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ADA seeks participants for 2020 SNODENT review

The American Dental Association is seeking qualified individuals to join a canvass committee to consider approval of the 2020 revision of the Systemized Nomenclature of Dentistry.




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ADA urges third-party payers to adapt coding, billing procedures to help patients recover

The American Dental Association sent a letter to third-party payers urging that administrators of dental benefit plans adjust and adapt reimbursement procedures important to dentists and patients — including coverage for temporary procedures and adjusting fee schedules to account for cost of increasing infection control procedures ¬— in the midst of the “unprecedented and extraordinary circumstances dentists and their patients face” during the pandemic.




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ADA advocates that third-party payers modify fee schedules as dentists consider going back to work

The ADA is urging third-party payers to alter their fees to account for the increasing cost of personal protective equipment that dentists are using to protect themselves, their staff and patients.




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UCLA dental school researchers create nanoparticle that could improve bone defect treatment

A team of researchers at the University of California, Los Angeles School of Dentistry has developed a nanoparticle that could improve treatment for bone defects.




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Department of Labor releases Pandemic Unemployment Assistance FAQ

The Department of Labor released an FAQ April 27 that addresses common questions about work search and job refusal when an individual receives Pandemic Unemployment Assistance.




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Dow, Total part of group that raised $1B to clean plastic in ocean

Some 30 companies including Dow, Total and other big makers of plastic raised $1 billion to contribute to cleaner ocean waters.




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Poverty, lack of insurance can make heart failure prognosis worse, AHA says

Poverty and poor or non-existent health insurance coverage might worsen the effects of heart failure, the American Heart Association said Thursday.




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Arthritis drug shows promise against respiratory distress caused by COVID-19

Anakinra, a drug developed to treat rheumatoid arthritis might help patients who have developed acute respiratory distress syndrome caused by COVID-19, a small study published by The Lancet Rheumatology has found.




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Diabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry

OBJECTIVE

We sought to determine the prevalence of diabetes and associated cardiovascular outcomes in a contemporary cohort of young individuals presenting with their first myocardial infarction (MI) at age ≤50 years.

RESEARCH DESIGN AND METHODS

We retrospectively analyzed records of patients presenting with a first type 1 MI at age ≤50 years from 2000 to 2016. Diabetes was defined as a hemoglobin A1c ≥6.5% (48 mmol/mol) or a documented diagnosis of or treatment for diabetes. Vital status was ascertained for all patients, and cause of death was adjudicated.

RESULTS

Among 2,097 young patients who had a type 1 MI (mean age 44.0 ± 5.1 years, 19.3% female, 73% white), diabetes was present in 416 (20%), of whom 172 (41%) were receiving insulin. Over a median follow-up of 11.2 years (interquartile range 7.3–14.2 years), diabetes was associated with a higher all-cause mortality (hazard ratio 2.30; P < 0.001) and cardiovascular mortality (2.68; P < 0.001). These associations persisted after adjusting for baseline covariates (all-cause mortality: 1.65; P = 0.008; cardiovascular mortality: 2.10; P = 0.004).

CONCLUSIONS

Diabetes was present in 20% of patients who presented with their first MI at age ≤50 years and was associated with worse long-term all-cause and cardiovascular mortality. These findings highlight the need for implementing more-aggressive therapies aimed at preventing future adverse cardiovascular events in this population.




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A Randomized Trial Evaluating the Efficacy and Safety of Fast-Acting Insulin Aspart Compared With Insulin Aspart, Both in Combination With Insulin Degludec With or Without Metformin, in Adults With Type 2 Diabetes (Onset 9)

OBJECTIVE

To evaluate the efficacy and safety of fast-acting insulin aspart (faster aspart) compared with insulin aspart (IAsp), both with insulin degludec with or without metformin, in adults with type 2 diabetes not optimally controlled with a basal-bolus regimen.

RESEARCH DESIGN AND METHODS

This multicenter, double-blind, treat-to-target trial randomized participants to faster aspart (n = 546) or IAsp (n = 545). All available information, regardless of treatment discontinuation or use of ancillary treatment, was used for evaluation of effect.

RESULTS

Noninferiority for the change from baseline in HbA1c 16 weeks after randomization (primary end point) was confirmed for faster aspart versus IAsp (estimated treatment difference [ETD] –0.04% [95% CI –0.11; 0.03]; –0.39 mmol/mol [–1.15; 0.37]; P < 0.001). Faster aspart was superior to IAsp for change from baseline in 1-h postprandial glucose (PPG) increment using a meal test (ETD –0.40 mmol/L [–0.66; –0.14]; –7.23 mg/dL [–11.92; –2.55]; P = 0.001 for superiority). Change from baseline in self-measured 1-h PPG increment for the mean over all meals favored faster aspart (ETD –0.25 mmol/L [–0.42; –0.09]); –4.58 mg/dL [–7.59; –1.57]; P = 0.003). The overall rate of treatment-emergent severe or blood glucose (BG)–confirmed hypoglycemia was statistically significantly lower for faster aspart versus IAsp (estimated treatment ratio 0.81 [95% CI 0.68; 0.97]).

CONCLUSIONS

In combination with insulin degludec, faster aspart provided effective overall glycemic control, superior PPG control, and a lower rate of severe or BG-confirmed hypoglycemia versus IAsp in adults with type 2 diabetes not optimally controlled with a basal-bolus regimen.




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2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes

OBJECTIVE

In 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children that included revised, lower normative blood pressure (BP) values and cut points for diagnosing high BP in adolescents. We studied the impact of the new AAP 2017 guideline on prevalence of HTN in children with type 1 diabetes mellitus (T1DM).

RESEARCH DESIGN AND METHODS

Up to September 2018, 1.4 million office BP measurements in 79,849 children and adolescents (aged 5–20 years) with T1DM have been documented in the DPV (Diabetes Prospective Follow-up) registry. BP values of the most recent year were aggregated, and BP values of 74,677 patients without antihypertensive medication were analyzed (median age 16 years and diabetes duration 5.3 years and 52.8% boys). BP values were classified according to AAP 2017 and the references of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2011) and the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents (fourth report) (2004).

RESULTS

Of the patients, 44.1%, 29.5%, and 26.5% were hypertensive according to AAP 2017, KiGGS, and fourth report, respectively. Differences in prevalence of HTN were strongly age dependent: <10 years, AAP 2017 31.4%, KiGGS 30.7%, fourth report 19.6%; 10 to <15 years, AAP 2017 30.9%, KiGGS 31.2%, fourth report 22.4%; and ≥15 years, AAP 2017 53.2%, KiGGS 28.4%, fourth report 30.0%. Among teenagers ≥15 years, 59.1% of boys but only 46.3% of girls were classified as hypertensive by AAP 2017 but only 21.1%/26% of boys and 36.7%/34.4% of girls by KiGGS/fourth report, respectively.

CONCLUSIONS

Classification of BP as hypertension depends strongly on the normative data used. Use of AAP 2017 results in a significant increase in HTN in teenagers ≥15 years with T1DM, particularly in boys. AAP 2017 enhances the awareness of elevated BP in children, particularly in patients with increased risk for cardiovascular disease.




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Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

OBJECTIVE

To determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI.

RESEARCH DESIGN AND METHODS

We randomized 56 patients with T2DM and HF with LV systolic dysfunction to dapagliflozin 10 mg daily or placebo for 1 year, on top of usual therapy. The primary end point was difference in LV end-systolic volume (LVESV) using cardiac MRI. Key secondary end points included other measures of LV remodeling and clinical and biochemical parameters.

RESULTS

In our cohort, dapagliflozin had no effect on LVESV or any other parameter of LV remodeling. However, it reduced diastolic blood pressure and loop diuretic requirements while increasing hemoglobin, hematocrit, and ketone bodies. There was a trend toward lower weight.

CONCLUSIONS

We were unable to determine with certainty whether dapagliflozin in patients with T2DM and HF had any effect on LV remodeling. Whether the benefits of dapagliflozin in HF are due to remodeling or other mechanisms remains unknown.




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Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT

OBJECTIVE

Although blood pressure variability is increasingly appreciated as a risk factor for cardiovascular disease, its relationship with heart failure (HF) is less clear. We examined the relationship between blood pressure variability and risk of HF in two cohorts of type 2 diabetes participating in trials of glucose and/or other risk factor management.

RESEARCH DESIGN AND METHODS

Data were drawn from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial and the Veterans Affairs Diabetes Trial (VADT). Coefficient of variation (CV) and average real variability (ARV) were calculated for systolic (SBP) and diastolic blood pressure (DBP) along with maximum and cumulative mean SBP and DBP during both trials.

RESULTS

In ACCORD, CV and ARV of SBP and DBP were associated with increased risk of HF, even after adjusting for other risk factors and mean blood pressure (e.g., CV-SBP: hazard ratio [HR] 1.15, P = 0.01; CV-DBP: HR 1.18, P = 0.003). In the VADT, DBP variability was associated with increased risk of HF (ARV-DBP: HR 1.16, P = 0.001; CV-DBP: HR 1.09, P = 0.04). Further, in ACCORD, those with progressively lower baseline blood pressure demonstrated a stepwise increase in risk of HF with higher CV-SBP, ARV-SBP, and CV-DBP. Effects of blood pressure variability were related to dips, not elevations, in blood pressure.

CONCLUSIONS

Blood pressure variability is associated with HF risk in individuals with type 2 diabetes, possibly a consequence of periods of ischemia during diastole. These results may have implications for optimizing blood pressure treatment strategies in those with type 2 diabetes.




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Instability of Insulin Aspart Diluted in Dextrose




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Coldest material in the cosmos could help scientists find dark matter particles

Researchers suggest the coldest material in the universe could reveal the presence of dark matter particles.




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Artificial tongue with gold taste buds to test maple syrup

Scientists in Quebec have developed an artificial tongue that can taste the flavor profiles of maple syrup, researchers revealed in a paper published on Tuesday.




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Astronomers find black hole just 1,000 light-years from Earth

Scientists have discovered the closest black hole to Earth, located just 1,000 light-years away.




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Smarter hardware to make artificial intelligence more energy efficient

Artificial intelligence requires a lot of energy. Simply solving a puzzle can require the equivalent of the energy produced by three nuclear plants in a single hour.




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Watch: Gwyneth Paltrow, Ben Schwartz read texts from their moms on 'Kimmel'

Gwyneth Paltrow, Ben Schwartz and other celebrities read text messages from their mothers on "Jimmy Kimmel Live" in honor of Mother's Day.




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YoungBoy Never Broke Again's '38 Baby 2' tops U.S. album chart

Rapper YoungBoy Never Broke Again's "38 Baby 2" is No. 1 on the U.S. album chart.





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[ Earth Sciences & Geology ] Open Question : Are earthquakes necessary to release the earth's energy?




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[ Politics ] Open Question : Why are other countries like New Zealand and Australia destroying the virus while America is killing people off to restart the economy?




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How the Brain Helps Partisans Admit No Gray

President Bush came to Washington promising to be a uniter, but public opinion polls show that apart from a burst of camaraderie after Sept. 11, 2001, America is more bitterly divided and partisan than ever.




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In Politics, Aim for the Heart, Not the Head

In 1935, researchers from Columbia University fanned out around the city of Allentown, Pa., and handed out leaflets ahead of local and state elections. What residents did not know was that they were part of an experiment in political persuasion -- an experiment whose results came to mind last week...




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The Magic Ingredient: Party Unity

Hillary Rodham Clinton has half a dozen good reasons she thinks she is the best Democratic candidate for president. They are called Pennsylvania and Ohio, Arkansas and Nevada, New Jersey and New Mexico -- states she has won in the Democratic primary contest.





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Dear first year, this isn’t something you can plan for (Part 3)

In case you want to catch up: here are Parts 1 & 2 of my first-year journey. We like to think that our life stories have happy endings, perhaps that we can carefully partition our lives into fourths of each … Continue reading




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Teaching in the Time of Coronavirus, Part I

Hi all, 2020 has been a complicated year so far, and things are only going to get more complicated as the COVID-19 pandemic. I’ve been thinking a lot about teaching recently, (as I’m the instructor for a class of undergrad … Continue reading




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Beyond Transactional Deals: Building Lasting Migration Partnerships in the Mediterranean

Since the 2015–16 refugee crisis, European policymakers have eagerly sought cooperation with origin and transit countries in the hopes of stemming unauthorized migration to Europe. This approach is neither new, nor without its limitations. By examining the evolution of two longstanding Mediterranean partnerships—between Spain and Morocco, and Italy and Tunisia—this report offers insights on what has and has not worked.




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EU Migration Partnerships: A Work in Progress

In 2016, the European Union announced with fanfare a new Migration Partnership Framework to inform cooperation with countries of origin and transit. While the bloc has long recognized collaboration as key to achieving its migration-management aims, EU partnerships face persistent challenges, including looking beyond short-term enforcement goals and taking into account partner needs, capacity, and objectives.




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Preparing for the Unknown: Designing Effective Predeparture Orientation for Resettling Refugees

Refugees encounter a range of challenges after resettlement—from adjusting to a new culture and language, to finding a job. Many resettlement countries invest in predeparture orientation to help refugees develop the knowledge, skills, and attitudes to face these challenges. This report explores the many forms these programs take, highlighting important design questions and key elements that effective programs share.




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Silt Part 1 - land and time under the sea

Warning: The Broomway is unmarked and very hazardous to pedestrians.
 
Warning: Do not approach or touch any object as it may explode and kill you.
 
 
The "Silt" chapter of the book contains some of Macfarlane's most hypnotic writing. It is also the chapter that made me realize that I am not innately the adventurous type of person. Unlike Macfarlane, I'm just not going to walk over unmarked mud paths at low time while running the risk of accidentally being sucked into the undertow and drowned(since he did the walk on a Sunday, he didn't have to worry about being accidentally shot by the Ministry of Defense). But I admire him for doing so.
 
The Broomway is called the deadliest path in Britain. It gets its name from 400 brooms which were used to mark the path to Foulness. When the tide comes in twice a day, other markers are swept away. Until compasses were affordable, people who walked the Broomway carried thread with them. As they passed a broom, they tied the end of the thread to the broom and continued walking. If they felt they had missed the next broom, they could follow the thread back to the previous broom.
 
Macfarlane walked the Broomway with his friend David Quentin, a book dealer turned tax lawyer who prefers to walk barefoot. In the end the mud was bad enough that Macfarlane also walked barefoot to save his sneakers. He left them at their starting point and was able to refind them when they doubled back to the beginning of their path.
 
As Macfarlane walked, he recollected that the land under the Broomway had once been called Doggerland, the home of Megolithic hunter-gatherers. This in turn made him recall the fact that the sea coasts of Norfolk and Suffolk in England are being eroded. Entire towns are being swallowed up by the sea, and houses that were once inland are now being abandoned because they are too close to the shore.
 
Although Macfarlane remembers many historical and geographical facts as he walks, he is also sucked in by the queer atmosphere of the The Broomland. Not entirely land, not entirely water, it exists in a liminal state. To Macfarlane:
 
"These borders do not correspond to national boundaries, and papers and documents are unrequired at them.Their traverse is generally unbiddable, and no reliable map exists of their routes and outlines. They exist even in unfamiliar landscapes: there when you cross a certain watershed, treeline or snowline, or enter rain, storm, or mist, or pass from boulder clay onto sand, or chalk onto greenstone. Such moments are rites of passage that reconfigure local geographies, leaving known placed outlandish or quickened, revealing continents within countries." (p. 78)
 
Space, distance, and direction become distorted because of the light over the sands, the movement of the tides, and the constant erosion of the land. A simple walk over the sea shore is a trek that could easily end in disaster where Macfarlane joins the dead of a drowned country.





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Silt Part 2 - Fighting the sea

On October 29th, 2012, Hurricane Sandy hit the tri-state area. I was lucky enough to be unaffected as I live on a hill in a central portion of Queens but I had two family members who lost power for a week. I also had co-workers who live in some of the most hard-hit areas of Brooklyn and Queens. Rereading Macfarlane's "Silt" chapter after Sandy was a sobering experience as I wondered what such a walk in parts of Queens or New Jersey would involve.

In the aftermath of Sandy, I've listened to radio interviews with Dutch engineers who have advocated sea gates and houses on stilts. I've read proposals about sea walls.  In the past week, Governor Cuomo has suggested a buyout of homes in areas likely to flooded again in the future. Once the state buys the land, the homes will be demolished and the land left empty. To quote Governor Cuomo, "there are some parcels that Mother Nature owns...She may only visit once every few years...but she owns the parcel and when she comes to visit, she visits."

However, people who live in flooded and devastated areas such as Freeport, Breezy Point or the Rockaways are reluctant to say goodbye to their communities and shore-based lifestyles. Mr. Cuomo accepts that man cannot ultimately defeat nature, which is why, for example, parts of the English coast are crumbling away without the UK spending billions on sea walls or sea gates (although London is protected by the Thames Barrier). Inhabitants of New York and New Jersey seem more willing to fight nature with man-made barriers, artificially-created natural shorelines, and architectural changes such as in the Netherlands. In the end, residents of NYC will have to decide how much money they wish to spend to protect and maintain their current lifestyles and residences.




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Memory in a House - part 1

Lucy Boston had led an adventurous life for a woman of her time. She had dropped out of Oxford University to become a nurse during WWI and worked in a hospital in Normandy. She had married her cousin, had her son Peter, divorced her husband, and moved to Germany and Italy to paint. When Peter started Cambridge, Lucy also moved to Cambridge and began obsessively painting King's College Chapel. Then in 1939, she bought The Manor, Hemingford Grey.

In Memory in a House, Lucy describes the two years that it took to restore The Manor as "which were by far the happiest of my life, even in spite of the war that broke out as soon as the builders began." (p. 19) In fact, she views her realtionship with the house as a love affair. She was aware that the house, which was built as a Norman manor in 1120 by Payne Osmundsen, was very historic, and she eventually documented everything she found and all the changes she made.

The forced restoration was brought about by the fact that the house was structually unsound due to cheap and unskillful renovations over the years. Faced with unsupported structural beams, walls cracking from top to bottom, and drastically sloping floors, Lucy was had no choice but to fix these problems. She was lucky enough to get honest and competent builders and architects to help her with the delicate job of historical renovation.

It becomes clear while reading the book that restoring the house was as much a creative endeavor for Lucy as painting a picture, or writing fiction. She was extremely sensitive to atmosphere, and accepted the physical imperfections of the house as part of the character that it had developed as it aged. She was also willing to change her mind about the alterations and restoration as she went along; the dining room, which she had thought was hopeless and would be used just as a corridor, became the center of her life, connecting the interior of the house with its equally important exterior garden.



  • Children of Green Knowe
  • Lucy Maria Boston
  • Manor at Hemingford Grey
  • Memory in a House

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Visiting Lucy Boston's House, Part 2

Since we were early for our 2 PM house tour, we decided to explore the gardens. Lucy talks about designing and building the gardens in her memoir Memory in a House, which also contains some black and white photos of the gardens back when she published the book. However, I did not realize until her daughter-in-law Diana Boston gave us the tour how much of the gardens Lucy build from scratch. Apparently most of the yard was just meadow until she set to work.

What stunned me, Val, and Dave was how large the gardens were in size. We split up in the gardens, and they saw only the more cultivated side:


 
 
 


until I took them to see the the other side of the house, which has a  moat that surrounds three sides of it, a flowering meadow, and a bamboo thicket:







The bamboo thicket is where the gorilla Hanno lives in A Stranger at Green Knowe. The moat is a a constant presence in the books because when it floods, the house is cut off on an island, the way it was originally designed to be by its Norman builder, Payne Osmundson. The story of the builders of the house is told in The Stones of Green Knowe, which is the last of the series. The River Ouse features in The River at Green Knowe, and can be seen from the yard and the windows of the house.

One of my friends commented that the house and garden must be smaller than I expected since I had read the books first as a child and was now an adult. This is not quite true. Although the house was small - the walls are three feet thick so the exterior is larger than the interior, the gardens were bigger than expected. Boston gardened in the warm weather and wrote and created patchwork in the cold weather. It is amazing to see the variety of garden sections that she created. In my next post, I will discuss the gardens in terms of the books and of my experiences as a child both as her reader and as someone who grew up in a decent-sized yard and in fine public parks.





  • Children of Green Knowe
  • Diana Boston
  • Lucy Maria Boston
  • Manor at Hemingford Grey

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Expansion of legal migration opportunities for third-country nationals, particularly in middle- and low-skill sectors, holds potential but should not be oversold as migration management tool, new study cautions

BRUSSELS — While the European Union has called on Member States to expand channels for foreign workers as a way to meet labour market needs and potentially tackle spontaneous migration, they have struggled to deliver on this pledge. To date, policies have focused more on attracting high-skilled workers, but less attention has been paid to admission of low- or middle-skilled nationals. Policymakers would do well not to overestimate the potential of legal channels to reduce irregular migration.




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As Global Refugee Forum approaches, MPI Europe brief offers a road map for smart investment in refugee sponsorship programmes

BRUSSELS — Even as the number of refugees in need of protection has reached an all-time high, the resettlement spots offered by countries in 2018 were less than half the level in 2016—and future commitments may shrink further. With refugee needs high and generosity dimming, there is increasing urgency for humanitarian actors to find new ways to bring refugees to safety as well as to rebuild public interest and consensus around the importance of protection.




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As European policymakers take stock of seasonal worker programmes, MPI Europe brief outlines principles to improve these schemes for all parties

Findings will be discussed during 25 February MPI Europe – SVR webinar





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Jerusalem artichokes cooked overnight with hazelnut praline

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Dan Hunter, chef and owner of Otways' restaurant Brae.




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Malibu strawberry tart with coconut thickened custard

I love the texture of a cool tasting coconut custard with market fragrant strawberries macerated in well more coconut liqueur.




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Upside down local tomato, goats cheese and onion tart

Always a winner taking advantage of the local summer tomatoes . Who doesn't like flaky puff pastry?




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French salted caramel ganache tart

An indulgent French chocolate and salted caramel tart. Decorate with fresh raspberries and pistachio nuts for great colour and a sweet zing.




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Start-Up Visas: A Passport for Innovation and Growth?

Over the last decade, a number of governments have launched start-up visa programs in the hopes of attracting talented immigrant entrepreneurs with innovative business ideas. With the track record for these programs a mixed one, this report explains how embedding start-up visas within a broader innovation strategy could lead to greater success.




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Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study

OBJECTIVE

Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD.

RESEARCH DESIGN AND METHODS

In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation—a cohort of 528 individuals with no previous cardiovascular event undergoing CCTA), participants were grouped into CAD (clean coronaries) and CAD+ (diffuse lumen narrowing or plaques). Plasma proteins were screened by aptamer analysis. Two-way partial least squares was used to simultaneously rank proteins by diabetes status and CAD.

RESULTS

Though CAD+ was more prevalent among participants with T2D (HbA1c 6.7 ± 1.1%) than those without diabetes (56 vs. 30%, P < 0.0001), CCTA-based atherosclerosis burden did not differ. Of the 20 top-ranking proteins, 15 were associated with both T2D and CAD, and 3 (osteomodulin, cartilage intermediate-layer protein 15, and HTRA1) were selectively associated with T2D only and 2 (epidermal growth factor receptor and contactin-1) with CAD only. Elevated renin and GDF15, and lower adiponectin, were independently associated with both T2D and CAD. In multivariate analysis adjusting for the Framingham risk panel, patients with T2D were "protected" from CAD if female (P = 0.007), younger (P = 0.021), and with lower renin levels (P = 0.02).

CONCLUSIONS

We concluded that 1) CAD severity and quality do not differ between participants with T2D and without diabetes; 2) renin, GDF15, and adiponectin are shared markers by T2D and CAD; 3) several proteins are specifically associated with T2D or CAD; and 4) in T2D, lower renin levels may protect against CAD.




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We're Just Getting Started: A Glimpse at the History of Uncertainty


We've had our cerebral cortex for several tens of thousands of years. We've lived in more or less sedentary settlements and produced excess food for 7 or 8 thousand years. We've written down our thoughts for roughly 5 thousand years. And Science? The ancient Greeks had some, but science and its systematic application are overwhelmingly a European invention of the past 500 years. We can be proud of our accomplishments (quantum theory, polio vaccine, powered machines), and we should worry about our destructive capabilities (atomic, biological and chemical weapons). But it is quite plausible, as Koestler suggests, that we've only just begun to discover our cerebral capabilities. It is more than just plausible that the mysteries of the universe are still largely hidden from us. As evidence, consider the fact that the main theories of physics - general relativity, quantum mechanics, statistical mechanics, thermodynamics - are still not unified. And it goes without say that the consilient unity of science is still far from us.

What holds for science in general, holds also for the study of uncertainty. The ancient Greeks invented the axiomatic method and used it in the study of mathematics. Some medieval thinkers explored the mathematics of uncertainty, but it wasn't until around 1600 that serious thought was directed to the systematic study of uncertainty, and statistics as a separate and mature discipline emerged only in the 19th century. The 20th century saw a florescence of uncertainty models. Lukaczewicz discovered 3-valued logic in 1917, and in 1965 Zadeh introduced his work on fuzzy logic. In between, Wald formulated a modern version of min-max in 1945. A plethora of other theories, including P-boxes, lower previsions, Dempster-Shafer theory, generalized information theory and info-gap theory all suggest that the study of uncertainty will continue to grow and diversify.

In short, we have learned many facts and begun to understand our world and its uncertainties, but the disputes and open questions are still rampant and the yet-unformulated questions are endless. This means that innovations, discoveries, inventions, surprises, errors, and misunderstandings are to be expected in the study or management of uncertainty. We are just getting started. 




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Review Article – Within a single lifetime: Recent writings on autism

AHP readers will be interested in a review article now available online from History of the Human Sciences “Within a single lifetime: Recent writings on autism.” Written by Gregory Hollin the piece reviews five recent books on autism.




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Seeking Participants for a Study on How COVID-19 is Affecting Sex and Relationships

The COVID-19 coronavirus pandemic is causing a number of societal changes that are new to nearly all of us, with governments around the world locking down cities and countries in an attempt to slow the spread of the virus. This situation is pushing some people together, but pulling others apart—and we’ve never seen anything quite like it in the modern era. Countless media articles have been written about the ways in which this is affecting people’s sex lives and relationships; however, most of them are purely speculative. This led some of my colleagues at the Kinsey Institute and I to wonder what’s really happening—and we’ve designed a study to help us better understand how emergency situations like this affect people’s sexual and romantic lives, which may help us to better plan and prepare for similar events in the future.



  • Professional Issues in Psychology

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How Do You Help a Partner Who is Depressed? Advice From a Sex Therapist

Depression is one of the most common mental health issues in the United States. In fact, according to the National Institutes of Mental Health, 1 in 14 Americans experienced an episode of major depression in the last year alone. Given the circumstances surrounding the current COVID-19 coronavirus pandemic, many in the mental health community predict that the number will be even higher this year because these circumstances are creating a “perfect storm” of depression risks. The widespread prevalence of depression has a lot of implications for our lives, even if we don’t personally have depression ourselves. Many of us will have loved ones, such as a romantic partner, who develops depression at some point. In these situations, it’s common for people to wonder how they can help their partner most effectively. So what should they do?