Ariana Grande praises her ‘adorable’ beau Ethan SlaterAriana Grande has recently expressed her admiration for beau and adorable Wicked co-star Ethan Slater.Speaking to Entertainment Tonight at Wicked press tour in Los Angeles over the weekend, the pop star praised Ethan for his...

The Nuggets are the top seed in Group C in the Western Conference.

This paper examines the causes of export success in East and South East Asia and assesses the role of industrial policy.

This week, I’m rerunning some popular posts while we put the finishing touches on DCI’s new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors.

Last week, the Federal Trade Commission (FTC) released the redacted version of administrative complaint against the three largest pharmacy benefit managers (PBMs). The FTC rightly calls out how the gross-to-net bubble can raise patients’ out-of-pocket costs, while also acknowledging how rebates can reduce a plan's (but not the patient’s) costs. Apparently, the FTC believes that PBMs’ customers are pretty dumb, because PBMs are able to prevent plans from “appreciating” such healthcare financing dynamics.

Section V.E. of the complaint (starting on page 23) focuses on the PBMs’ alleged unlawful conduct related to preferring high-list/high-rebate insulin products over versions with lower list prices. I thought it would therefore be fun to take the Wayback Machine to November 2021, when I wrote about this specific topic.

Below, you can review my commentary about the warped incentives behind Viatris’ dual-pricing strategy for its interchangeable biosimilar of Lantus. Much of the FTC’s description of the drug channel aligns with my commentary. But before you fist pump too hard for Ms. Khan’s FTC, you should pause to reflect on the agency’s legal theories in light of plans’ revealed preferences.

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The Food & Drug Administration (FDA) recently approved the first interchangeable biosimilar insulin product: the insulin glargine-yfgn injection from Viatris. Read the FDA’s press release.

Alas, I’m sad to report that the warped incentives baked into the U.S. drug channel will limit the impact of this impressive breakthrough.

Viatris is being forced to launch both a high-priced and a low-priced version of the biosimilar. However, only the high-list/high-rebate, branded version will be available on Express Scripts’ largest commercial formulary. Express Scripts will block both the branded reference product and the lower-priced, unbranded—but also interchangeable—version. Meanwhile, Prime Therapeutics will place both versions on its formularies, leaving the choice up to its plan sponsor clients.

Consequently, many commercial payers will adopt the more expensive product instead of the identical—but cheaper—version. As usual, patients will be the ultimate victims of our current drug pricing system.

Below, I explain the weird economics behind this decision, highlight the negative impact on patients, and speculate on what this all could mean for biosimilars’ future. Until plan sponsors break their addiction to rebates, today’s U.S. drug channel problems will remain.
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Eeek! It's time for Drug Channels’ Halloween roundup of terrifying tales to share with your ghoulish fiends. This month’s tricks and treats:

• Spooky! Blue Shield of California frightens away the gross-to-net bubble with its Humira biosimilar strategy

• Vampiric! Prior authorization sinks its fangs into providers’ time

• Wicked! How the IRA will put a stake through specialty physician practices

• Eerie! Google’s monstrous AI podcasts leave me petrified

• Zoinks! Join the vampire hunters at Drug Channels Institute

Plus, Dr. Glaucomflecken tells us a frightening tale of copayments.

P.S. Stretch out your arms and join the ever-growing zombie horde who shamble after me on LinkedIn. You’ll find my ghostly rantings along with commentary from the undead hordes in the DCI community.
Read more »

Sep 2, 2023

Amid the global energy transition, investors are anxious to pour billions of dollars into many of these countries to turn the new fossil fuel finds into hydrogen. The element is the key feedstock for fuel cells, which use chemical reactions to generate electricity cleanly, with water as the main byproduct. Notwithstanding the considerable technological challenges ahead, demand for the gas in Europe and elsewhere is widely expected to surge as vehicles, factories, and other energy users seek to reduce greenhouse gas emissions.

For Southern Rim nations, however, this tantalizing opportunity for economic development risks turning into just another Sahara mirage. That’s because the hype surrounding hydrogen may continue to distract the regions’ leaders from addressing the tough domestic social issues that are behind the migration crisis. If the technology does become viable, revenue from hydrogen exports to Europe could just perpetuate rent-seeking behavior by political and economic elites at the expense of their own citizens.

Saori Hayami plays mysterious girl Hisui, performs ending song 'Kisekiralink' with Rie Takahashi, Yui Horie

Anti-Fibrotic Data from Amira Pharmaceuticals' LPA1 Receptor Antagonist Program Published in the British Journal of Phar

The world-famous god man and Spiritual leader Sri Sathya Sai Baba passed away at his Sathya Sai super specialty hospita

Threat type: Backdoor

Aliases:

Platforms: Unix

Overall Risk Rating: Low

Damage Potential: High

Distribution Potential: Low

Reported Infection: Low

Information Exposure: Low

Overview:

This new Mirai variant exploits CVE-2020-10173, a vulnerability in Comtrend VR-3033 routers. Similar to earlier variants, this Mirai variant uses telnet and SSH brute-forcing techniques to attack vulnerable devices.

This Backdoor arrives on a system as a file dropped by other malware or as a file downloaded unknowingly by users when visiting malicious sites.

Mira Murati, the OpenAI CTO who announced her departure last month, is raising VC funding for a new AI startup, according to Reuters. This startup will reportedly focus on building AI products based on proprietary models and could raise more than $100 million in this round. When she left, Murati wrote on X that OpenAI […]

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They are his most precious treasure at the moment. Award winning cultivator Shreekishan Suman on growing the world’s most expensive mango variety in the Indian desert state

As soon as Rajkumar Pal scored the winning goal in the shoot-off, an emotional Dhanraj, glued to the TV at home, jumped in joy.

Paul, Miranda, author

Pátzcuarao, Michoacán : Programa de Etnolingüística : SEP : CIESAS : INI, 1981.

Moskva : Samolet, 2000.

Miranda Cosgrove visits WIRED to answer her most searched questions from Google. When did Miranda start acting? Does she sing the 'iCarly' theme? How old was Miranda Cosgrove when she made the film 'School of Rock?' Miranda answers these questions and plenty more for the WIRED Autocomplete Interview.DESPICABLE ME 4 is in theaters July 3, 2024 https://www.despicable.me/Director: Kristen DeVoreEditor: Louville MooreTalent: Miranda CosgroveCreative Producer: Justin WolfsonLine Producer: Joseph BuscemiAssociate Producer: Paul GulyasProduction Manager: Peter BrunetteTalent Booker: Meredith JudkinsProduction Assistant: Lauren BoucherPost Production Supervisor: Christian OlguinPost Production Coordinator: Scout AlterSupervising Editor: Erica DeLeoAssistant Editor: Justin SymondsSpecial Thanks: Glass Engine

In a shocking revelation, senior journalist Rajeev Bhattacharyya’s latest book ‘ULFA : The Mirage of Dawn‘s page no 280 reads that “A former Director General of Assam police hired a surrendered ULFA (SULFA) activist to assassinate editor Anil Mazumdar in Guwahati on 24 March 2009.” The same also added “After two weeks, the police chief […]

The post Journalist Anil Majumdar was Killed By Former DGP of Assam | ULFA : The Mirage of Dawn appeared first on TIMES OF ASSAM by Dhruba Jyoti Deka.

Mirae Asset Nifty MidSmallcap400 Momentum Quality 100 ETF offers a blend of passive and smart-beta investing

Open to spinning off passive fund business under MF Lite, says Swarup Mohanty, Vice-Chairman and CEO, Mirae Asset Investment Managers

Large-caps offer relative safety from froth and Mirae Asset Large Cap Fund performed well in the class

It takes very little effort to plant your own little herb garden at home

The Miranda Brothers is short on humour, romance and real drama, observes Deepa Gahlot.

Westminster : Nichols and Sons, 25 Parliament Street, MDCCCLXXXV [1885]

TikTok star Nagma Mirajkar has been doing rounds on the internet by coming up with many superb videos each day. From comedy to serious, the pretty lady has not an area left, where she can't entertain people with her talent

After Sri Lanka Cricket (SLC), the Emirates Cricket Board has offered to host the Indian Premier League (IPL) 2020 in the United Arab Emirates (UAE).

The state-owned airline, which suspended regular passenger flights in March reported a 21% rise in profit for its financial year that ended on March 31

God unexpectedly provides just what a family needs.

Limardes Domingo, an OM worker in Mecula, Mozambique, has seen church growth over two years through God's faithful answers to prayer.

“What a feeling it is to know you can be someone’s miracle…” shares a short-term worker after outreach with the OM Transit team in Romania.

Rachel's personal transformation through Jesus inspires her to serve the women in her community.

Gulf aviation giant Emirates said Sunday it would take at least 18 months for travel demand to return to "a semblance of normality", despite reporting bumper pre-pandemic profits.

1 Ugandan Shilling = 0.001 United Arab Emirates Dirham

1 Salvadoran Colon = 0.4197 United Arab Emirates Dirham

1 Romanian Leu = 0.8248 United Arab Emirates Dirham

1 Ukrainian Hryvnia = 0.1369 United Arab Emirates Dirham

1 Tanzanian Shilling = 0.0016 United Arab Emirates Dirham

1 Venezuelan Bolivar Fuerte = 0.3678 United Arab Emirates Dirham

1 Yemeni Rial = 0.0147 United Arab Emirates Dirham

1 Paraguayan Guarani = 0.0006 United Arab Emirates Dirham

1 Hong Kong Dollar = 0.4729 United Arab Emirates Dirham

1 Kuwaiti Dinar = 11.8737 United Arab Emirates Dirham

1 Saudi Riyal = 0.9779 United Arab Emirates Dirham

1 Tunisian Dinar = 1.2612 United Arab Emirates Dirham

1 South African Rand = 0.2002 United Arab Emirates Dirham