana’s 24-year long democratic journey.Juan Manuel Santos, President of Colombia: nominated for formally ratifying a peace agreement with the FARC rebel group and bringing an end to the war in Colombia.Jens Stoltenberg, Secretary-General of NATO: nominated for steering NATO through one of the most complicated periods in its recent history.The winner will be announced later this year, and an award ceremony will take place in the autumn.More about the 2017 nomineesMore about the Prize and previous winners Full Article
z President Juan Manuel Santos named winner of the Chatham House Prize 2017 By feedproxy.google.com Published On :: Wed, 18 Oct 2017 10:29:49 +0000 19 October 2017 President Juan Manuel Santos of Colombia has been voted the winner of this year’s Chatham House Prize. SantosPrize2017.jpg The Chatham House Prize is presented annually to the person, persons or organization deemed by members of the Royal Institute of International Affairs to have made the most significant contribution to the improvement of international relations in the previous year.This year, members of the institute voted for President Juan Manuel Santos in recognition of his role in formally ratifying a peace agreement with the FARC rebel group and bringing an end to the armed conflict in Colombia.In 2016, after four years of negotiation, Juan Manuel Santos led the Colombian government in ratifying a peace agreement with the FARC. Success was by no means certain: after coming to a ceasefire and disarmament agreement in June, followed by a peace accord in September, Santos was forced to return to the drawing board with FARC negotiators after a referendum in October rejected the initial deal. But Santos persevered, drafting and signing a new deal that incorporated changes suggested by the No camp and was ratified by the Colombian congress on 24 November 2016.The deal ended one of the world’s longest running armed conflicts, during which 220,000 people were killed and 6 million displaced. This was a complex, sensitive and intense process which required exceptional political diplomacy and perseverance. Ultimately, his determination and commitment to peace guided the main parties and international partners to one of the biggest successes in brokering peace in modern history.NomineesThe nominees for the Chatham House Prize 2017 were:Charlotte Osei, Chairperson of the Electoral Commission of GhanaJuan Manuel Santos, President of ColombiaJens Stoltenberg, Secretary-General of NATOEventPresident Santos will be presented the award at an event in London on Thursday 9 November.About the Chatham House PrizeThe Chatham House Prize is presented to the person, persons or organization deemed by members of Chatham House to have made the most significant contribution to the improvement of international relations in the previous year.The selection process is independent, democratic and draws on the deep knowledge of Chatham House's research teams, making the Prize a distinctive and unique award in the field of international affairs.A short-list of nominees is selected by the institute's three presidents from a longer list submitted by the research programmes and departments in their areas of expertise. The recipient is then determined by Chatham House's broad membership base on a one-member, one-vote basis. The award is presented on behalf of the institute's patron, Her Majesty the Queen, representing the non-partisan and authoritative character of the Prize.The Chatham House Prize was launched in 2005. Previous recipients of the Prize include Burmese democracy campaigner Aung San Suu Kyi, Médecins Sans Frontières, former US Secretary of State Hillary Clinton, and Melinda Gates, co-founder of the Bill and Melinda Gates Foundation.For more information, please contact: Jenny Williams, Head of MediaEmail: jwilliams@chathamhouse.orgPhone: +44 (0) 207 314 3687 Full Article
z Queen Elizabeth II Academy for Leadership Announces 2018/19 Fellows By feedproxy.google.com Published On :: Mon, 24 Sep 2018 08:16:49 +0000 1 October 2018 The Queen Elizabeth II Academy for Leadership in International Affairs, based at Chatham House, is delighted to announce the arrival of its new cohort of Academy fellows. 2018-10-01-CH.jpg The Academy was launched by Her Majesty the Queen in November 2014 to offer potential and established leaders from around the world the opportunity to spend ten months as Academy fellows and develop the tools needed to address the major policy challenges and critical issues facing the world today.Academy fellows are drawn from government and the broader policy community, the private sector, media and civil society. During their time at the Academy, fellows deepen their understanding of critical issues, learn new skills, develop their networks and propose new ideas and solutions to complex policy challenges and opportunities.Dr Leslie Vinjamuri, Dean, QEII Academy for Leadership in International Affairs says:'Chatham House recognizes the need for inspirational and effective leadership in today’s complex and rapidly changing global environment. We remain absolutely committed to the mission of developing leadership skills and feel privileged to welcome the 2018-19 Academy Fellows. The Queen Elizabeth II Academy is uniquely well-positioned, drawing on the historical depth of expertise at Chatham House, our international and national networks, and the dynamism of London to develop skills, knowledge, and global insights that benefit emerging and accomplished leaders across diverse sectors in Europe, Africa, the Middle East, Asia and the Americas.'Academy Fellows 2018/19Rustam AnshbaRustam’s research will explore the prospects for transforming the Georgian-Abkhaz conflict. He will be hosted by the Russia and Eurasia Programme. His fellowship is supported by the Robert Bosch Stiftung.Rita DayoubRita will analyse attacks against healthcare systems during conflicts in Syria and South Sudan. She will be hosted by the Centre on Global Health Security. Her fellowship is supported by the Asfari Foundation.Isabel DunstanIsabel’s research will focus on digital literacy among women as a means to counter radicalization and intolerance in Indonesia. She will be hosted by the Asia-Pacific Programme. Her fellowship is supported by Mr Richard Hayden.Sophia IgnatidouSophia will examine the political and security implications of Artificial Intelligence. She will be hosted by the International Security Department. Her fellowship is supported by the Stavros Niarchos Foundation.Anna KorbutAnna’s research will examine the current media landscape in Ukraine and its transformative potential. She will be hosted by the Russia and Eurasia Programme. Her fellowship is supported by the Robert Bosch Stiftung.Damir KurtagicDamir will research the challenges and possibilities of private sector engagement in Sub-Saharan Africa. He will be hosted by the Africa Programme. His fellowship is supported by the Robert Bosch Stiftung.Zaki MehchyZaki will research the role and dynamics of non-state actors in Syria and their relationship with state institutions. He will be hosted by the Middle East and North Africa Programme. His fellowship is supported by the Asfari Foundation.Anne NyambaneAnne will examine the synergies and trade-offs involved in the implementation of the Sustainable Development Goals (SDGs). She will be hosted by the Energy, Environment and Resources Department. Her fellowship is supported by the Mo Ibrahim Foundation.MasterclassThe Academy is also pleased to welcome three Masterclass participants from the European Bank for Reconstruction and Development. Full Article
z The Committee to Protect Journalists named winner of the Chatham House Prize 2018 By feedproxy.google.com Published On :: Fri, 05 Oct 2018 10:53:06 +0000 8 October 2018 The Committee to Protect Journalists (CPJ) has been voted the winner of this year’s Chatham House Prize. 2018-10-08-CPJ5.png The Chatham House Prize is presented annually to the person, persons or organization deemed by members of the Royal Institute of International Affairs to have made the most significant contribution to the improvement of international relations in the previous year.The CPJ has been recognized for its efforts in defending the right of journalists to report the news without fear of reprisal, at a time when the free press is under serious pressure in many parts of the world.Highlights of the work of the CPJ during 2017 include the launch of the US Press Freedom Tracker documenting attacks on press freedom in the US and the launch of its Free the Press campaign to raise awareness of journalists imprisoned on anti-state charges around the world. In addition, last year its advocacy helped secure the early release from prison of at least 75 journalists worldwide and helped to win convictions in the murders of six reporters, including Marcos Hernández Bautista in Mexico and Syrian editor Naji Jerf, who was killed in Turkey.In a climate where the term ‘fake news’ is used to discredit much reporting, the CPJ has robustly supported the fourth estate’s role in contributing to a sustainably secure, prosperous and just world.EventsThe Chatham House Prize 2018 was awarded in a ceremony on Wednesday 28 November at Chatham House in London. The executive director of the committee, Joel Simon, accepted the award and spoke about the importance of safeguarding journalism and free speech, followed by a discussion about the challenges of reporting today with a panel of journalists who have faced these pressures in their work.NomineesThe nominees for the Chatham House Prize 2018 were:The Committee to Protect JournalistsMario Draghi, President, European Central BankZeid Ra'ad Al Hussein, UN High Commissioner for Human RightsHalima Ismail Ibrahim, Chair, National Independent Electoral Commission, Federal Republic of SomaliaAbout the Chatham House PrizeThe Chatham House Prize is presented to the person, persons or organization deemed by members of Chatham House to have made the most significant contribution to the improvement of international relations in the previous year.The selection process is independent, democratic and draws on the deep knowledge of Chatham House's research teams, making the Prize a distinctive and unique award in the field of international affairs.A short-list of nominees is selected by the institute's three presidents from a longer list submitted by the research programmes and departments in their areas of expertise. The recipient is then determined by Chatham House's broad membership base on a one-member, one-vote basis. The award is presented on behalf of the institute's patron, Her Majesty the Queen, representing the non-partisan and authoritative character of the Prize.The Chatham House Prize was launched in 2005. Previous recipients of the Prize include former Colombian president Juan Manuel Santos, former president of Ghana John Kufuor, Médecins Sans Frontières and Melinda Gates, co-founder of the Bill and Melinda Gates Foundation.For more information, please contact:Chatham House press officeEmail: pressoffice@chathamhouse.orgPhone: +44 (0)207 957 5739CPJ Communications Associate Beatrice Santa-WoodEmail: press@cpj.orgPhone: +1 212 300 9032 Related pages Chatham House Prize 2018: The Committee to Protect Journalists Full Article
z Sir David Attenborough and the BBC Studios Natural History Unit awarded Chatham House Prize 2019 for ocean advocacy By feedproxy.google.com Published On :: Mon, 18 Nov 2019 13:13:54 +0000 19 November 2019 The 2019 Chatham House Prize is awarded to Sir David Attenborough and Julian Hector, head of BBC Studios Natural History Unit, for the galvanizing impact of the Blue Planet II series on tackling ocean plastic pollution. 2019-06-06-DavidAttenboroughB.jpg The Chatham House Prize is awarded to the person, persons or organization who is deemed to have made the most significant contribution to the improvement of international relations in the previous year. The presentation ceremony and panel discussion with the winners will be livestreamed on Wednesday.The Blue Planet II series highlighted the damage caused by discarded plastics to the world’s oceans and marine wildlife. It is estimated that there are more than 150 million tonnes of plastic in the world’s oceans; resulting in the deaths of 1 million birds and 100,000 sea mammals each year. Dr Robin Niblett, director of Chatham House said: ‘Plastic pollution is one of the gravest challenges facing the world’s oceans, and undoubtedly an international issue. Sir David and the BBC Studios Natural History Unit played an instrumental role in helping to put this issue at the forefront of the public agenda. Blue Planet II spurred a passionate global response and generated clear behavioural and policy change.’This year the G20 agreed on an international framework to address marine plastic litter, acknowledging the increasing urgency of the issue and the need for an international solution. This follows action from the UK government, including a plan to ban common plastic items and investment in global research.See full award citationRead more about Chatham House's research work in this areaOther nomineesDr Niblett thanked Chatham House members for voting and acknowledged the outstanding achievements of the 2019 nominees:Abiy Ahmed, prime minister of Ethiopia, nominated for his efforts to transform civic leadership and promote plural politics, free speech and peace in Ethiopia Katrín Jakobsdóttir, prime minister of Iceland, nominated for her commitment to gender equality and women’s financial inclusion in Iceland EventThe Prize was presented to Sir David and Julian Hector by Her Majesty The Queen at Chatham House on Wednesday 20 November.Watch video from the eventFor more information please contactChatham House Press Officepressoffice@chathamhouse.org+44 (0)207 957 5739BBC Studios Natural History Unit Communications ManagerLynn.li@bbc.co.uk+44 (0) 7513 137893About the Chatham House PrizeThe Chatham House Prize is voted for by Chatham House members, following nominations from the institute’s staff. The award is presented on behalf of the institute's patron, Her Majesty the Queen, representing the non-partisan and authoritative character of the Prize.The Chatham House Prize was launched in 2005. Previous recipients of the Prize include the Committee to Protect Journalists, Colombian president Juan Manuel Santos, president of Ghana John Kufuor, Médecins Sans Frontières and Melinda Gates, co-founder of the Bill and Melinda Gates Foundation.Chatham House is a world-leading policy institute based in London. Our mission is to help governments and societies build a sustainably secure, prosperous and just world. We engage governments, the private sector, civil society and our members in open debate and private discussions about the most significant developments in international affairs. Our research and policy ideas involve rigorous analysis of critical global, regional and country-specific challenges and opportunities.About BBC Studios Natural History Unit BBC Studios Natural History Unit produces the world’s most iconic natural history programmes, such as Blue Planet II and Planet Earth II, which have been watched by more than a billion people globally. Ranging from technically challenging live shows and super-landmarks to long-running series and children’s content, The Natural History Unit programmes include Dynasties, Blue Planet Live, Springwatch, Animal Babies: First Year On Earth, Andy’s Dinosaur Adventures as well as the currently on air Seven Worlds, One Planet presented by Sir David Attenborough and third-party commissions for Discovery, Apple, Quibi, National Geographic and BBC America. The Natural History Unit is part of BBC Studios, a subsidiary of the BBC, which develops, produces and distributes bold, British content, making over 2,500 hours of content each year, operating in 22 markets globally and generating revenue of around £1.4bn. In the year to March 2019, it returned £243m to the BBC Group, complementing the BBC’s licence fee and enhancing programmes for UK audiences. Related pages Managing Natural Resources Energy, Environment and Resources Programme Full Article
z Realizing TTIP’s Strategic Potential By feedproxy.google.com Published On :: Tue, 12 Jul 2016 15:34:44 +0000 14 July 2016 The strategic case for TTIP is greater – and the stakes higher – now that the UK has decided to leave the EU. But TTIP will create new risks for the West whether it succeeds or fails. Download PDF Gregor Irwin Chief economist, Global Counsel 2016-07-14-ttip.jpg The container ship Osaka Express, operated by Hapag-Lloyd AG, leaves the container terminal at the port in Southampton, UK, on 2 October 2015. Photo: Getty Images. SummaryThe Transatlantic Trade and Investment Partnership (TTIP) – currently being negotiated between the United States and the European Union – represents a bolder and riskier approach to liberalizing trade than traditional trade deals. It is bolder because it aims to cover a wide range of policy issues that are not typically included, and because it aims to be strategic and extraterritorial in its impact. It is riskier because of the difficulty in getting agreement on these issues between the parties concerned, and because the responses of other countries are uncertain.EU and US negotiators have much work to do if a deal is to be reached that realizes TTIP’s full potential. While progress has been made on tariff reduction, considerable ground still needs to be covered on setting standards and regulations affecting trade, which is where TTIP has the most potential to make an impact at a strategic level. Meanwhile, trade scepticism is rising on both sides of the Atlantic, with concerns about the impact of deals like TTIP on jobs and regulatory standards. The negotiation process is also now complicated by the United Kingdom’s decision to leave the EU. Making a clear and credible strategic case for TTIP may be necessary if the negotiations are to continue and be successful.If the United States and the EU are able to agree on the regulations and standards affecting international trade, they will have the scale to define these globally for years to come. International leadership in this area brings commercial advantages and benefits for consumers in the EU and the United States, and it also often is a global public good. However, it sometimes pits EU and US interests against those of other countries, creating scope for conflict over policies in areas such as the rules governing state-owned enterprises.There would be benefits to the United Kingdom, the EU and the United States if the United Kingdom joins TTIP once it is agreed. In the intervening period, it makes sense for the United Kingdom to participate actively in EU decisions regarding TTIP while still a member of the EU, as this could help to smooth an eventual British accession to the partnership.The soft-power benefits from TTIP are potentially substantial, but they would only be maximized if other strategically important countries, such as Turkey, are able to join. Perhaps the clearest sign of TTIP being likely to meet or exceed the highest ambitions for its strategic impact would be if it has an even broader geographical reach, drawing in countries in other regions.The potential security benefits from TTIP are marginal and overhyped. The benefits that unity on trade would bring to transatlantic security are intangible and hard to substantiate. The energy security benefits are likely to be limited, as the volumes of US liquefied natural gas (LNG) exports to the EU are likely to be small. If the EU and the United States are serious about using TTIP to improve security, they should include defence procurement, but this has never been on the agenda.Not only do the differences between the EU and the United States mean that it will be difficult to get a deal, they also constrain how any deal would be implemented and exploited for strategic purposes. If TTIP is to succeed at a strategic level, both sides must be disciplined, consistent and coordinated in using it as the reference point in their negotiations with other countries. The United States is more capable of acting strategically than the EU, in part because of the difficulties for EU member states in coalescing around a shared set of strategic objectives. Until the EU is able to do this, the United States is likely to have much more influence over the strategic direction of TTIP. If the EU wants to bridge this gap, then the European Council should start by reaching a political agreement on its objectives and priorities for bringing other countries into TTIP.There are also strategic risks from TTIP. One is that by emphasizing the values that are reflected in international rules, the EU and the United States could make it harder for other countries to accept these rules, or make TTIP seem like an attempt to reassert the old world order. Thus, instead of having a magnetic effect, TTIP could create a rift with emerging countries, with some choosing to maintain a distance for political reasons.The bigger risk for TTIP, however, is failure. If negotiations break down or a deal is reached that falls short of the ambition set for it, this would send a damaging signal to the rest of the world about the inability of the EU and the United States to work together. The damage would be all the greater if the process was acrimonious, or if it exposed US indifference to Europe or latent anti-Americanism in the EU. The United Kingdom’s decision to leave the EU raises the stakes, particularly for the latter, as it is a blow to the international credibility of the EU. Agreeing TTIP would help to offset this blow, while failure would amplify it. Department/project US and the Americas Programme, US Geoeconomic Trends and Challenges Full Article
z Institutionalization, path dependence and the persistence of the Anglo- American special relationship By feedproxy.google.com Published On :: Fri, 26 Aug 2016 10:57:44 +0000 1 September 2016 , Volume 92, Number 5 Ruike Xu Full Article
z The oversecuritization of global health: changing the terms of debate By feedproxy.google.com Published On :: Wed, 04 Sep 2019 14:01:47 +0000 4 September 2019 , Volume 95, Number 5 Read online Clare Wenham Linking health and security has become a mainstream approach to health policy issues over the past two decades. So much so that the discourse of global health security has become close to synonymous with global health, their meanings being considered almost interchangeable. While the debates surrounding the health–security nexus vary in levels of analysis from the global to the national to the individual, this article argues that the consideration of health as a security issue, and the ensuing path dependencies, have shifted in three ways. First, the concept has been broadened to the extent that a multitude of health issues (and others) are constructed as threats to health security. Second, securitizing health has moved beyond a rhetorical device to include the direct involvement of the security sector. Third, the performance of health security has become a security threat in itself. These considerations, the article argues, alter the remit of the global health security narrative; the global health community needs to recognize this shift and adapt its use of security-focused policies accordingly. Full Article
z Up in smoke? Global tobacco advocacy and local mobilization in Africa By feedproxy.google.com Published On :: Wed, 04 Sep 2019 14:05:11 +0000 4 September 2019 , Volume 95, Number 5 Amy S. Patterson and Elizabeth Gill Read online Even though most African states have signed and ratified the Framework Convention on Tobacco Control (FCTC), a global treaty to limit tobacco use, African states have been slow to pass and implement tobacco control policies like regulations on sales, smoke-free environments and taxes. This article examines how the ineffectiveness of local tobacco-control advocacy contributes to this suboptimal outcome. It asserts that the disconnect between the global tobacco-control advocacy network and local advocates shapes this ineffectiveness. With funding and direction predominately from the Bloomberg Initiative, local advocates emulate the funders' goal of achieving quick, measurable policy results. Their reliance on the network drives African advocates to strive to pass legislation, even in difficult political climates, and to remake their agendas when funders change their priorities. They also emulate the network's focus on evidence-based arguments that stress epidemiological data and biomedical interventions, even when this issue frame does not resonate with policy-makers. Financial dependence can draw local advocates into expectations about patronage politics, undermine their ability to make principled arguments, and lead them to downplay the ways that their home country's socioeconomic and cultural contexts affect tobacco use and control. Based on key informant interviews with African advocates, media analysis and the case-studies of Ghana and Tanzania, the article broadens the study of philanthropy in global health, it adds an African perspective to the literature on global health advocacy, and it deepens knowledge on power dynamics between external funders and local actors in the realms of health and development. Full Article
z Elena Lazarou By feedproxy.google.com Published On :: Wed, 11 Dec 2019 09:45:04 +0000 Associate Fellow, US and the Americas Programme (based in Brussels) Biography Elena Lazarou is an associate fellow in the US and the Americas Programme, providing insights on themes relates to Brazilian politics and foreign policy and EU relations with Latin America. Her research focuses on EU relations with Brazil and Latin America, regionalism, and foreign policy analysis.Dr Lazarou is assistant professor of international relations at the Getulio Vargas Foundation (FGV) in Brazil. Between 2012 and 2015 she was head of FGV’s Centre of International Relations. She is currently on extended leave, working as a policy analyst at the European Parliament’s Research Service since 2015.Dr. Lazarou is a frequent panellist at conferences and events on international affairs and Latin America. She received her MPhil and PhD from the University of Cambridge and has held post-doctoral research positions at the University of Cambridge and the LSE. Areas of expertise Brazilian foreign policyBrazilian politicsLatin AmericaEU foreign policyGlobal governance Past experience 2015 - presentPolicy analyst, European Parliamentary Research Service 2012-15Head, Centre of International Relations, FGV Brazil 2010 - presentAssistant professor of International Relations, FGV Brazil Email @elenlazarou LinkedIn Full Article
z Centralization is Hobbling China’s Response to the Coronavirus By feedproxy.google.com Published On :: Thu, 06 Feb 2020 11:10:49 +0000 6 February 2020 Dr Yu Jie Senior Research Fellow on China, Asia-Pacific Programme @yu_jiec LinkedIn The sluggish early reaction by officials should not have come as a surprise. 2020-02-06-CVT.jpg Chinese police officers wearing masks stand in front of the Tiananmen Gate on 26 January. Photo: Getty Images. The coronavirus outbreak in China poses a tremendous test for Beijing. Beyond the immediate public health crisis, the Chinese Communist Party faces a stuttering economy, growing public anger and distrust, and a potentially heavy blow to its global reputation.The hesitant early response to the outbreak sheds light on the way the Chinese bureaucracy approaches crises at a time when the party leadership is tightening control at almost all levels of society. At first, officials in Wuhan attempted to censor online discussions of the virus. This changed only after President Xi Jinping’s call for a much more robust approach was followed by a sudden increase in the state media coverage of the outbreak. There is no doubt that Xi’s intervention will greatly speed up the response to the crisis, which should be welcomed.Despite China’s experience with the SARS epidemic between 2002 and 2004, the sluggish reaction by officials in Wuhan should not have come as a surprise. The tendency among bureaucrats to play down crises is deeply entrenched. And, ironically, the party leadership’s recent push for greater bureaucratic accountability and its promise of stiffer punishment for those who take a 'do little' approach have also contributed to the habit of covering up disasters.Xi has launched an ambitious programme to reform the governance of the Communist Party and re-centralize political control. This has reinforced the tendency of officials to avoid making important decisions and instead to wait for instructions from the party leadership.For decades, local governments have made things happen in China. But with tighter regulation of lower-level bureaucrats, civil servants across the system now seem less ready, and able, to provide their input, making ineffective and even mistaken policy more likely. Explainer: Coronavirus - What You Need to Know World-renowned global health expert Professor David Heymann CBE explains the key facts and work being done on the coronavirus outbreak. Moreover, the coronavirus outbreak could not have happened at a worse time. Last year was tumultuous and saw China fighting an economic slowdown while also dealing with an increasingly hostile international environment. Now, as the authorities take steps to contain the disease, economic activity has come to a near standstill, with public transport curbed and restaurants and entertainment venues shuttered.This contrasts with SARS, when double-digit growth in gross domestic product enabled Beijing to raise government expenditure to tackle the outbreak. Today, the Chinese economy is running into some of the most difficult challenges it has faced since the global financial crisis.In response to the slowdown in growth, Beijing has adopted loose fiscal policy, with an emphasis on public investment. It also continues to push big banks to cut interest rates for individual borrowers and small businesses which were already suffering from the effects of the trade war with the US before the coronavirus struck.The outbreak should give new impetus to governments, not least those that have close economic ties with China. Being a great power with ambitions for global leadership, as well as domestic reform, is not easy. Even without multi-party elections, it involves increasing, and often uncomfortable, scrutiny. As President Xi himself has put it: the road is long and the task is weighty.This article was originally published in the Financial Times. Full Article
z Coronavirus: All Citizens Need an Income Support By feedproxy.google.com Published On :: Mon, 16 Mar 2020 10:50:49 +0000 16 March 2020 Jim O'Neill Chair, Chatham House We cannot expect policies such as the dramatic monetary steps announced by the Federal Reserve Board and others like it, to end this crisis. A People's Quantitative Easing (QE) could be the answer. 2020-03-16-coronavirus-delivery.jpg Delivery bike rider wearing a face mask as a precaution against coronavirus at Madrid Rio park. Photo by Pablo Cuadra/Getty Images. Linked to the call for a global response to the Covid-19 pandemic that I, Robin Niblett and Creon Butler have outlined, the case for a specific dramatic economic policy gesture from many policymakers in large economies is prescient.It may not be warranted from all G20 nations, although given the uncertainties, and the desire to show collective initiative, I think it should be G20 driven and inclusive.We need some sort of income support for all our citizens, whether employees or employers. Perhaps one might call it a truly People’s QE (quantitative easing).Against the background of the previous economic crisis from 2008, and the apparent difficulties that more traditional forms of economic stimulus have faced in trying to help their economies and their people - especially against a background of low wage growth, and both actual, and perception of rising inequality - other ideas have emerged.Central banks printing moneyBoth modern monetary theory (MMT) and universal basic income (UBI) essentially owe their roots to the judgement that conventional economic policies have not been helping.At the core of these views is the notion of giving money to people, especially lower income people, directly paid for by our central banks printing money. Until recently, I found myself having very little sympathy with these views but, as a result of COVID-19, I have changed my mind.This crisis is extraordinary in so far as it is both a colossal demand shock and an even bigger colossal supply shock. The crisis epicentre has shifted from China - and perhaps the rest of Asia - to Europe and the United States. We cannot expect policies, however unconventional by modern times, such as the dramatic monetary steps announced by the Federal Reserve Board and others like it, to put a floor under this crisis.We are consciously asking our people to stop going out, stop travelling, not go to their offices - in essence, curtailing all forms of normal economic life. The only ones not impacted are those who entirely work through cyberspace. But even they have to buy some forms of consumer goods such as food and, even if they order online, someone has to deliver it.As a result, markets are, correctly, worrying about a collapse of economic activity and, with it, a collapse of companies, not just their earnings. Expansion of central bank balance sheets is not going to do anything to help that, unless it is just banks we are again worried about saving.What is needed in current circumstances, are steps to make each of us believe with high confidence that, if we take the advice from our medical experts, especially if we self-isolate and deliberately restrict our personal incomes, then we will have this made good by our governments. In essence, we need smart, persuasive People’s QE.Having discussed the idea with a couple of economic experts, there are considerable difficulties with moving beyond the simple concept. In the US for example, I believe the Federal Reserve is legally constrained from pursuing a direct transfer of cash to individuals or companies, and this may be true elsewhere.But this is easily surmounted by fiscal authorities issuing a special bond, the proceeds of which could be transferred to individuals and business owners. And central banks could easily finance such bonds.It is also the case that such a step would encroach on the perception and actuality of central bank independence, but I would be among those that argue central banks can only operate this independence if done wisely. Others will argue that, in the spirit of the equality debate, any income support should be targeted towards those on very low incomes, while higher earners or large businesses, shouldn’t be given any, or very little.I can sympathise with such spirit, but this also ignores the centrality of this particular economic shock. All of our cafes and restaurants, and many of our airlines, and such are at genuine risk of not being able to survive, and these organisations are considerable employers of people on income.It is also the case that time is of the essence, and we need our policymakers to act as soon as possible, otherwise the transmission mechanisms, including those about the permanent operation of our post World War 2 form of life may be challenged.We need some kind of smart People’s QE now. Full Article
z On the measure of maximal entropy for finite horizon Sinai Billiard maps By www.ams.org Published On :: Tue, 10 Mar 2020 10:59 EDT Viviane Baladi and Mark F. Demers J. Amer. Math. Soc. 33 (2020), 381-449. Abstract, references and article information Full Article
z In Vivo Identification of Human Small Ubiquitin-like Modifier Polymerization Sites by High Accuracy Mass Spectrometry and an in Vitro to in Vivo Strategy By feedproxy.google.com Published On :: 2008-01-01 Ivan MaticJan 1, 2008; 7:132-144Research Full Article
z Global Identification and Characterization of Both O-GlcNAcylation and Phosphorylation at the Murine Synapse By feedproxy.google.com Published On :: 2012-08-01 Jonathan C. TrinidadAug 1, 2012; 11:215-229Research Full Article
z Phosphate-binding Tag, a New Tool to Visualize Phosphorylated Proteins By feedproxy.google.com Published On :: 2006-04-01 Eiji KinoshitaApr 1, 2006; 5:749-757Technology Full Article