Introduction Financial services firms’ corporate governance and risk cultures is a ‘hot’ topic with financial regulators globally. Regulators have noted that serious corporate governance and conduct failings of financial services f...

Key points: • In a judgment supportive of the rescue culture in English insolvency, the court has reaffirmed its flexible approach to the application of insolvency provisions and willingness to look at the practical effect of transactions in re...

80 young African scholars are tackling the business of agriculture through the innovativeness and freshness that comes with youth — while obtaining their masters or doctoral degrees in the process.

The post Africa’s Youth Scholars Harvest Ideas on the Business of Agriculture appeared first on Inter Press Service.

With the West now taking another look at widespread use of face masks to stop the spread of the new coronavirus, it's worth noting another ...

Twenty-first century evangelists and missionaries are confronted with a vastly different world to that of the early church. In the realms of communication and technology, the changes are immense. And in the eyes of many church growth proponents, a lot of modern advancements have left the Bible looking older than ever.

Over 6,000 farmers have already planted the new varieties. The factory will need over eight tonnes of banana produce daily.

1

Safeguards due diligence reports are prepared as part of safeguard due diligence and review to ensure compliance with ADB safeguard policy due diligence requirements. This document dated May 2020 is provided for the ADB project 51039-002 in Afghanistan.

Safeguards due diligence reports are prepared as part of safeguard due diligence and review to ensure compliance with ADB safeguard policy due diligence requirements. This document dated May 2020 is provided for the ADB project 2020-05-07 in Afghanistan.

CHENNAI: As if land grab bids and ‘double documents’ are not menace enough for property owners/buyers, the state registration department shocked the Madras high court on Monday, saying it is difficult to issue encumbrance certificates without any fault. An encumbrance certificate (EC) is the basic document which reveals the current status of an immovable property. It is supposed to contain correct ownership details of a piece of property and inform the applicant whether it is encumbered or mortgaged in favour of a bank or any individual. However, responding to an anticipatory bail petition of a landowner who ended up purchasing another person’s property as the EC did not reflect latest […]

In December 2006, the Asian Development Bank (ADB) approved a $900.0 million equivalent multitranche financing facility (MFF) for the Punjab Irrigated Agriculture Investment Program (PIAIP) to finance improvements to Punjab’s irrigation sector. At the same time, two loans for tranche 1 totaling $227.8 million equivalent were approved using the MFF for $217.8 million equivalent from ADB’s ordinary capital resources and $10.0 million equivalent from ADB’s Asian Development Fund (ADF).

Approved project 51423-002 in Mongolia.

The remote Fijian island of Cicia has launched a novel business in organic produce that could prove to be a template for other developing communities around the world. The island declared itself chemical free and fully organic eight years ago and is now producing food that's attracting the interest of foreign buyers. Tara Cleary reports.

Encouraging the growth of benign bacteria is a tasty way to preserve vegetables, such as with this easy kimchi recipe, says Sam Wong

Watch Apple TV's See where vision becomes a heresy, discover non-human animals that also rely on culture and enjoy the International Space Station from your own home

Making butter at home the traditional way is easy and the result is far more flavourful than the shop-bought version, says Sam Wong

Gymnasts around the world have been trying to stay fit amid tough restrictions during the COVID-19 crisis, and Italy is no exception.      With the country's gym clubs and training facilities closed for more than two months as part of government measures to contain the spread of the coronavirus, gymnast Marco Lodadio, a silver medallist in the rings event at the 2019 world championships, turned his garden into a fitness studio.      Without the sophisticated faci

Making butter at home the traditional way is easy and the result is far more flavourful than the shop-bought version, says Sam Wong

Clinical teaching is a cornerstone of health sciences education; it is also the most challenging aspect. The University of Pittsburgh Schools of Dental Medicine, Nursing, and Pharmacy developed a new evidence-based interprofessional course framed as a faculty learning community (FLC) around the principles of learning in a clinical environment. The aim of this study was to assess the overall effectiveness of this two-semester FLC at four health professions schools in academic year 2014-15. The assessment included anonymous participant surveys in each session and an anonymous end-of-course survey. Thirty-five faculty members from dental, health and rehabilitation sciences, nursing, and pharmacy enrolled in the FLC, with six to 32 enrollees attending each session. All attendees at each session completed the session evaluation surveys, but the attendance rate at each session ranged from 17.1% to 91.4%. Sixteen participants (46%) completed the end-of-course survey. The results showed overall positive responses to the FLC and changes in the participants’ self-reported knowledge. Session surveys showed that the participants found the FLC topics helpful and appreciated the opportunity to learn from each other and the interprofessional nature of the FLC. Responses to the end-of-course survey were in alignment with the individual session surveys and cited specific benefits as being the content, teaching materials, and structured discussions. In additional feedback, participants reported interest to continue as a cohort and to extend the peer-support system beyond the FLC. This outcomes assessment of the first round of the FLC confirmed that this cohort-based faculty development in an interprofessional setting was well received by its participants. Their feedback provided valuable insights for changes to future offerings.

The aim of this cross-sectional study was to examine the faculty mentoring practices in seven dental schools in the U.S. A 34-item survey was administered electronically to dental faculty members of all ranks, tracks, and job categories in seven dental schools using faculty listservs. Survey questions addressed current mentoring practices in which the faculty members were involved; their perceptions of those mentoring practices; their perceived characteristics of an ideal mentoring program, mentor, and mentee; perceived best practices; and respondents’ demographics. The survey was conducted from October 2017 to February 2018. A total of 154 surveys were completed (response rate 22%). Over 58% (90/154) of the respondents reported receiving no mentoring; 31.9% (49/154) said they received informal mentoring; and 9.7% (15/154) received formal mentoring. Of the 64 respondents who received mentoring, both formal and informal, 92.2% (59/64) were full-time faculty, and 7.8% (5/64) were part-time faculty (p=0.001). Approximately 39% of the respondents indicated that their mentoring program was not overseen by anyone and that participation was voluntary. The top three perceived benefits of mentoring were increased overall professional development, development of a career plan, and increased professional networks. The three most important characteristics of an ideal mentoring program for the respondents were a program based on the needs of the mentee, a mentor who has the desire to help the mentee, and a mentee who is eager to learn. The results of this study showed a very low level of formal or informal faculty mentoring programs in the dental schools surveyed. Future studies are needed to determine best practices and strategies to expand and enhance mentoring of faculty members.

ABSTRACT

Interactions between microorganisms in mixed communities are highly complex, being either syntrophic, neutral, predatory, or competitive. Evolutionary changes can occur in the interaction dynamics between community members as they adapt to coexistence. Here, we report that the syntrophic interaction between Geobacter sulfurreducens and Pseudomonas aeruginosa coculture change in their dynamics over evolutionary time. Specifically, Geobacter sp. dominance increases with adaptation within the cocultures, as determined through quantitative PCR and fluorescence in situ hybridization. This suggests a transition from syntrophy to competition and demonstrates the rapid adaptive capacity of Geobacter spp. to dominate in cocultures with P. aeruginosa. Early in coculture establishment, two single-nucleotide variants in the G. sulfurreducens fabI and tetR genes emerged that were strongly selected for throughout coculture evolution with P. aeruginosa phenazine wild-type and phenazine-deficient mutants. Sequential window acquisition of all theoretical spectra-mass spectrometry (SWATH-MS) proteomics revealed that the tetR variant cooccurred with the upregulation of an adenylate cyclase transporter, CyaE, and a resistance-nodulation-division (RND) efflux pump notably known for antibiotic efflux. To determine whether antibiotic production was driving the increased expression of the multidrug efflux pump, we tested Pseudomonas-derived phenazine-1-carboxylic acid (PHZ-1-CA) for its potential to inhibit Geobacter growth and drive selection of the tetR and fabI genetic variants. Despite its inhibitory properties, PHZ-1-CA did not drive variant selection, indicating that other antibiotics may drive overexpression of the efflux pump and CyaE or that a novel role exists for these proteins in the context of this interaction.

IMPORTANCE Geobacter and Pseudomonas spp. cohabit many of the same environments, where Geobacter spp. often dominate. Both bacteria are capable of extracellular electron transfer (EET) and play important roles in biogeochemical cycling. Although they recently in 2017 were demonstrated to undergo direct interspecies electron transfer (DIET) with one another, the genetic evolution of this syntrophic interaction has not been examined. Here, we use whole-genome sequencing of the cocultures before and after adaptive evolution to determine whether genetic selection is occurring. We also probe their interaction on a temporal level and determine whether their interaction dynamics change over the course of adaptive evolution. This study brings to light the multifaceted nature of interactions between just two microorganisms within a controlled environment and will aid in improving metabolic models of microbial communities comprising these two bacteria.

Legumes tend to be nodulated by competitive rhizobia that do not maximize nitrogen (N2) fixation, resulting in suboptimal yields. Rhizobial nodulation competitiveness and effectiveness at N2 fixation are independent traits, making their measurement extremely time-consuming with low experimental throughput. To transform the experimental assessment of rhizobial competitiveness and effectiveness, we...

Routine identification of fungal pathogens from positive blood cultures by culture-based methods can be time-consuming, delaying treatment with appropriate antifungal agents. The GenMark Dx ePlex investigational use only blood culture identification fungal pathogen panel (BCID-FP) rapidly detects 15 fungal targets simultaneously in blood culture samples positive for fungi by Gram staining. We aimed to determine the performance of the BCID-FP in a multicenter clinical study. Blood culture samples collected at 10 United States sites and tested with BCID-FP at 4 sites were compared to the standard-of-care microbiological and biochemical techniques, fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) and matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS). Discrepant results were analyzed by bi-directional PCR/sequencing of residual blood culture samples. A total of 866 clinical samples, 120 retrospectively and 21 prospectively collected, along with 725 contrived samples were evaluated. Sensitivity and specificity of detection of Candida species (C. albicans, C. auris, C. dubliniensis, C. famata, C. glabrata, C. guilliermondii, C. kefyr, C. krusei, C. lusitaniae, C. parapsilosis, and C. tropicalis) ranged from 97.1 to 100% and 99.8 to 100%, respectively. For the other organism targets, sensitivity and specificity were as follows: 100% each for Cryptococcus neoformans and C. gattii, 98.6% and 100% for Fusarium spp., and 96.2% and 99.9% for Rhodotorula spp., respectively. In 4 of the 141 clinical samples, the BCID-FP panel correctly identified an additional Candida species, undetected by standard-of-care methods. The BCID-FP panel offers a faster turnaround time for identification of fungal pathogens in positive blood cultures that may allow for earlier antifungal interventions and includes C. auris, a highly multidrug-resistant fungus.

Quantitative bacterial culture of bronchoalveolar lavage fluids (BALF) is labor-intensive, and the delay involved in performing culture, definitive identification, and susceptibility testing often results in prolonged use of broad-spectrum antibiotics. The Unyvero lower respiratory tract (LRT) panel (Curetis, Holzgerlingen, Germany) allows the multiplexed rapid detection and identification of 20 potential etiologic agents of pneumonia within 5 h of collection. In addition, the assay includes detection of gene sequences that confer antimicrobial resistance. We retrospectively compared the performance of the molecular panel to routine quantitative bacterial culture methods on remnant BALF. Upon testing 175 BALF, we were able to analyze positive agreement of 181 targets from 129 samples, and 46 samples were negative. The positive percent agreement (PPA) among the microbial targets was 96.5%, and the negative percent agreement (NPA) was 99.6%. The targets with a PPA of <100% were Staphylococcus aureus (34/37 [91.9%]), Streptococcus pneumoniae (10/11 [90.9%]), and Enterobacter cloacae complex (2/4 [50%]). For the analyzable resistance targets, concordance with phenotypic susceptibility testing was 79% (14/18). This study found the Unyvero LRT panel largely concordant with culture results; however, no outcome or clinical impact studies were performed.

Pyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently reliable for routine application. Although molecular tests are endorsed, their application is limited to known PZA resistance associated mutations. Microbiological DSTs for PZA have been restricted by technical limitations, especially the necessity for an acidic pH. Here, for the first time, MODS culture at neutral pH was evaluated using high PZA concentrations (400 and 800 μg/ml) to determine PZA susceptibility directly from sputum samples. Sputum samples were cultured with PZA for up to 21 days at 37°C. Plate reading was performed at two time points: R1 (mean, 10 days) and R2 (mean, 13 days) for each PZA concentration. A consensus reference test, composed of MGIT-PZA, pncA sequencing, and the classic Wayne test, was used. A total of 182 samples were evaluated. The sensitivity and specificity for 400 μg/ml ranged from 76.9 to 89.7 and from 93.0 to 97.9%, respectively, and for 800 μg/ml ranged from 71.8 to 82.1 and from 95.8 to 98.6%, respectively. Compared to MGIT-PZA, our test showed a similar turnaround time (medians of 10 and 12 days for PZA-sensitive and -resistant isolates, respectively). In conclusion, MODS-PZA is presented as a fast, simple, and low-cost DST that could complement the MODS assay to evaluate resistance to the principal first-line antituberculosis drugs. Further optimization of test conditions would be useful in order to increase its performance.

In vitro approaches for predicting drug-drug interactions (DDIs) caused by alterations in transporter protein regulation are not well established. However, reports of transporter regulation via nuclear receptor (NR) modulation by drugs are increasing. This study examined alterations in transporter protein levels in sandwich-cultured human hepatocytes (SCHH; n = 3 donors) measured by liquid chromatography–tandem mass spectrometry–based proteomic analysis after treatment with N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide (T0901317), the first described synthetic liver X receptor agonist. T0901317 treatment (10 μM, 48 hours) decreased the levels of organic cation transporter (OCT) 1 (0.22-, 0.43-, and 0.71-fold of control) and organic anion transporter (OAT) 2 (0.38-, 0.38-, and 0.53-fold of control) and increased multidrug resistance protein (MDR) 1 (1.37-, 1.48-, and 1.59-fold of control). The induction of NR downstream gene expression supports the hypothesis that T0901317 off-target effects on farnesoid X receptor and pregnane X receptor activation are responsible for the unexpected changes in OCT1, OAT2, and MDR1. Uptake of the OCT1 substrate metformin in SCHH was decreased by T0901317 treatment. Effects of decreased OCT1 levels on metformin were simulated using a physiologically-based pharmacokinetic (PBPK) model. Simulations showed a clear decrease in metformin hepatic exposure resulting in a decreased pharmacodynamic effect. This DDI would not be predicted by the modest changes in simulated metformin plasma concentrations. Altogether, the current study demonstrated that an approach combining SCHH, proteomic analysis, and PBPK modeling is useful for revealing tissue concentration–based DDIs caused by unexpected regulation of hepatic transporters by NR modulators.

John Deere, the nearly 200-year-old tractor manufacturer, now considers itself a software company

It’s a new year but it has the same old shenanigans. Not finishing games, PC hackers, getting distracted by shiny new toys, and Tarutaru addiction....

The COVID-19 pandemic has placed unprecedented pressure on societies worldwide, given the pandemic's rapid, often deadly spread. In health care, the pandemic has raised the pressing question of how society should allocate scarce resources during a crisis.

New research finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis, but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

Players at the back face an uphill struggle to win awards even before a ball has been kicked, according to the last defender to win the coveted prize

Debate over Earth’s oldest fossils fuels the search for our deepest origins

It’s still joyous, and moving online has made it even more inclusive. 

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The post The Long Shadow of Cultural Anthropology appeared first on The Nation.

SXScreeners: Shorts and soundtracks rule this Amazon-hosted digital film fest

'We must act, and act fast'

McGowan previously called her 'Charmed' co-star Alyssa Milano a 'fraud' for endorsing Biden

Actor is famous for making her opinions known during interviews

(Matador)
Will Toledo’s alt-rockers have emerged out of lo-fi fuzz, but seem unsure of where to turn as they drift toward the mainstream

Anyone wondering how things have changed in the world of lauded US alt-rockers Car Seat Headrest might consider the four years that separate Making a Door Less Open from their last album of new material. Ordinarily there would be nothing unusual about that gap – but in the first four years of Car Seat Headrest’s existence, its mastermind, Will Toledo, released seven albums (one of them a two-hour double), four EPs (one of them as long as an album) and two compilations of outtakes. That’s more than 150 songs and 12 hours of music: a lo-fi spewing forth of ideas that won Toledo a cult following, which then grew exponentially, both in size and rabidity, when he recruited a band and signed to the august US indie label Matador.

Ty, who has died aged 47 of coronavirus, was a sharp and witty MC who ably nourished the UK hip-hop scene despite being ignored by the media

• Mercury prize-nominated UK rapper Ty dies of coronavirus

The death of British rapper Ty, aged 47, to complications from coronavirus came as a shock because it had appeared he was on his way to recovery after being moved out of intensive care. And for those of us who grew up with Ty’s voice circling our bedrooms, the shock resonates: this is an artist who touched so many with his humour and sharpness on the mic.

While all eyes were on grime in the early 2000s, Ty was charting a journey to a frontier that had yet to be fully explored. In 2001, he released his debut album, Awkward, on Big Dada, one of the few labels that would give a home to UK hip-hop acts such as Roots Manuva, Juice Aleem and Speech Debelle. It was the year of era-defining US albums such as Jay-Z’s The Blueprint and Nas’s Stillmatic, when the mainstream had gone the way of the shiny suit. But across the Atlantic, Ty ushered in the UK’s own hip-hop golden age, leaning towards the genre’s soul, jazz and funk origins.

Shriver’s contentious views on diversity thread through the story of a couple’s strained relationship with exercise

Lionel Shriver’s scabrously funny 15th novel presents a dyspeptic view of people in thrall to exercise. In 2013 Shriver’s own daily regime involved “130 press-ups, 200 side crunches, 500 sit-ups and 3,000 star jumps … The jumps take 32½ minutes, or three every two seconds”. The Motion Of The Body Through Space was written, she recently revealed, after she realised that she may be more dedicated to her exercise than to her writing.

The protagonist, Serenata Terpsichore (“rhymes with chicory”), is a 60-year-old woman from upstate New York with a beguiling voice and ruined knees. The former she puts to lucrative use as a voiceover artist and narrator of audiobooks. The latter are the result of a lifetime’s adherence to the doctrine of working out; in particular the belief that 10-mile runs are the key to longevity and good health.

The morality brigade loathed the hit teen horror on release but hockey mask-wearing villain Jason Voorhees has been with us ever since

Before production on the teen slasher A Long Night at Camp Blood had even started, before a final draft of the screenplay had even been submitted, thirtysomething writer-producer-director Sean S Cunningham decided to make an audacious statement. Not only would he use an advert in the industry paper Variety to confirm an inarguably ingenious title change but he would also use it to declare that his next film would be the most terrifying ever made, after a decade that saw The Texas Chainsaw Massacre, The Last House on the Left (which he also produced), The Exorcist and Halloween.

Related: Final Destination at 20: the bleakest teen horror film ever made?

When the coronavirus crisis hit, Yolngu elders moved back to east Arnhem Land homelands where they found freedom, peace, and power

• This is part two of a four-part series about Indigenous caretakers of culture in the time of coronavirus
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Adapting to change is something Yolngu are good at, senior Rirratjingu songman Witiyana Marika says.

When the coronavirus first started making news, community leadership met to plan how they would manage if Covid-19 arrived in eastern Arnhem land. Senior men and women met with the emergency taskforce, the local Miwatj health service and the Laynhapuy homelands organisation to take the most vulnerable people further away from risk.

Inside the darker side of Instagram