Nobel prizewinning theoretical physicist Peter Higgs has died aged 94. He proposed the particle that gives other particles mass – now named the Higgs boson and discovered by the Large Hadron Collider at CERN in 2012

People conceived during the UK's 1940s and 50s sugar rationing have a lower risk of type 2 diabetes and high blood pressure than those conceived after rationing ended

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely manifesting as increased pain sensitivity (allodynia) in distal extremities. Despite its prevalence, effective treatment options are limited. Cannabinoids are increasingly being evaluated for their ability to treat chronic pain conditions, including CIPN. While previous studies have revealed sex differences in cannabinoid-mediated antinociception in acute and chronic pain models, there is a paucity of studies addressing potential sex differences in the response of CIPN to cannabinoid treatment. Therefore, we evaluated the long-term antiallodynic efficacy of cannabinoid receptor type 1 (CB₁)-selective, cannabinoid receptor type 2 (CB₂)-selective, and CB₁/CB₂ mixed agonists in the cisplatin CIPN model, using both male and female mice. CB₁ selective agonism was observed to have sex differences in the development of tolerance to antiallodynic effects, with females developing tolerance more rapidly than males, while the antiallodynic effects of selective CB₂ agonism lacked tolerance development. Compound-specific changes to the female estrous cycle and female plasma estradiol levels were noted, with CB₁ selective agonism decreasing plasma estradiol while CB₂ selective agonism increased plasma estradiol. Chronic administration of a mixed CB₁/CB₂ agonist resulted in increased mRNA expression of proinflammatory cytokines and endocannabinoid regulatory enzymes in female spinal cord tissue. Ovarian tissue was noted to have proinflammatory cytokine mRNA expression following administration of a CB₂ acting compound while selective CB₁ agonism resulted in decreased proinflammatory cytokines and endocannabinoid regulatory enzymes in testes. These results support the need for further investigation into the role of sex and sex hormones signaling in pain and cannabinoid-mediated antinociceptive effects.

It's been a week full of news, some exciting, some alarming. Chris breaks the site...repeatedly. Kelley comes to terms with the fact mowing the lawn is hard in real life. Josh explains Japanese tabloid scandals. Anna Marie assigns a tedious task to Pascal.

The post RPG Cast – Episode 594: “The Queen Needs a Monster Rig” appeared first on RPGamer.

Chris sets out to get justice for Hana. Kelley complains about vegan technology. Robert tells us all about the vacuum cleaner machine gun. And Ryan wonders why the "silent" princess won't shut up.

The post RPG Cast – Episode 694: “There’s No D in Journey” appeared first on RPGamer.

The Health and Human Services Department employs 294 people whose jobs focus on diversity, and the department maintains seven separate "minority health" offices spread across its various agencies, according to a new report that suggests it will be tough for the incoming Trump administration to unwind it all.

People conceived during the UK's 1940s and 50s sugar rationing have a lower risk of type 2 diabetes and high blood pressure than those conceived after rationing ended

A prolific figure in Tamil cinema, the versatile actor appeared in over 400 films across Tamil, Telugu, and Malayalam languages

Pakistan is one of a handful of countries (including India, Brazil, and South Africa) that routinely oppose the United States in multilateral debates despite strong bilateral ties to the U.S.

S.M. Zafar, Khan's prominent and highly respected lawyer, had pledged to the government that the meeting with the press would be Khan's "first and last" such encounter.

Sep 21, 2023

Recent scholarship on Sino-Indian relations in the 1950s has emphasized cooperation, revising previous narratives of an inexorable march towards the 1962 border war. This article reassesses that cooperation by focusing on India's role as an intermediary between the unrecognized government in Beijing and the United Nations (UN). Chinese sources reveal that Sino-Indian cooperation over UN affairs was complicated by competing conceptions of how the decolonizing world should fit into the international system and who should be at the helm. Despite such disagreements, the Cold War UN provided a setting where divergent post-colonial visions could be sublimated into meaningful international cooperation.

Barclaycard Arrival Plus now with EMV

Plackers presents nutrition and dental health tips to keep kids� teeth clean and mouths healthy.

Viva� and Monica Potter Unleash Clean Event Video

Professional lumberjack Adrian Flygt teaches a dedicated team of off-the-street lumbersexuals on how to use the �misery whip� saw during their training in Stillwater, Minn.

Buy a new Clayton home and receive gift cards from Lowe�s* to build your dream backyard.

Hear from Professor Stefan M�ller-H�lsbeck, M.D., PhD, MAJESTIC trial principal investigator

VolitionRx�s Nucleosomics� diagnostic platform detects epigenetic changes to fragments of chromosomes, called nucleosomes, that circulate in the blood of cancer patients. Credit: VolitionRx.

Miami Gala celebrity B-roll for download

GOVERNMENT OF INDIAMINISTRY OF FINANCE (DEPARTMENT OF REVENUE)Notification No.27/2024-Central ExciseNew Delhi, the 28th October, 2024G.S.R.(E)...–In exercise of the powers conferred by sub-section(1) o

People conceived during the UK's 1940s and 50s sugar rationing have a lower risk of type 2 diabetes and high blood pressure than those conceived after rationing ended

BBC producer Dominic Sutherland tells the story of the sometimes farcical race to stage the 1948 Olympics in London.

Mr. Pavan Kumar Nath, Advocate for the petitioner.

2. Mr. Hari Mohan Bhatia, Advocate for the respondents.

3. Petitioner has impugned order dated 23.09.2024 issued by respondent no.2 (annexure no.4), passed under Section 271 AAC(1) of the Income Tax Act, 1961 (hereinafter referred to as "Act of 1961").

4. It is submitted by learned counsel for the petitioner that husband of the petitioner was employed with Van Vikas Nigam, who expired while still in service on 15.01.2018 leaving behind the petitioner and other legal heirs. The death benefits of the deceased husband of the petitioner to the tune of ₹24,00,000/- were transferred to the account of the petitioner. On receipt of ₹24,00,000/- in the account of the petitioner the income skipping assessment was undertaken by the respondent-Department on 11.03.2024 and a tax liability of ₹39,00,000/- inclusive of interest was imposed upon the petitioner. This order was passed under Sections 147/144/144-B of the Act of 1961. Feeling aggrieved by the said order, the petitioner has preferred an appeal on 12.09.2024 before Joint Commissioner (Appeals).

Heard learned Advocates for both the parties.

2. We have considered the materials on record. The dispute arose out of a commercial transaction. Mere failure to comply with the terms of a commercial arrangement per se would not attract the ingredients of the alleged offence. Under such circumstances, we are of the opinion though custodial interrogation of the accused/petitioner is not necessary and he may be granted anticipatory bail, he requires to cooperate with the investigation.

ప్రముఖ స్మార్ట్‌ఫోన్‌ ల తయారీ సంస్థ వివో భారత్‌ మార్కెట్‌లో (Vivo India) ఎంట్రీ లెవల్‌ హ్యాండ్‌సెట్‌ ను విడుదల చేసింది. ఎటువంటి ముందస్తు ప్రకటన లేకుండా కొత్త Y సిరీస్‌ స్మార్ట్‌ఫోన్‌ను లాంచ్‌ చేసింది. ఈ ఫోన్‌ వివో Y18t పేరుతో (Vivo Y18t Smartphone Launched) విడుదల అయింది. ఒకే స్టోరేజీ వేరియంట్‌లో అందుబాటులోకి

കൊവിഡ് കാലം ഓര്‍ക്കാന്‍ തന്നെ ഭയക്കുന്നവരാണ് നമ്മൡ പലരും. ഉറ്റവരില്‍ നിന്നും ഉടയവരില്‍ നിന്നും മാറ്റി നിര്‍ത്തപ്പെട്ട് പരസ്പരം കാണാനാകാതെ ലോക്ക്ഡൗണ്‍ കാലത്ത് വിഷമിച്ചവരായിരിക്കും നമ്മളില്‍ പലരും. അതിനാല്‍ തന്നെ ലോക്ക്ഡൗണ്‍ പിന്‍വലിച്ചത് സ്വാതന്ത്ര്യം ലഭിച്ചതിന് തുല്യമായിരുന്നു എന്നാണ് പലരും അഭിപ്രായപ്പെട്ടിരുന്നത്. കൊവിഡ് കാലം ഏറ്റവും ബുദ്ധിമുട്ടിച്ചത് വയോധികരെയാണ്. ഹൈ റിസ്‌ക് കാറ്റഗറിയില്‍ ഉള്‍പ്പെട്ടിരുന്നവരായതിനാല്‍ തന്നെ ഇവരുടെ

Göttingen : Wallstein Verlag, 2023.

München ; Wien : De Gruyter Oldenbourg, [2023]

Abingdon, Oxon ; New York, NY : Routledge, 2020.

Manchester : Manchester University Press, [2020]

New York; Oxford : Berghahn Books, [2016]

München ; Wien : De Gruyter Oldenbourg, [2021]

Goy-Houten : Hes & De Graaf, c2001.

Singapore : Horizon Books, 2002.

Burbank, CA : Warner Home Video, [2011]

[Salt Lake City] : BG Media, [2003]

[France] : S.P.H.E. Distribution, [2008]

Fort Worth, TX : Modern Art Museum of Fort Worth ; New York, NY : DelMonico Books, [2024]

México, D.F. : Instituto Nacional de Antropología e Historia, 1997.

St Albans : Triad Panther, 1978.

Chicago : International Historic Films Inc., [2020]

[New York] : Criterion Collection, [2014]

Chicago : International Historic Films Inc., [2007]

[New York] : Criterion Collection, [2014]

[Austin, Texas] : MovieDetective.net, [2023]

[New York] : Criterion Collection, [2014]

[New York] : Criterion Collection, [2014]