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There is a war on the car, a war on the bike, a war on pedestrians and soon there will be a war on old people.

ICC cricket ranking is the player and country ranking given out by the International Cricket Council, the world governing body of cricket.

Tax return preparation can be done in several ways to calculate your taxes and pay it to the government in time. You just have to make choice of finding out the best way of doing this to pay your taxes.

Acoustic’s head of product marketing said his company made major pivots at the start of last month. This is how he built a martech stack that allowed for such massive shifts.

Please visit Marketing Land for the full article.

Susan Cramm, founder and president of Valuedance.

Dan McGinn, HBR senior editor.

Jabin Botsford/The Washington Post via Getty Images

• San Antonio City Council in Texas has unanimously voted to label terms including "Chinese virus" and "kung-fu virus" as hate speech.
• It was responding to a growth in racist and antisemitic incidents in the city, triggered by the coronavirus crisis.
• "Unfortunately, during times of crises, we do see the best of humanity and sometimes we also see the worst," said Mayor Ron Nirenberg. 
• Senator Ted Cruz called the decision "nuts," saying that the city council was "behaving like a lefty college faculty lounge." 
• It comes after Trump faced criticism for his use of the term "Chinese virus" at a White House Coronavirus Task Force press briefing.
• Visit Business Insider's homepage for more stories.

The city of San Antonio in Texas has unanimously passed a resolution condemning the use of terms such as "Chinese virus" and "kung-fu virus" as hate speech.

It also encouraged residents to report "any such antisemitic, discriminatory or racist incidents" to the relevant authorities following several incidents in the city since the pandemic began, reports San Antonio's WOAI-TV.

See the rest of the story at Business Insider

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• Half of all Brooklynites are white, but 97.5% of the borough's social distancing arrests were of people of color
• Russia is fast becoming a coronavirus epicenter, with health workers still reporting PPE shortages. Putin is already thinking about reopening.

Four graduating Glenelg High School seniors were arrested after allegedly spray painting racist graffiti.

The 2013 Triple Crown not only marked the 40th anniversary of Secretariat's memorable performances as he marched to glory in 1973, it also was notable for also being 35 years since Affirmed and Alydar dueled through the three classic races. One other important, although not as well-known, observance was that it also marked the 50th […]

The post Golden Anniversary: ‘The Healer’ Behind ’63 Derby/Belmont Winner Chateaugay appeared first on Horse Racing News | Paulick Report.

I understand the above quote completely. Life would be so much simpler if my work was just reviewed by my personal friends and by people whose careers are tied to mine. Sure, they’d point out problems, but they’d do it in a nice way, quietly. They’d understand that any mistakes I made would never have […]

After getting 80 zillion comments on that last post with all that political content, I wanted to share something that’s purely technical. It’s something Bob Carpenter wrote in a conversation regarding implementing algorithms in Stan: One thing we are doing is having the matrix library return more expression templates rather than copying on return as […]

Ivan Oransky points us to this amusing retraction of a meta-analysis. The problem: “Standard errors were used instead of standard deviations when using data from one of the studies”! Actually, I saw something similar happen in a consulting case once. The other side had a report with estimates and standard errors . . . the […]

Reports suggest that Cheryl is pushing for Girls Aloud to get back together after The Greatest Dancer was axed by the BBC

KARINE HATESA LEOTA-EVANS
Cedar Rapids

Karine Hatesa Leota-Evans, 16, of Cedar Rapids, passed away on April 20, 2020 at St. Luke's Hospital. Home going services will be held at 2 p.m. Sunday, May 17, at Cedar Memorial Park Cemetery, Garden of Serenity.
Karine was a sweet, loving, well-mannered and soft-spoken daughter, granddaughter, sister, niece and cousin.
She loved to watch and take pictures of sunsets, road trips to her aunts and uncles in Missouri and Wisconsin, sing, dance, connecting on social media, shopping and her cat Miss Samoa. She will be greatly missed by her family and everyone who knew and loved her.
Karine was preceded in death by her mother/grandmother, Karine Hatesa Apineru-Evans.
Left to cherish Karine's memories are her parents, Jennifer and Nofoasaefa Leota; sisters, Fagaeolemasina "Mary" and Taofegauia'i "Amayah"; brother, Rapi Quincy; father/grandfather, Shawn Evans; her Apineru Family; and her Leota Family.
Condolences may be left at www.cedarmemeorial.com under obituaries.
Messages from your sisters.
A message to my little sister:
Karine, this was such unexpected timing, I was hoping to go see grandma first, but I guess you beat me to it. You were such a special girl, beautiful and always full of imagination and the resemblance between the two of us is uncanny. This year 2020, I am to graduate high school, and I was hoping to finally get to meet you in person, I loved our long phone calls but I wanted the real life version of everything but I guess that shall wait till it is my turn to join you up there. It has been four years since I have heard your sweet voice, and it pains me to say I was not able to hear it again one final time before your departure. Here on Earth everything feels different, there is an emptiness. I hope you're dancing in the sky; I hope you're singing in the angel's choir, and I hope the angels know what they have. It must be so nice up in Heaven since you arrived. Never had I ever cried a river of tears, but when you decided to leave there was no holding back, the 4 oceans could not withstand the flood of tears that ran quickly down my face. But I am sorry, I never told you all I wanted to say, never had I imagined living without you, but I know you're shining down on me from Heaven. Tell grandma, Mama Susie, Pops, Nana, Pago and everyone we love up there with you that I said I hope one day I can make all of them proud, and that I miss all of them very much. I am your big sister Rine, and I hope you know how much I love you uso! Always and forever, till no end.
-- Taofegauiai Amayah Leota

To my dearest beloved baby sister,
No words can explain how much I love and miss you, it's even harder for me to write this to you because I never thought of losing you in such a short period of time. Ever since I heard the news of your loss I didn't know what to do or how to feel but deep inside there's a pain that I never felt in a long time, especially losing my own baby sister it was something really unexpected and heartbreaking. I was really looking forward to seeing you one day and spending time with you and have a sisterly bond with you that I will cherish every moment of it. But now without you, my life will be like a book without page numbers. The story will go on, but it might feel out of order. I miss her, my sister, her spirit dulled to a whisper. My sister was a gift I never asked for, but I always wanted. A lost sister is like the missing piece in the game of life. When she was alive, I didn't always miss my sister - now I can't stop missing her. See you when I see you ok, kisses to the sky to you uso. I love you with every beat of my heart and I miss you every day of my life.
--Your older sister, Fagaeolemasina Mary Leota.

It’s simple—I don’t like recurring payments. And I don’t know about you, but with most recurring payments, I feel anxiety around this need to “get my money’s worth.” In other words, I often feel like I under-utilize the product and thus overpay to some extent. So why do I sell my software under a recurring […]

https://uxdesign.cc/i-hate-photoshop-49781b426aed

““I always hated that word—marketing—and I hate it now. Because for me, and this may sound simplistic, the key to marketing is to make something people want. When they want it, they buy it. When they buy it, you have sales. So the product has to speak. The product is what markets things.””

- Interview with Tom Ford.

[IMAGE-1] Part of being a music lover is also being a snob, and even though my mind has opened considerably as I've aged, I still remember all the genres I just couldn't give any time to when I was growing up. Southern rock was definitely verboten for much of my life.…

A glycerol derivative which is effective to reduce blood pressure and has the formula: ##STR1## wherein R1 is an alkyl group having 10-22 carbon atoms, R2 is a lower acyl group or benzoyl, each of R3 and R4 independently is hydrogen or a straight or branched chain alkyl group having 1-6 carbon atoms; each of R5, R6 and R7 independently is hydrogen, a straight or branched chain alkyl group having 1-6 carbon atoms, an aryl group or an aralkyl group; and each of m and n independently is 0 or a positive integer under the condition of m+n=2-8.

The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R1, R2, R3 and R4 are substituent groups.The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.

The invention provides an improved process for the synthesis of compounds carrying at least one phosphate group, especially polyalkylene glycol phosphate compounds, said process comprising the steps of: (a) reacting a compound containing at least one primary alcohol moiety with a diaryl- or diaralkyl-halophosphate whereby to form the corresponding diaryl- or diaralkyl-phosphate ester; (b) reductively cleaving the resulting product; and (c) if desired, repeating steps (a) and (b) with the product of step (b) whereby to produce a compound carrying two or more phosphate groups. Advantages of the process in accordance with the invention are that this avoids the production of by-products and results in products which are low in impurities. Also provided are novel diaryl- and diaralkyl-phosphate ester compounds, in particular polyethylene glycol diphenylphosphate ester and derivatives thereof.

The invention relates to a process for preparing triethyl phosphate by reacting phosphorus oxychloride with a greater than stoichiometric quantity of ethanol under reduced pressure at temperatures of from 0 to 50° C. in a reaction vessel, wherein a) the volatile components resulting from the reaction are predominantly condensed by means of a reflux condenser and the remaining volatile components are passed into a scrubber filled with water,b) after the end of the reaction, the reaction mixture is separated distillatively in an outgassing column into a top product and a bottom product which predominantly comprises triethyl phosphate,c) the top product of the outgassing column is combined with the contents of the scrubber andd) the contents of the scrubber are separated distillatively in an azeotropic distillation to obtain water and ethanol as top product and the ethanol, preferably after dewatering, is preferably returned to the reaction.

Degradation of phosphate esters, particularly neurotoxins and pesticides, is performed using high oxidative state molybdenum complexes, more particularly molybdenum(VI) complexes. A molybdenum(VI) complex is dissolved in water and then reacted with a phosphate ester. The phosphate esters can include, but are not limited to, VX, VE, VG, VM, GB, GD, GA, GF, parathion, paraoxon, triazophos, oxydemeton-methyl, chlorpyrifos, fenitrothion and pirimiphos-methyl, representing both chemical warfare agents as well as pesticides and insecticides.

This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate.

Compounds which are trehalose-6-phosphate or trehalose-6-phosphonate precursors of formula (I) or agriculturally acceptable salts thereof are provided: (I) The compounds are useful in increasing starch production in plants.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

The present invention provides a phosphate group-containing resin comprising, as polymerized units, a polymerizable unsaturated polyester having at least one phosphate group and/or having at least one phosphoric acid group, a (meth)acrylate based polymerizable monomer, and an alkoxylated (meth)acrylic acid polymerizable monomer; and a use of the phosphate-group containing resin as a treating agent of a metallic pigment or an inorganic pigment, especially used in a water-based coating composition.

Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.

An object the invention is to provide a phosphorus pentafluoride producing process wherein phosphorus pentafluoride is separated/extracted from a pentavalent phosphorus compound or a solution thereof, or a composition obtained by allowing the pentavalent phosphorus compound or the solution thereof to react with hydrogen fluoride, thereby producing phosphorus pentafluoride; and a phosphate hexafluoride producing process wherein the resultant phosphorus pentafluoride is used as raw material to produce a phosphate hexafluoride high in purity. The present invention relates to a process for producing phosphorus pentafluoride, wherein a carrier gas is brought into contact with either of the following one: a pentavalent phosphorus compound, a solution thereof, or a solution in which a composition obtained by allowing the pentavalent phosphorus compound or the solution thereof to react with hydrogen fluoride is dissolved, thereby a phosphorus pentafluoride is extracted into the career gas.

In an embodiment, the cement compositions comprise: (i) hydraulic cement, wherein the hydraulic cement has a ratio of CaO to SiO2 in the range of 2.0 to 4.0; and (ii) a water-soluble metaphosphate in a concentration of at least 2.5% bwoc. In another embodiment, the cement compositions comprise: (i) hydraulic cement, wherein the hydraulic cement has a ratio of CaO to SiO2 of less than 2.0; and (ii) a water-soluble metaphosphate; wherein any alkali nitrate is in a concentration of less than 2% bwoc; and wherein any alkali hydroxide, alkali carbonate, or alkali citrate is in a concentration of less than 0.2% bwoc. Methods of cementing in a well comprising forming either of such cement compositions and introducing it into the well are provided.

A method for slicing a workpiece into wafers in which a polyphosphate solution is applied to the workpiece during the slicing process. The method comprises the steps of positioning the workpiece, such as a silicon ingot, in the vicinity of a wire saw that can cut through the workpiece without the use of an abrasive slurry; causing an aqueous polyphosphate solution to contact the workpiece; and causing the wire saw to cut into the workpiece while the polyphosphate solution is in contact with the workpiece. After the workpiece has been cut into wafers, the polyphosphate solution is rinsed off of the wafers. Preferably, the wire saw used in this method is a diamond wire saw.

A method and processes to solubilize and transform phosphorus contents of rock phosphate (RP) into bio-organo-phosphate (BOP) fertilizer have been developed and integrated. The methods include collecting and sorting of organic wastes; blending with RP; subjecting the blend to biocomposting; collection, isolation, selection and growth optimization of consortia of efficient phosphorus solubilizing microorganisms (PSM) and novel plant growth regulating microorganisms (PGRM); where in PSM produce organic acids and other organic compounds using compost substrate at mesophillic stage, whereas the organic acids released during composting also act in synergism of PSM, thus forming a carbon rich acidic culture resulting in the solubilization of rock phosphate.

The invention employs composites of zeolite and ferric oxide hydroxide for removal of inorganic nitrogen and phosphorus wastes from animal environments.

A water-insoluble phosphate fertilizer, methods of producing, and methods of using the same are provided. The fertilizer may comprise at least one alkaline earth metal selected from calcium and magnesium and optionally at least one nutrient ion selected from the group consisting of potassium, ammonium, zinc, iron, manganese, copper, boron, chlorine, iodine, molybdenum or selenium. The fertilizer compounds are preferably water-insoluble, dilute acid-soluble, and free-flowing powders.

The present invention relates to oral and dental care and cleaning agents comprising an aqueous dispersion of a phosphate-containing and/or phosphonate-containing polyurethane polymer and anionic surfactant(s), to tooth cleaning methods using these agents, and to the use of oral and dental care and cleaning agents comprising an aqueous dispersion of a phosphate-containing and/or phosphonate-containing polyurethane polymer and anionic surfactant(s) to reduce the restaining of teeth and/or to reduce biofilm development on dental surfaces and/or to reduce the adhesion of bacteria to dental surfaces and/or to extend the antibacterial action of antibacterial substances.

A composite particle and a population of particles comprising a water-insoluble polyphosphate composition, methods of producing, and methods of using the same are provided. The polyphosphate composition may comprise at least one alkaline earth metal selected from calcium and magnesium and optionally at least one nutrient ion selected from the group consisting of potassium, ammonium, zinc, iron, manganese, copper, boron, chlorine, iodine, molybdenum, selenium or sulfur.

The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of Vitamin B1 (TPP) and Vitamin B6 (PLP) from human whole blood.

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