Central sleep apnoea (CSA) is characterised by recurrent episodes of airway cessation or reduction in the absence of respiratory effort. Although CSA is less common than obstructive sleep apnoea, it shares similar symptoms. CSA can be secondary to various medical conditions, high altitude and medication exposure. CSA can also emerge during obstructive sleep apnoea therapy. There are a range of treatment options and selecting the right therapy requires an understanding of the pathophysiology of CSA. This review explores the aetiology, pathophysiology and clinical management of non-hypercapnic CSA.

It's a quiet news week before the big push of releases before the holiday gaming rush. Chris invites hate mail for his crazy views on Final Fantasy VII and Mario 64. Kelley discovers her friendship isn't worth an iPad. And Anna Marie wants easy modes to actually be easy. Is that too much to ask? Wait...it IS a bunny!

The post RPG Cast – Episode 605: “Have You Saved Recently?” appeared first on RPGamer.

CAPTCHA tests are supposed to distinguish humans from bots, but an AI system mastered the problem after training on thousands of images of road scenes

Google, Microsoft and others have taken big steps towards error-free devices, hinting that quantum computers that solve real problems aren’t far away

A type of mathematical problem that was previously impossible to solve can now be successfully analysed with artificial intelligence

Oil and water can be separated efficiently by pumping the mixture through thin channels between two semipermeable membranes

Imagine a world without Facebook. For just half an hour. A group of AI leaders get together but don’t seem to invite Elon Musk. Amazon takes data centres nuclear. A new competitor for ChatGPT and Google. And public trust in AI is declining.  All this and more on the “just breath, Facebook will be back” […]

Artificial intelligence can be the key to unlocking better relationships with work, HP revealed in its new Work Relationship Index (WRI) report. “AI represents a significant opportunity to transform our work dynamics and unlock a more positive and productive environment for all,” stated Dave Shull, president of HP Workforce Solutions at HP Inc.. “To foster […]

ALS, the most common form of motor neuron disease, can take a long time to diagnose, but a blood test could help doctors spot the condition sooner

New NatGeo documentary was directed by the same duo who brought us the Oscar-winning Free Solo.

"If we hold strong together, we will come through this."

Ars speaks with users and partners unhappy with Broadcom's changes.

A police officer from the Mexican border state of Tamaulipas faces a murder charge for his role in the killing of an underage teenager he allegedly mistook for a gunman. He and five other officers are also charged with planting evidence to cover up the incident.

The post Mexican Cops Accused of Killing Innocent Teen, Cover Up appeared first on Breitbart.

Join Sean Gallagher, Dell's Ivan Nekrasov, and me today, January 21, at 3:15pm Eastern!

Adjacent angles are one of the earliest and most important concepts to learn in basic geometry, as they have applications in further subjects like trigonometry, physics, and engineering. Effective students of geometry should be able to identify adjacent angles on sight and calculate them to a great degree of accuracy without a protractor.

The winter holidays are upon us and despite the festive feelings we might be hoping for, this time of year is often paired with increased stress, worry and anxiety. Fortunately, there are some great tools for helping to manage those negative emotions while promoting positive ones. One of those tools is the Headspace mental health app, which is running a three-week Black Friday deal. From November 12 through December 4, you can snag a Headspace annual plan for half off. This subscription normally costs $70 a year, but during this promotion, you can access the service for $35 billed annually. And what better time than the holiday chaos to gift someone (or heck, to gift yourself) a little bit of mindfulness?

Headspace's service has features to help users with meditation, sleep tools, mindfulness and general mental health. Its holistic approach made Headspace stand out as one of our top picks for meditation apps. Reviewer Lawrence Bonk appreciated how well Headspace created progression across its courses, as well as the chance to pick from different instructors so that any user can find the meditation guidance that will work best for their individual brains. This app is also getting the AI treatment. Headspace has introduced an AI companion named Ebb that can help users by recommending meditations and activities to best match their current challenges. 

Since this is a year-long subscription, it's a gift that keeps on giving for whoever you choose to buy this plan for. Having a happier brain is a present anyone can appreciate.

Follow @EngadgetDeals on Twitter and subscribe to the Engadget Deals newsletter for the latest tech deals and buying advice.

I'm a big fan of Anker's chargers, especially its portable ones, as they tend to be sleek, fast and small enough to shove in my pocket (the last bit is a requirement for me). While the company's products run the gambit price-wise, there's a big sale on one of Anker's more expensive options: the 200W Prime Power Bank. Right now, you can get this power bank and its 100W charging base for just $110, down from $185 — a 41 percent discount.

Anker's 200W portable charger is our choice for best premium power bank thanks to features like charging an iPhone in an average of one hour and 48 minutes. One of the best parts of the power bank is its sleek screen, which shows the power coming in or out and how much battery the accessory is holding. This feature is much more exact than the four dots on my cheaper (but still loved) Anker Nano Power Bank. 

The power bank and charging base both offer one USB port and two USB-C ports so there's plenty of ways to charge your devices. The base also uses magnets to secure its pins to the power bank and charge it upright. Our biggest quip with the power bank was its high price, but with this sale it's definitely worth looking into. 

Check out all of the latest Black Friday and Cyber Monday deals here.

Meta has long been at loggerheads with European Union officials over its approach to targeted Facebook and Instagram ads. The company is hoping to placate regulators with some changes to its ad model in the bloc, which includes lowering the price of its ad-free subscription. Starting November 13, the plan will cost 40 percent less — €6 ($6.36) per month for signups via the web and €8 ($8.48) for those who subscribe on an iOS or Android device. The fee for each additional Facebook and Instagram account is €4 per month on the web and €5 via mobile.

The company will automatically drop current subscribers down to the lower pricing. It says that it will once again ask users in the bloc if they'd like to sign up.

When they see this prompt (which can only be ignored for a certain period of time), there will be a third option for EU Facebook and Instagram users to choose from. Those who don't want to pay for a subscription can instead opt to only view ads that are based on what they see in a given session in the apps. Meta will also factor in a few key data markers such as "a person’s age, location, gender and how a person engages with ads."

These less-personalized ads naturally won't be as tailored to a given user's interests, the company notes. As such, people are perhaps less likely to click on such ads. To make up for that (and make sure this option doesn't hit Meta in the pocket too hard), folks who choose the less-personalized ads option will sometimes encounter unskippable ads. According to The Wall Street Journal, these will be displayed full screen.

"Such ad breaks are common across other services, and are already offered by many of our competitors," Meta argues. "This change will help us continue to provide value to advertisers which ensures we can offer people a less personalized ads experience at no charge."

Targeted ads are Meta's biggest revenue driver, but EU officials have reportedly been pressuring the company to offer a free, less-personalized option in its apps. Meta has argued that would negatively impact its bottom line. Although it has seemingly caved to officials' requests, the unskippable ad aspect may be construed as malicious compliance, as it worsens the user experience.

Meta claims that these changes to its ad model "meet EU regulator demands and go beyond what’s required" by the bloc's laws. The company introduced its ad-free subscription a year ago to comply with laws such as the Digital Markets Act (DMA), as well as stricter interpretations of the General Data Protection Regulation. It was previously ordered to seek permission from users in the bloc before showing them personalized ads.

The EU didn't take too kindly to the paid ad-free approach, however. An investigation into the "consent or pay" model is ongoing. In July, the EU said that in its preliminary findings, Meta was violating the DMA with this plan.

These latest changes are said to be Meta's attempt to settle the case, but according to the Journal, the EU's discussions with the company haven't concluded. The bloc's regulatory body has until late March to finish its investigation and make a final decision. If it determines that Meta has indeed violated the DMA, the company could be on the hook for a fine of up to 10 percent of its annual global revenue. Based on its total revenue for 2023, it could have to pay up as much as $13 billion or so.

More than 200 employees of 23andMe are being laid off as part of the company’s ongoing cost-cutting measures. The layoffs will impact 40 percent of the genetic testing company’s workforce.

23andMe CEO and co-founder Anne Wojcicki said in a statement released on Monday that the staff reduction would save the beleaguered company more than $35 million. She called the layoffs “difficult but necessary actions as we restructure 23andMe and focus on the long-term success of our core consumer business and research partnerships.”

The company also announced it will start to shut down its therapeutics clinical programs that used its genetic database to research and develop new drugs. The therapeutics division housed two “immuno-oncology programs” that investigated therapeutic antibodies “designed to restore the ability of the body’s immune cells to kill cancer cells,” according to the division’s website.

The San Francisco-based company has not had an easy year. Hackers hit the genetics giant in April of last year and leaked information of 6.9 million customers. The data breach went unnoticed for a year and a half, leading to a $30 million settlement of a class action lawsuit and resignations from the company’s entire board.

Apple is rumored to be working on a new smart home product. Mark Gurman at Bloomberg reported that the company is developing a wall-mounted display for controlling appliances, interacting with Siri and videoconferencing. The tablet is said to look "like a square iPad" with "a roughly 6-inch screen." It would have a camera at the top as well as internal speakers and a built-in rechargeable battery. His sources said this smart home display could be officially announced as soon as March following three years in development.

This description sounds a lot like the Google Home Hub, which came out in 2018, or the Echo Show, which is already up to its eighth iteration. If Apple wants to be a serious competitor in this smart home space, it'll have to prove to customers that it has something to offer that these more established brands and products don't.

Right now, the only distinguishing feature is likely Apple Intelligence, which finally began rolling out to users in late October, and the upcoming App Intents system for controlling software programs with AI. But Apple may be looking farther ahead toward something more extravagant than just a smart device control panel. Gurman reported that Apple is already working on a version with a robotic arm that could move the tablet around. It should be interesting to see exactly what Apple does formally launch and when.

The sound of silence, no more: Paul Simon and Art Garfunkel, who as folk duo Simon & Garfunkel were one of the most popular American musical acts of the 20th century, recently reunited after years without speaking.

Centrelink’s controversial data-matching program will be ‘refined’ as pressure mounts for it to be suspended.

In an effort to strengthen the regulatory activities for medical devices in the country, the Union health ministry has framed and finalised rules regulating the method of recruitment to various posts under the Central

The recent amendments brought by the Union Ministry of Ayush to the Drugs and Cosmetics Rules, 1945 are significant, as they introduce new regulatory requirements for the manufacturing and sale of traditional

Exports of Ayush and herbal products for the first six months of the current fiscal has reported a 10.34 per cent growth, as compared to an almost stagnant exports reported in the same period of previous fiscal

The U.S. Food and Drug Administration posted a photo:

Catherine Dasenbrock, director of the U.S. Food and Drug Administration’s National Forensic Chemistry Center, speaks to guests prior to officially reopening the center during a ribbon-cutting ceremony, Sept. 24, 2024, celebrating the completion of the 64,000-square-foot expansion and renovation of the facility in Cincinnati, Ohio. The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

U.S. Food and Drug Administration officials and General Services Administration leaders officially reopen the National Forensic Chemistry Center during a ribbon-cutting ceremony, Sept. 24, 2024, highlighting the completion of the 64,000-square-foot expansion and renovation of the center in Cincinnati, Ohio. The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

(From left)
Marie Maguire, Assistant Special Agent in Charge, Headquarters Operations, Office of Criminal Investigations, FDA
James Sigg, Deputy Commissioner for Operations and Chief Operating Officer, Office of the Commissioner, FDA
Catherine Dasenbrock, Director, National Forensic Chemistry Center, Office of Inspections and Investigations (OII), FDA
Duane Satzger, Associate Director, Office of Medical Products and Specialty Laboratory Operations, OII, FDA
Katy Kale, Deputy Administrator, GSA
Douglas Stearn, Principal Deputy Associate Commissioner, OII, FDA

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

Scientists explain the work they do to guests attending a ribbon-cutting ceremony celebrating the completion of a 64,000-square-foot expansion and renovation of the U.S. Food and Drug Administration’s National Forensic Chemistry Center in Cincinnati, Ohio, Sept. 24, 2024.

The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

Scientists explain the work they do to guests attending a ribbon-cutting ceremony celebrating the completion of a 64,000-square-foot expansion and renovation of the U.S. Food and Drug Administration’s National Forensic Chemistry Center in Cincinnati, Ohio, Sept. 24, 2024.

The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

Scientists explain the work they do to guests attending a ribbon-cutting ceremony celebrating the completion of a 64,000-square-foot expansion and renovation of the U.S. Food and Drug Administration’s National Forensic Chemistry Center in Cincinnati, Ohio, Sept. 24, 2024.

The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

The good folks down at eyeforpharma have asked me to write a few blog posts in the run-up to their Patient Centered Clinical Trials conference in Boston this September. In my second article -Buzzword Innovation: The Patient Centricity “Fad” and the Token Patient - I went over some concerns I have regarding the sudden burst of enthusiasm for patient centricity in the clinical trial world.

Apparently, that hit a nerve – in an email, Ulrich Neumann tells me that “your last post elicited quite a few responses in my inbox (varied, some denouncing it as a fad, others strongly protesting the notion, hailing it as the future).”

In preparing my follow up post, I’ve spoken to a couple people on the leading edge of patient engagement:

• Abbe Steel, CEO of HealthiVibe, which is focused on bringing greater patient input into the earliest stages of trial design through focus groups and patient surveys
• Casey Quinlan, co-founder of Patients for Clinical Research, which aims to be a force in patient education and engagement for clinical trials

To get a better idea of what other folks think of the idea, I am sending out a little ad hoc survey. Only 4 questions (so people hopefully do it). Added benefit: There is a massive 50% one-time discount for completed surveys until Friday connected to it as an incentive).

1. Complete the survey and share your thoughts
2. Come to the conference and tell us all exactly what you think

We’ve all seen Medicare Advantage (MA) plans become a significant player in the healthcare industry. Yet, with the […]

Who controls India’s water resources: Centre, States or both? How are inter-State river disputes settled? Who supplies drinking water to Indian citizens?

Elections in Karnataka have increasingly become bipolar, with 77% of the seats recording bipolar contests in 2018

Jun 2, 2024

Ethnic cleansing is not only a modern phenomenon. The medieval Catholic Church saw non-Christians as a threat and facilitated the ethnoreligious cleansing of Muslim and Jewish communities across Western Europe. Three conditions made this possible: The rising power of the papacy as a supranational religious authority; its dehumanization of non-Christians; and competition among Catholic Western European monarchs that left them vulnerable to papal-clerical demands to eradicate non-Christians. These findings revise our understanding twentieth- and twenty-first-century ethnic cleansing in places like Cambodia, Iraq, Myanmar, the Soviet Union, and Syria.

Settlement Overview Video. If you lived at Huronia, Rideau, or Southwestern Regional Centres, you may be eligible to make a claim.

Long Term Care Consumer Resources

Video One

Edmunds.com�s roundup of new vehicles at the 2014 LA Auto Show

Presenting The Great Carol Comeback.

Where lives and goals come together in one place � S&T Bank.

Rob Riggle Stars alongside Brice Williams in the newest Easter Seals Dixon Center PSA, directed by Jim Fabio with support from Judd Apatow

InComm Incentives takes the stress out of planning and executing rewards and promotions with an easy-to-use, B2B e-commerce portal.

Clayton Homes is pumping up the savings through the end of the year.

Denny�s extends food quality commitment with cage-free eggs.