High-speed camera recordings show that springtails spin at up to 368 rotations per second when they jump away from danger

A traditional yogurt-making practice from south-eastern Europe uses live ants as a starter, with the insects providing the bacteria and acid needed to initiate fermentation

Puppies that are raised in someone's home seem to benefit from that extra human interaction, by asking for help at a younger age than those brought up in kennels

A fossil of a tadpole from Argentina is 161 million years old - and isn't that different from some modern species

A super-stretchy hydrogel can stretch to 15 times its original length and return to its initial shape, and could be used to make soft inflatable robots

The gamma ray burst known as GRB221009A is the biggest explosion astronomers have ever glimpsed and we might finally know what caused the blast

Earth appears to have less mass beneath a certain part of the Indian Ocean compared with the rest of the planet. Plumes of magma at the location could explain why

Climate researchers thought that current global average sea levels were the highest in more than 100,000 years, but new models suggest oceans just 6000 years ago may have been higher than at the beginning of the industrial revolution, and possibly even higher than today

Earth’s iron-rich inner core may owe some of its surprising softness to the motion of atoms, suggest experiments with iron at high temperature and pressure coupled to AI simulations

In an ongoing swarm of earthquakes that began hitting Japan in 2020, the shifting weight of surface water may have spurred the shaking

After over a year of record-high global sea temperatures, the equatorial Atlantic is cooling off more quickly than ever recorded, which could impact weather around the world

A fossil of a tadpole from Argentina is 161 million years old - and isn't that different from some modern species

The earliest evidence of livestock with modified horns has been discovered in ancient Egypt – sheep skulls with horns that point in unnatural directions suggest humans forced them to grow that way

Genetic analysis of 50,000-year-old Neanderthal skeletons has uncovered the remnants of three viruses related to modern human pathogens, and the researchers think they could be recreated

Cut marks on a 4000-year-old skull suggest ancient Egyptian doctors tried to treat a man with nasopharyngeal cancer

Rock art along the Orinoco river in South America is made up of some of the largest etchings we know of and could date back 2000 years

Pictograms and petroglyphs depicting abstract lines and shapes offer a rare glimpse into the culture of people who lived in South America thousands of years ago

Thousands of bones found in a Tibetan cave have been analysed to learn how mysterious ancient humans known as Denisovans lived

A new radiometric dating technique reveals that cave paintings on Sulawesi, Indonesia, are even older than previously thought, pushing back the earliest evidence of storytelling

A monument in southern Spain that dates to between 3600 and 3800 BC appears to have been built with an understanding of geology and physics

On a recent expedition, researchers braved summer storms in northern Greenland to learn the secrets of the ancient peoples who lived there 4500 years ago

The earliest evidence of livestock with modified horns has been discovered in ancient Egypt – sheep skulls with horns that point in unnatural directions suggest humans forced them to grow that way

Title: Antibiotics Now Recommended Before C-Sections
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The prognosis of people with cystic fibrosis (pwCF) has improved dramatically with the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulators (CFTRm). The ageing of the cystic fibrosis (CF) population is changing the disease landscape with the emergence of different needs and increasing comorbidities related to both age and long-term exposure to multiple treatments including CFTRm. Although the number of pwCF eligible for this treatment is expected to increase, major disparities in care and outcomes still exist in this population. Moreover, the long-term impact of the use of CFTRm is still partly unknown due to the current short follow-up and experience with their use, thus generating some uncertainties. The future spread and initiation of these drugs at an earlier stage of the disease is expected to reduce the systemic burden of systemic inflammation and its consequences on health. However, the prolonged life expectancy is accompanied by an increasing burden of age-related comorbidities, especially in the context of chronic disease. The clinical manifestations of the comorbidities directly or indirectly associated with CFTR dysfunction are changing, along with the disease dynamics and outcomes. Current protocols used to monitor slow disease progression will need continuous updates, including the composition of the multidisciplinary team for CF care, with a greater focus on the needs of the adult population.

The diagnostic work-up of patients with fever of unknown origin (FUO) begins with a thorough history and physical examination, complete blood count with differential, chest x-ray, urinalysis and culture, electrolyte panel, liver enzymes, erythrocyte sedimentation rate, and C-reactive protein level. Additional imaging procedures, including nuclear medicine tests, are generally used as second-line procedures, with ¹⁸F-FDG PET and PET/CT assuming increasingly important roles in the diagnostic work-up. The Society of Nuclear Medicine and Molecular Imaging, the Infectious Diseases Society of America, and the American College of Nuclear Medicine convened an autonomous expert work group to comprehensively review the published literature for nuclear imaging in adults and children with FUO and establish appropriate use criteria (AUC). This process was performed in accordance with the Protecting Access to Medicare Act of 2014, which requires that all referring physicians consult AUC by using a clinical decision support mechanism before ordering advanced diagnostic imaging services. The complete findings and discussions of the work group were published on January 8, 2023, and are available at https://www.snmmi.org/ClinicalPractice/content.aspx?ItemNumber=15666. The AUC in the final document are intended to assist referring health care providers in appropriate use of nuclear medicine imaging procedures in patients with FUO. The work group noted limitations in the current literature on nuclear medicine imaging for FUO, with the need for well-designed prospective multicenter investigations. Consensus findings from published data and expert opinions were used to create recommendations in common clinical scenarios for adults and children. Included in the complete document is a discussion of inflammation of unknown origin (IUO), a recently described entity. In view of the fact that the criteria for FUO and IUO are similar (except for fever > 38.3°C [100.9°F]) and that the most common etiologies of these 2 entities are similar, it is the expert opinion of the work group that the recommendations for nuclear medicine imaging of FUO are also applicable to IUO. These recommendations are included in the full guidance document. This summary reviews rationale, methodology, and main findings and refers the reader to the complete AUC document.

Patient expectations of receiving antibiotics for common symptoms can trigger unnecessary use. We conducted a survey (n = 564) between January 2020 to June 2021 in public and private primary care clinics in Texas to study the prevalence and predictors of patients’ antibiotic expectations for common symptoms/illnesses. We surveyed Black patients (33%) and Hispanic/Latine patients (47%), and over 93% expected to receive an antibiotic for at least 1 of the 5 pre-defined symptoms/illnesses. Public clinic patients were nearly twice as likely to expect antibiotics for sore throat, diarrhea, and cold/flu than private clinic patients. Lack of knowledge of potential risks of antibiotic use was associated with increased antibiotic expectations for diarrhea (odds ratio [OR] = 1.6; 95% CI, 1.1-2.4) and cold/flu symptoms (OR = 2.9; 95% CI, 2.0-4.4). Lower education and inadequate health literacy were predictors of antibiotic expectations for diarrhea. Future antibiotic stewardship interventions should tailor patient education materials to include information on antibiotic risks and guidance on appropriate antibiotic indications.

"Kate Forbes still has her own leadership ambitions, setting them aside this Spring in the interest of party unity to accept Mr Swinney's offer to become Deputy First Minister."

AS the nights draw in, and we wake up and it’s still dark out, it just feels that little harder to get out of bed. For some, however, kicking off those warm, cosy covers is far harder than for others.

A "renowned" restructuring advisory business has been acquired by a major player.

Kelley dodge rolls into graves in Elden Ring, Chris is tempted by the Diablo FOMO, and Anna Marie is spreading fake news? Yep, it's the weekly RPG Cast.

The post RPG Cast – Episode 635: “TMNT Is an RPG Now” appeared first on RPGamer.

Kelley tries to capture a goat. Robert is trapped in a corner by the nightmares. Josh upgrades his tank and hopes to get a good ending this time. Will Chris beat FFXVI this week?

The post RPG Cast – Episode 685: “You Erased My Save, Now You Have to Beat It” appeared first on RPGamer.

You remember Lucas Pope, right? He who casually dropped two of the most influential puzzle games ever then got distracted by yellow cranks for six years, occasionally popping up to drop a demake of Papers Please? Well, Pope has ceased hogging that crank, for now at least, and just released Haloween-y adventure game Moida Mansion. It’s on Itch here, and it’s completely free to play in your browser.

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Real gamblers play russian roulette with shotguns. That is the core concept of Buckshot Roulette, the Inscryption-looking game of blinksweat and bulletworry. It's been out for a while now but the developers have just added a fun extra - a 4-person multiplayer mode.

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Typing Of The Dead released in arcades 25 years ago remains a masterpiece - funny, absurd, tense, and novel. I am keen on any game that aims to follow in its footsteps, and there are a few. The latest is Blood Typers, a horror game where you tippity-tap on your keyboard to fight montsters in a spooky mansion, but this isn't a rail shooter, so you'll be typing to explore and navigate, too.

It's now got a release of February 2025, and there's a demo you can play now.

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Steam's built-in game recording feature has been usable in beta since the summer, but it has now been properly launched for every user, following a client update to Steam yesterday. It's basically another method of capturing funny ragdoll glitches and posting them on the "lol-games-are-dumb" channel of your friend's Discord. Or for posting that flukey knife throw in Call Of Duty to Twitter, as if you really meant to kill the man from across the map all along. Or saving a clip for your personal records, like the footage of that time you yeeted an innocent citizen off the 50-foot wall of a castle town in Dragon's Dogma 2. We all do that, right? Right?

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I would never have predicted there'd be an isometric tactics game based on run-and-gun series Metal Slug, yet here Metal Slug Tactics is, and I am here for it. We've been following its development for a while but it's out now on Steam, and seemingly as strong as its demo suggested.

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We'll have a review of Planet Coaster 2 soon, but I keep making Brendy do other tasks so he's not had enough time yet to ride the rails. That means it falls to me to at least let you know that Frontier's theme park builder is out now.

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