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Applying Low Levels of Strain to Model Nascent Phenomenon of Retinal Pathologies

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00205A, Paper
Chase Paterson, Elizabeth Vargis
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly. A better understanding of the mechanisms of the disease, especially at early stages, could elucidate new...
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Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90093F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Madhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien Liu
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Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

Lab Chip, 2024, 24,5085-5100
DOI: 10.1039/D4LC00633J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
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RTO to probe operator’s failure to provide accommodation to students




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Day 1 of Modi 3.0: PM signed file to release Kisan Nidhi, Cabinet approves 3 cr homes

PM Kisan Nidhi provides income support to 14.5 crore small and marginal farmers




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Atmanirbhar push: MoD requests 156 LCH Prachand from HAL for Army and IAF

Of the 156 helicopters, 90 are designated for the Army Aviation Corps and 66 for the Indian Air Force 




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PM Modi pledges threefold effort and results in third term; appeals for responsible Opposition

Emphasising the increased responsibility following a significant electoral victory, Modi promised to work harder and achieve greater outcomes 




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Modi pivots to welfarism, free private sector growth

PM’s replies to the debate in Parliament with aggressive rebuttal of the Opposition’s barbs and a vision for the economy




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On eve of Modi’s Moscow visit, Indo-Russia JV delivers 35,000 AK-203s to Indian Army

The Indo-Russian Rifles Private Ltd, a joint venture between India and Russia, has production facility at Amethi, UP and is expected to manufacture more than 600,000 rifles as per a deal between the two sides




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Two pre-Independence era acts to be re-enacted: Aircraft Act and Boilers Act get modern overhaul

In the upcoming Lok Sabha session, the Government will re-enact the Aircraft Act of 1934, introduce the Coffee Promotion Bill, and revamp the Indian Boilers Act of 1923 to modernise regulations and support the ‘Make in India’ initiative




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Bond between India, Russia is deep-rooted: Modi

Modi meets Putin on the sidelines of  BRICS summit in Kazan; talks focus on partnership across diverse sectors




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Indirect tax related quasi-judicial adjudication, appeal cases to mandatorily heard in virtual mode

An advisory issued on GST portal lowered the AATO (Aggregate Annual Turnover) for reporting e-Invoices on IRP portals within 30 days to Rs ₹10 crore and above from Rs ₹100 crore and above




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TN: Textile industry seeks govt support for powerloom modernisation




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ModaXL 200 mg Review - Dosage, Interactions, Side Effects (Full Guide)

Want to order ModaXL 200 mg in 2024? Read this guide and learn more about the smart drug ModaXL. Safety, correct dosages, possible side effects, best places to buy the nootropic and much more in this helpful review.




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Hundreds of govt. employees mobilised for PM Modi’s Kashmir rally

It is reported that as many as 7,000 employees from 13 departments will attend the PM’s rally in Srinagar’s Bakshi Stadium




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PM Modi on Chess Olympiad gold medals: ‘A new chapter in India’s sports trajectory’




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Kondamodu-Perecherla National Highway project in A.P. gets Centre’s nod

The Union Ministry has approved the bid submitted by RRS Infra, amounting to ₹506.88 crore.




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Capillary action-driven surface-enhanced Raman spectroscopy (SERS) for the identification of phthalocyanine blue in modern paintings based on the BPG spot test

Anal. Methods, 2024, 16,2147-2151
DOI: 10.1039/D3AY01378B, Technical Note
Shao-Chun Hsueh, Ling-Hsuan Wang, Yung-Chen Liao, Hui-Yu Chiang, Cheng-Huang Lin
A method for the extraction and accumulation of Ag nanoparticles utilizing capillary action through a piece of triangular-shaped cotton paper is reported.
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Construction of a three-mode sensor based on gold nanoparticles and carbon quantum dots as probes for the detection of thiosemicarbazone

Anal. Methods, 2024, 16,2127-2134
DOI: 10.1039/D4AY00256C, Paper
Zhili Liu, Xiaojun Wang, Jing Li, Wenfeng Zhou, Haixiang Gao, Runhua Lu
A three-mode sensor for thiocarbazone (TSC) was constructed based on gold nanoparticles and carbon quantum dots (CQDs). (A) Synthesis process of CQDs using ginkgo leaves. (B) Colorimetric and chrominance TSC detection. (C) Fluorescence detection of TSC.
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A screening method for the quantitative determination of selective androgen receptor modulators (SARMs) in capsules by high resolution 19F- and 1H-NMR spectroscopy

Anal. Methods, 2024, 16,2135-2146
DOI: 10.1039/D4AY00188E, Paper
Alessandro Maccelli, Anna Borioni, Federica Aureli, Maria Cristina Gaudiano, Livia Manna, Mariangela Raimondo
A new method for rapid determination of selective androgenic receptor modulators (SARMs) andarine, cardarine, ligandrol, ostarine and S-23 in capsules by 1H- and 19F-high resolution NMR spectroscopy was described and validated.
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Study on the affinity sites of cadmium's binding to ligands by thermodynamics and nuclear magnetic resonance spectroscopy

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02253F, Paper
Jinsong Yu, Xu Huang, Xiuxiu Wu, Hui Cao, Min Yuan, Tai Ye, Fei Xu
According to the experimental parameters for the interaction of Cd(II) with ligands, the binding sites of Cys and GSH were –SH, –NH2 and –COOH, and the thermodynamic behaviour of Cd(II) with Cys/GSH in boric acid and HEPES buffers was different, exothermic in HEPES but endothermic in boric acid.
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Dual-mode detection of 2,6-pyridinedicarboxylic acid based on the enhanced peroxidase-like activity and fluorescence property of novel Eu-MOFs

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00331D, Paper
Jintao Yi, Xianqin Han, Jiahao Jian, Yayan Lai, Jun Lu, Lei Peng, Zhongkai Liu, Jun Xue, Hui Zhou, Xun Li
The dual-mode fluorescence and colorimetric detection of 2,6-pyridinedicarboxylic acid (DPA) based on the enhanced peroxidase-like activity and fluorescence property of a novel MOF.
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A Multimode Biosensor Based on Prussian Blue Nanoparticle Loaded with Gold Nanoclusters for the Detection of Aflatoxin B1

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02330C, Paper
zhaodi Fu, juan Huang, Wei Wei, zhihui Wu, Xingbo Shi
Herein, a novel fluorescent/colorimetric/photothermal biosensor is proposed for aflatoxin B1 (AFB1) detection in food based on Prussian blue nanoparticles (PBNPs) (~50 nm), gold nanocluster (AuNCs) and aptamer (Apt) within three...
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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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A novel ratiometric sensor for fluorimetric and visual dual-mode detection of Al3+ in environmental water based on the target-regulated formation of Eu MOFs

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00324A, Paper
Tao-Li Chen, Xiang-Juan Kong, Xin-Xin Dong, Zhi-Jie Mao, Fang-Fang Kong, Qiang Xiao
The illustration of the ratiometric sensor for fluorimetric (A) and visual detection (B) of Al3+.
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Phenylboronic acid modification-based novel dumbbell-shaped Au–Ag nanorod SERS substrates for ultrasensitive detection of SO42−

Anal. Methods, 2024, 16,2311-2321
DOI: 10.1039/D3AY01831H, Paper
Kang Shen, Caili Bi, Haifan Yang, Miaowen Xu, Lili Huang, Youwei Wang
Based on the coordination principle of Lewis acids, a novel 4-MPBA-modified dumbbell-shaped Au–Ag nanorod (4-MPBA@DS Au–AgNR) SERS substrate was developed to realize the high sensitivity and specificity of SO42− detection.
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Advancements in the development of fluorescent chemosensors based on CN bond isomerization/modulation mechanistic approaches

Anal. Methods, 2024, 16,2198-2228
DOI: 10.1039/D3AY02321D, Critical Review
Arpna Tamrakar, Manzoor Ahmad Wani, Gargi Mishra, Ankur Srivastava, Rampal Pandey, Mrituanjay D. Pandey
The CN bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules.
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A chemodosimetric chemosensor for the ratiometric detection of nerve agent-mimic DCP in solution and vapor phases

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00451E, Paper
Shilpita Banerjee, Pintu Ghosh, Anirban Karak, Dipanjan Banik, Ajit Kumar Mahapatra
The probe MNFZ undergoes a hydrolysis reaction in the presence of DCP to exhibit a naked eye color change from blue to cyan. It was successfully applied to sense DCP in the vapor phase.
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Visit wrap-up: On PM Modi’s U.S. visit, announcements

The Modi U.S. visit announcements will see New Delhi being put to the test




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
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Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00662C, Research Article
Rajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank Schweizer
We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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Library to hold Group II-A Mains, Group IV TNPSC model test




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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life

When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.




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572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]




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583: Language Models, AI, and Digital Gardens with Maggie Appleton

Maggie Appleton talks with us about her work at Elicit, working with large and small language models, how humans vet the responses from AI, the discussion around the Soggoth meme in AI, using Discord as UI, what to do if your boss wants AI in your app, and why does she call her blog a digital garden?




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The commodification of water

Water purification systems in cities and villages may look attractive but do they actually benefit the needy?




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New venture Zerofifty from ad veterans wants to simplify the agency model

ZeroFifty Mediaworks, set up by three ad veterans, wants to bring in Bandra vibes into the agency model




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India’s agri transformation a lesson for others: Modi

India has become the second-largest producer of food grains, fruits, vegetables, cotton, sugar, and tea, says PM Modi at the inauguration of the 32nd International Conference of Agricultural Economists




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PM Modi expresses condolences over demise of renowned organic farmer Pappammal

In 2021, she was given the Padma Shri award for popularising organic farming in India and was regarded as a pioneer in the agriculture field




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Observability and mathematics [electronic resource] : Quantum Yang-Mills theory and modelling / Boris Khots.




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Pammal Sambandha Mudaliar’s contribution to modern Tamil drama remembered

SASTRA’s the School of Arts, Sciences, Humanities and Education, in collaboration with Sahitya Akademi, organises seminar on the celebrated playwright in Thanjavur




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Revisiting the density profile of the fuzzy sphere model for microgel colloids

Soft Matter, 2024, 20,8181-8184
DOI: 10.1039/D4SM01045K, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Frank Scheffold
Microgel density profiles evaluated with the complementary error function and the popular fuzzy sphere model are not compatible with each other.
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The cellular Potts model on disordered lattices

Soft Matter, 2024, 20,8337-8352
DOI: 10.1039/D4SM00445K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hossein Nemati, J. de Graaf
Extending the cellular Potts model to disordered Voronoi lattices reduces artifacts observed on regular lattices. An order–disorder transition is observed as a function of surface tension on the disordered lattice and the regular lattices.
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Chemo-mechanical model of cell polarization initiated by structural polarity

Soft Matter, 2024, 20,8407-8419
DOI: 10.1039/D4SM00800F, Paper
Hexiang Wang, Zhimeng Jia, Yuqiang Fang
We establish a multiscale model of a cell to explore the chemomechanical mechanisms of cell polarization initiated by structural polarity. The two-dimensional vertex model is built by coupling the cytoskeletal reorganization and the Cdc42 activation.
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Development of a coarse-grained molecular dynamics model for poly(dimethyl-co-diphenyl)siloxane

Soft Matter, 2024, 20,8480-8492
DOI: 10.1039/D4SM00875H, Paper
Weikang Xian, Amitesh Maiti, Andrew P. Saab, Ying Li
Polydimethylsiloxane and its copolymer systems have a wide range of application. We systematically develop a coarse-grained MD model for PDMS-co-PDPS system. The model preserves the structural and dynamic properties of the material quantitatively.
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