Archives, Room Use Only - TK6545.A1 G86 1992

Archives, Room Use Only - TK5262.C65 1925

His wife had approached police thrice earlier complaining about him

Hospital authorities said of the deceased at the GTB, at least nine received gun shots. One of the deceased is also a woman, they said.

AAP MLA Prakash Jarwal arrested in connection with doctor's suicide

3 arrested over teacher’s killing

AAP MLA Prakash Jarwal, who was booked by the Delhi Police on the charges of extortion and abetment to suicide after a doctor allegedly committed suicide

Train journey from Chennai deferred by one day

The Karnataka government said it'll work with industry associations and workers' unions to arrive at amicable solutions on the number of working hours and wage arrears in the current scenario.

Karnataka government to decide on working hours & wage arrears

A 23-year-old youth was arrested on Friday for repeatedly raping and blackmailing a 17-year-old girl at a village in Khanpur police station area of Jhalawar district. He was produced before a local court on Saturday that sent him to police remand for two days.

Note left behind blamed the leader

The Mambalam police on Saturday arrested Prasanth, 32, owner of T. Nagar-based Jain Bakeries and Confectioneries, on the charge of outraging religious

Document had Mumbai Police’s emblem and ‘Essential Service Pass’ written on it

His friend, organiser too booked; three women rescued

Melting of the semicrystalline structure of native tapioca starch granules is correlated to solution viscosity for elucidating gelatinization and gelation processes.

Earthquake strikes Sussex/Surrey border | Meridian - ITV News  ITV News

'Surrey swarm' quakes 'not caused by oil extraction'  BBC News

'Surrey swarm' earthquakes not caused by nearby oil extraction, study suggests  Science Daily

Surrey named as one of the UK's earthquake hotspots  Surrey Live

This study explores the possibility of measuring the dynamics of proteins in solution using X-ray photon correlation spectroscopy (XPCS) at nearly diffraction-limited storage rings (DLSRs). We calculate the signal-to-noise ratio (SNR) of XPCS experiments from a concentrated lysozyme solution at the length scale of the hydrodynamic radius of the protein molecule. We take into account limitations given by the critical X-ray dose and find expressions for the SNR as a function of beam size, sample-to-detector distance and photon energy. Specifically, we show that the combined increase in coherent flux and coherence lengths at the DLSR PETRA IV yields an increase in SNR of more than one order of magnitude. The resulting SNR values indicate that XPCS experiments of biological macromolecules on nanometre length scales will become feasible with the advent of a new generation of synchrotron sources. Our findings provide valuable input for the design and construction of future XPCS beamlines at DLSRs.

Characterizing and controlling the uniformity of nanoparticles is crucial for their application in science and technology because crystalline defects in the nanoparticles strongly affect their unique properties. Recently, ultra-short and ultra-bright X-ray pulses provided by X-ray free-electron lasers (XFELs) opened up the possibility of structure determination of nanometre-scale matter with Å spatial resolution. However, it is often difficult to reconstruct the 3D structural information from single-shot X-ray diffraction patterns owing to the random orientation of the particles. This report proposes an analysis approach for characterizing defects in nanoparticles using wide-angle X-ray scattering (WAXS) data from free-flying single nanoparticles. The analysis method is based on the concept of correlated X-ray scattering, in which correlations of scattered X-ray are used to recover detailed structural information. WAXS experiments of xenon nanoparticles, or clusters, were conducted at an XFEL facility in Japan by using the SPring-8 Ångstrom compact free-electron laser (SACLA). Bragg spots in the recorded single-shot X-ray diffraction patterns showed clear angular correlations, which offered significant structural information on the nanoparticles. The experimental angular correlations were reproduced by numerical simulation in which kinematical theory of diffraction was combined with geometric calculations. We also explain the diffuse scattering intensity as being due to the stacking faults in the xenon clusters.

Tryptophan synthase catalyzes the last two steps of tryptophan biosynthesis in plants, fungi and bacteria. It consists of two protein chains, designated α and β, encoded by trpA and trpB genes, that function as an αββα complex. Structural and functional features of tryptophan synthase have been extensively studied, explaining the roles of individual residues in the two active sites in catalysis and allosteric regulation. TrpA serves as a model for protein-folding studies. In 1969, Jackson and Yanofsky observed that the typically monomeric TrpA forms a small population of dimers. Dimerization was postulated to take place through an exchange of structural elements of the monomeric chains, a phenomenon later termed 3D domain swapping. The structural details of the TrpA dimer have remained unknown. Here, the crystal structure of the Streptococcus pneumoniae TrpA homodimer is reported, demonstrating 3D domain swapping in a TIM-barrel fold for the first time. The N-terminal domain comprising the H0–S1–H1–S2 elements is exchanged, while the hinge region corresponds to loop L2 linking strand S2 to helix H2'. The structural elements S2 and L2 carry the catalytic residues Glu52 and Asp63. As the S2 element is part of the swapped domain, the architecture of the catalytic apparatus in the dimer is recreated from two protein chains. The homodimer interface overlaps with the α–β interface of the tryptophan synthase αββα heterotetramer, suggesting that the 3D domain-swapped dimer cannot form a complex with the β subunit. In the crystal, the dimers assemble into a decamer comprising two pentameric rings.