Bone crystallite chemistry and structure change during bone maturation. However, these properties of bone can also be affected by limited uptake of the chemical constituents of the mineral by the animal. This makes probing the effect of bone-mineralization-related diseases a complicated task. Here it is shown that the combination of vibrational spectroscopy with two-dimensional X-ray diffraction can provide unparalleled information on the changes in bone chemistry and structure associated with different bone pathologies (phosphate deficiency) and/or health conditions (pregnancy, lactation). Using a synergistic analytical approach, it was possible to trace the effect that changes in the remodelling regime have on the bone mineral chemistry and structure in normal and mineral-deficient (hypophosphatemic) mice. The results indicate that hypophosphatemic mice have increased bone remodelling, increased carbonate content and decreased crystallinity of the bone mineral, as well as increased misalignment of crystallites within the bone tissue. Pregnant and lactating mice that are normal and hypophosphatemic showed changes in the chemistry and misalignment of the apatite crystals that can be related to changes in remodelling rates associated with different calcium demand during pregnancy and lactation.

The residual strain distribution has been measured as a function of depth in both top coat and bond coat in as-received and heat-treated air plasma sprayed thermal barrier coating samples. High-energy synchrotron X-ray beams were used in transmission to produce full Debye–Scherrer rings whose non-circular aspect ratio gave the in-plane and out-of-plane strains far more efficiently than the sin2ψ method. The residual strain in the bond coat is found to be tensile and the strain in the β phase of the as-received sample was measured. The residual strains observed in the top coat were generally compressive (increasing towards the interface), with two kinds of nonlinear trend. These was a `jump' feature near the interface, and in some cases there was another `jump' feature near the surface. It is shown how these trend differences can be correlated to cracks in the coating.

The Smithsonian’s National Air and Space Museum recently obtained two monumental instruments on loan from NASA’s Goddard Space Flight Center.

The post New Acquisition: Corrective instruments from the Hubble Space Telescope appeared first on Smithsonian Insider.

NASA's Chandra X-ray Observatory has discovered the first direct evidence for a superfluid, a bizarre, friction-free state of matter, at the core of a neutron star.

The post Astronomers detect bizarre superfluid in core of neutron star appeared first on Smithsonian Insider.

If intelligent and more advanced civilizations exist on other planets then its a good bet that some of these civilizations turned to asteroid mining long ago. If so, the hallmarks of their mining activities, such as unusual dirty halos of cast-off dust and debris around large asteroids, might be detectable from earth.

The post Evidence of asteroid mining in our galaxy may lead to the discovery of extraterrestrial civilizations appeared first on Smithsonian Insider.

Even dying stars could host planets with life – and if such life exists, we might be able to detect it within the next decade. […]

The post New evidence of extraterrestrial life may come from dying stars appeared first on Smithsonian Insider.

Tiny and transparent the marine crustacean Paraphronima gracilis sees the world through two large eyes that envelope its head like a high-tech space helmet. Now, […]

The post Bizarre ocean amphipod has 16 retinas in each eye appeared first on Smithsonian Insider.

An extraordinary arrangement of bristles, wrinkles and wart-like bumps cover the cold skin of Sphaerephesia amphorata, a new deep-sea worm described and named by researchers […]

The post Bizarre new marine worms covered in bristles, wrinkles & bumps appeared first on Smithsonian Insider.

Two separate teams of scientists have identified major challenges for the development of life in what has recently become one of the most famous exoplanet […]

The post There’s more to extraterrestrial life than planets in “habitable zone” orbits appeared first on Smithsonian Insider.

Flying through the air? Check. Surviving snake bites? Check. One of the most adorable creatures on earth? Absolutely! Do you think you know everything about […]

The post This Squirrel Appreciation Day we have a few surprising squirrely facts for you appeared first on Smithsonian Insider.

Samantha-Su Z. Taylor, Nicole L. Jacobsen, Tasha K. Pontifex, Paul Langlais, and Janis M. Burt

Connexin 37 (Cx37) expression profoundly suppresses proliferation of rat insulinoma (Rin) cells in a manner dependent on gap junction channel (GJCh) functionality and the presence and phosphorylation status of its carboxyl-terminus (CT). In Rin cells growth arrested by induced Cx37 expression, serine 319 (S319) is frequently phosphorylated. Preventing phosphorylation at this site (alanine substitution; S319A) relieved Cx37 of its growth suppressive effect whereas mimicking phosphorylation at this site (aspartate substitution; S319D) enhanced Cx37's growth suppressive properties. Like Cx37-WT, -S319D GJChs and hemichannels (HChs) preferred the closed state, rarely opening fully, and gated slowly. In contrast, Cx37-S319A channels preferred open states, opened fully, and gated rapidly. These data indicate that phosphorylation-dependent conformational differences in Cx37 protein and channel function underlie Cx37-induced growth arrest vs. growth permissive phenotypes. That the closed state of -WT and Cx37-S319D GJChs and HChs favors growth arrest suggests that rather than specific permeants mediating cell cycle arrest, the closed conformation instead supports interaction of Cx37 with growth regulatory proteins that result in growth arrest.

Appendices B4 and B5 of Cayron [Acta Cryst. (2019), A75, 411–437] contain equations involving the point group and the metric tensor in which the equality symbol should be substituted by the inclusion symbol.

Relativistic electron diffraction depends on linear and quadratic terms in the electric potential, the latter being neglected in the frequently used relativistically corrected Schrödinger equation. The quadratic electric potential term modifies atomic scattering amplitudes in particular for large-angle scattering and backscattering. The respective correction increases with increasing scattering angle, increasing atomic number and increasing kinetic energy. Conventional tabulations for electron scattering and its large-angle extrapolations can be amended in closed form by a universal correction based on the screened Coulomb potential squared.

The post Museum Conservation Institute research scientist Ed Vicenzi discusses his work analyzing daguerreotypes appeared first on Smithsonian Insider.

The National Park Service and the Smithsonian Institution have announced a new partnership to share responsibility for selected National Park Service natural history collections, making them more readily available to researchers through the Smithsonian.

The post National Park Service natural history collections transferred to care of the Smithsonian appeared first on Smithsonian Insider.

For centuries untold numbers of this tiny arachnid (cousin to spiders and ticks) have ended up in teapots, invisibly steeping alongside the leaves of the tea plant on which it lives.

The post Primitive, bizarre, beautiful: New mite species reveal a lost world awaiting discovery appeared first on Smithsonian Insider.

When a mosquito lands and begins to feed, the saliva it deposits in the skin stops blood from coagulating and makes the bite itch. A […]

The post The beautiful and bizarre treehopper appeared first on Smithsonian Insider.

It is shown how to reconstruct the stacking sequence from the pairwise correlation functions between layers in close-packed structures. First, of theoretical interest, the analytical formulation and solution of the problem are presented when the exact pairwise correlation counts are known. In the second part, the practical problem is approached. A simulated annealing procedure is developed to solve the problem using as initial guess approximate solutions from previous treatments. The robustness of the procedure is tested with synthetic data, followed by an experimental example. The developed approach performs robustly over different synthetic and experimental data, comparing favorably with the reported methods.

Attempting to display the contents of an HDF5 file containing fixed-length UTF-8 encoded strings results in an unexpected error in MATLAB.

For example, the following code

  h5disp('myHDF5FileWithFixedLenUTF8Strings.h5')

returns this error:

Error using h5infoc
UTF-8 encoding is only supported for variable length strings.

Error in h5info (line 108)
hinfo = h5infoc(filename,location, useUtf8);

Error in h5disp>display_hdf5 (line 121)
hinfo = h5info(options.Filename,options.Location);

Error in h5disp (line 99)
display_hdf5(options);

Simulink might produce an incorrect sorted order for a model that meets all of the following conditions:

• The model contains blocks from the SoC Blockset
• The Signal logging option is selected in the model configuration set
• Signals using asynchronous sample time are configured for logging

If you try to open a text file with UTF-16 or UTF-32 encoding, the Import Tool displays a warning message stating that the encoding is not supported.  If you continue to load the file anyways, it is opened with UTF-8 encoding, and the file may not be displayed or imported as expected.This bug exists in the following release(s):
R2020a

This bug has a workaround

Interested in Upgrading?

The Debye scattering equation (DSE) is generalized and augmented in order to account for moderate texture effects, yielding the differential cross section as a function of atomic coordinates and texture coefficients subject to symmetry constraints. Implications for the evaluation of the pair distribution function (PDF) as a direct transform of powder diffraction data from textured samples are also discussed.

File: California school employees can now take their required training to spot child abuse and neglect by going online.; Credit: Cayoup/Flickr

Public school employees can take their required annual training to spot child abuse or neglect online, California State Superintendent of Public Instruction Tom Torlakson announced Monday.

“Nothing is more important than the safety of our students,” Torlakson said in a written statement. “The new online training lessons will help school employees carry out their responsibilities to protect children and take action if they suspect abuse or neglect.”

A new California law requires school employees, including teachers, teacher aides, and substitute teachers, to show proof to their employers that they’ve taken the training.

“We were hearing anecdotally that there may have been suspicions of abuse and neglect that was not always reported and we wanted to do something about that issue,” said Stephanie Papas, a California Department of Education consultant.

Recent high-profile cases, such as that of former Miramonte Elementary teacher Mark Berndt, revealed that school employees failed to report allegations of abuse. Los Angeles Unified agreed to pay a record $140 million to settle claims filed by one group of students in the case and $30 million to a second group. Berndt is serving a 25-year sentence after pleading no contest to the charges of committing lewd acts on children.

Papas, who helped create the new two-hour online training, said the course will help employees tell if a child has been hurt from abuse or from an accident, for example.

“We have photos that are examples of, say, a welt that is in the shape of a belt buckle or a slap on a child’s cheek that’s left a hand imprint,” she said.

In-person trainings are more effective, she said, but they’re more expensive than online trainings. That pushed the Department of Education to provide the free online training for school districts still under budget constraints.

She said current employees have until this fall to show their school districts proof that they’ve taken the training.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Canada-based digital transaction processor Carta Worldwide teamed with

Despite being used for several decades, test-based incentives have not consistently generated positive effects on student achievement, says a new report from the National Research Council.

Research to date on the effect of capital punishment on homicide rates is not useful in determining whether the death penalty increases, decreases, or has no effect on these rates, says a new report from the National Research Council.

In the United States, most long-distance trips begin in one metropolitan region and end in another less than 500 miles away.

U.S. adults perform comparably to adults in other economically developed countries on most measures of science knowledge and support science in general, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Despite the importance of eyesight, millions of people grapple with undiagnosed or untreated vision impairments — ranging from mild conditions to total blindness — and eye and vision health remain relatively absent from national health priority lists, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine calls for an international, multi-institutional comprehensive campaign of research, observation, and analysis activities that would help improve understanding and prediction of the Gulf of Mexico’s Loop Current System (LCS).

A systemwide change to the culture and climate in higher education is needed to prevent and effectively respond to sexual harassment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Following recommendations from a National Academies of Sciences, Engineering, and Medicine report released earlier this year, the National Academies’ Gulf Research Program (GRP) is developing a long-term research campaign to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

NASA’s investment in new instruments to analyze extraterrestrial samples is insufficient to provide for replacement of existing instruments, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced a new funding opportunity to provide up to $2.5 million in grants to foster innovative approaches that support its ongoing efforts to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

Current evidence supports the classification of the contemporary red wolf as a distinct species of wolf, although additional genomic evidence from historic wolf specimens could change that assessment, says Evaluating the Taxonomic Status of the Mexican Gray Wolf and the Red Wolf, a new report from the National Academies of Sciences, Engineering, and Medicine.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced $2 million in grant awards for seven new projects through its Understanding Gulf Ocean Systems (UGOS) Grants 2 competition.

A new report by research company

UATP has partnered the payment technology company

Ghost wasn’t the only victim of break-ins over the weekend that exploited critical holes in infrastructure automation software for which patches were available

The post Ghost blogging platform servers hacked to mine cryptocurrency appeared first on WeLiveSecurity

Misreported fishing catches in the Baltic Sea have probably led to incorrect fishing quotas, new research suggests. The study found that total catches between 1996 and 2009 have been underestimated for a significant period, skewing quota calculations.

A new class of drugs called HIF-2 inhibitors is more effective and better tolerated than the standard of care drug sunitinib in treating kidney cancer, researchers with the Kidney Cancer Program at Harold C. Simmons Comprehensive Cancer Center have found.

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People exposed to fine particle (PM2.5) and ozone pollution are at increased risk of suffering out-of-hospital cardiac arrests, according to a recent Finnish study. Cardiac arrest is more likely within 24 hours after exposure to PM2.5 and up to several days after exposure to ozone.

A recent report has summarised what is currently known about the effects of ocean fertilisation as a climate change mitigation measure. The report highlights gaps in scientific understanding of the long term-effects of large-scale ocean fertilisation activities and raises questions about the effectiveness of the approach and the possibility of unintended impacts.