This book. This book is grounded inside its main character's mind and body in an almost visceral way, and if you've ever had a "crazy" friend--and who hasn't, but I mean one who is actually diagnosed with anxiety disorder and/or OCD--even though this book is entertaining and wonderful and all the things good fiction should be, it will help you to "get" them in a way they might not have been able to articulate to you.

Aza is the star of the show. Or maybe she's not. She's so stuck inside her head, where twisty thoughts and logic have her spinning about the bacteria in her body and how it might just take over and kill her, that maybe she's the victim. Worse, maybe she is the bad guy. And the victim. And the star.

Life is complicated.

Aza is lucky in that she has a best friend, Daisy. Daisy, who talks all. the. time. but who sticks by Aza even though Aza isn't easy to stick by. So when Daisy suggests that she and Aza make like Nancy Drew and Trixie Belden to solve the mystery of the missing billionaire, Aza goes along with it.

Things happen. So many things. And I don't want to talk about any of them, really, because it would spoil this book, which unspools almost magically. It starts from a very clenched place and almost literally unwinds to a a better stasis.

Read it. Read it to find out what role Aza plays in her own life. To see if she can find her way out of her own head, at least a little. And to find out what the title means: "turtles all the way down."

So yeah - consider this review the equivalent of me standing next to you, shoving this book into your hands, making almost uncomfortable levels of eye contact while imploring you to read it.

But really. Read it.

Two Princeton University studies are opening important new windows into understanding an untreatable group of common genetic disorders known as RASopathies that affect approximately one child out of 1,000 and are characterized by distinct facial features, developmental delays, cognitive impairment and heart problems. The findings could help point the way toward personalized precision therapies for these conditions.

Princeton University researchers have drastically shrunk the equipment for producing terahertz — important electromagnetic pulses lasting one millionth of a millionth of a second — to the size of a microchip. The simpler, cheaper generation of terahertz has potential for advances in medical imaging, communications and drug development.

Two years ago, Galway lost their All-Ireland hurling crown to Limerick after a draining two-game semi-final against Clare.

Planning a little solo jaunt across the land? If this is your first time planning your virgin solo adventure, I understand completely how excited and nervous you are. I was once in your shoes.

Before you slap on your backpack and march out that door, here’s a small checklist of things you might want to do to ensure a better trip.

Research, Research, Research

It doesn’t matter if you’re headed into uncharted territory or a bustling metropolis, it only helps if you already know what to expect when you set foot in your destination. A quick google search should give you enough information on things like the local culture, geography, weather and political climate to start with. Oh, and do not forget to check out the local laws, either-written and unwritten. People have in the past gotten into trouble for using the wrong gesture or for looking the wrong person in the eye. Did you also know that shaking your head can be interpreted as ‘yes’ in India?

“Hi, would you like to buy some drugs?

– Nervously shakes head –

“Great! Here’s two kilograms of cocaine!”

Kuh-Myoo-Nick-Ashion

Learn a few words and phrases from the local language and the appropriate situations to use them in. You would be surprised at how much a ‘Yallah’ or a ‘Habibi’ can get people to warm up to you in the Middle East. Also, knowing the language makes ordering food that much easier. Just saying.

Who Ya’ Gonna Call?

It’s very useful to have in hand a bunch of contacts that you can get in touch with if-knock on wood- you should ever find yourself in trouble, eg: Your home country’s Embassy/Consulate(stolen passports are a thing in some countries you know?), local emergency numbers etc. If you have friends or relatives in the country/area, make sure you have their numbers as well. There’s no telling what kind of emergency you might encounter on the road.

Link Up With Other Travellers And Locals!

This is for many people, the single greatest reward of solo travel-meeting new people. There’s so much you discover from engaging with people from different cultures and backgrounds. Yes, I’m being captain obvious here, but it’s a point that just had to be reiterated.  Being alive in the internet age has its perks.

A slew of apps and websites have made it that much easier for travelers to get in touch with people at their destinations. It doesn’t matter if you’re just hanging out with your host from ‘AirBnB’ and ‘Couchsurfing’ or finding fellow travelers to share in your adventure from ‘Penroads’, you’re guaranteed to meet some cool people on your journey. As a matter of fact, Penroads is the best way for you to connect with international travellers coming in from all over the world, so it’s definitely a useful tool to have (It’s a shameless plug. I am so sorry. But it really works!).

Stay Healthy!

Last but never the least, take care of your body. Stay hydrated. It’s no good if your mind yells “Onward!” and your body groans “Hell no!”. Find out if you need to get vaccinated before setting off. Carry some basic medicines and bandages if you can, especially if you’re venturing into the wilderness. On occasion you might have to be careful about where and what you eat as well. Talk to someone who has travelled to India and you just might hear the story about how the delicious chicken Tikka from a street vendor gave them a bad case of ‘Delhi Belly’.

Happy tripping!

Parag Murali is the Marketing & Happiness Manager at penroads.com. He combines his love for travelling and people into a daily passion for bringing travellers together. You can contact him at parag@penroads.com for just about anything, so feel free!

 

Filed under: Arts and Culture, North America, United States

Joanne and Gary, rival travel agents compete for their industry's top honor, the Globel Prize, while trying to address their clients' impossible demands in an Off-Broadway comedy that debuts this week, "Craving for Travel."

The 85-minute, two-actor, 30-character comedy was commissioned and produced by Jim Strong, president of the Dallas-based Strong Travel Services travel agency.

"Travel agents are always asked to do the impossible, and this play shows how that is done, from finding the impossible rooms to making dreams come true," Strong told the "Dallas Morning News." "I decided to bring it to life on stage as a comedy in New York."

From "Craving for Travel's" press release:

With their reputations on the line, travel agents Joanne and Gary will tackle any request, no matter how impossible, and any client, no matter how unreasonable. Full of overzealous travelers, overbooked flights, and hoteliers who are just over it, Craving for Travel reminds us why we travel-and everything that can happen when we do.

"Craving for Travel" opens Thursday at the Peter J. Sharp Theater, where it'll run through Feb. 9. Tickets are $32.50 and $49. They can be purchased at CravingForTravel.com, 212-279-4200 or the Ticket Central Box Office (416 W. 42nd St., 12-8 p.m. daily). More than half of the shows are already sold out.

Continue reading Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible

Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible originally appeared on Gadling on Tue, 07 Jan 2014 10:19:00 EST. Please see our terms for use of feeds.

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"I think it's always important to think about suicide as individual vulnerabilities and context," Eric Caine said.

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

Extracytoplasmic sugar decoration of glycopolymer components of the bacterial cell wall contributes to their structural diversity. Typically, the molecular mechanism that underpins such a decoration process involves a three-component glycosylation system (TGS) represented by an undecaprenyl-phosphate (Und-P) sugar-activating glycosyltransferase (Und-P GT), a flippase, and a polytopic glycosyltransferase (PolM GT) dedicated to attaching sugar residues to a specific glycopolymer. Here, using bioinformatic analyses, CRISPR-assisted recombineering, structural analysis of cell wall–associated polysaccharides (CWPS) through MALDI-TOF MS and methylation analysis, we report on three such systems in the bacterium Lactococcus lactis. On the basis of sequence similarities, we first identified three gene pairs, csdAB, csdCD, and csdEF, each encoding an Und-P GT and a PolM GT, as potential TGS component candidates. Our experimental results show that csdAB and csdCD are involved in Glc side-chain addition on the CWPS components rhamnan and polysaccharide pellicle (PSP), respectively, whereas csdEF plays a role in galactosylation of lipoteichoic acid (LTA). We also identified a potential flippase encoded in the L. lactis genome (llnz_02975, cflA) and confirmed that it participates in the glycosylation of the three cell wall glycopolymers rhamnan, PSP, and LTA, thus indicating that its function is shared by the three TGSs. Finally, we observed that glucosylation of both rhamnan and PSP can increase resistance to bacteriophage predation and that LTA galactosylation alters L. lactis resistance to bacteriocin.

For drummer Conroy Gordon, the hardest part of being locked away day after day in the narrow confines of a stranded cruise ship is his inability to tell his two daughters when Daddy will be home. For the past month, he has been battling this...

Brutal. Horrific. Tragic. Choose your ­description. The April jobs report showed, in harrowing ­detail, just how terribly the coronavirus outbreak has pummelled the United States economy. Most obviously, there’s the 14.7 per cent unemployment rate...

Jamaica is now two cases shy of 500 confirmed COVID-19 infections with the confirmation of eight new cases in the past 24 hours.  The new infections bring the total number to 498 confirmed COVID-19 cases.  In a release a short while...

New research suggests that neurons which track our movements are also involved in imaginary navigation

Brain cells involved in spatial navigation and mapping the environment also fire when we merely imagine moving through familiar surroundings, according to a new study by researchers at University College London. The research, published today in the journal Current Biology, shows that memory and imagination are intimately linked in the brain at the cellular level, and could help to explain some of the changes that occur in the early stages of Alzheimer’s Disease.

Related: The fly's neural compass works just like a mammal's

Related: 3D compass cells found in the bat brain

Continue reading...

The discovery of an inhibitory memory circuit could lead to novel treatments for conditions such as PTSD

In order to remember, we must forget. Recent research shows that when your brain retrieves newly encoded information, it suppresses older related information so that it does not interfere with the process of recall. Now a team of European researchers has identified a neural pathway that induces forgetting by actively erasing memories. The findings could eventually lead to novel treatments for conditions such as post-traumatic stress disorder (PTSD).

We’ve known since the early 1950s that a brain structure called the hippocampus is critical for memory formation and retrieval, and subsequent work using modern techniques has revealed a great deal of information about the underlying cellular mechanisms. The hippocampus contains neural circuits that loop through three of its sub-regions – the dentate gyrus and the CA3 and CA1 areas – and it’s widely believed that memories form by the strengthening and weakening of synaptic connections within these circuits.

Related: Light switches memories on and off | Mo Costandi

Related: The Homer Simpson effect: forgetting to remember

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A toxin isolated from the Togo starburst tarantula provides new insights into pain mechanisms and could lead to new treatments for irritable bowel syndrome

With their large, hairy bodies and long legs, tarantulas are an arachnophobe’s worst nightmare. For pain researchers, however, these outsized spiders are a dream come true: Their venom contains a cocktail of toxins, each of which activates pain-sensing nerve fibres in different ways, and researchers in the United States have now identified one such toxin that will help them to better understand pain, and could also lead to treatments for the chronic pain associated with irritable bowel syndrome.

Physical pain signals are transmitted from the body to the brain by specialised sensory neurons called nociceptors. These pain-sensing neurons have cell bodies located just outside the spinal cord, and possess a single conductive fibre that splits in two, with one branch extending out towards the skin surface, and the shorter one entering the back of the cord.

Related: Uncomfortably numb: The people who feel no pain

Related: Researchers identify gatekeeper neurons that control pain and itch

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Why did right-winger Yosemite Sam have problem with the leftist Bugs Bunny?

In the absence of new U.S. immigration reform legislation, this report examines the opportunities that exist within the executive branch and the administration to refine and strengthen current U.S. immigration laws and policies. The administration can exercise its authority to field policies, programs, and procedures that are effective and fair in advancing the goals of the U.S. immigration system. 

(May 6, 2020) On April 16, 2020, the Norwegian government launched a smartphone app to track the spread of the coronavirus in Norway. By downloading the app, users voluntarily allow the app to track their physical location and notify them if they have been in close proximity to a person who later becomes infected with […]

1. Happy Mother's Day: Karisma to Sushmita, a look at Bollywood's single mum's who have paved their own way  PINKVILLA
2. Mother’s Day 2020: From Aishwarya Rai to Kareena Kapoor, check out pics of these Bollywood moms and...  Hindustan Times
3. Happy Mother's Day 2020: Kareena Kapoor, Shilpa Shetty lead B-Town stars celebrate motherhood, wish mothers on this precious day | In Pics  Jagran English
4. When Aishwarya Rai Bachchan was asked to pick between Kareena Kapoor Khan & Rani Mukerji; Here’s what she said  PINKVILLA
5. Mother’s Day 2020: Single Mothers of Bollywood  News18
6. View Full coverage on Google News

Some businesses have been more successful than others finding ways with new business practices to maintain the same level of success they did pre-pandemic. 

By providing holistic care and support to victims of human trafficking, OM hopes to lead them to freedom in Christ.

God uses three OM Russia Discipleship Centre students to bring hope and help to members of a remote church in Siberia.

Over 50 pastors and family members from Tacloban enjoy a weekend getaway organised by OM Philippines from 7-9 March.

In January 2013, OM Norway and Norwegian Naval Training Agency agreed on internship programme for deckhands and motormen on board MV Logos Hope.

OM's Riverboat will bring the gospel to six ports in three European countries over the course of three months, starting in December 2017.

A community of believers from across the world come together to establish houses of prayer along what has been called the Isaiah 19 Highway.

Ten years ago, Lydia* arrived on the field as a single woman. Now married and with two kids, her method of ministry has changed entirely.

Source: api-internal.usatoday.com.akadns.net - Friday, May 08, 2020
Vice President Pence's trip to Iowa shows how the Trump administration's aims to move past coronavirus are sometimes complicated by the virus itself.            

Courtney Kantoski has created a line of T-shirts and tank tops which she is selling to benefit the United Way of Blair County’s COVID-19 Emergency Relief Fund.

OM Ecuador team members and volunteers see God open doors and protect the team during a recent trip to the highlands of Ecuador.

Three migrant workers who were on their way to Utttar Pradesh from Maharashtra, mostly walking, died in Barwani district of Madhya Pradesh on Saturday, officials said.

We test drive the all new Tata Altroz in the beautiful city of Jaisalmer to see if this new premium hatchback from the homegrown automaker is good enough to beat the mighty Maruti Suzuki Baleno and Hyundai Elite i20 or not.

After a fiscal that saw the pace of work slowing down, a first for the NDA govt, FY21 is likely to be impacted by Covid-19 and its aftermath.

Easing financial burden, preventing project failures and protecting jobs are a must if sector’s to preserve its health.

US courts have been heavily relying on a 50-year-old legal loophole to shield cops from misconduct allegations, an investigation by Reuters claims. It allows officers to get off the hook even when their conduct is deemed unlawful.
Read Full Article at RT.com

PM Modi said that the action should be taken for a more proactive approach to handhold the investors.