Giant-scale physics experiments are increasingly reliant on big data and complex algorithms fed into powerful computers, and managing this multiplying mass of data presents its own unique challenges. To better prepare for this data deluge posed by next-generation upgrades and new experiments, physicists are turning to the fledgling field of quantum computing.

The Big Questions series features perspectives from the five recipients of the Department of Energy Office of Science's 2019 Distinguished Scientists Fellows Award describing their research and what they plan to do with the award. Sally Dawson is a senior scientist at DOE's Brookhaven National Laboratory.

The Big Questions series features perspectives from the five recipients of the Department of Energy Office of Science's 2019 Distinguished Scientists Fellows Award describing their research and what they plan to do with the award. Ian Foster is the director of Argonne National Laboratory's Data Science and Learning Division.

There are a few days left to put in a submission on the Electoral (Registration of Sentences Prisoners) Amendment Bill.
The bill would allow prisoners serving sentence of imprisonment under three years to vote, essentially restoring the status quo ante that existed before the members bill advanced by then National MP Paul Quinn was passed by a slim majority
For anyone interested in my views, they're published below. I've been sufficiently organised this time to publish them here a few days before submissions close, so if there are any errors, please let me know. 
The Justice Committee
Electoral (Registration of…

Regular readers will know that I've been hanging out for the "market allocation" parts of the proposed Cannabis Legalisation and Control Bill, which will be the subject of a referendum this year.
While most media outlets ran inane stories last year on how many joints 14 grams added up to, it was clear to anyone who took the subject seriously that the questions of who would get to produce and sell cannabis and how licences would be awarded were vastly more important. And we've had to wait for answers to those.
Well, they're here. And it's very good news. From…

how long in time is a million seconds 11 days how long in time is a billion seconds 31 YEARS the country is in lockdown if every American billionaire would donate 2 million dollars a pandemic patriotic tax for the country you love and have profited greatly from for its very survival we look to […]

Back when T-Mobile and Sprint were trying to gain regulatory approval for their $26 billion merger, executives repeatedly promised the deal would create jobs. Not just a few jobs, but oodles of jobs. Despite the fact that US telecom history indicates such deals almost always trigger mass layoffs, the media dutifully repeated T-Mobile and Sprint executive claims that the deal would create "more than 3,500 additional full-time U.S. employees in the first year and 11,000 more people by 2024."

About that.

Before the ink on the deal was even dry, T-Mobile began shutting down its Metro prepaid business and laying off impacted employees. When asked about the conflicting promises, T-Mobile refused to respond to press inquiries. Now that shutdown has accelerated, with estimates that roughly 6,000 employees at the T-Mobile subsidiary have been laid off as the freshly-merged company closes unwanted prepaid retailers. T-Mobile says the move, which has nothing to do with COVID-19, is just them "optimizing their retail footprint." Industry insiders aren't amused:

"Peter Adderton, the founder of Boost Mobile in Australia and in the U.S. who has been a vocal advocate for the Boost brand and for dealers since the merger was first proposed, figures the latest closures affect about 6,000 people. He cited one dealer who said he has to close 95 stores, some as early as May 1.

In their arguments leading up to the merger finally getting approved, executives at both T-Mobile and Sprint argued that it would not lead to the kind of job losses that many opponents were predicting. They pledged to create jobs, not cut them.

“The whole thing is exactly how we called it, and no one is calling them out. It’s so disingenuous,” Adderton told Fierce, adding that it’s not because of COVID-19. Many retailers in other industries are closing stores during the crisis but plan to reopen once it’s safe to do so."

None of this should be a surprise to anybody. Everybody from unions to Wall Street stock jocks had predicted the deal would trigger anywhere between 15,000 and 30,000 layoffs over time as redundant support, retail, and middle management positions were eliminated. It's what always happens in major US telecom mergers. There is 40 years of very clear, hard data speaking to this point. Yet in a blog post last year (likely to be deleted by this time next year), T-Mobile CEO John Legere not only insisted layoffs would never happen, he effectively accused unions, experts, consumer groups, and a long line of economists of lying:

"This merger is all about creating new, high-quality, high-paying jobs, and the New T-Mobile will be jobs-positive from Day One and every day thereafter. That’s not just a promise. That’s not just a commitment. It’s a fact....These combined efforts will create nearly 5,600 new American customer care jobs by 2021. And New T-Mobile will employ 7,500+ more care professionals by 2024 than the standalone companies would have."

That was never going to happen. Less competition and revolving door, captured regulators and a broken court system means there's less than zero incentive for T-Mobile to do much of anything the company promised while it was wooing regulators. And of course such employment growth is even less likely to happen under a pandemic, which will provide "wonderful" cover for cuts that were going to happen anyway.

Having watched more telecom megadeals like this than I can count, what usually happens is the companies leave things generally alone for about a year to keep employees calm and make it seem like deal critics were being hyperbolic. Then, once the press and public is no longer paying attention (which never takes long), the hatchets come out and the downsizing begins. When the layoffs and reduced competition inevitably arrives, they're either ignored or blamed on something else. In this case, inevitably, COVID-19.

In a few years, the regulators who approved the deal will have moved on to think tank, legal or lobbying positions at the same companies they "regulated." The same press that over-hyped pre-merger promises won't follow back up, because there's no money in that kind of hindsight policy reporting or consumer advocacy. And executives like John Legere (who just quit T-Mobile after selling his $17.5 million NYC penthouse to Giorgio Armani) are dutifully rewarded, with the real world market and human cost of mindless merger mania quickly and intentionally forgotten.

Given all we know about facial recognition tech, it is literally jaw-dropping that anyone could make this claim… especially without being vetted independently.

A group of Harrisburg University professors and a PhD student have developed an automated computer facial recognition software capable of predicting whether someone is likely to be a criminal.

The software is able to predict if someone is a criminal with 80% accuracy and with no racial bias. The prediction is calculated solely based on a picture of their face.

There's a whole lot of "what even the fuck" in CBS 21's reprint of a press release, but let's start with the claim about "no racial bias." That's a lot to swallow when the underlying research hasn't been released yet. Let's see what the National Institute of Standards and Technology has to say on the subject. This is the result of the NIST's examination of 189 facial recognition AI programs -- all far more established than whatever it is Harrisburg researchers have cooked up.

Asian and African American people were up to 100 times more likely to be misidentified than white men, depending on the particular algorithm and type of search. Native Americans had the highest false-positive rate of all ethnicities, according to the study, which found that systems varied widely in their accuracy.

The faces of African American women were falsely identified more often in the kinds of searches used by police investigators where an image is compared to thousands or millions of others in hopes of identifying a suspect.

Why is this acceptable? The report inadvertently supplies the answer:

Middle-aged white men generally benefited from the highest accuracy rates.

Yep. And guess who's making laws or running police departments or marketing AI to cops or telling people on Twitter not to break the law or etc. etc. etc.

To craft a terrible pun, the researchers' claim of "no racial bias" is absurd on its face. Per se stupid af to use legal terminology.

Moving on from that, there's the 80% accuracy, which is apparently good enough since it will only threaten the life and liberty of 20% of the people it's inflicted on. I guess if it's the FBI's gold standard, it's good enough for everyone.

Maybe this is just bad reporting. Maybe something got copy-pasted wrong from the spammed press release. Let's go to the source… one that somehow still doesn't include a link to any underlying research documents.

What does any of this mean? Are we ready to embrace a bit of pre-crime eugenics? Or is this just the most hamfisted phrasing Harrisburg researchers could come up with?

A group of Harrisburg University professors and a Ph.D. student have developed automated computer facial recognition software capable of predicting whether someone is likely going to be a criminal.

The most charitable interpretation of this statement is that the wrong-20%-of-the-time AI is going to be applied to the super-sketchy "predictive policing" field. Predictive policing -- a theory that says it's ok to treat people like criminals if they live and work in an area where criminals live -- is its own biased mess, relying on garbage data generated by biased policing to turn racist policing into an AI-blessed "work smarter not harder" LEO equivalent.

The question about "likely" is answered in the next paragraph, somewhat assuring readers the AI won't be applied to ultrasound images.

With 80 percent accuracy and with no racial bias, the software can predict if someone is a criminal based solely on a picture of their face. The software is intended to help law enforcement prevent crime.

There's a big difference between "going to be" and "is," and researchers using actual science should know better than to use both phrases to describe their AI efforts. One means scanning someone's face to determine whether they might eventually engage in criminal acts. The other means matching faces to images of known criminals. They are far from interchangeable terms.

If you think the above quotes are, at best, disjointed, brace yourself for this jargon-fest which clarifies nothing and suggests the AI itself wrote the pullquote:

“We already know machine learning techniques can outperform humans on a variety of tasks related to facial recognition and emotion detection,” Sadeghian said. “This research indicates just how powerful these tools are by showing they can extract minute features in an image that are highly predictive of criminality.”

"Minute features in an image that are highly predictive of criminality." And what, pray tell, are those "minute features?" Skin tone? "I AM A CRIMINAL IN THE MAKING" forehead tattoos? Bullshit on top of bullshit? Come on. This is word salad, but a salad pretending to be a law enforcement tool with actual utility. Nothing about this suggests Harrisburg has come up with anything better than the shitty "tools" already being inflicted on us by law enforcement's early adopters.

I wish we could dig deeper into this but we'll all have to wait until this excitable group of clueless researchers decide to publish their findings. According to this site, the research is being sealed inside a "research book," which means it will take a lot of money to actually prove this isn't any better than anything that's been offered before. This could be the next Clearview, but we won't know if it is until the research is published. If we're lucky, it will be before Harrisburg patents this awful product and starts selling it to all and sundry. Don't hold your breath.

One of the key points we've been making concerning Attorney General William Barr and his DOJ's eager support for the terrible EARN-IT Act, is that much of it really seems to be to cover up the DOJ's own failings in fighting child porn and child exploitation. The premise behind the EARN IT Act is that there's a lot of child exploitation/child abuse material found on social media... and that social media companies should do more to block that content. Of course, if you step back and think about it, you'd quickly realize that this is a form of sweeping the problem under the rug. Rather than actually tracking down and arresting those exploiting and abusing children, it's demanding private companies just hide the evidence of those horrific acts.

And why might the DOJ and others be so supportive of sweeping evidence under the rug and hiding it? Perhaps because the DOJ and Congress have literally failed to live up to their mandates under existing laws to actually fight child exploitation. Barr's DOJ has been required under law to produce reports showing data about internet crimes against children, and come up with goals to fight those crimes. It has produced only two out of the six reports that were mandated over a decade ago. At the same time, Congress has only allocated a very small budget to state and local law enforcement for fighting internet child abuse. While the laws Congress passed say that Congress should give $60 million to local law enforcement, it has actually allocated only about half of that. Oh, and Homeland Security took nearly half of its "cybercrimes" budget and diverted it to immigration enforcement, rather than fighting internet crimes such as child exploitation.

So... maybe we should recognize that the problem isn't social media platforms, but the fact that Congress and law enforcement -- from local and state up to the DOJ -- have literally failed to do their job.

At least some elected officials have decided to call the DOJ's bluff on why we need the EARN IT Act. Led by Senator Ron Wyden (of course), Senators Kirsten Gillbrand, Bob Casey, Sherrod Brown and Rep. Anna Eshoo have introduced a new bill to actually fight child sex abuse online. Called the Invest in Child Safety Act, it would basically make law enforcement do its job regarding this stuff.

The Invest in Child Safety Act would direct $5 billion in mandatory funding to investigate and target the pedophiles and abusers who create and share child sexual abuse material online. And it would create a new White House office to coordinate efforts across federal agencies, after DOJ refused to comply with a 2008 law requiring coordination and reporting of those efforts. It also directs substantial new funding for community-based efforts to prevent children from becoming victims in the first place.

Basically, the bill would do a bunch of things to make sure that law enforcement is actually dealing with the very real problem of child exploitation, rather than demanding that internet companies (1) sweep evidence under the rug, and (2) break encryption:

• Quadruple the number of prosecutors and agents in DOJ’s Child Exploitation and Obscenity Section from 30 FTEs to 120 FTEs;
• Add 100 new agents and investigators for the Federal Bureau of Investigation’s Innocent Images National Initiative, Crimes Against Children Unit, Child Abduction Rapid Deployment Teams, and Child Exploitation and Human Trafficking Task Forces;
• Fund 65 new NCMEC analysts, engineers, and mental health counselors, as well as a major upgrade to NCMEC’s technology platform to enable the organization to more effectively evaluate and process CSAM reports from tech companies;
• Double funding for the state Internet Crimes Against Children (ICAC) Task Forces;
• Double funding for the National Criminal Justice Training Center, to administer crucial Internet Crimes Against Children and Missing and Exploited Children training programs;
• Increase funding for evidence-based programs, local governments and non-federal entities to detect, prevent and support victims of child sexual abuse, including school-based mental health services and prevention programs like the Children’s Advocacy Centers and the HHS’ Street Outreach Program;
• Require tech companies to increase the time that they hold evidence of CSAM, in a secure database, to enable law enforcement agencies to prosecute older cases;
• Establish an Office to Enforce and Protect Against Child Sexual Exploitation, within the Executive Office of the President, to direct and streamline the federal government’s efforts to prevent, investigate and prosecute the scourge of child exploitation;
• Require the Office to develop an enforcement and protection strategy, in coordination with HHS and GAO; and
• Require the Office to submit annual monitoring reports, subject to mandatory Congressional testimony to ensure timely execution.

While I always have concerns about law enforcement mission creep and misguided targeting of law enforcement efforts, hopefully everyone can agree that child exploitation does remain a very real problem, and one that law enforcement should be investigating and going after those who are actually exploiting and abusing children. This bill would make that possible, rather than the alternative approach of just blaming the internet companies for law enforcement's failure to take any of this seriously.

Well, this one hits the sweet spot of topics I keep trying to demonstrate: both a Streisand Effect and Masnick's Impossibility Theorem. As you may have heard, a group of Republican political consultants and strategists, who very much dislike Donald Trump, put together an effort called The Lincoln Project, which is a PAC to campaign against Trump and Trumpian politics. They recently released an anti-Trump campaign ad about his terrible handling of the COVID-19 pandemic, called Mourning in America, which is a reference to Ronald Reagan's famous Morning in America campaign ad for the 1984 Presidential election. The new ad is, well, pretty powerful:

And while it's unlikely to convince Trump fans deep into their delusions, it certainly got under the President's skin. He went on one of his famous late night Twitter temper tantrums about the ad, and later lashed out at the Lincoln Project when talking to reporters. He was super, super mad.

And what did that do? Well, first it got the ad a ton of views. Earlier this week, one of the Lincoln Project's founders, Rick Wilson, noted that the ad had already received 15 million views across various platforms in the day or so since the ad had been released. Also, it resulted in the Lincoln Project getting a giant boost in funding:

The Lincoln Project, which is run by Republican operatives who oppose President Donald Trump, raised $1 million after the president ripped the group on Twitter this week – marking it the super PAC’s biggest day of fundraising yet.

Reed Galen, a member of the Lincoln Project’s advisory committee, told CNBC that the total came after the president’s Tuesday morning Twitter tirade in reaction to an ad titled “Mourning in America,” which unloads on Trump’s response to the coronavirus pandemic. It recently aired on Fox News, which Trump often watches and praises. Galen said it was the Lincoln Project’s best single-day fundraising haul

Not only that, but it has opened up more opportunity for the Lincoln Project team to get their word out. With so much interest in the ad, it opened up opportunities for the project members to get their message in various mainstream media sources. Reed Galen wrote a piece for NBC:

What we accomplished this week was not something to be celebrated. No commercial should have the power to derail the leader of the free world.

And another Lincoln Project founder, George Conway (who, of course, is the husband of Trump senior advisor Kellyanne Conway), wrote something similar for the Washington Post:

It may strike you as deranged that a sitting president facing a pandemic has busied himself attacking journalists, political opponents, television news hosts and late-night comedians — even deriding a former president who merely boasted that “the ‘Ratings’ of my News Conferences etc.” were driving “the Lamestream Media . . . CRAZY,” and floated bogus miracle cures, including suggesting that scientists consider injecting humans with household disinfectants such as Clorox.

If so, you’re not alone. Tens of thousands of mental-health professionals, testing the bounds of professional ethics, have warned for years about Trump’s unfitness for office.

Some people listened; many, including myself, did not, until it was too late.

That's the kind of media exposure you can't buy, but which you get when you have a President who appears wholly unfamiliar with the Streisand Effect.

And that then takes us to the Impossibility Theorem, regarding the impossibility of doing content moderation at scale well. After Trump's ongoing tirade, Facebook slapped a "Partly False" warning label on the video when posted on Facebook. While the whole situation is ridiculous, it's at least mildly amusing, considering how frequently clueless Trumpkins insist that Facebook censors "conservative" (by which they mean Trumpian) viewpoints. Also, somewhat ironic in all of this: the only reason that Facebook now places such fact check labels on things is because anti-Trump people yelled at how Facebook needed to do more fact checking of political content on its site. So, now you get this.

Part of the issue is that Politifact judged one line in the ad as "false." That line was that Trump "bailed out Wall St. but not Main St." Politifact says that since the CARES Act Paycheck Protection Program has given potentially forgivable loans to some small businesses, and because the bill was done by Congress, not the President, that line is "false." And yet, because angry (usually anti-Trump) people demanded that Facebook do more useless fact checking, the end result is that the video now gets a "false" label.

Of course, this shows both the impossibility of doing content moderation well and the silliness of betting big on fact checking with a full "true or false" claim. One could argue that that line has misleading elements, but is true in most cases. Tons of small businesses are shuttering. Many businesses have been unable to get PPP loans, and under the current terms of the loans, they're useless for many (especially if they have no work for people to do, since the loans have to be mostly used on payroll over the next couple months). But does that make the entire ad "false"? Of course not.

And Rick Wilson is super mad about this. He's right to be mad about Politifact's designation, though it's really a condemnation of the religious focus on "true or false" in fact checking, rather than in focusing on what is misleading or not:

But the ad doesn’t actually claim that small businesses received zero help. Rather, it makes the point that Main Street America is still seriously struggling as the economic fallout from the coronavirus pandemic continues.

But Wilson is also mad at Facebook:

Speaking exclusively to Mediaite, Wilson called the decision “the typical fuckery we’ve come to expect from both the Trump camp and their tame Facebook allies.”

“Facebook is perfectly content to allow content from QAnon lunatics, anti-vaxxers, alt-righters, and every form of Trump/Russian — but I repeat myself — disinformation,” he pointed out. “This is a sign of just how powerfully ‘Mourning In America’ shook Donald Trump and his allies. Their attempt to censor our ad isn’t a setback for us; it’s a declaration of an information war we will win.”

Separately, the Lincoln Project also sent out an email to supporters, again blaming Facebook:

... it's no secret that Facebook has stood by and done little to nothing as lie after lie — from the Liar-In-Chief himself — runs wild on their platform.

(Oh, and let's also not forget the conspiracy theories, foreign disinformation campaigns and negligence that got Mark Zuckerberg questioned by the United States Congress.)

But, this? This is an entirely different and dangerous kind of collusion.

And what is Facebook's excuse for playing favorites with its recently-transferred former employees in the Trump campaign?

They say a "fact-checker" labeled our claim that "Donald Trump helped bailout Wall Street, not Main Street" was untrue.

....Really?

The email goes on to justify the "main street" line with a bunch of links, and then again argues that Facebook is "censoring the truth" to help Trump:

Is that "Partly False?" Of course not.

We told the truth about Donald Trump...

He lost his damn mind over it on Twitter...

Attacked us in front of Air Force One...

Then sent his spin machine to discredit us...

And now his allies at Facebook are doing his damage control by censoring the truth he doesn't like.

I get the frustration -- and I find it at least a bit ironic that the whole "fact checking" system was a response to anti-Trump folks mad at Facebook for allowing pro-Trump nonsense to spread -- but this is just another example of the Impossibility Theorem. There is no "good" solution here. We live in a time where everyone's trying to discredit everyone they disagree with, and many of these things depend on your perspective or your interpretation of a broad statement, like whether or not Trump is helping "main street."

We can agree that it's silly that Facebook has put this label on the video, but also recognize that it's not "Trump's allies at Facebook" working to "censor the truth he doesn't like." That's just absurd (especially given the reason the fact checking set up was put together in the first place).

But, hey, outrage and claims of censorship feed into the narrative (and feed into the Streisand Effect), so perhaps it all is just designed to work together.

People have tried to develop many different attack vectors on cryptocurrencies, from codebase flaws, cryptographic algorithms, mining processes, consensus protocols and block propagation mechanisms to the underlying network layer. Most attacks could be patched quickly by modifying the source code, but preventing attacks that exploit the network layer remains a non-trivial problem as the network … Continue reading Three Paper Thursday: Attacking the Bitcoin Peer-to-Peer Network →

Instant Pot Cranberry Cornbread Bites shaped like Christmas Jingle Bells, pair up for the perfect bite of sweet and tart spiced cranberries.

craving more? check out TasteSpotting

Hibiscus tea mixed with tequila, lime, jalapeno, and pineapple makes this one delicious cocktail!

craving more? check out TasteSpotting

Multinationals' UK arms pair up to take on Voda and former state-owned telco

Telcos Telefónica and Liberty Global today confirmed plans to join their O2 UK and Virgin Media subsidiaries into one combined entity in a deal analysts branded a "blockbuster merger".…

Things will change forever, nods ex-Facebooker Alex Stamos

Video conferencing software biz Zoom has bought Keybase in a surprise move just weeks after hiring Facebook's one-time CSO.…

Secarma may be next for Inflexion buyout

Cloud hosting biz UKFast's founders, Laurence and Gail Jones, have "exited the business" as a private equity firm ups its stake – all as UKFast itself starts eyeing up Jones-owned infosec biz Secarma.…

'Extra time for you to test,' you lucky, lucky developers

Google has applied the brakes to Android 11, pushing things out by a month as it grapples with a world that is much changed since planning for the release began.…

There's revenue to be had with being a participant in the payments web, and the Apple experience to measure up against

Samsung has announced it will launch a debit card.…

iGiant not only screwed up the wiring, it knew it was shipping dodgy gear, it is claimed

Apple is potentially facing a class-action lawsuit over the failure of displays on its MacBook Pro line.…

A review by Rob Cranley (9). A great flight sim that absorbed many, many hours of my youth

A review by ALLEN HALL (6). Excellently showcased what a computer could offer a gamer over a board game

Показали игрокам нарезку из динамичных кадров, который хватило на полторы минуты хронометража.

Креативный директор игры Ашраф Измаил решил ответить геймерам и успокоить аудиторию.

Every house resident understands how quickly she or he can build up a lot of unwanted junk, broken items as well as simply simple rubbish. For those who often tend to hoard, or delay disposal of garbage, this buildup can… Continue Reading →

In between topics to rant about, I thought I would tell you a little bit more about what it's like to be a biotech scientist. I've been in many different sized biotechs and even between them, the culture can vary quite a bit. Therefore, I'll try and describe it in general terms to give you an overview of the life of an industry scientist in research and development (R&D). Of course, some people wi; (read more)

Source: Suzy - Discipline: BioTech

As more and more of my academic scientist friends become disillusioned with their prospects for a balanced life or financial freedom, moving to industry seems the logical choice. If you really want to make the big dollars, you'll want to move out of the lab and try out marketing or sales. Now, you won't be able to go directly to a marketing position from the lab without some marketing experience o; (read more)

Source: Suzy - Discipline: BioTech

I am a scientist for profit. This means, as you are well aware, I have to work with marketing people to generate pretty pictures showing perfect results with any product that we sell. You know those flyers and brochures and ads in BioTechniques where a tiny picture of a gel or a qPCR assay with photoshop perfect curves or bands is plopped on the page next to some meaningless picture and supposed t; (read more)

Source: Suzy - Discipline: BioTech

I would like to thank AGreenMonster for these great questions for discussion. I am going to answer these from my perspective, which is from a life science company. I welcome anyone to give their feedback as well. In fact, if any of the readers out there feels like they have a lot to share, I would be happy to host your article on my blog so that you may provide more details. Just drop me a line.Hi; (read more)

Source: Suzy - Discipline: BioTech

My grad schools days are long behind me, and as time goes on, my memories of the pain and suffering become more of a blur. But, there was one day that I will never forget.  Not only did I lose an entire days work, but I was lucky to avoid serious injury. It was the day I made the biggest mistake I ever made in the lab.My graduate school was in a southern area of the country where obnoxio; (read more)

Source: Suzy - Discipline: Misc

I thought long and hard about the blog topic today because really, when you think about the subject of "what would I be doing now, if I could be doing something else" well, that's a complicated question.There's the thing you could have been doing if you had chosen a completely different path a long, long time ago. That's totally different from what I would; (read more)

Source: Suzy - Discipline: Research

I began a series of posts that explained how products are born, that is, how they go from a concept or idea to a product on the shelf waiting to be bought. So far we've discussed what R&D does and what marketing does to make sure that a product has the greatest possibility for success. Well there is another person on this team who plays a critical role in the product development ; (read more)

Source: Suzy - Discipline: BioTech

This week I will answer questions sent to me by a LabSpaces reader. I welcome additional input from readers who have their own experiences with industry job hunting and using recruiters. Please do feel free to share your knowledge. Questions: I have really been enjoying your posts on your experience with working in industry. I am coming to decide that I want to jump off the academia boat and try; (read more)

Source: Suzy - Discipline: BioTech

This question is about the hiring process and the discussion around salary. The answer is quite involved so it would be easiest to post it separately so we can discuss the topic and also, as always, I welcome others to share their experiences. Just wondering if you might be able to comment on the hiring process. Specifically in my case, I'm just wondering how salary negotations occurs in a compa; (read more)

Source: Suzy - Discipline: BioTech

 Last week the biotech community in San Diego suffered a tough blow as many positions were eliminated as part of a plan to save $20 million dollars in the hopes that Life Tech will please their investors.  People who lost jobs included veterans with the company, many who were loyal and hard-working to the almighty borg of biotechs, sacrificing their nights, vacations, and weekend; (read more)

Source: Suzy - Discipline: BioTech

Anyone with strong bioinformatics skills looking for a job with a fantastic energetic new PI at the University of Arizona? Today I spent time with a friend and new PI at the University of Arizona talking about her metagenomics projects. She's been advertising for an opening for a computational biologist for quite a while.  She tells me that she can't find anyone to fill this position beca; (read more)

Source: Suzy - Discipline: Careers

Check out this qz article: The robot that takes your job should pay taxes, says Bill Gates. About 35-40 years ago secretary was the biggest job in most states. Those days are long past. As you can see by advancing the time bar for the USA states map on that page, by 2000 truck driver was the biggest job. So I have a question for Bill Gates: Do you want to tax word processors too? Also, autonomous vehicle technology will surely wipe out most truck driving jobs in the next 20 years. Do you want to tax autonomous truck technology to slow the rate of that transition? Keep in mind that thousands of lives will be saved each year once...

Levodopa-induced dyskinesia (LID) poses a significant health care challenge for Parkinson’s disease (PD) patients. Amantadine is currently the only drug proven to alleviate LID. Although its efficacy in treating LID is widely assumed to be mediated by blockade of N-methyl-D-aspartate (NMDA) glutamate receptors, our experiments demonstrate that at therapeutically relevant concentrations, amantadine preferentially blocks inward-rectifying K+ channel type 2 (Kir2) channels in striatal spiny projection neurons (SPNs) — not NMDA receptors. In so doing, amantadine enhances dendritic integration of excitatory synaptic potentials in SPNs and enhances — not antagonizes — the induction of long-term potentiation (LTP) at excitatory, axospinous synapses. Taken together, our studies suggest that the alleviation of LID in PD patients is mediated by diminishing the disparity in the excitability of direct- and indirect-pathway SPNs in the on state, rather than by disrupting LTP induction. This insight points to a pharmacological approach that could be used to effectively ameliorate LID and improve the quality of life for PD patients.

Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface–expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cells against these targets using 2 different approaches. The first achieves pHLA recognition via affinity-enhanced versions of natural TCRs (e.g., immune-mobilizing monoclonal T cell receptors against cancer [ImmTAC] molecules), whereas the second harnesses an antibody-based format (TCR-mimic antibodies). For both classes of reagent, target specificity is vital, considering the vast universe of potential pHLA molecules that can be presented on healthy cells. Here, we made use of structural, biochemical, and computational approaches to investigate the molecular rules underpinning the reactivity patterns of pHLA-targeting bispecifics. We demonstrate that affinity-enhanced TCRs engage pHLA using a comparatively broad and balanced energetic footprint, with interactions distributed over several HLA and peptide side chains. As ImmTAC molecules, these TCRs also retained a greater degree of pHLA selectivity, with less off-target activity in cellular assays. Conversely, TCR-mimic antibodies tended to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater degree of crossreactivity. Our findings extend our understanding of the basic principles that underpin pHLA selectivity and exemplify a number of molecular approaches that can be used to probe the specificity of pHLA-targeting molecules, aiding the development of future reagents.

Nerve growth factor (NGF) regulates many aspects of neuronal biology by retrogradely propagating signals along axons to the targets of those axons. How this occurs when axons contain a plethora of proteins that can silence those signals has long perplexed the neurotrophin field. In this issue of the JCI, Li et al. suggest an answer to this vexing problem, while exploring why the Elp1 gene that is mutated in familial dysautonomia (FD) causes peripheral neuropathy. They describe a distinctive function of Elp1 as a protein that is required to sustain NGF signaling by blocking the activity of its phosphatase that shuts off those signals. This finding helps explain the innervation deficits prominent in FD and reveals a unique role for Elp1 in the regulation of NGF-dependent TrkA activity.

Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms.

We're still waiting to hear news about Apple Card's performance relative to the major card issuers, but that hasn't stopped Samsung from announcing plans to launch an "innovative" debit card as part of a new mobile-first money management platform the company has been developing over the last year.


Announced on Thursday in a blog post by Samsung Pay vice-president Sang Ahn, the forthcoming debit card is in partnership with finance company SoFi and will be backed by a cash management account.

"In 2020, Samsung Pay will be expanding our service from being a rewarding way to shop and pay, to also being a rewarding way to manage money," writes Ahn. "Over the past year we have been busy developing a mobile-first money management platform. Our vision is to help consumers better manage their money so that they can achieve their dreams and goals. Now more than ever, mobile financial services and money management tools will play an even bigger role in our daily lives while also opening up new possibilities."

The debit card is scheduled to launch this summer. Other than that, Samsung hasn't offered any details on how it will work, but expect it to integrate with Samsung's existing mobile payment system.

Launched in August 2019, ‌Apple Card‌ is a credit card linked to Apple Pay and built into the Wallet app on iPhone. Apple partnered with Goldman Sachs to launch the card, and in October the investment bank hailed it as "the most successful credit-card launch ever." Nine months later, neither Apple nor Goldman Sachs has offered any concrete details on its performance.

During the global health crisis, Apple has introduced an ‌Apple Card‌ Assistance Program that allows ‌‌Apple Card‌‌ holders to skip their March and April payments without incurring interest charges for that billing cycle. For more details on how the card works, check out our comprehensive Apple Card guide.
This article, "Samsung Announces 'Innovative' Debit Card Launching this Summer" first appeared on MacRumors.com

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The Label's "The_Otherside" is this week's addition to Apple Arcade on the iPhone, iPad, and Apple TV. The game is described as both a turn-based RPG and a strategy board game:

Otherside is a turn based RPG and strategy board game where you will control four survivors who hope to push back the shadowy threat. Make your way through each level solving puzzles, fighting monsters, and destroying the spirit anchors that threaten our dimension.

Do you have what it takes to restore the town back to normal and save the day?

"The_Otherside" is available on the App Store with an Apple Arcade subscription. The service provides iPhone, iPad, Apple TV, and Mac users with access to over 100 games with no in-app purchases or ads for $4.99 per month.
This article, "Apple Arcade's Latest Game Combines Turn-Based RPG With Strategy Board Game" first appeared on MacRumors.com

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Woot is ending the week with a refurbished sale on the 15-inch MacBook Pro, available in multiple storage sizes and colors. The sale starts with the 256GB SSD model (16GB RAM, Intel Core i7) for $1,579.99.

Note: MacRumors is an affiliate partner with Woot. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

For more storage, the 512GB SSD model (16GB RAM, Intel Core i9) is on sale for $1,849.99. Woot's refurbished sales are offering more than $800 in savings when compared to the original prices of these notebooks, which began at $2,399.00 when they launched in May 2019.

Similar to previous Woot sales, each MacBook Pro comes with a One Year Limited Woot Warranty. Each device has been refurbished and is ensured to be in full working condition. When shipped, they are packaged in a generic white box.

You can find even more discounts on new MacBooks by visiting our Best Deals guide for MacBook Pro and MacBook Air. In this guide we track the steepest discounts for the newest MacBook models every week, so be sure to bookmark it and check back often if you're shopping for a new Apple notebook.

This article, "Deals: Refurbished 15-Inch MacBook Pro Notebooks on Sale at Woot From $1,580 ($800+ Off)" first appeared on MacRumors.com

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Apple's next-generation Apple Watch and watchOS 7 will focus on new mental health capabilities, according to leaker Jon Prosser who recently spoke on the Geared Up podcast. The mention of new ‌Apple Watch‌ features comes towards the end of the podcast.


The next-generation version of the ‌Apple Watch‌, the ‌Apple Watch‌ Series 6, has been rumored to include a blood oxygen sensor, which Prosser says Apple will take advantage of to implement new mental health-related features, such as detecting panic attacks.

What their biggest focus on is right now and I hope it comes this year, it might come next year, but I hope it's coming to WWDC is mental health capabilities. Where they can take the oxygen levels in your blood with your heart rate and determine if you're hyperventilating.

They can identify a panic attack before it happens and warn you on your watch. Especially if you're driving, they'll ask you to pull over and they'll offer breathing exercises once you get pulled over.

Prosser says that while he hopes the feature is released this year, "it might come next year." He also says he hopes for a WWDC unveiling, but if the new feature relies on a blood oxygen sensor in an unreleased version of the ‌Apple Watch‌, it's not likely Apple will unveil the capability until the fall when new ‌Apple Watch‌ models that support it are released.

There is, however, a possibility that it will be revealed at WWDC if older ‌Apple Watch‌ models have a latent ability to detect blood oxygen level, which is not clear at this time, or if the feature does not involve blood oxygen monitoring.

The panic attack detecting rumor was first shared by EverythingApplePro and leaker Max Weinbach back in April, who said that the ‌Apple Watch‌ will also be able to determine when a user is experiencing high levels of stress. Weinbach and EverythingApplePro did not suggest the feature would rely on blood oxygen monitoring, however, and said that it would be available on the ‌Apple Watch‌ Series 4 or later.

Hints that blood oxygen tracking capabilities are coming to a future version of the ‌Apple Watch‌ were found in a leaked version of iOS 14. Blood oxygen monitoring is an important feature because a drop in blood oxygen levels can suggest a serious respiratory or cardiac problem that requires immediate medical attention.

Multiple prior rumors from Bloomberg and other sources have also indicated that the next-generation ‌Apple Watch‌ and watchOS 7 will include sleep tracking features, allowing the ‌Apple Watch‌ to measure sleep quality, length, and other metrics.
This article, "Rumor Claims watchOS 7 Will Have 'Mental Health Capabilities' to Detect Panic Attacks" first appeared on MacRumors.com

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Disney has announced that it will be producing a new Robin Hood movie.

Yes, that Robin Hood.

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Rick May, best known to furries and non-furries alike as the voice of Peppy Hare in the English version of the game Star Fox 64 passed away April 13, 2020 due to COVID-19. May was born September 21, 1940 (with the full name of Richard J. May), meaning he would have turned 80 later this year. May had also recently suffered a stroke in February, making him even more vulnerable to the disease caused by the novel coronavirus.

May will forever be known as the man who originally uttered the memetic line "Do a barrel roll! (Z or R twice.)" in Star Fox 64, explaining to players how to perform what is technically an aileron roll in order to deflect enemy attacks. May also played the villain of Star Fox 64, Andross. Outside of furry video games, May is probably best known for voicing the Soldier of Team Fortress 2; furries might also recognize his voice behind the villainous Dr. M from the third Sly Cooper game. In addition to voice work for video games, May has had a long history of working both on and for the stage as both a director and actor, beginning with USO shows while stationed in Japan. His part in a Renton, Washington production of Cotton Patch Gospel featured a combination of his voice and stage work, as he used different voices to portray 21 characters in what was reportedly his favorite stage role.

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