The disclosure provides compounds and methods of using Apogossypolone derivatives for treating diseases and disorders. In particular, the disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and provides methods for the preparation of compounds of Formula I; and methods for treating cancer, autoimmune diseases, and inflammation by administering a compound of Formula I.

The invention concerns a method for optimizing antenna pattern assignment for a first wireless communication device forming a wireless network with at least one second wireless communication device, each of said communication device being equipped with a multi-sector antenna, an antenna pattern being a combination of said antenna sectors, said communication devices being adapted for sending a request and for receiving a response using a current antenna pattern assignment, said method comprising a step of: evaluating by said first communication device a first value;sending by said first communication device to said second communication device a broadcast request comprising said valuereceiving by said first communication device, a response to said broadcast request, said response being sent by said second communication device, said response depending on a second value evaluated by said second device;Switching or not, by said first communication device, to a new antenna sector assignment depending on said response; According to the invention the first value is evaluated by minimizing a first local function according to the received signal strength received by said first communication device having said current antenna pattern assignment and the second value is evaluated by minimizing a second local function according to the received signal strength received by said second communication device for its own current antenna pattern assignment.

Systems, among other embodiments, include topologies (data and/or control/address information) between an integrated circuit buffer device (that may be coupled to a master, such as a memory controller) and a plurality of integrated circuit memory devices. For example, data may be provided between the plurality of integrated circuit memory devices and the integrated circuit buffer device using separate segmented (or point-to-point link) signal paths in response to control/address information provided from the integrated circuit buffer device to the plurality of integrated circuit buffer devices using a single fly-by (or bus) signal path. An integrated circuit buffer device enables configurable effective memory organization of the plurality of integrated circuit memory devices. The memory organization represented by the integrated circuit buffer device to a memory controller may be different than the actual memory organization behind or coupled to the integrated circuit buffer device. The buffer device segments and merges the data transferred between the memory controller that expects a particular memory organization and actual memory organization.

A fill level measurement device for determining a topology of a filling material surface in a container including an antenna apparatus, a receiver and control circuitry. An emission angle of the antenna apparatus and a spatial position of the antenna apparatus relative to the filling material surface is settable by the control circuitry. A resultant emission direction of the fill level measurement device is changeable by the control circuitry by controlling a position of the antenna apparatus and by controlling an emission and/or receiving angle of the antenna apparatus.

Masta Ace is a legendary rhymer whose career began with the Juice Crew and has continued through a series of beloved solo and group albums. Marco Polo is a Toronto-born producer who moved to New York City in the early 2000s, and took his adopted hometown’s traditional boom-bap aesthetic to heart. Marco has brought his rugged sound to Torae, Pharoahe Monch, Ruste Juxx, Sean Price, Vinnie Paz, Rah Digga, and many more.

Now, Marco and Ace have joined up for a new album. A Breukelen Story combines a set of incredible songs with a series of skits that follow Marco’s journey from Toronto to NYC—an Ace-written storyline that both mirrors and features people from the producer’s real life.

See http://theciphershow.com/episode/250/ for full show notes and comments.

Questions implying that terrorism is encouraged under the Islamic faith elicited a public apology from Scottsdale Community College after they appeared on a class quiz.

"We would like to wholeheartedly apologise. We have paid our landlords the rent for April." Adidas, which made a net profit of nearly two billion euros ($2.2 billion) in 2019, has been hard hit by a slump in Chinese sales and store closures around the world.

Lee Jae-yong is vice-chairman of Samsung Electronics and was jailed for five years in 2017 for bribery, embezzlement and other offences in connection with the scandal that brought down South Korean president Park Geun-hye.

What's so monumental about turning 40 that women need their own Facebook group? Turns out--pretty much everything. Nina Collins has created an "environment that's a little like Vegas...our special place to talk about what's really going on in our lives..." But why don't real life friends fill that need? Collins turned what she learned from the group--and her own experience with hitting 40--into a book "What Would Virginia Woolf Do?" Hear it all this week on Inflection Point with Lauren Schiller.

Mississippi State's new coach posted, and later deleted, a tweet of a photo of an elderly woman resting in a chair and simultaneously knitting a noose to pass her time during coronavirus self-quarantine.

Mississippi State's new coach posted, and later deleted, a tweet of a photo of an elderly woman resting in a chair and simultaneously knitting a noose to pass her time during coronavirus self-quarantine.

Hindmarsh Shire mayor Ron Ismay comes under criticism for using sexist language when introducing the Nationals MP Emma Kealy at an event in Nhill in western Victoria, later saying it "was not that big of a deal".

A man with a disability was strip searched and prosecuted after a false claim he was photographing children at a beachside suburb, leading to calls for an apology from WA Police.

Former Queensland shadow police minister Trevor Watts says it was a mistake to have "driveway drinks" with neighbours — caught by a police patrol — with officers alleging it was more like a "street party" that did not follow coronavirus physical distancing rules.

Health insurer apologises for failing to respond to a young man left fighting an aggressive leukaemia in Brisbane, who is unable to return to his home country of Colombia during the coronavirus pandemic.

Melbourne Storm winger Josh Addo-Carr and the South Sydney Rabbitoh's fullback Latrell Mitchell post an apology on their social media accounts after footage emerged of the NRL players on a camping holiday with around 10 other men. The trip prompted a NSW Police investigation.

A NSW Health official breaks down in tears while apologising for the government department's failures in dealing with the Ruby Princess coronavirus outbreak, an inquiry hears.

The family and friends of Naomi Williams, who died, along with her unborn son, after 20 attempts to get help, say the apology they have received via a statement from the health district is not good enough.

Rugby Australia apologises to Israel Folau as part of a confidential settlement reached over his sacking, avoiding a protracted court hearing after the former Wallaby sued for wrongful dismissal.

An investigation is launched after relatives were told their loved one had been discharged, prompting a search for the missing man whose body was actually in a Melbourne morgue all along.

The headmaster of St Kevin's College in Melbourne has labelled the behaviour of his own students "offensive" and "misogynistic", after a group were filmed screaming an offensive song during the weekend.

It may be the game of choice for the Royal family, but in the NSW Hunter Valley, the popularity of polo is galloping ahead.

Annastacia Palaszczuk is forced to apologise to Parliament over her threats to strip Katter's Australian Party MPs of resources when they refused to denounce former colleague Fraser Anning's speech calling for a Muslim immigration ban.

Energy Australia has apologised to a customer for issuing him multiple bills that 'did not make sense' despite his repeated complaints.

An Adelaide council insists it has made a suburban football club facing eviction fully aware of the sexual harassment allegations against some of its players, despite claims by the club it remains in the dark. Meanwhile, another club facing financial woes has been given a reprieve.

An Adelaide man, who founded a network which promotes online safety, issues an apology for possessing child exploitation material and exchanging nude pictures with teenagers.

A mining company whose lawyers have been accused of engaging in bullying and intimidation against an Adelaide Hills winery says it will formally apologise to the family-run business.

A magistrate has apologised to a man who spent months behind bars waiting to be dealt with by the courts for minor theft charges.

Two brothers who beat up a police officer so hard they broke his ribs apologise to a court for their actions over what a judge describes as "a quantum leap in offending".

A Catholic order settles out of court paying $4 million to survivors of historic sex abuse and apologising to them, their families and the Latrobe Valley community.

A Newcastle pub has apologised for promoting a Wolf of Wall Street-style "midget-tossing" game during a casino-themed night later this month, saying they only planned to throw a doll, not a real person.

DAILY BRIEFING: Two people plead not guilty to charges relating to the deaths of 16 polo ponies, police charge two men after last week's stabbing, and there are concerns over the second Bass Strait interconnector.

For Luke and Mary-Anne McNeven, participating in polocrosse takes serious dedication averaging a two-day, 1,700-kilometre journey for each competition during the season.

NSW resident Sonia Smallacombe says she was racially targeted by a police auxiliary stationed outside a bottle shop who demanded she produce hotel receipts to prove where she was staying.

Former water polo star Nick Dempsey will leave his Albury home to continue therapy at one of Australia's leading rehabilitation facilities on the Gold Coast.

Canberra's youth detention centre issues an apology and an undisclosed financial settlement after an Indigenous teenager filed a lawsuit alleging her human rights had been violated when she was separated from her peers and her belongings for two months.

The head of the Murray-Darling Basin Authority apologises for mistakenly publishing a report that identified farms via satellite imagery, which is now subject to investigation.

(United States Tenth Circuit) - In an action claiming trademark infringement, unfair competition, and cybersquatting, summary judgment for defendant is affirmed where: 1) trademark infringement and unfair competition claims failed as plaintiff did not show that "Utah Lighthouse" was protectable, that defendant's use was in connection with any goods or services, and that defendant was likely to cause confusion among consumers as to the source of goods sold on its online bookstore; 2) defendant lacked a bad faith intent to profit from the use of plaintiff's trademark in several domain names under the Anti-Cybersquatting Protection Act (ACPA); and 3) defendant's website met safe harbor conditions of the ACPA since it was a parody.

(United States Ninth Circuit) - Held that a child who suffered head injuries while playing in a youth water polo league stated a claim that USA Water Polo acted negligently and unlawfully by failing to implement concussion-management and return-to-play protocols. Reversed the dismissal of a proposed class action brought by her parent on her behalf.

Politically Fueled Debate Leads To A Rogue Social Media Employee

Watch a live performance of Polo G and Tjay's "Pop Out."

Polo G and Lil Tjay's performance is lit.

The victim gets a lawyer after the assault.