Rick Wright’s Greenville Triumph have advanced to the United Soccer League [USL] League One play-off semi-finals after beating One Knoxville 2-1 at home yesterday [November 2]. Goals from Evan Lee and a Lyam MacKinnon penalty handed Greenville victory. Greenville will travel to Union Omaha or host Richmond next weekend depending on the outcome of the […]

Khano Smith’s Rhode Island claimed a 3-2 win away to Indy Eleven in the United Soccer League [USL] Championship play-off quarter-finals yesterday [November 3]. JJ Williams scored a hat-trick for Smith’s side to ensure they advance to the Eastern Conference semi-finals, where they will take on Louisville City away on Saturday [November 9]. Smith, a […]

Zeiko Lewis will look to help Union Omaha reach the United Soccer League [USL] League One final when they face Greenville Triumph at home in the play-off semi-finals on Saturday [November 9]. Lewis, a Bermuda national team winger, impressed in his side’s 1-0 win at home to Richmond in the play-off quarter-finals last weekend. The […]

Rick Wright’s Greenville Triumph lost 2-1 away to Union Omaha in the USL League One play-off semi-finals yesterday [November 9], and one one of the goals scored by Union Omaha was actually scored by Bermudian Zeiko Lewis. A former Saltus Grammar School student, Wright made appearances for the Bermuda and United States national teams. He was appointed […]

Zeiko Lewis scored in Union Omaha’s 2-1 win at home to Greenville Triumph in the USL League One play-off semi-final yesterday [November 9]. The Bermuda winger struck the winner in the 58th minute to ensure his side advance to the final, where they will meet the winner of Forward Madison or Spokane Velocity. Lewis joined […]

The Bermuda Cricket Board [BCB] announced the Athene T20 KO Cup Semi-Finalist of 2024. A spokesperson said, “The semi-final matches are based on the final standings of the Athene T20 leagues. The matches will see the League Champions in each division face the 4th ranked team and the runners-up will face the 3rd ranked team. […]

St. George’s Cricket Club, Flatt’s Victoria, and Willow Cuts all recorded victories in the Athene Premier and First Division T20 KO Cup Semi-Finals. Athene Premier Division T20 KO Cup Semi-Finals St. George’s Cricket Club Win by 6 Wickets: Bailey’s Bay 86/9 St. George’s Cricket Club 87/4 At the White Hill Field, the St. George’s Cricket […]

Johnie Berntsson, Chris Poole, Nick Egnot-Johnson, and Eric Monnin advanced to the Bermuda Gold Cup semi-finals after winning their quarter-final matches. A spokesperson said, “The final four skippers advancing to the semi-final were decided on Day 3 of the Bermuda Gold Cup in Hamilton Harbour. Defending 2023 event winner Johnie Berntsson [SWE] joins Chris Poole […]

[Written by Stephen Wright] Bermuda rower Dara Alizadeh experienced his first victory in an Olympic Games race after winning his E/F semi-final at the Vaires-sur-Marne Nautical Stadium today [July 29]. Alizadeh, who competes in the men’s single sculls, claimed a comfortable win, finishing his two-kilometre race in 7min 33.38sec. The 30-year-old said he was encouraged […]

In what could be seen as an unfortunate irony, a seminar on hurricanes has been postponed due to the impending arrival of Hurricane Gonzalo. The RICS Hurricane presentation by visiting academics from Western Ontario and Dr. Mark Guishard from BIOS is postponed from Thursday [Oct 16] until Thursday 6th November. The presentation was due to […]

Defending champions Cork beat Down 2-17 to 1-12 in the National League Division One semi-final at Croke Park.

President-elect Donald Trump's reelection was credited for emboldening a group of people waving Nazi flags in Michigan over the weekend.

WLNS reported that the flags were seen in two cities, including at a Jewish play.

According to the report, "many people" were seen displaying flags with swastikas on Saturday night as the Fowlerville Community Theater performed the "Diary of Anne Frank." The same group was also seen outside the American Legion Post in Howell.

"It was upsetting," cast member Becky Frank said. "You know, just knowing the character I was playing, knowing a lot of the research that I did on my character."

Witnesses said the protest began in Howell before moving to Fowlerville. Protesters were seen wearing masks with the number 1488, a white supremacist symbol.

"There was a group of people at the four-way intersection in downtown that had swastika flags and American flags," witness Alex Sutfill told WLNS. "They were sticking their arms up and yelling hail Hitler and Hail Trump and everything like that."

Peter Damerow said the group told him to go back to his country.

"They looked at me and one of them said," Damerow recalled. "No this is Pureville now, and we're here to make sure it stays pure."

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Geosciences Department Lecture Series

Nearly every Wednesday of the semester, The Mossavar-Rahmini Center for Iran and Persian Gulf Studies invites a scholar to speak on their area of study. Topics relate to Iran and the Persian Gulf area while employing an interdisciplinary lens. To view the details of upcoming seminar topics, please visit iran.princeton.edu/upcoming-events.

Please join the BusinessToday Seminars Team as we present Mr. Fred Cooper, Senior Vice President of Strategic Partnerships at Toll Brothers. Toll Brothers (NYSE: TOL) is a ~$10 billion revenue and ~$15 billion market cap, Fortune 500 Company founded in 1967 and ranked the 4th largest U.S. home builder by revenues. Toll is also among the largest multifamily rental apartment developers, and land and community developers in the U.S. In addition, Toll is one of the nation’s largest urban high-rise/high-density condo and rental tower developers, with 50+ buildings and over 7,000 units completed.

Geosciences Department Lecture Series

Register for our "Writing Seminar Research Clinic" to be held in the Firestone Library Tea Room on Sunday November 17 between 2:00 p.m. and 8:00 p.m. Consult with Writing Center Fellows and Librarians to move your Research Paper to the next level while munching on movie theater style popcorn, cookies, and sipping caffeinated beverages! Please register for a time slot here: 2:00pm-2:30pm 2:30pm-3:00pm 3:00pm-3:30pm 3:30pm-4:00pm 4:00pm-4:30pm 4:30pm-5:00pm 5:00pm-5:30pm 5:30pm-6:00pm 6:00pm-6:30pm 6:30pm-7:00pm 7:00pm-7:30pm 7:30pm-8:00pm If you need research help and none of these time slots work for you, feel free to sign up for a consultation with your seminar librarian.

Please note this event begins at 1pm and ends at 2pm. The Ludwig Princeton Distinguished Lectureship features world class cancer researchers. Jeff Rathmell, leading cancer immunologist from Vanderbilt University, will present his talk "Metabolic Control of Immunotherapy and Inflammation." T cells in tumors and other inflamed tissues accumulate signs of stress and mitochondrial damage that affect cell metabolism but remain poorly understood. The metabolism of T cells and other immune cells is dynamically regulated and influences biosynthesis, signaling, and cell fate. We have shown that CD4 T cell subsets are metabolically distinct and that each requires a specific metabolic program for their function. Immune cells do not act in isolation, however, and are subject to systems and microenvironmental factors that shape their metabolism and function. On a systemic level, obesity leads to a state of chronic inflammation and is a risk factor for cancer incidence and progression. However, cancer immunotherapy can be enhanced in obesity in the cancer-obesity paradox. We have shown that induction of the immune checkpoint molecule PD-1 on tumor associated macrophages contributes to this paradox and immunotherapy responses in obese individuals. At a microenvironmental level, tissue temperature changes with body location, fever, and inflammation. We tested the effects of elevated temperatures found that T cells broadly become more pro-inflammatory but a subset of CD4 T cells, Th1 cells, selectively experience mitochondrial stress that activates a heat-sensitive molecular circuit to shape T cell fate. The metabolic interaction of immune cells with their environment can both drive disease and offer new therapeutic opportunities.

Nearly every Wednesday of the semester, The Mossavar-Rahmini Center for Iran and Persian Gulf Studies invites a scholar to speak on their area of study. Topics relate to Iran and the Persian Gulf area while employing an interdisciplinary lens. To view the details of upcoming seminar topics, please visit iran.princeton.edu/upcoming-events.

Mark Williams progresses to the semi-finals of the Champion of Champions tournament by defeating Kyren Wilson 6-5 in Bolton.

Willem-Alexander says Jewish people must feel safe in the Netherlands after Israeli football supporters come under attack.

England prop Ellis Genge admits last year's World Cup semi-final defeat by South Africa is something he will carry for the rest of his career.

Holders Rangers will take on Celtic in the SWPL Cup semi-finals, with Hibernian facing Aberdeen in the other last-four tie.

Ahmed Elshafei, Ana Cristina Ferreira, Miguel Sánchez and Abdelghani Zeghib
Trans. Amer. Math. Soc. 377 (), 5837-5862.
Abstract, references and article information

LONDON and TORONTO, Sept. 30, 2024 — Alphawave Semi, a global leader in high-speed connectivity and compute silicon for the world’s technology infrastructure, has unveiled the availability of the industry’s […]

The post Alphawave Semi and TSMC Collaborate on 3nm UCIe Die-to-Die Subsystem for AI and HPC appeared first on HPCwire.

Quantum error correction specialist Riverlane today released a fascinating report — The Quantum Error Correction Report 2024 — that’s worth scanning; IBM and 28 collaborators last week released V-score, a […]

The post Quantum Nuggets: Riverlane’s 2024 QEC Study, IBM’s V-score, Twisted Semiconductors appeared first on HPCwire.

A bill prohibiting anti-Semitism in Florida's public schools and universities is going to Republican Gov. Ron DeSantis.

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

Informal Seminar: Human resources policies - Invitation for all Permanent Representatives

 Friday, 12 October 2018 - 15.00 to 17.30 (Green Room)

This special seminar calls us to take a new look at how to channel our knowledge, stimulate innovative thinking and guide our actions to expedite agri-food system transformation and achieve [...]

Carleton Watkins' 19th-Century Photographs of Yosemite Valley (Produced and Narrated by: Brendan McCabe. Text by Bruce Hathaway). Read more at https://www.smithsonianmag.com/history/john-muirs-yosemite-10737/

OM Ukraine and experts in crisis management held a seminar for pastors serving on both sides of the conflict line in Eastern Ukraine.

Azamat was living in the streets, but through the ministry of OM team members in Central Asia he moved into rehabilitation and then seminary.

Wilmington, Del. (March 10, 2022) – From a field of ten Delaware high school students, Natalie Kim Ramos, a senior from Saint Mark’s High School, earned the title of 2022 Poetry Out Loud Delaware State Champion at the virtual state finals held on March 10. The first runner-up was Kai Schmiedel from Delaware Valley Classical […]

Wilmington, Del. (March 3, 2023) – From a field of twelve Delaware high school students, Maiss Hussein, a junior from Paul M. Hodgson Vocational Technical High School, earned the title of 2023 Poetry Out Loud Delaware State Champion at the state finals held on March 2 at the Smyrna Opera House. The first runner-up was […]

2024 Changing Faces Women's Leadership Seminar

Proceeding to the discovery phase means both parties must collect and exchange evidence.

Former French MP Meyer Habib describes his worries about France's future as antisemitism soars across Europe and violence becomes normalized.

“Ixe! If it wasn’t for solar energy, we would have closed down, you can be sure. We had to stop due to the pandemic on 15 March 2020, but the energy costs were fixed,” said Erika Cazuza, administrative and financial manager of the Brazilian Cooperative of Rural Producers of Monteiro (Capribom). Ixe is a word […]

Title: furosemide
Category: Medications
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

BACKGROUND AND PURPOSE:

Low-field 64 mT portable brain MRI has recently shown diagnostic promise for MS. This study aimed to evaluate the utility of portable MRI (pMRI) in assessing dissemination in space (DIS) in patients presenting with optic neuritis and determine whether deploying pMRI in the MS clinic can shorten the time from symptom onset to MRI.

PURPOSE

Meeting scholarly activity requirements continues to be a challenge in many family medicine (FM) residency programs. Studies comprehensively describing FM resident scholarship have been limited. We sought to identify institutional factors associated with increased scholarly output and meeting requirements of the Accreditation Council for Graduate Medical Education (ACGME).

As misinformation about the upcoming US elections rockets across social media, creating chaos, companies need to be honest about where this content is coming from, says Annalee Newitz

Hurricane Helene hit a quartz mine in North Carolina that is key to global semiconductor production, which could impact the entire tech industry. Here is everything we know so far

A man from Eugene, Oregon, pleaded guilty to federal hate crimes on Tuesday after he spray-painted antisemitic graffiti on a synagogue in 2023 and 2024.

Someone has to speak out against the pro-Hamas factions.