vivo

New Zealand PM delivers landmark apology to survivors of state abuse

Some 2,00,000 vulnerable New Zealanders were abused in state care in the seven decades since the 1950s, according to an inquiry




vivo

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




vivo

Design, synthesis, and in vitro and in vivo biological evaluation of triazolopyrimidine hybrids as multitarget directed anticancer agents

RSC Adv., 2024, 14,35239-35254
DOI: 10.1039/D4RA06704E, Paper
Open Access
Heba A. Adawy, Samar S. Tawfik, Abdullah A. Elgazar, Khalid B. Selim, Fatma E. Goda
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.
The content of this RSS Feed (c) The Royal Society of Chemistry




vivo

Nobel Peace Prize awarded to Japanese atomic bombing survivors’ group Nihon Hidankyo

We wish to honour all survivors who, despite physical suffering and painful memories, have chosen to use their costly experience to cultivate hope and engagement for peace, says Jørgen Watne Frydnes, chair of the Norwegian Nobel Committee




vivo

Holocaust survivors mark 80 years since mass Paris roundup

French President Emmanuel Macron has decried his Nazi-collaborator predecessors and vigorously vowed to stamp out Holocaust denial




vivo

In vivo mechanism of interaction between trimethylamine lyase expresssion and glycolytic pathways

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03809F, Paper
Qian Li, Di Wu, Yu Song, Lu Zhang, Ting Wang, Min Zhang
Recent findings have confirmed that the interaction between host and gut microbiota can alter the formation of the disease-associated metabolite, trimethylamine (TMA), via intestinal microbial TMA lyase. Nevertheless, little is...
The content of this RSS Feed (c) The Royal Society of Chemistry




vivo

Preparation and characterization of white shrimp hydrolysate-xylooligosaccharides Maillard products and their in vivo promotive effects of zinc absorption in mice

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03709J, Paper
Shijie Dou, Xuening Yu, Yuewen Xu, Xiaoyang Liu, Fawen Yin, Deyang Li, Da-Yong Zhou
The Maillard reaction products, as a kind of glycosylation-based reaction, possess the metal-chelating ability. In this study, the white shrimp hydrolysate (WH) and xylooligosaccharides (XOS) were used to prepare the...
The content of this RSS Feed (c) The Royal Society of Chemistry




vivo

Folic acid-targeted redox responsive polylactic acid-based nanoparticles co-delivering pirarubicin and salinomycin suppress breast cancer tumor growth in vivo

Nanoscale, 2024, 16,20131-20146
DOI: 10.1039/D4NR02365J, Paper
Priya Gupta, Ankushi Bansal, Harshdeep Kaur, Mohd Anees, Neetu Singh, Harpal Singh
Schematic illustration of design, administration, and mechanism of action of Pira/Sal dual-loaded FA-conjugated redox responsive [S-(PLA-b-PEG-CONH)]2 block copolymeric nanoparticles.
The content of this RSS Feed (c) The Royal Society of Chemistry




vivo

Application of a meshed artificial dermal scaffold and negative-pressure wound therapy in the treatment of full-thickness skin defects: a prospective in vivo study

Biomater. Sci., 2024, 12,1914-1923
DOI: 10.1039/D3BM01675G, Paper
Open Access
Pei Wei, Lijiao Wu, Hongteng Xie, Zhaohong Chen, Rongwei Tan, Zhaorong Xu
A novel meshed ADS combined with NPWT can reduce the risk of scaffold-related complications, which helps to improve the quality of wound repair and promotes a broader range of applications.
The content of this RSS Feed (c) The Royal Society of Chemistry




vivo

Vivo X100 Pro review: Capturing bison and bonfires, with the first flagship launched in 2024

The smartphone with its 225 grams isn’t exactly lightweight, but it looks classy with its trademark graphite glass finish rear panel




vivo

Vivo V30 Pro Review: Picture perfect synergy

The phone features a large 6.78-inch edge-to-edge display with a 120 Hz refresh rate and Andaman Blue colour variant, lending a premium feel.




vivo

Asus Vivobook S15 review: Ready to rise?

Slim, Snapdragon-powered and raring to go — but hold the games!




vivo

Vivo to introduce its newest X90 series in India today

Vivo X90 series will include two handset variants – Vivo X90 and Vivo X90 Pro



  • Mobiles & Tablets

vivo

Vivo launches X90 series starting at ₹59,999

Vivo has launched Vivo X90 and Vivo X90 Pro smartphones in India



  • Mobiles & Tablets

vivo

Vivo X90 Pro Review

Getting up close with a surprisingly snazzy snapper




vivo

Google Pixel 9 Pro Fold and Vivo X Fold 3 Pro compared | Specs, features, prices

The Google Pixel 9 Pro Fold and the Vivo X Fold 3 Pro are both ultra-premium foldable smartphones




vivo

Xiaomi 14 Ultra vs Vivo X100 Pro | Features, prices, specs, and more

The Xiaomi 14 Ultra and Vivo X100 Pro are both ultra-premium phones nearing the ₹1 lakh mark, but how do they differ?




vivo

The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo




vivo

Impacting survivours of trafficking one climb at a time

“I climb in the name of the young women we serve,” said Boris Salinas, who will participate in a Freedom Climb event on 26 April.




vivo

Vivo V19 स्मार्टफोन इस दिन भारतीय बाजार में लेगी एंट्री, जानें कीमत और फीचर्स

चीनी स्मार्टफोन निर्माता कंपनी वीवो (Vivo) अपने लेटेस्ट डिवाइस वी19 (Vivo V19) को भारत में लॉन्च करने जा रही है। कंपनी के मुताबिक, इस स्मार्टफोन को 12 मई के दिन भारतीय बाजार में उतारा जाएगा।




vivo

Fear, judgment, hysteria: six survivors talk about life after coronavirus

After facing the existential threat of testing positive for Covid-19, these Australians describe the reactions of their communities

When they emerged from isolation, one felt like an escapee, another saw friends turn on their heels and some questioned if they had really recovered. Though their symptoms varied, all the accounts from these people who have recovered from coronavirus echo the same sentiment: recovery came at a price. Weeks after getting better, strangers and loved ones still scrabble to create distance, afraid of contagion.

At the time of writing, 5,984 Australians had recovered from the 6,875 confirmed cases. While the emerging consensus is that recovery induces, at least, short-term immunity, the World Health Organization urges caution, and researchers and health authorities are racing to determine how long this defence lasts.

Continue reading...




vivo

New scoping document on in vitro and ex vivo assays for the identification of modulators of thyroid hormone signalling

This scoping document brings forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, and provide recommendations for their further development/use, and also, to identify aspects of the thyroid signalling pathway that are not covered and would require further attention




vivo

Will Covid-19 survivors face a lifetime of illness like those who battled polio?

Kirstin Coutney, pictured with her daughter Tilly, contracted Covid-19.  The 49-year-old mother of two from Bath is still suffering crippling fatigue, six weeks after developing the virus.




vivo

Will Covid-19 survivors face a lifetime of illness like those who battled polio?

Kirstin Coutney, pictured with her daughter Tilly, contracted Covid-19.  The 49-year-old mother of two from Bath is still suffering crippling fatigue, six weeks after developing the virus.




vivo

The tale of an acid-attack survivor


The government's move to regulate the retail sale of acid is a welcome one, but for the many hundreds who have been prey to such heinous acts, life continues to be a daily struggle against physical and social odds. Priyanka Nadgir talks to one such survivor.




vivo

Survivor of Aurangabad Rail Accident Recalls Horror of Waking up to Bodies of His Deceased Colleagues

Sixteen migrant workers, walking home to Madhya Pradesh, were mowed down by a passing train in Maharashtra's Aurangabad district early on Friday.




vivo

Fear continues to grip Delhi riot survivors

Many of those who fled during the violence are still fearful about returning.




vivo

Bombay high court lets teen rape survivor abort 24-week fetus | Mumbai News - Times of India

Bombay high court lets teen rape survivor abort 24-week fetus | Mumbai News - Times of India




vivo

COVID-19 survivor Zoa Morani donates blood for plasma therapy




vivo

Double Black-Hole Mystery: Dance Partners or Breakup Survivors?

Smithsonian astronomers have just discovered a rare example of a galaxy that appears to have a pair of giant black holes. Now they are trying to determine if those black holes are partners tied together by gravity, or if one of the two has been kicked out in a cosmic breakup.

The post Double Black-Hole Mystery: Dance Partners or Breakup Survivors? appeared first on Smithsonian Insider.




vivo

Dodo bird a resilient island survivor before the arrival of humans, study reveals

A new study on the dodo’s island home of Mauritius in the Indian Ocean, paints a picture of this unusual bird as an intrepid survivor on par with the giant tortoise for its resiliency.

The post Dodo bird a resilient island survivor before the arrival of humans, study reveals appeared first on Smithsonian Insider.




vivo

Study determines microscopic water bears will be Earth’s last survivors

The world’s most indestructible species, the tardigrade, an eight-legged micro-animal, also known as the water bear, will survive until the Sun dies, according to a […]

The post Study determines microscopic water bears will be Earth’s last survivors appeared first on Smithsonian Insider.




vivo

Dramatic video shows tsunami survivor's rescue

Video: Images continue to appear showing the scale of the tsunami. ITN's Louisa James describes the rescue of one woman, plucked to safety as the water surged t



  • Climate & Weather

vivo

ViVood: A pared-down pop-up vacation shack that's perfect for semi-roughing it

This teeny-tiny wooden cabin from Spain can be built in several hours (provided you can wrangle several friends to help you).



  • Remodeling & Design

vivo

This shelter is making things right for survivors of violence — including their pets

Ahimsa House brings healing to survivors of domestic violence, by giving both humans and animals a safe place to start over.



  • Protection & Safety

vivo

Film Debut Honors the Journeys of Childhood Cancer Survivors

‘Moments of Joy’ highlights Aflac’s near-25-year commitment to raising awareness for childhood cancer while addressing the challenges kids face.




vivo

Dr. Paul Sussman, Dentist in Rochester, New York, Restores Smile of Domestic Violence Survivor

Center for Cosmetic Dentistry provides quality dental restorations and cosmetic care




vivo

"Girls Cruise" Star Tiffany Panhilason Hosts Yoga Session For Human Trafficking Survivors

Actress and Reality TV Star Tiffany Panhilason Hosts A Powerful Yoga Session For Mentari USA's Human Trafficking Survivor Empowerment Program




vivo

Elk River, Minnesota Teen Wins John Foy & Associates Survivor Of A Car Accident Scholarship

John Foy & Associates is pleased to announce the recipient of the Survivor Of A Car Accident Scholarship




vivo

"Girls Cruise" Star Tiffany Panhilason Hosts Intimate Thanksgiving Dinner For Human Trafficking Survivors

Actress and Reality TV Star Tiffany Panhilason Hosts Thanksgiving Meal For Mentari USA's Human Trafficking Survivors




vivo

College HUNKS Hauling Junk & Moving Provides Free Services to Domestic Violence Survivors




vivo

75 Years of Freedom for Holocaust Survivor Turning 100 this Year: May 5, 2020 Marks the 75th Anniversary Holocaust Survivor Joe Rubinstein Walked Out of the Terezín (Theresienstadt) Ghetto Camp

On a frigid morning in Radom, Poland, German soldiers forced twenty-one-year-old Icek "Joe" Rubinsztejn onto a crowded, open-air truck. The next day, several around him were dead. From there, things got worse for young Joe—much worse.




vivo

Vivo India donates 15,000 PPE suits, 50,000 litres of sanitizer

Smartphone maker Vivo India has donated 15,000 PPE suits and 50,000 litre of sanitizer to the central government to protect caregivers and healthcare professionals from coronavirus, the company said.




vivo

Samsung, Oppo, Vivo & Lava get Uttar Pradesh government nod to restart operations

“Permissions have been received by the majority of the companies, though the workforce has been truncated to 20-30%. It is extremely difficult to reach any kind of optimisation and efficiency in this manner,” Pankaj Mohindroo, chairman of India Cellular & Electronics Association (ICEA), told ET.




vivo

Belfast Coronavirus survivor urges people to stay home this Bank Holiday weekend

"It's the most dangerous, aggressive experience of my life but I consider myself to be one of the lucky ones. This virus as we all know is a killer."




vivo

AHA Media Alert: COVID-19 prompts questions on increased risk for those with CVD and stroke survivors

AHA COVID-19 newsroom   DALLAS, April 3, 2020 — COVID-19 is prompting widespread questions and concerns about the heightened risk for those with heart disease and stroke survivors.   The American Heart Association, the world’s leading nonprofit...




vivo

Telemonitoring plus phone counseling lowers blood pressure among black and Hispanic stroke survivors

Research Highlights: Minority stroke survivors experience better blood pressure control when lifestyle counseling by phone from a nurse is added to home blood pressure telemonitoring. Improved blood pressure control could lower strokes and stroke ...




vivo

Stroke survivors honored with national award for resilience and creativity

DALLAS, April 27, 2020 — Stroke is a leading cause of death and a major cause of disability in the U.S. Yet millions of survivors, caregivers and supporters overcome the challenges stroke presents each day. This year, the American Stroke Association, ...




vivo

Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing

Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags. An “optical window,” farther red than most autofluorescence sources and in a region of low hemoglobin and water absorbance, lies between 650 and 900 nm. This valley of relative optical clarity is an attractive target for fluorescence-based studies within tissues, intact organs, and living organisms. Novel fluorescent tags were developed herein, based upon a genetically targeted fluorogen activating protein and cognate fluorogenic dye that yields emission with a peak at 733 nm exclusively when complexed as a “fluoromodule”. This tool improves substantially over previously described far-red/NIR fluorescent proteins in terms of brightness, wavelength, and flexibility by leveraging the flexibility of synthetic chemistry to produce novel chromophores.




vivo

Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest.