La Luciérnaga se enciende para hablar de la entrevista en la que Gustavo Petro asegurá que no crío a su hijo Nicolás, involucrado en escandalos por presunta corrupción. Además, le contamos sobre la reforma a la salud. También, ¿Colombia es el país más madrugador?La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

The Canadian Pharmacy Spammers are at it again, or should we say still at it again.

“Black people have the right to control their bodies."

Three women – Catara Mattie, Shantori Daniels, and Shaliquah Talbot — have been jailed in the UK for attempting to smuggle around £50,000 [$67,840] worth of cocaine. A statement from the UK National Crime Agency said, “Three drug couriers who attempted to smuggle cocaine worth around £50,000 into the UK on the same flight into Gatwick […]

Police have arrested three men and “seized two firearms, a quantity of ammunition, as well as a large quantity of controlled drugs with a street value of over $700,000.” A police spokesperson said, “On Monday, September 30, officers from the Specialist Investigations Unit and Task Force conducted an operation that resulted in the arrests of […]

A 29-year-old man wanted in connection with the recent seizure of firearms, drugs, and ammunition turned himself in to police and “another male has also since been arrested in relation to this matter, making it five suspects arrested as part of this operation.” A police spokesperson said, “Around 10:40 a.m. on Wednesday, October 2nd, 2024, […]

Quick, guess the lighting.

If you said two lights, and use of high-speed sync to get the shallow depth of field, that's a pretty good guess.

If you said zero lights and a rigid high-efficiency reflector, that's an even better (and correct) guess.

When working with an inexperienced assistant — or looking to introduce someone to the world of off-camera lighting — a rigid/high-efficiency reflector is a fantastic and inexpensive place to start.

1. Brisbane Broncos star Ezra Mam charged over head-on collision, allegedly failing second drug test  ABC News
2. Brisbane news live: Broncos’ Ezra Mam charged over drug test result after crash | Stab victim’s widower wants knife checks in schools | Dog rescued near abandoned boat  Brisbane Times
3. Broncos player charged after car crash: 9News Latest Stories Season 2024, Short Video  9Now
4. Ezra Mam issued court notice after allegedly failing secondary drug test  Fox Sports
5. Club Statement: Ezra Mam  Broncos

Join our daily and weekly newsletters for the latest updates and exclusive content on industry-leading AI coverage. Learn More Google DeepMind has unexpectedly released the source code and model weights of AlphaFold 3 for academic use, marking a significant advance that could accelerate scientific…

This Spanish-language musical about a cartel boss who undergoes gender-affirming surgery won two big prizes at Cannes, including a shared best actress award for its four women leads.

The rise of these treatments has major implications for how we think about obesity, says James Gallagher.

NHS experts report unprecedented demand for the new generation of obesity treatments.

Jeannie Ambrose, one of about 1,000 affected patients, says the drug should be made available on the NHS

A new drug that slows the pace of Alzheimer's disease is too expensive for too little benefit to be used on the NHS, the watchdog says.

Lys234 is one of the residues present in class A β-lactamases that is under selective pressure due to antibiotic use. Located adjacent to proton shuttle residue Ser130, it is suggested to play a role in proton transfer during catalysis of the antibiotics. The mechanism underpinning how substitutions in this position modulate inhibitor efficiency and substrate specificity leading to drug resistance is unclear. The K234R substitution identified in several inhibitor-resistant β-lactamase variants is associated with decreased potency of the inhibitor clavulanic acid, which is used in combination with amoxicillin to overcome β-lactamase–mediated antibiotic resistance. Here we show that for CTX-M-14 β-lactamase, whereas Lys234 is required for hydrolysis of cephalosporins such as cefotaxime, either lysine or arginine is sufficient for hydrolysis of ampicillin. Further, by determining the acylation and deacylation rates for cefotaxime hydrolysis, we show that both rates are fast, and neither is rate-limiting. The K234R substitution causes a 1500-fold decrease in the cefotaxime acylation rate but a 5-fold increase in kcat for ampicillin, suggesting that the K234R enzyme is a good penicillinase but a poor cephalosporinase due to slow acylation. Structural results suggest that the slow acylation by the K234R enzyme is due to a conformational change in Ser130, and this change also leads to decreased inhibition potency of clavulanic acid. Because other inhibitor resistance mutations also act through changes at Ser130 and such changes drastically reduce cephalosporin but not penicillin hydrolysis, we suggest that clavulanic acid paired with an oxyimino-cephalosporin rather than penicillin would impede the evolution of resistance.

Investigations of bacterial resistance strategies can aid in the development of new antimicrobial drugs as a countermeasure to the increasing worldwide prevalence of bacterial antibiotic resistance. One such strategy involves the TipA class of transcription factors, which constitute minimal autoregulated multidrug resistance (MDR) systems against diverse antibiotics. However, we have insufficient information regarding how antibiotic binding induces transcriptional activation to design molecules that could interfere with this process. To learn more, we determined the crystal structure of SkgA from Caulobacter crescentus as a representative TipA protein. We identified an unexpected spatial orientation and location of the antibiotic-binding TipAS effector domain in the apo state. We observed that the α6–α7 region of the TipAS domain, which is canonically responsible for forming the lid of antibiotic-binding cleft to tightly enclose the bound antibiotic, is involved in the dimeric interface and stabilized via interaction with the DNA-binding domain in the apo state. Further structural and biochemical analyses demonstrated that the unliganded TipAS domain sterically hinders promoter DNA binding but undergoes a remarkable conformational shift upon antibiotic binding to release this autoinhibition via a switch of its α6–α7 region. Hence, the promoters for MDR genes including tipA and RNA polymerases become available for transcription, enabling efficient antibiotic resistance. These insights into the molecular mechanism of activation of TipA proteins advance our understanding of TipA proteins, as well as bacterial MDR systems, and may provide important clues to block bacterial resistance.

The organic anion transporters (OATs) and organic anion–transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles in handling various endogenous and exogenous compounds of anionic charge. The OATs and OATPs are often implicated in drug therapy by impacting the pharmacokinetics of clinically important drugs and, thereby, drug exposure in the target organs or cells. Various mechanisms (e.g. genetic, environmental, and disease-related factors, drug-drug interactions, and food-drug interactions) can lead to variations in the expression and activity of the anion drug-transporting proteins of OATs and OATPs, possibly impacting the therapeutic outcomes. Previous investigations mainly focused on the regulation at the transcriptional level and drug-drug interactions as competing substrates or inhibitors. Recently, evidence has accumulated that cellular trafficking, post-translational modification, and degradation mechanisms serve as another important layer for the mechanisms underlying the variations in the OATs and OATPs. This review will provide a brief overview of the major OATs and OATPs implicated in drug therapy and summarize recent progress in our understanding of the post-translational modifications, in particular ubiquitination and degradation pathways of the individual OATs and OATPs implicated in drug therapy.

The allergy and asthma drug montelukast, also known as Singulair, can cause psychiatric side effects—and researchers aren’t sure why

Background: Faced with the limits of synthetic antipyretic substances, in particular their involvement in the occurrence of numerous and often serious adverse effects; the challenge is in search of new antipyretics especially from the African traditional pharmacopoeia. The objective of this study was to evaluate the antipyretic activity of an aqueous extract and a formulation of Ceiba pentandra, with a view to designing an herbal antipyretic drug. Methods: Trials of formulation of an antipyretic syrup with leaves extract of Ceiba pentandra were carried out. The antipyretic activity was investigated by the bewer's yeast induced pyrexia. Physicochemical and microbiological stability tests were carried out on the syrup. Results: It was found with the extract an antipyretic activity at doses of 125 mg/kg and 150 mg/kg. The effect was greater for the 125 mg/kg dose with inhibition percentages ranging from 27.58% to 71.25%. This antipyretic activity was early (from 30 minutes) and was preserved during the four hours of the experiment. The syrup dosed at 125 mg/kg gave an activity similar to that of the extract by significantly reducing the hyperthermia in the rats. Regarding the stability tests, the syrup remained stable both physico-chemically and microbiologically throughout the study period (28 days) both when exposed to low temperature (5 °±3 ° C) and at high temperature (40°±2° C). Conclusions: Ceiba pentandra leaves have antipyretic activity and could be used for the development of an herbal antipyretic drug.

Lose weight with no effort using the ripple effect.

Lindsay P. Cameron
Nov 8, 2023; 43:7472-7482
Symposium and Mini-Symposium

A date has been set for an inquest into the circumstances surrounding the death of a 37-year-old man in police custody in Atikokan, Ont. who overdosed while in police custody in October 2020. The incident led to an investigation by the province's Special Investigations Unit.

Across Canada, there’s a growing number of political leaders proposing to force people into treatment for drug addiction, despite inconclusive evidence about its effectiveness.

Wade Cudmore told the jury at his first-degree murder trial that he was not present when brothers Carlo and Erick Fryer were killed during a drug deal in May 2021.

Falkland locals are still wrapping their heads around the raid of the rural property, likened to a scene out of Breaking Bad, which was part of an RCMP operation that seized drugs and guns worth almost half a billion dollars.

Penn State Health will collect unwanted, unneeded or expired medications, needles and syringes for safe disposal on Saturday, Oct. 26, as part of National Prescription Drug Take-Back Day.

Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

Google DeepMind has silently open-sourced its frontier artificial intelligence (AI) model that can predict the interaction between proteins and other molecules. Dubbed AlphaFold 3, the large language model is the successor of AlphaFold 2, whose research led to the creators of the large language model (LLM) Demis Hassabis and John Jumper getting the Nobel Prize in Chemistry in 2024.

Prateik clarified that it was not money and recognition that pushed him into taking drugs, as people often think

Defendant faces multiple felonies after stealing drug evidence  The Department of Justice’s Division of Civil Rights & Public Trust has indicted a Millsboro police sergeant and evidence custodian after an investigation revealed that he tampered with and used drugs stored in the Department’s evidence locker.   Matthew Dufour, 34, faces ten charges—including multiple felonies such […]

Delaware will hold its 22nd National DEA Prescription Drug Take-Back Day on Saturday, April 30, 2022. Delawareans can discard their expired or unused medications at locations statewide between 10:00 a.m. and 2:00 p.m. There will also be Sharps disposals for needle disposal at select locations, and overdose response education with free Narcan available at select locations.

DOVER, DE (August 30, 2022) – The Division of Public Health (DPH) is releasing a 2020 State Unintentional Drug Overdose Reporting System (SUDORS) fact sheet on all drug overdose deaths that occurred in Delaware. This snapshot contains fatality data abstracted from the state’s Overdose Data to Action (OD2A) collaborative. DPH collects and analyzes unintentional drug overdose […]

*Editor/Reporter note: We originally stated that five DEA National Prescription Drug Take Back locations would be offering Overdose Response Training and Narcan distribution to the public; there are only two – Milford and Middletown. We also erroneously stated that there are 23 locations currently participating in the National Prescription Drug Take Back event; there are 22.    […]

The Delaware Division of Public Health (DPH) recently held its 24th Prescription Drug Take-Back Day event. Organized nationally by the Drug Enforcement Administration (DEA), Prescription Drug Take-Back Day is operated locally by DPH. The twice-a-year event (April and October) aims to reduce the risk of prescription medications being diverted for misuse and has resulted in 114,470 pounds of medication being collected in Delaware since 2010. […]

In collaboration with the Delaware Division of Forensic Science (DFS), the Delaware Division of Public Health (DPH) announces the addition of suspected drug overdose death counts to the agency’s publicly available My Healthy Community (MHC) data dashboard. These data can be viewed on the Drug Overdose Deaths tab within the Mental Health and Substance Use Disorder section of MHC. […]

NEW CASTLE – The Delaware Department of Health and Social Services (DHSS) announced today enhancements to the CostAware website, designed to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical and pharmacy claims in Delaware. […]

Amidst a shortage of prescription stimulants, concerns have been raised about the potential increase in illicit drug use. With many individuals relying on prescription stimulants to manage conditions such as attention-deficit/hyperactivity disorder (ADHD), the shortage has left many struggling to access the medication they need. This has led some individuals to turn to illicit drugs […]

Delaware will hold its 25th National DEA Prescription Drug Take-Back Day on Saturday, October 28, 2023. Delawareans can discard their expired or unused medications at locations statewide between 10:00 a.m. and 2:00 p.m. Sharps disposals for needle disposal will be available at select locations, as well as overdose response education with free Narcan available at […]