Title: Skipping Sleep to Watch Sports is The Real March Madness
Category: Health News
Created: 3/6/2020 12:00:00 AM
Last Editorial Review: 3/6/2020 12:00:00 AM

Virus-like-particle (VLP) influenza vaccines can be given intramuscularly (i.m.) or intranasally (i.n.) and may have advantages over split-virion formulations in the elderly. We tested a plant-made VLP vaccine candidate bearing the viral hemagglutinin (HA) delivered either i.m. or i.n. in young and aged mice. Young adult (5- to 8-week-old) and aged (16- to 20-month-old) female BALB/c mice received a single 3-μg dose based on the HA (A/California/07/2009 H1N1) content of a plant-made H1-VLP (i.m. or i.n.) split-virion vaccine (i.m.) or were left naive. After vaccination, humoral and splenocyte responses were assessed, and some mice were challenged. Both VLP and split vaccines given i.m. protected 100% of the young animals, but the VLP group lost the least weight and had stronger humoral and cellular responses. Compared to split-vaccine recipients, aged animals vaccinated i.m. with VLP were more likely to survive challenge (80% versus 60%). The lung viral load postchallenge was lowest in the VLP i.m. groups. Mice vaccinated with VLP i.n. had little detectable immune response, but survival was significantly increased. In both age groups, i.m. administration of the H1-VLP vaccine elicited more balanced humoral and cellular responses and provided better protection from homologous challenge than the split-virion vaccine.

PURPOSE

We aimed to evaluate the efficacy and safety of use of the Fasting Algorithm for Singaporeans with Type 2 Diabetes (FAST) during Ramadan.

Omadacycline is a broad-spectrum aminomethylcycline approved in October 2018 by the U.S. Food and Drug Administration for treating acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous once-daily formulation. In this report, the activities of omadacycline and comparators were tested against 49,000 nonduplicate bacterial isolates collected prospectively during 2016 to 2018 from medical centers in Europe (24,500 isolates, 40 medical centers [19 countries]) and the United States (24,500 isolates, 33 medical centers [23 states and all 9 U.S. census divisions]). Omadacycline was tested by broth microdilution following the methods in Clinical and Laboratory Standards Institute document M07 (Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard, 11th ed., 2018). Omadacycline (MIC_50/90, 0.12/0.25 mg/liter) inhibited 98.6% of Staphylococcus aureus isolates at ≤0.5 mg/liter, including 96.3% of methicillin-resistant S. aureus isolates and 99.8% of methicillin-susceptible S. aureus isolates. Omadacycline potency was comparable for Streptococcus pneumoniae (MIC_50/90, 0.06/0.12 mg/liter), viridans group streptococci (MIC_50/90, 0.06/0.12 mg/liter), and beta-hemolytic streptococci (MIC_50/90, 0.12/0.25 mg/liter), regardless of species and susceptibility to penicillin, macrolides, or tetracycline. Omadacycline was active against all Enterobacterales tested (MIC_50/90, 1/8 mg/liter; 87.5% of isolates were inhibited at ≤4 mg/liter) except Proteus mirabilis (MIC_50/90, 16/>32 mg/liter) and indole-positive Proteus spp. (MIC_50/90, 8/32 mg/liter) and was most active against Escherichia coli (MIC_50/90, 0.5/2 mg/liter), Klebsiella oxytoca (MIC_50/90, 1/2 mg/liter), and Citrobacter spp. (MIC_50/90, 1/4 mg/liter). Omadacycline inhibited 92.4% of Enterobacter cloacae species complex and 88.5% of Klebsiella pneumoniae isolates at ≤4 mg/liter. Omadacycline was active against Haemophilus influenzae (MIC_50/90, 0.5/1 mg/liter), regardless of β-lactamase status, and against Moraxella catarrhalis (MIC_50/90, ≤0.12/0.25 mg/liter). The potent activity of omadacycline against Gram-positive and -negative bacteria indicates that omadacycline merits further study in serious infections in which multidrug resistance and mixed Gram-positive and Gram-negative bacterial infections may be a concern.

Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory infections. Omadacycline exhibited extracellular activity similar to comparator antibiotics; intracellular penetrance was found by day 3 of omadacycline exposure. These results support the utility of omadacycline as an effective antibiotic for the treatment of CABP caused by L. pneumophila.

Regardless of age, all first-time real estate investors are prone to making the same mistakes. Here are some dos and don’ts for new investors.

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Two Windsor men face multiple drug, property and weapon charges after police pulled over a vehicle for a traffic violation Thursday night. At around 8 p.m., officers from the Windsor police property crimes unit in the area of Tecumseh Road East and Mercer Road saw a black Chrysler 300 commit a traffic violation, police said […]

In winter, the veins of leaves don’t get completely covered in frost. Mimicking this effect could be the best way to create ice-resistant surfaces

Pollen has a natural tendency to adsorb mercury and forms the basis of a new class of tiny robots that speed through toxic water to purify it

SAVANNAH, Georgia—Allegations Friday that a Georgia district attorney blocked police officers from arresting the killers of 25-year-old Ahmaud Arbery were just the latest blow to a local law enforcement apparatus that has been rocked by a series of troubling and deadly scandals.

Brunswick DA Jackie Johnson’s office allegedly prevented the Glynn County Police Department from arresting Travis and Gregory McMichael in connection with the shooting death of Arbery, an unarmed black man, in late February, the Atlanta Journal-Constitution reported. Johnson has recused herself from that case. But one Glynn County commissioner suggested she personally intervened in early plans to make arrests “to protect her friend” Gregory McMichael. McMichael was a former cop and investigator in the Brunswick DA’s office for 25 years who had reportedly investigated Arbery in the past. 

It is far from the first time the office—and local law enforcement more generally—had come under scathing scrutiny. 

Read more at The Daily Beast.

Liverpool are looking to make Sadio Mane an offer that would tarnish Real Madrid's hopes of signing him.

This clay robot can squeeze and squish itself into different shapes

OpenAI’s GPT-2 program churns out natural language that’s remarkably coherent—and that’s a problem

Please go ahead and download _____ to your _____. You can hear about how Anna is _____ because _____ is delayed. Chris is looking _____...

If you're not too busy swinging through the streets, perfecting your armour, or exploring the Dreaming City we've got a new RPG Cast for you. And if the current fall lineup wasn't already overwhelming, then get ready for a long list of new titles announced or shown recently that are going to make you wonder how you can ever get caught up.

Goodbye mainstream fashion and hello menswear made of table linen, the founder of new publication TRASHmag thinks the future of style lies in the bin

• Read more from the spring/summer 2020 edition of The Fashion, our biannual style supplement

What will the fashion industry look like in a decade? If I had my way, it would have reinvented its approach to ‘waste’, mass-produced fashion would no longer exist and we would value clothes for how they are made, not by whom. I believe this is possible: last year, I launched TRASHMag - a magazine focusing on designers and artists producing ethical work. The nine young innovators here are part of that cohort. From the milliner growing plant-based biomaterials to the designer collaging old trainers, their ideas are blueprints for a fashion future that doesn’t cost the earth.

From his fateful game of chess to a moving turn in The Diving Bell and the Butterfly, Von Sydow was the last standard bearer of Bergman’s high-minded movie idiom

•Max von Sydow dies aged 90
•A life in pictures

The opening of the seventh seal in the Book of Revelation, disclosing the truth of God’s existence and the second coming, will result in a mysterious silence in the kingdom of heaven – then the sound of trumpets and the thunderous uproar of Earth’s apocalyptic ending. In the movies, no actor has ever represented these ideas more seriously, nor shown humanity’s anguish in the face of God’s implacable silence or unassuageable anger more clearly, than Max von Sydow. He was virtually a book of revelation in himself.

The passionate severity of Von Sydow – and his ability to impersonate the ascetic nobility of some impossibly remote priestly or knightly order but with very human flaws – formed the bedrock of Ingmar Bergman’s The Seventh Seal and the staggering series of films he was to make with Bergman in the 1950s and 1960s. Beyond that, he virtually epitomised an entire, distinctively high-minded attitude to cinematic art in Europe. His films for Bergman were composed in a movie idiom that drew on Ibsen and Strindberg, Sjöström and Dreyer – and of which, since Bergman’s death in 2007, Von Sydow could be said to be the final standard bearer.

Alf Ingve Berntsen, who worked with the teenage striker at Byrne FK, believes a heavyweight European outfit should already have signed the Norwegian

The former Reds midfielder has saluted the efforts of a team that could have regressed again after missing out on the Premier League crown in 2019

Robert De Niro, Joaquin Phoenix, Juliette Binoche, and Cate Blanchett have signed an op-ed in French newspaper Le Monde.

The Material Girl singer was plagued with health woes and injuries on her last tour and had to scrap and postpone a series of dates.

The 61-year-old singer recently revealed she has antibodies for the respiratory condition and sparked confusion when she was then seen

Tara Reade addressed her past praise for Joe Biden during an interview released on Friday as well as her cryptic "tic toc" tweet skeptics have pointed to while assessing her claims. 

Jordan Goudreau once pushed a plan to protect U.S. schools. Then he moved on to a more daring pursuit, which also didn't end well.

The green-and-white banner from an Illinois high school recalls the first Earth Day 50 years ago

The fourth installment in our weekly series spotlights titles that may have been lost in the news amid the COVID-19 crisis

Follow our live coronavirus updates here

The Prince of Wales has paid tribute to NHS staff who have made the "ultimate sacrifice" serving the British public during the coronavirus pandemic.

Ten years worth of ventilators are to be made in around just ten weeks to cope with demand during the coronavirus outbreak, the head of a consortium of manufacturers has said.

Matt Hancock has praised Muslims across the UK for making changes to how they mark Ramadan due to the coronavirus lockdown.

Muslims around the world have begun the month long fasting period of Ramadan as many countries remain under coronavirus lockdown.

Prince Charles said he was left "utterly heartbroken" by the "tragic story" of the 13-year-old Muslim boy who died alone after contracting coronavirus.

The Prince of Wales has paid tribute to a 13-year-old Muslim boy who died alone after contracting Covid-19.

Captain Tom Moore has been appointed as an honorary colonel to mark his 100th birthday after raising almost £30 million for the NHS by walking laps of his garden.

Coronavirus was "not man-made or genetically modified," US intelligence agencies have said.

Some 450 UK coronavirus patients will be recruited to take part in a new trial of a "promising" Covid-19 drug.

Thank early May bank holiday means payments will be disrupted

A 100-year-old Muslim man has raised more than £70,000 for coronavirus victims after being inspired by Colonel Tom Moore.

Drive-thru restaurants such as McDonald's are "made for social distancing", Environment Secretary George Eustice has said.

A mutation in the virus seems to be getting more common, but we don't know why.

Greasy food and Bloody Marys not cutting through the wretchedness? Try this instead

100-year-old British Muslim Dabirul Islam Choudhury has raised almost £90,000 so far for charities which help people affected by coronavirus here and in Bangladesh

Channing Tatum and his ex-wife are in disagreement over their daughter Everly. Jenna claims that Channing had broke lockdown rules during the coronavirus pandemic and she asked for a court-appointed parenting plan coordinator. Tatum (40) and Dewan (39) divorced in 2018 and had a joint custody agreement in place. Now, Jenna claims that Channing disregarded […]

The post Jenna Dewan Mad At Ex Channing Tatum For Putting Their Daughter At Risk Of CoViD-19 appeared first on Chart Attack.

Katrina vanden Heuvel

The post The Pandemic Has Made the Poor People’s Campaign Virtual—and Vital appeared first on The Nation.

Fans think they might be going official