leukaemia

Optimisation with deep learning for leukaemia classification in federated learning

The most common kind of blood cancer in people of all ages is leukaemia. The fractional mayfly optimisation (FMO) based DenseNet is proposed for the identification and classification of leukaemia in federated learning (FL). Initially, the input image is pre-processed by adaptive median filter (AMF). Then, cell segmentation is done using the Scribble2label. After that, image augmentation is accomplished. Finally, leukaemia classification is accomplished utilising DenseNet, which is trained using the FMO. Here, the FMO is devised by merging the mayfly algorithm (MA) and the fractional concept (FC). Following local training, the server performs local updating and aggregation using a weighted average by RV coefficient. The results showed that FMO-DenseNet attained maximum accuracy, true negative rate (TNR) and true positive rate (TPR) of 94.3%, 96.5% and 95.3%. Moreover, FMO-DenseNet gained minimum mean squared error (MSE) and root mean squared error (RMSE) of 5.7%, 9.2% and 30.4%.





leukaemia

Trial of novel leukaemia drug is stopped for second time after two more deaths




leukaemia

Advancing triage of acute lymphoblastic leukaemia subtypes diagnosis: label-free Raman spectroscopy for precise single-cell phenotyping and subtype classification

Analyst, 2024, 149,5443-5454
DOI: 10.1039/D4AN00956H, Paper
Patrycja Leszczenko, Anna M. Nowakowska, Patrycja Dawiec, Karolina Czuja, Justyna Jakubowska, Marta Zabczynska, Agata Pastorczak, Kinga Ostrowska, Szymon Tott, Wojciech Mlynarski, Malgorzata Baranska, Katarzyna Majzner
Acute lymphoblastic leukaemia (ALL) is a complex disease in pediatric oncology, necessitating accurate diagnostic strategies for effective treatment planning.
The content of this RSS Feed (c) The Royal Society of Chemistry




leukaemia

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




leukaemia

Rishi Kapoor Passes Away Of Acute Myeloid Leukaemia: Know More About This Cancer

Veteran actor Rishi Kapoor (67) passed away on Thursday at 8:45 a.m after a long battle with leukaemia. This Bollywood star was diagnosed with the disease two years back in 2018 and has undergone a bone marrow treatment in the US




leukaemia

Research finds link between road proximity and childhood leukaemia

Living near busy roads is associated with an increased risk of childhood leukaemia, according to French researchers. The study found that children living within 500 metres of major roads were more likely to develop leukaemia than those who lived far from such roads. It is possible that high levels of traffic pollution from the roads are responsible for the higher rates of the illness.




leukaemia

Cure Leukaemia announces 100% nursing funds increase

Birmingham-based Cure Leukaemia has announced record financial results that will see the charity double the amount of funding for research nurses in the West Midlands.





leukaemia

Cure Leukaemia runners reveal motivations for Great Birmingham Run

Fundraisers share their own poignant memories.




leukaemia

Leukaemia diagnosis shocks student during coronavirus pandemic as private health fund considers covering treatment

Colombian student Angelo Romero, unable to fly home due to coronavirus, is receiving emergency treatment in a Brisbane hospital for a shock leukaemia diagnosis, concerned his private health policy won't cover it.




leukaemia

Boxer Troy Waters dies aged 53 after battle with leukaemia

Legendary Australian boxer Troy Waters, a former junior middleweight world title boxing contender, dies at the age of 53 following a long battle with leukaemia.




leukaemia

Trial of novel leukaemia drug is stopped for second time after two more deaths




leukaemia

Family forced to rent $5,000-a-month Sydney apartment during boy's leukaemia treatment

Chayse Gannon and his mother, forced to leave dad and baby brother behind, have changed accommodation around Sydney more than 12 times since he was diagnosed in February.




leukaemia

High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




leukaemia

Rishi Kapoor Passes Away Of Acute Myeloid Leukaemia: Know More About This Cancer

Veteran actor Rishi Kapoor (67) passed away on Thursday at 8:45 a.m after a long battle with leukaemia. This Bollywood star was diagnosed with the disease two years back in 2018 and has undergone a bone marrow treatment in the US