A RARE portrait of an early suffragette and Titanic survivor has been discovered by an auctioneer whose own ancestor shared a lifeboat with her after the liner sank.

An exhibit at the James Art Gallery inside Ohio State University's Comprehensive Cancer Center reveals the power art can have in someone's darkest days. Mike Foley explains.

Edmonton father and son describes how son is recovering from vicious random attack, Grade three car lover goes to Auto Show, Sudbury teen pursues acting career and overcomes bullying and Orleans Ontario teen wins 100K Loran prize.

It was the New South Wales rail disaster that killed six people and injured 100 more. Some of those on board share their recollections of that day.

Visitors to the City of Greater Geraldton's council chambers earlier this week were greeted with a display of more than 200 pink silhouettes strategically placed on the grassed area near the main entrance .

Hundreds of abuse survivors could benefit from reforms that will allow them to sue their abusers, even if they signed "unfair" agreements not to take legal action.

The Catholic Church may have opened itself up to hundreds of potential damages claims from sexual abuse survivors after admitting liability in court documents.

A child abuse survivor says the priest who assaulted him did so in the 'welcoming' home of another clergyman. His claim comes amid new allegations that paedophiles acted in concert within the Catholic Church.

This 83-year-old ketch, Julie Burgess, is the last survivor of more than 100 built by the Burgess family and all were named after Burgess women.

The survivor of a boating accident in SA's Coorong, which claimed the life of another man, was found curled up with hypothermia and in shock after he swam to shore and walked about a kilometre.

Those who suffered devastating loss in the January bushfires say they didn't have time to rebuild before the coronavirus came along and dealt them another crippling blow.

A Catholic order settles out of court paying $4 million to survivors of historic sex abuse and apologising to them, their families and the Latrobe Valley community.

An openly gay and Christian psychologist says gay conversion therapy nearly killed him and some of his clients and the sooner it is outlawed the better.

A seven-year-old Perth girl who picked up her toddler sister and held her aloft to save her from an attacking rottweiler dog is among a group of West Australians to be honoured with bravery awards.

DAILY BRIEFING: A Tasmanian shark attack victim commemorates a year since the incident, cattle deaths hearing delayed and basketball stars arrive in the state.

Daniel Bradshaw experienced his first epileptic seizure aged 8 and was until recently enduring up to 50 seizures a day, until life-changing brain surgery. Now he has joined the push to change public perception of the disorder.

Survivors of sexual assault in regional Australia are driving for hours to access forensic medical examinations, even though any GP or nurse can be trained to administer them.

On a cool March morning in 1968, a television commercial shoot slated for the top of Uluru went horribly wrong.

With Tasmania committed to changing its laws, the Northern Territory will be the only place in Australia where sexual assault survivors are not legally allowed to share their own stories and journalists can face time behind bars if they name victims.

From smart watches to exercise monitors and devices that correct your posture, wearable tech is everywhere and now cancer survivor Kathy Reid has invented a smart breast.

Filmmakers hope to debut "Red Winter" next winter.

She brought some joy into a friend’s life.

The Hot Girl leader has been a bright spot for her fans.

Cases have increased since the coronavirus outbreak began.

Alexis Martin will soon be a free woman.

Cases have increased since the coronavirus outbreak began.

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we find that androgens suppress CDCP1 expression and that androgen deprivation in combination with loss of PTEN promotes the upregulation of CDCP1 and the subsequent activation of the SRC/MAPK pathway. Moreover, we demonstrate that anti-CDCP1 immunoliposomes (anti–CDCP1 ILs) loaded with chemotherapy suppress prostate cancer growth when administered in combination with enzalutamide. Thus, our study identifies CDCP1 as a powerful driver of prostate cancer progression and uncovers different potential therapeutic strategies for the treatment of metastatic prostate tumors.

Vivol and Luga

Last Feb. 14, Gov. Cuomo signed the Child Victims Act into law. He did it in the newsroom of the Daily News, because it was this paper that, over many years, spotlighted the wrenching cases of people abused as children, perversely prevented from seeking justice as adults.

Martin Greenfield Clothiers, creator of Joaquin Phoenix’s “Joker” suit and tailor to the well-dressed from President Obama to Mayor Bloomberg, is taking on coronavirus. The venerable custom suit maker teamed with its union workers to start producing protective face masks, with local community groups first on their list of beneficiaries.

Blood centers are ramping up efforts to collect plasma from people who recovered from COVID-19 in hopes their coronavirus antibodies could save lives.

Kiss frontman Gene Simmons said his mother almost never spoke about her Holocaust ordeal, including time in Nazi camps.

Four boys were executed in a Parke County, Indiana, mobile home on Feb. 14, 1977. There was only one survivor: Betty Jane Spencer.

An average of 907 Hoosiers are killed by guns each year, and 85 of those are children, a letter to the editor says.

Sita Tyasutami foi identificada como a 'paciente zero' da doença na Indonésia.

Girls who fled Boko Haram attacks are being enslaved and raped by human traffickers who then sell their babies.

Expectations were high for Jacksonville heading into the season. The game charters at Pro Football Focus ranked them as the league’s top secondary, the second-best pass rush and the seventh-best run-stopping unit in 2018.

The Patriots put their stamp back on the AFC East after throttling the Miami Dolphins 38-7 on Sunday. The Colts are next.

Houston’s defensive front, featuring one-man wrecking crew J.J. Watt, has the sixth-highest adjusted sack rate.

Colts have the the fifth-best run-stopping unit per PFF and the fourth-highest stuff rate per Football Outsiders.

Pittsburgh is stuffing 25 percent of rushers in 2018, eighth-most in the NFL.

Against No. 1 receiver types like Mike Evans, the Panthers rank fourth-best per Football Outsiders' Defense-adjusted Value Over Average.

Kansas City's opponent, Arizona, is scoring slightly more than a point per possession, making it the NFL's second-worst offense.

The Chargers are scoring 2.4 points per drive, the sixth-most this season, and are only forced to go three-and-out once out of every four drives.