Yellow Brick Cafe has been a local stalwart since it opened in 2014.

CBS's Stephen Colbert revealed on Monday's show that he has been stress eating in the days since President-elect Donald Trump won the election.

The post Stephen Colbert Reveals He Is Stress-Eating Following Trump Win appeared first on Breitbart.

Several Colorado cities have been "zoom-bombed" by people making offensive remarks from afar while shrouded in anonymity.

Nearly every state shifted distinctly to the right in Tuesday's election -- but Colorado is looking like a rare exception.

Beat Deion. Because if Jay Norvell can notch CSU's first Rocky Mountain Showdown win since 2014, the load of those first two seasons lightens considerably.

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The listed phone number for Wyatts rings to Elite Towing. An operator who answered the phone on Tuesday said “Wyatts Towing no longer exists.”

David Treadwell's advice for Alex Forsyth right about now? Forget Travis Kelce. Remember Taylor Swift.

A company planning to build a new data center in north Denver will no longer seek a $9 million tax break from the city, but CoreSite still plans to build the center.

Commissioner of Police Darrin Simons urged the public to come forward with any information regarding recent firearms incidents. Commissioner Simons said, “The Bermuda Police Service [BPS] is appealing for the public to provide any information they may have regarding recent firearms incidents in our community. When we work together, the evidence of our success is clear. […]

A 36-year-old suspect has been arrested in relation to the aggravated burglary and sexual assault at a Smiths Parish residence yesterday [Oct 19], the police have confirmed, adding that the investigation continues and anyone with any information should contact them. A police spokesperson said, “A 36-year-old suspect has been arrested in relation to the aggravated […]

[Updated] The police have arrested two suspects following an armed robbery at the Rubis service station on St. John’s Road in Pembroke today. A police spokesperson said, “At around 12.45pm today, Thursday 28th May, police received a report of an armed robbery at the Rubis service station at 61 St. John’s Road, Pembroke. “Reports are […]

The police have arrested two suspects — a 16-year-old male and a 17-year-old male — after an 18-year-old male was “robbed of his motorcycle at knifepoint.” A police spokesperson said, “Around 11:00 p.m. on Sunday, July 2nd, 2023, an 18-year-old male attended Hamilton Police Station and reported that he was robbed of his motorcycle at […]

Christopher Perinchief — who was convicted of possession of ammunition without a licence — had his 12 year sentence reduced to 8.5 years following an appeal. The Court’s ruling said, “The Appellant in this case, Christopher Perinchief, pleaded guilty to possession of ammunition without a licence, contrary to section 3[1][a] of the Firearms Act 1973 […]

“We respect the integrity of the judicial process and accept the court’s decision,” the police said following the recent trial in the Supreme Court, adding that “it is essential that we come together as a community to show empathy and understanding, as we navigate the aftermath of this trial.” This follows after Raheem Wray was found not guilty of […]

AI-powered search engine Perplexity says it’ll begin experimenting with ads on its platform starting this week. Ads will appear in the U.S. to start, formatted as “sponsored follow-up questions.” (E.g., “How can I use LinkedIn to enhance my job search?”) Paid media will be positioned to the side…

Suspicious Activity Detected Activity violating our Terms of Use has been detected on your TipRanks account. Such activity could comprise of any of the following: Exceeding 80 page views of a specific page type within a 24 hour period. Utilizing bots, crawlers or other scraping tools. In most…

The Problem Recently an individual was trying to understand why their website had been dropped from the search engine results. There are several factors that can cause your website to lose placement completely or drop significantly enough that you may need to search several pages back in the results to find your site again. There are […]

Amichai Feit had known Seema Jayachandran as a Twitter-famous development economist.  She became Feit’s senior thesis advisor for a policy-analysis project that included economic field research in India.

India travel to Australia for their five-Test series - here's everything you need to know including the schedule, squads and how to follow on the BBC.

Donald Trump's impending White House return poses questions once again about conflicts of interest related to his business empire, with new cryptocurrency and other ventures raising fresh concerns.

velocityconf: @da3mon Sorry! We were just doing some followup with past Velocity attendees. Sorry to intrude. No harm intended. :-(

If you’re an entrepreneur nurturing your own company to a full-blown success, you are always looking for insights and ideas to take your business to the next level, right? But you’re probably super busy as well, and don’t always have the time to figure out where you should be looking for those insights.

Modern commerce is a highly complex global business that is always evolving – and the pace of change is only accelerating. If you work in digital commerce, it’s crucial to stay up-to-date with the latest developments in technology, business, shopper behavior and trends, laws and regulations, payments, logistics and more. How can you stay on […]

The following article, Will These Deranged Celebrities Who Promised To End Their Lives Or Flee The Country If Trump Wins Actually Follow Through?, was first published on Conservative Firing Line.

(Natural News) Similar to what happened in 2016, a host of celebrities and influencers made wild claims that they would leave the country or even end their lives if Donald Trump won another term in the White House. Will any of them actually follow through? Take Rob Reiner, for instance. He promised to “set himself on …

Continue reading Will These Deranged Celebrities Who Promised To End Their Lives Or Flee The Country If Trump Wins Actually Follow Through? ...

Left-wing networks had plenty of bad news for their viewers as former President Donald Trump stormed to victory in the Nov. 5 election. Now, they’re getting plenty of bad news […]

The post Insult to Injury: MSNBC and CNN Suffer Staggering Ratings Plunge Following Trump Victory appeared first on The Western Journal.

Following its snap election, Japanese politics has entered uncharted waters Expert comment LToremark 5 November 2024

Prime Minister Ishiba’s election gamble has failed. Japan now faces another period of political uncertainty, which could affect its international standing.

In Japan’s snap election on 27 October, the ruling coalition of the Liberal Democratic Party (LDP) and New Komeito lost the overwhelming majority it had held since the 2012 general election. The ruling coalition now has 215 seats, leaving it 18 seats short of a majority. 

The largest opposition party is the Constitutional Democratic Party of Japan (CDP), which gained 50 seats to 148. The second largest opposition party is the Japan Innovation Party (Ishin), which lost six seats to 38, and the third largest opposition party is the National Democratic Party (NDP), which gained 21 seats to 28.

But the opposition is divided and there is no real appetite to form a coalition government. This will likely result in a hung parliament, which will further destabilize Japan’s government.

The election results reveal three key things  about the state of Japanese politics and what comes next.

First, that Prime Minister Ishiba’s snap election gamble has failed. The aim was for Ishiba, a non-mainstream member of the LDP, to strengthen the party base and stabilize his administration. But with the ruling coalition losing its majority, the party base has been further weakened and the Ishiba administration is now more likely to be short-lived. LDP voters as well as the public in general  had hoped that Ishiba, as the ‘opposition within the party’, would change the LDP’s structure and government policies, eliminate the uncertainty surrounding party funding and increase transparency on how MPs use public funds to finance political activities.

However, when Ishiba became LDP leader and prime minister, he abandoned his previously more critical stance and prioritized carrying on the policies of the mainstream LDP, leaving his supporters feeling betrayed.

Second, while the ruling coalition has been punished, the people of Japan still did not vote for a change of government. The opposition is divided and, despite its gains in this election, the CDP is not fully committed to take the lead and consolidate the opposition to form a coalition. The CDP also suffers from internal division. The left wing of the party would prefer a coalition with the Communist Party, while the right wing of the party does not want to form a coalition with the LDP or the Communist Party, preferring a partner such as the NDP.

Third, the NDP has become the key to future Japanese politics. By becoming the minority ruling party, the NDP is in a position to control the fate of Ishiba administration. While the CDP has no intention of cooperating with the LDP, the NDP is more willing to do so in order to implement its own policies. As the budget cannot be passed without the NDP’s cooperation, the ruling coalition will have no choice but to accept the NDP’s policy of substantial tax cuts through the expansion of tax credits. It will also likely have to accept an option for married couples to decide their family names, which requires a change of civil codes and is something it has been reluctant to do so far. 

If the NDP’s demands are rejected, a no-confidence motion will likely be submitted and passed, leaving the Ishiba cabinet with no choice but to resign or dissolve the House of Representatives (the lower house of Japan’s parliament).

But the NDP has chosen to not form a coalition with the ruling party and enter government. Why? From the NDP’s point of view, forming a coalition with the LDP, would mean getting involved in the LDP’s internal turmoil – something it wishes to avoid. In addition, elections to the House of Councillors (upper house of parliament) will be held in the summer of 2025. The NDP may have judged that it will have a better chance of implementing its policies by cooperating with the government on a case-by-case basis, rather than forming a coalition with a party that is losing public support and risk following suit.

The minority ruling system that has emerged after the election is extremely rare in Japan’s political history and is likely to make its politics even more unstable in the years ahead. The Ishiba administration will probably be able to survive until the budget is passed in March next year by cooperating with the NDP, but beyond that its prospects are unclear.

As the House of Councillors elections get closer, some in the LDP may say that they cannot fight the election with Ishiba as prime minister. If so, they may choose the option of a same-day election for the lower and the upper house. The cost of an election campaign is significant, and the LDP’s financial strength gives it an advantage in the case of a same-day election. There is also a strong possibility that the public will choose the LDP to regain stability in government. However, this election has shown that public distrust of the LDP is high, and if Ishiba continues to be pushed around by the NDP, his party’s chances of winning would be reduced.

Japanese politics has entered uncharted waters, where the patterns and customs of the past do not apply. There are now doubts both at home and abroad as to whether Ishiba, who has a weak party base, will be able to stay on and steer the government. Over the past decade, the Abe and Kishida administrations have provided Japan with political stability, which has in turn enhanced its international presence. An unstable political system, with frequent changes of government, will likely lead to a decline in Japan’s international influence.

There is also a risk that US–Japan relations  could become unstable. Although the NDP does not have a strong agenda to change the course of this relationship, Ishiba may struggle to keep the promise made by his predecessors to increase defence spending. Ishiba’s nationalist posture could also create a confrontational relationship with the United States, while his weak leadership means he may not seek to invest in strengthening the US–Japan alliance. 

Donald Trump’s win in the US presidential election could pose a further risk. Although Trump might be open to Ishiba’s demand for parity with the US, he could become irritated with Ishiba’s weak domestic position. Ishiba may not be able to make decisions – or a deal with Trump – unless the NDP agrees to it.

Chiara Pavanello
Dec 1, 2020; 61:1784-1788
Patient-Oriented and Epidemiological Research

Marco De Giorgi
Dec 1, 2020; 61:1675-1686
Research Articles

Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed weight-loss procedures, but how severe obesity and RYGB affects circulating HDL-associated microRNAs (miRNAs) remains unclear. Here, we aim to investigate how HDL-associated miRNAs are regulated in severe obesity and how weight loss after RYGB surgery affects HDL-miRNAs. Plasma HDL were isolated from patients with severe obesity (n=53) before, 6 and 12 months after RYGB by immunoprecipitation using goat anti-human apoA-I microbeads. HDL were also isolated from 18 healthy participants. miRNAs were extracted from isolated HDL and levels of miR-24, miR-126, miR-222 and miR-223 were determined by TaqMan miRNA assays. We found that HDL-associated miR-126, miR-222 and miR-223 levels, but not miR-24 levels, were significantly higher in patients with severe obesity when compared with healthy controls. There were significant increases in HDL-associated miR-24, miR-222 and miR-223 at 12 months after RYGB. Additionally, cholesterol efflux capacity and paraoxonase (PON1) activity were increased and intracellular adhesion molecule-1 (ICAM-1) levels decreased. The increases in HDL-associated miR-24 and miR-223 were positively correlated with increase in cholesterol efflux capacity (r=0.326, P=0.027 and r=0.349, P=0.017 respectively). An inverse correlation was observed between HDL-associated miR-223 and ICAM-1 at baseline. Together, these findings show that HDL-associated miRNAs are differentially regulated in healthy versus patients with severe obesity and are altered after RYGB. These findings provide insights into how miRNAs are regulated in obesity before and after weight reduction, and may lead to the development of novel treatment strategies for obesity and related metabolic disorders.

Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents the leading cause of morbidity and mortality in FLD cases. However, the prognosis is not known and the rate of deterioration of kidney function is variable and unpredictable from patient to patient. In this article, we present data from a follow-up of the large Italian cohort of FLD patients, who have been followed for an average of 12 years. We show that renal failure occurs at the median age of 46 years, with a median time to a second recurrence of 10 years. Additionally, we identify high plasma unesterified cholesterol level as a predicting factor for rapid deterioration of kidney function. In conclusion, this study highlights the severe consequences of FLD, underlines the need of correct early diagnosis and referral of patients to specialized centers, and highlights the urgency for effective treatments to prevent or slow renal disease in patients with LCAT deficiency.

HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesylated and geranylgeranylated proteins. Here, we investigated the effects of Hmgcr inhibition on nonsterol isoprenoids in the liver. We have generated new genetic models to acutely delete genes in the mevalonate pathway in the liver using AAV-mediated delivery of Cre-recombinase (AAV-Cre) or CRISPR/Cas9 (AAV-CRISPR). The genetic deletion of Hmgcr by AAV-Cre resulted in extensive hepatocyte apoptosis and compensatory liver regeneration. At the biochemical level, we observed decreased levels of sterols and depletion of the nonsterol isoprenoids, dolichol and ubiquinone. At the cellular level, Hmgcr-null hepatocytes showed ER stress and impaired N-glycosylation. We further hypothesized that the depletion of dolichol, essential for N-glycosylation, could be responsible for ER stress. Using AAV-CRISPR, we somatically disrupted dehydrodolichyl diphosphate synthase subunit (Dhdds), encoding a branch point enzyme required for dolichol biosynthesis. Dhdds-null livers showed ER stress and impaired N-glycosylation, along with apoptosis and regeneration. Finally, the combined deletion of Hmgcr and Dhdds synergistically exacerbated hepatocyte ER stress. Our data show a critical role for mevalonate-derived dolichol in the liver and suggest that dolichol depletion is at least partially responsible for ER stress and apoptosis upon potent Hmgcr inhibition.

NEW YORK, Nov. 1, 2024 — NANO Nuclear Energy Inc. has announced the October 29, 2024 closing of the sale of an additional 317,646 shares of its common stock at […]

The post NANO Nuclear Energy Raises Over $40M from Recent Underwritten Follow-On Offering appeared first on HPCwire.

St. Louis led 2-0 after two periods, was outscored 3-0, allowed game-winner to Pastrnak with 1:47 remaining

Campaigns to get rid of police in schools catch a wave of momentum in some communities, but activists still face deep resistance from educators nationally.

The Governing Body took a number of decisions that require action by Contracting Parties. This communication draws the attention of Contracting Parties to those decisions that are addressed to [...]

Addressing the plenary meeting in the closing session of the 159^th Session of the Council, the Director-General expressed his appreciation to delegates for their commitment and hard work to [...]

The Pre-Summit will bring together the global efforts to shape the transformation of agri-food systems.

As of last Wednesday, at least 3,500 sea turtles have been rescued from freezing waters in the midst record-breaking winter storm

Paris police said Sunday that 4,000 officers and 1,600 stadium staff will be deployed for a France-Israel soccer match to ensure security a week after violence against Israeli fans in Amsterdam.

OMer Gyöngyi served around the world, then the Riverboat led her back home to Hungary.

In a largely unreached nation, where Christians often face persecution, OM comes alongside local churches to see more vibrant communities of Jesus followers established.

One man is so determined to be baptised that he braves the odds to take the opportunity God has given him.

Two high school basketball coaches and an assistant principal/athletic director are facing criminal charges stemming from an alleged hazing incident that resulted in the hospitalization of a 15-year-old boy.

Districts could face a rising tide of special education-related lawsuits and complaints when schools resume, experts say, if they still cannot offer the services that students with disabilities missed out on for months.

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A single mother finds hope through a Self Help Group and is sharing the good news.

A decade after teaching middle school, this college dean has seen 11 of her former students pursuing degrees in education at her graduate school.