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En Banc: Federal Circuit Provides Guidance on Application of On-Sale Bar to Contract Manufacturers

Pharmaceutical and biotech companies breathed a sigh of relief Monday when the Federal Circuit unanimously ruled in a precedential opinion that the mere sale of manufacturing services to create embodiments of a patented product is not a “commercial sale” of the invention that triggers the on-sale bar of 35 U.S.C. § 102(b) (pre-AIA).[1]  The en banc opinion...… Continue Reading




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New MDCG guidance on temporary extraordinary measures related to medical device Notified Body audits during COVID-19 quarantine orders and travel restrictions

When it rains guidance, it pours. The MDCG just released Guidance on temporary extraordinary measures related to medical devices Notified Body audits during COVID-19 quarantine orders and travel restrictions. The guidance takes immediate effect and is valid for the whole period of duration of the pandemic COVID-19 as declared by the World Health Organisation. It […]




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First coronavirus, now 'murder hornets'? 'The Simpsons' predicts the future again

Bill Oakley, a writer on "The Simpsons," admitted on Twitter that perhaps the animated TV show did forecast some of our troubling current events.




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Even if you want to buy a home, it's harder now to get a loan. Or tap home equity

As the economy has cratered, mortgage lenders tightened standards for people who are still interested in buying or refinancing a home.




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Column: America's tolerance for mass murder is the coronavirus' best friend

The America that condones mass murder of children is allowing the coronavirus to spread.




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News Analysis: Is the coronavirus crisis reason to worry about how other nations view U.S. leadership?

U.S. leadership, or the lack thereof, in the time of coronavirus




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Riverside County officials vote to rescind all local coronavirus public health orders

After nearly seven hours of debate, Riverside County officials voted unanimously late Friday to rescind all of the county's stay-at-home orders that go beyond the governor's restrictions.




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Older does not equal expendable. We need to act in a way that protects our elders from coronavirus

Older Americans deserve our protection from coronavirus. They want to get back to their busy lives, too




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Hershey Felder salutes Irving Berlin, plus 13 other must-sees on Mother's Day weekend

Celebrate Mother's Day with a livestream of the musical bio-drama "Hershey Felder as Irving Berlin"




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Pharmacy Compounders Practicing Pursuant to Section 503A Can Get in the Mix: Compounding Shortage Drugs for Hospital Patients, with Some Limitations

By Karla L. Palmer



  • COVID19
  • Prescription Drugs and Biologics

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New Zealand's winning virus tactics spell election risks for Ardern




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Vote Results of 2019 Annual General Meeting of Shareholders




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Yokogawa Makes CDP Water Security A List and Supplier Engagement Leader Board

Yokogawa Electric Corporation (TOKYO: 6841) announces that it has made it onto CDP's Water Security A List and Supplier Engagement Leader Board. The A listing is for the company's sustainable water management practices and disclosure of information on these activities, and the selection to the leader board is for the company's leadership in engaging with its suppliers around the world to reduce carbon emissions and combat global warming.




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Yokogawa Wins Order to Provide Control System and Field Instruments for Gas-fired Power Plant in Turkmenistan

Yokogawa Electric Corporation (TOKYO: 6841) announces that its subsidiary Yokogawa Turkey Industrial Automation Solutions A.S. (Yokogawa Turkey) has won an order to provide a control system and field instruments for the Zerger gas-fired power plant in Turkmenistan. The order was received from Renaissance Heavy Industries, a major construction company in Turkey that is involved in the construction of this plant for Turkmenenergo, a state-owned power utility in Turkmenistan. This is Yokogawa's first control systems order for a power plant in this country.




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Yokogawa Releases AI-enabled Versions of SMARTDAC+ Paperless Recorders and Data Logging Software, and Environmentally Robust AI-enabled e-RT3 Plus Edge Computing Platform for Industry Applications

Yokogawa Electric Corporation (TOKYO: 6841) announces the release of artificial intelligence (AI)-enabled versions of the GX series panel-mount type paperless recorders, GP series portable paperless recorders, and GA10 data logging software, which are components of the highly operable and expandable SMARTDAC+data acquisition and control system. This new AI functionality includes the future pen, a function developed by Yokogawa that enables the drawing of predicted waveforms. Yokogawa is also releasing a new CPU module for the e-RT3 Plus edge computing platform that is environmentally robust and Python compatible. The GX/GP and e-RT3 release is set for April 8, and the GA10 software will be released on May 13. The SMARTDAC+ system is a product in the OpreX Data Acquisition family, and the e-RT3 Plus is part of the OpreX Control Devices family.




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Yokogawa Acquires Fluid Imaging Technologies, a Provider of Flow Imaging Particle Analysis Solutions

Yokogawa Electric Corporation (TOKYO: 6841) announces that on April 8, it completed the acquisition of all shares of Fluid Imaging Technologies, Inc., as mutually agreed.




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Reply to: An appeal to cost undermines food security risks of delayed mitigation




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An appeal to cost undermines food security risks of delayed mitigation




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Reply to: An appeal to cost undermines food security risks of delayed mitigation




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An appeal to cost undermines food security risks of delayed mitigation




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Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE2




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Psychosocial challenges and hormonal treatment in gender diverse children and adolescents. A narrative review




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Reply to Comment on “Suprapubic Pedicled Phalloplasty in Transgender Men: a Multicentric Retrospective Cohort Analysis”




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Personality and psychiatric disorders in chronic pain male affected by erectile dysfunction: prospective and observational study











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Correction to: A universal pipeline for mobile mRNA detection and insights into heterografting advantages under chilling stress




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Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer




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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis




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Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation




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Philip Warren Anderson (1923–2020)




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Larger bacterial populations evolve heavier fitness trade-offs and undergo greater ecological specialization




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Genetic structure in hybrids and progenitors provides insight into processes underlying an invasive cattail (<i>Typha</i> × <i>glauca</i>) hybrid zone




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Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy




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A stereotyped light chain may shape virus-specific B-cell receptors in HCV-dependent lymphoproliferative disorders




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Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders




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Mechanism of collective interstitial ordering in Fe–C alloys




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Adenomyoepithelial tumors of the breast: molecular underpinnings of a rare entity




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Modern Pathology




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Gasdermin D inhibitor protects against sepsis




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The duality of human oncoproteins: drivers of cancer and congenital disorders




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Reconsidering marrow stem cell cycle status: insights into an actively cycling hematopoietic stem cell population




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Geometry v. Gerrymandering

Mathematicians are developing forensics to identify political maps that disenfranchise voters




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Time for Women Leaders

The gender gap in leadership narrows when groups spend more time together




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Dereliction of Duty

The U.S. Congress has not protected health or the environment. Time to make it step up