A study conducted by Harvard-affiliated Brigham and Women’s Hospital revealed that individuals experiencing a broad array of long COVID symptoms are twice as likely to have traces of SARS-CoV-2 proteins in their blood compared to those without symptoms of long COVID. The symptoms frequently associated with long COVID include fatigue, brain fog, muscle and joint pain, back pain, headaches, sleep issues, loss of smell or taste, and gastrointestinal problems.These findings were published in the journal Clinical Microbiology and Infection.

These novel insights will hopefully lead to better treatments for lupus patients, now that we may know why the body attacks itself in this disease.

Viruses are invading pathogens that infect host cells and rapidly replicate throughout the body. They carry a small piece of genetic material such as DNA o

These novel insights will hopefully lead to better treatments for lupus patients, now that we may know why the body attacks itself in this disease.

These novel insights will hopefully lead to better treatments for lupus patients, now that we may know why the body attacks itself in this disease.

For many people, getting chickenpox is a rite of passage in childhood. About 95% of people carry the virus that causes it, known as varicella zoster virus (VZV)

Viruses are invading pathogens that infect host cells and rapidly replicate throughout the body. They carry a small piece of genetic material such as DNA o

Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development  Nature.com

Exploring protein relative relations in skeletal muscle proteomic analysis for insights into insulin resistance and type 2 diabetes  Nature.com

Candidate protein biomarkers in chronic kidney disease: a proteomics study  Nature.com

Beyond protein lists: AI-assisted interpretation of proteomic investigations in the context of evolving scientific knowledge  Nature.com

Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping  Nature.com

Proteomics analysis reveals the differential protein expression of female and male adult Toxocara canis using Orbitrap Astral analyzer  Infectious Diseases of Poverty - BioMed Central

Nanoparticle–Protein Corona-Based Tissue Proteomics for the Aging Mouse Proteome Atlas  ACS Publications

scPROTEIN: a versatile deep graph contrastive learning framework for single-cell proteomics embedding  Nature.com

Pick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell  Nature.com

An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases  Nature.com

Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells  Nature.com

DIP-MS: ultra-deep interaction proteomics for the deconvolution of protein complexes  Nature.com

Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures  Nature.com

Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies  Nature.com

Single-tissue proteomics in Caenorhabditis elegans reveals proteins resident in intestinal lysosome-related organelles  pnas.org

Novel FFPE proteomics method suggests prolactin induced protein as hormone induced cytoskeleton remodeling spatial biomarker | Communications Biology  Nature.com

Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank  Nature.com

Serum proteomics reveal APOE-ε4 -dependent and APOE-ε4 -independent protein signatures in Alzheimer’s disease  Nature.com

The latest step in brand's sustainability journey is expected to reduce more than 90 percent of plastic use across all canister offerings.

For years, the health-and-wellness and food industries have been bringing Americans back to a traditional mindset — the decades-old foundational thought that eating a good breakfast can jumpstart the day and in some ways, assist with healthy goals in individual consumers.

The update to its line of Protein + Fiber Oatmeal Cups and Cartons follows a recent redesign to its High Protein Bars.

The new visual identity is being rolled out across all packaging and on e-commerce and digital channels. 

As we see consumer preference grow for high-protein products, Direct UHT (ultra-high temperature) becomes the stand-out processing method for its gentler treatment of protein-rich formulations, alongside other benefits.

Sustainable retail packaging solution replaces expanded polystyrene on processor production lines.

Part of the company’s GeoPack range of sustainability-minded products, the protein tray has been officially designated as biodegradable in industrial compost settings.

Commercial Changes / Commercial viability

Commercial Changes / Commercial viability

Custom designing proteins — a breakthrough recognized by the latest Nobel Prize in chemistry — could yield treatments that stop the worst of COVID-19 before it begins.

The post Stanford Medicine experts help Nobel winner custom design proteins for COVID-19 therapy appeared first on Scope.

Location: Electronic Resource- 

Location: Electronic Resource- 

Compartmentalized protein expression in the spider silk gland provides clues to spinning more sustainable materials. 

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular architecture.1?

If there is one nutrient that you need to support your training and recovery, protein would be it! All the exercise in the world won’t help you build muscle or get lean if it is not supported with proper nutrition, which should always include a good dose of some high-quality protein or high quality protein powder.
Read the full article here==>How Much Protein?

1. 9 protein-packed Indian breakfasts to fuel your day  Business Insider India
2. 6 Protein-Packed Breakfast Without Eggs  HerZindagi
3. 8 High-Protein Indian Breakfast Recipes to Fuel Your Day  Recipes
4. Wholesome Indian breakfasts that boost energy  Business Insider India
5. Have a protein-rich breakfast every day for these 7 benefits  Hindustan Times

Numerous iron-sulfur (Fe-S) proteins with diverse functions are present in the matrix and respiratory chain complexes of mitochondria. Although [4Fe-4S] clusters are the most common type of Fe-S cluster in mitochondria, the molecular mechanism of [4Fe-4S] cluster assembly and insertion into target proteins by the mitochondrial iron-sulfur cluster (ISC) maturation system is not well-understood. Here we report a detailed characterization of two late-acting Fe-S cluster-carrier proteins from Arabidopsis thaliana, NFU4 and NFU5. Yeast two-hybrid and bimolecular fluorescence complementation studies demonstrated interaction of both the NFU4 and NFU5 proteins with the ISCA class of Fe-S carrier proteins. Recombinant NFU4 and NFU5 were purified as apo-proteins after expression in Escherichia coli. In vitro Fe-S cluster reconstitution led to the insertion of one [4Fe-4S]2+ cluster per homodimer as determined by UV-visible absorption/CD, resonance Raman and EPR spectroscopy, and analytical studies. Cluster transfer reactions, monitored by UV-visible absorption and CD spectroscopy, showed that a [4Fe-4S]2+ cluster-bound ISCA1a/2 heterodimer is effective in transferring [4Fe-4S]2+ clusters to both NFU4 and NFU5 with negligible back reaction. In addition, [4Fe-4S]2+ cluster-bound ISCA1a/2, NFU4, and NFU5 were all found to be effective [4Fe-4S]2+ cluster donors for maturation of the mitochondrial apo-aconitase 2 as assessed by enzyme activity measurements. The results demonstrate rapid, unidirectional, and quantitative [4Fe-4S]2+ cluster transfer from ISCA1a/2 to NFU4 or NFU5 that further delineates their respective positions in the plant ISC machinery and their contributions to the maturation of client [4Fe-4S] cluster-containing proteins.

The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin II to control vasodilatation and vascular permeability. Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spike protein, we investigated how this interaction would affect the enzymatic activity of ACE2. Surprisingly, SARS-CoV-2 trimeric spike protein increased ACE2 proteolytic activity ∼3-10 fold against model peptide substrates, such as caspase-1 substrate and Bradykinin-analog. The enhancement in ACE2 enzymatic function was mediated by the binding of SARS-CoV-2 spike RBD domain. These results highlighted the potential for SARS-CoV-2 infection to enhance ACE2 activity, which may be relevant to the cardiovascular symptoms associated with COVID-19.

IQGAP1 is a key scaffold protein that regulates numerous cellular processes and signaling pathways. Analogous to many other cellular proteins, IQGAP1 undergoes post-translational modifications, including phosphorylation. Nevertheless, very little is known about the specific sites of phosphorylation or the effects on IQGAP1 function. Here, using several approaches, including MS, site-directed mutagenesis, siRNA-mediated gene silencing, and chemical inhibitors, we identified the specific tyrosine residues that are phosphorylated on IQGAP1 and evaluated the effect on function. Tyr-172, Tyr-654, Tyr-855, and Tyr-1510 were phosphorylated on IQGAP1 when phosphotyrosine phosphatase activity was inhibited in cells. IQGAP1 was phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src signaling, including in human lung cancer cell lines. This phosphorylation was significantly reduced by chemical inhibitors of MET or c-Src or by siRNA-mediated knockdown of MET. To investigate the biological sequelae of phosphorylation, we generated a nonphosphorylatable IQGAP1 construct by replacing Tyr-1510 with alanine. The ability of hepatocyte growth factor, the ligand for MET, to promote AKT activation and cell migration was significantly greater when IQGAP1-null cells were reconstituted with IQGAP1 Y1510A than when cells were reconstituted with WT IQGAP1. Collectively, our data suggest that phosphorylation of Tyr-1510 of IQGAP1 alters cell function. Because increased MET signaling is implicated in the development and progression of several types of carcinoma, IQGAP1 may be a potential therapeutic target in selected malignancies.

Alfred C. O. Vertegaal
Dec 1, 2006; 5:2298-2310
Research

Lars Jønson
May 1, 2007; 6:798-811
Research

Michal Bassani-Sternberg
Mar 1, 2015; 14:658-673
Research

Ileana M. Cristea
Dec 1, 2005; 4:1933-1941
Research

Ilka Wittig
Jul 1, 2007; 6:1215-1225
Research