sms Flexibility mechanisms in environmental regulations: Their use and impacts - Environment Working Paper By www.oecd-ilibrary.org Published On :: Fri, 16 Aug 2019 15:03:00 GMT Based on an in-depth literature review and responses to a survey among OECD member countries, this paper discusses the use of flexibility mechanisms in environmental regulations. The literature on these issues is limited, but it is clear that some such mechanisms can have important environmental and economic impacts. Full Article
sms OECD Conference on the Environmental Uses of Micro-organisms, 26-27 March 2012, Paris, France By www.oecd.org Published On :: Mon, 26 Mar 2012 00:00:00 GMT The conference will cover developments and the state-of-the art of environmental microbiology, as it is applied for biotechnological purposes, and the role of genetic engineering of micro-organisms intended for use in the environment, now and in the near future. Full Article
sms Biosafety and the Environmental Uses of Micro-Organisms By www.oecd.org Published On :: Thu, 22 Jan 2015 10:17:00 GMT Micro-organisms play a fundamental role in the environment. Yet their role is the result of complex biogeochemical processes by consortia of micro-organisms and the function of individual species is not clear in many cases. This publication provides an overview of the current situation and relevant developments in environmental microbiology. Full Article
sms SBI : ग्राहकों को किया अलर्ट, ऐसा SMS खाली कर सकता है आपका खाता By hindi.goodreturns.in Published On :: Wed, 06 May 2020 07:45:51 +0530 नई दिल्ली: कोरोना वायरस के चलते देशभर में लॉकडाउन किया गया है। लॉकडाउन के चलते बड़ी संख्या में लोग मोबाइल बैंकिंग का इस्तेमाल कर रहे है। लेकिन इसी कारण लॉकडाउन में तेजी से ऑनलाइन बैंकिंग धोखाधड़ी बढ़ रही है। Full Article
sms Printing telegraph systems and mechanisms / by H.H. Harrison By library.mit.edu Published On :: Sun, 9 Feb 2014 06:34:19 EST Archives, Room Use Only - TK5543.H37 1923 Full Article
sms Syntheses and structures of piperazin-1-ium ABr2 (A = Cs or Rb): hybrid solids containing `curtain wall' layers of face- and edge-sharing ABr6 trigonal prisms By scripts.iucr.org Published On :: 2019-07-26 The isostructural title compounds, poly[piperazin-1-ium [di-μ-bromido-caesium]], {(C4H11N2)[CsBr2]}n, and poly[piperazin-1-ium [di-μ-bromido-rubidium]], {(C4H11N2)[RbBr2]}n, contain singly-protonated piperazin-1-ium cations and unusual ABr6 (A = Cs or Rb) trigonal prisms. The prisms are linked into a distinctive `curtain wall' arrangement propagating in the (010) plane by face and edge sharing. In each case, a network of N—H⋯N, N—H⋯Br and N—H⋯(Br,Br) hydrogen bonds consolidates the structure. Full Article text
sms Gene-Drive Modified Organisms Are Not Ready to Be Released Into Environment- New Report By feedproxy.google.com Published On :: Wed, 08 Jun 2016 05:00:00 GMT The emerging science of gene drives has the potential to address environmental and public health challenges, but gene-drive modified organisms are not ready to be released into the environment and require more research in laboratories and highly controlled field trials, says a new report from the National Academies of Sciences, Engineering, and Medicine. Full Article
sms Stretchable wireless sensor could monitor healing of cerebral aneurysms By feedproxy.google.com Published On :: 2019-09-03T07:00:00Z Full Article
sms Stretchable wireless sensor could monitor healing of cerebral aneurysms By feedproxy.google.com Published On :: 2019-09-03T07:00:00Z Full Article
sms Microplastic particles in North Sea could harm marine organisms and enter human food chain By ec.europa.eu Published On :: Thu, 18 Apr 2013 09:22:46 +0100 Researchers have discovered high levels of plastic particles and fibres, as well as black carbon (BC), which is formed by the incomplete burning of fossil fuels, in the waters of the Jade Bay, an inshore basin off the coast of Germany in the Southern North Sea. The concentration of suspended particles are of concern because they have the potential to be ingested by fish and other marine life, and enter the food chain. Full Article
sms Lower diversity of soil organisms in new farmland By ec.europa.eu Published On :: Thu, 6 Sep 2012 11:58:31 +0100 Converting grassland to arable land can reduce the diversity of nematodes, predatory mites, earthworms and enchytraeid worms in the soil, according to a study by Dutch researchers. However, they found that restoring arable land to grassland did not fully restore the diversity of these four groups during the course of the four-year study. Full Article
sms Cleaning up after smss-DoOoMs virus attack By www.bleepingcomputer.com Published On :: 2018-05-30T17:54:28-05:00 Full Article
sms Innovative funding mechanisms for urban brownfield regeneration analysed By ec.europa.eu Published On :: Thu, 9 May 2013 15:41:18 +0100 A recent study highlights the role of the public sector in encouraging private investment in natural and cultural brownfield regeneration projects by analysing four models of financing: public-private partnerships, land value finance mechanisms, urban development funds and impact investment funds. Local governments, it is suggested, are well placed to identify and select the most suitable financing mechanisms for redevelopment projects. Full Article
sms Lower diversity of soil organisms in new farmland By ec.europa.eu Published On :: Thu, 6 Sep 2012 11:41:38 +0100 Converting grassland to arable land can reduce the diversity of nematodes, predatory mites, earthworms and enchytraeid worms in the soil, according to a study by Dutch researchers. However, they found that restoring arable land to grassland did not fully restore the diversity of these four groups during the course of the four-year study. Full Article
sms Nocturnal use of LEDs negatively affects freshwater microorganisms, Germany By ec.europa.eu Published On :: Thur, 31 Jan 2019 11:23:19 GMT Almost a quarter of the world’s non-polar land surface experiences light pollution, and there is concern that this adversely affects illuminated ecosystems. Currently there is a global move from yellow sodium lighting to white LED lighting, which emits different wavelengths of light. A recent study found that LED artificial light at night (ALAN) reduced the biomass of periphyton by 62% in a freshwater drainage ditch in Westhavelland Nature Park, Brandenburg, Germany. Full Article
sms Silver nanoparticles in sewage sludge harmful to soil microorganisms By ec.europa.eu Published On :: Thu, 21 Nov 2013 08:48:34 GMT Recent research has found that silver nanoparticles in sewage sludge, which is used on agricultural land as a fertiliser, can be toxic to soil microorganisms. The researchers calculated that a maximum of 30mg of silver nanoparticles per kilogram of sludge can be applied to land before harm occurs, based on typical application rates in Germany of five tons per hectare of farmland every three years. Full Article
sms Nanoparticles’ ecological risks: effects on soil microorganisms By ec.europa.eu Published On :: Thu, 14 Jul 2016 09:12:34 GMT Nanotechnology is a key enabling technology predicted to have many societal benefits, but there are also concerns about its risks to the environment. This study reviewed the effects of nanoparticles on soil microorganisms, showing that toxicity depends on the type of particle. The researchers make recommendations for improving environmental risk assessment, including performing experiments in soil and over longer time periods. Full Article
sms Transformed nanoparticles in effluent can affect aquatic organisms By ec.europa.eu Published On :: Thur, 07 March 2019 11:23:19 GMT Silver nanoparticles present in the effluent from waste-water treatment plants could have toxic effects on aquatic organisms, new research suggests. The lab-based study tested the effects of nanoparticle-containing effluent on several crustacean and algae species. The researchers observed that epibenthic crustaceans (those living in or on sediments at the bottom of water bodies) were the most sensitive; notably, a 20–45% higher death rate was observed compared with those exposed to nanoparticle-free effluent. Full Article
sms Orgasms during birth? Yes, it really can happen By www.mnn.com Published On :: Mon, 03 Jun 2013 14:23:03 +0000 Though childbirth is frequently spoken of in terms of pain and punishment, some women do experience what are known as orgasmic or ecstatic births. Full Article Babies & Pregnancy
sms What those beautiful glass prisms in the sidewalk are really for By www.mnn.com Published On :: Fri, 10 Jan 2020 13:26:27 +0000 Vault lights in the sidewalks were useful ways to light the rooms down below. Full Article Arts & Culture
sms D&P Corp. Begins AR Demo! Let's Meet AR Tidal Flat Organisms! By www.24-7pressrelease.com Published On :: Tue, 06 Aug 2019 07:00:00 GMT AR contents showing tidal flat organisms popular in Muan Ecological Tidal Flat Science Museum Full Article
sms Telcos back 50 paise/spam SMS regime By economictimes.indiatimes.com Published On :: 2020-05-06T18:26:28+05:30 TRAI had said that despite the higher charge on SMS, the complaints of UCC were on a rise and thus the regime for charging for SMSes should be brought under forbearance. In 2018, TRAI had mandated telcos to adopt distributed ledger technology (DLT) with ‘permissioned and private DLT networks’ where only identified and registered users can participate. Full Article
sms Surgeons successfully treat brain aneurysms using a robot By newsroom.heart.org Published On :: Fri, 21 Feb 2020 20:15:00 GMT Research Highlights: A robot was used to treat brain aneurysms for the first time. The robotic system could eventually allow remote surgery, enabling surgeons to treat strokes from afar. Embargoed until 11:15 a.m. Pacific Time / 2:15 p.m. Eastern ... Full Article
sms How to Send SMS Notifications From WordPress (Step by Step) By www.isitwp.com Published On :: Mon, 27 Apr 2020 07:31:40 +0000 Want to send SMS messages to your WordPress users? With automated SMS notification, you can keep your customers updated by sending order notification, shipment delivery status, cancellation notification, and more. In this article, we’ll show you how to send SMS messages to your WordPress users with ease. Sending Automated SMS Messages From WordPress SMS messages […] The post How to Send SMS Notifications From WordPress (Step by Step) appeared first on IsItWP - Free WordPress Theme Detector. Full Article WordPress Tutorials send sms messages send sms messages to wordpress users send sms to wordpress users sms messages to wordpress users
sms Automorphisms of shift spaces and the Higman--Thomspon groups: the one-sided case. (arXiv:2004.08478v2 [math.GR] UPDATED) By arxiv.org Published On :: Let $1 le r < n$ be integers. We give a proof that the group $mathop{mathrm{Aut}}({X_{n}^{mathbb{N}}, sigma_{n}})$ of automorphisms of the one-sided shift on $n$ letters embeds naturally as a subgroup $mathcal{h}_{n}$ of the outer automorphism group $mathop{mathrm{Out}}(G_{n,r})$ of the Higman-Thompson group $G_{n,r}$. From this, we can represent the elements of $mathop{mathrm{Aut}}({X_{n}^{mathbb{N}}, sigma_{n}})$ by finite state non-initial transducers admitting a very strong synchronizing condition. Let $H in mathcal{H}_{n}$ and write $|H|$ for the number of states of the minimal transducer representing $H$. We show that $H$ can be written as a product of at most $|H|$ torsion elements. This result strengthens a similar result of Boyle, Franks and Kitchens, where the decomposition involves more complex torsion elements and also does not support practical extit{a priori} estimates of the length of the resulting product. We also give new proofs of some known results about $mathop{mathrm{Aut}}({X_{n}^{mathbb{N}}, sigma_{n}})$. Full Article
sms Locally equivalent Floer complexes and unoriented link cobordisms. (arXiv:1911.03659v4 [math.GT] UPDATED) By arxiv.org Published On :: We show that the local equivalence class of the collapsed link Floer complex $cCFL^infty(L)$, together with many $Upsilon$-type invariants extracted from this group, is a concordance invariant of links. In particular, we define a version of the invariants $Upsilon_L(t)$ and $ u^+(L)$ when $L$ is a link and we prove that they give a lower bound for the slice genus $g_4(L)$. Furthermore, in the last section of the paper we study the homology group $HFL'(L)$ and its behaviour under unoriented cobordisms. We obtain that a normalized version of the $upsilon$-set, introduced by Ozsv'ath, Stipsicz and Szab'o, produces a lower bound for the 4-dimensional smooth crosscap number $gamma_4(L)$. Full Article
sms Surjective endomorphisms of projective surfaces -- the existence of infinitely many dense orbits. (arXiv:2005.03628v1 [math.AG]) By arxiv.org Published On :: Let $f colon X o X$ be a surjective endomorphism of a normal projective surface. When $operatorname{deg} f geq 2$, applying an (iteration of) $f$-equivariant minimal model program (EMMP), we determine the geometric structure of $X$. Using this, we extend the second author's result to singular surfaces to the extent that either $X$ has an $f$-invariant non-constant rational function, or $f$ has infinitely many Zariski-dense forward orbits; this result is also extended to Adelic topology (which is finer than Zariski topology). Full Article
sms PACT: Privacy Sensitive Protocols and Mechanisms for Mobile Contact Tracing. (arXiv:2004.03544v4 [cs.CR] UPDATED) By arxiv.org Published On :: The global health threat from COVID-19 has been controlled in a number of instances by large-scale testing and contact tracing efforts. We created this document to suggest three functionalities on how we might best harness computing technologies to supporting the goals of public health organizations in minimizing morbidity and mortality associated with the spread of COVID-19, while protecting the civil liberties of individuals. In particular, this work advocates for a third-party free approach to assisted mobile contact tracing, because such an approach mitigates the security and privacy risks of requiring a trusted third party. We also explicitly consider the inferential risks involved in any contract tracing system, where any alert to a user could itself give rise to de-anonymizing information. More generally, we hope to participate in bringing together colleagues in industry, academia, and civil society to discuss and converge on ideas around a critical issue rising with attempts to mitigate the COVID-19 pandemic. Full Article
sms Process for separation of renewable materials from microorganisms By www.freepatentsonline.com Published On :: Tue, 17 Mar 2015 08:00:00 EDT Methods of separating renewable materials, such as lipids, from microorganisms, such as oleaginous yeasts, may include conditioning cell walls of the microorganisms to form, open or enlarge pores, and removing at least a portion of the renewable material through the pores. These methods may result in delipidated microorganisms with cell walls that are substantially intact and with mesopores. These delipidated microorganisms may be used to produce biofuels. Full Article
sms Method for controlling noxious organisms By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT To provide a method which exerts excellent controlling effects on noxious organisms in a field of soybean, corn or cotton. A method for controlling noxious organisms in a field of soybean, corn or cotton, wherein at least one PPO inhibitor compound selected from the group consisting of flumioxazin, sulfentrazone, saflufenacil, oxyfluorfen, fomesafen-sodium, and a compound represented by formula (I): is applied to the field before, at or after sowing a soybean, corn or cotton seed treated with fludioxonil. Full Article
sms Method for controlling noxious organisms By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT To provide a method which exerts excellent controlling effects on noxious organisms in a field of soybean, corn or cotton. A method for controlling noxious organisms in a field of soybean, corn or cotton, wherein at least one PPO inhibitor compound selected from the group consisting of flumioxazin, sulfentrazone, saflufenacil, oxyfluorfen, fomesafen-sodium, and a compound represented by formula (I): is applied to the field before, at or after sowing a soybean, corn or cotton seed treated with ethaboxam. Full Article
sms Convertible ski systems having toe binding mounts and associated quick-release locking mechanisms By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A ski system includes a ski, a heel binding provided on an upper surface of the ski, a toe binding mount provided on the upper surface of the ski forward of the heel binding, a toe binding releasably mounted to the toe binding mount, and a quick-release locking mechanism for locking the toe binding to the toe binding mount. The quick-release locking mechanism is configured for release by hand. Full Article
sms Mechanisms and methods for stabilizing archery bows By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An archery stabilizer which, by utilizing a carbon fiber tube or a comparable material in a tube configuration, provides for preloading the tube in compression, thereby effectively increasing the stiffness of the tube. The stabilizer includes weights, and the preloading of the tube compensates for the bending moment applied to the tube by the weights attached to the end of the tube or contained within the tube. In effect, the present invention presents an apparatus and method for loading the tube so as to allow a user to adjust the elastic modulus of the tube. Full Article
sms Method and system for enhancing growth and survivability of aquatic organisms By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A method for enhancing the production of aquatic organisms under cultivation, including the steps of exposing the aquatic organisms to a submerged illumination source inside water of a rearing unit; and maintaining illumination in the rearing unit for a rearing period. Full Article
sms Multi-level aquaculture device for benthic organisms such as bivalves, aquaculture method, and biofilter using same By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT An elongate rectangular cultivation box having an open top, is configured so as to allow an outer tank, which serves as a cultivating water storage part, and an inner tank, which serves as a receptacle for bivalves (benthic organisms) S that are to be cultivated, to be both combined and separated. A gap that serves as a water supply opening and a gap that serves as a space in which sediments can accumulate on the bottom of the outer tank are defined when the inner tank is accommodated in the outer tank. Water passage holes are provided in the bottom of the shellfish receptacle (inner tank) and a mesh filter such as netting is stretched across the top face of the bottom. The cultivation boxes are arranged in a vertically stacked manner, with the front portions and rear portions thereof staggered so that cultivation water W that overflows over a front ledge of a shellfish receptacle flows downward into the supply water storage part of a lower cultivation box. Full Article
sms Blade deployment mechanisms for surgical forceps By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A forceps includes first and second shafts, each having a jaw member disposed at a distal end thereof. At least one jaw member is moveable from an open to a closed position for grasping tissue therebetween. At least one jaw member is configured for reciprocation of a blade therethrough. A trigger assembly includes a trigger and at least one linkage coupled to the trigger and to the blade such that rotation of the trigger translates the blade between the retracted and the extended position. An interference member moveable between a locked position and an unlocked position is also provided. The interference member is configured to engage the linkage(s) when in the locked position to inhibit translation of the blade from the retracted to the extended position. Full Article
sms Process of producing bio-organo-phosphate (BOP) fertilizer through continuous solubilization of rock phosphate by a composting bioprocess and bioaugmentation with phosphorus solubilizing microorganisms By www.freepatentsonline.com Published On :: Tue, 13 Jan 2015 08:00:00 EST A method and processes to solubilize and transform phosphorus contents of rock phosphate (RP) into bio-organo-phosphate (BOP) fertilizer have been developed and integrated. The methods include collecting and sorting of organic wastes; blending with RP; subjecting the blend to biocomposting; collection, isolation, selection and growth optimization of consortia of efficient phosphorus solubilizing microorganisms (PSM) and novel plant growth regulating microorganisms (PGRM); where in PSM produce organic acids and other organic compounds using compost substrate at mesophillic stage, whereas the organic acids released during composting also act in synergism of PSM, thus forming a carbon rich acidic culture resulting in the solubilization of rock phosphate. Full Article
sms Composition and method for control of plant pathogenic bacteria and endophytic microorganisms using silver phosphite By www.freepatentsonline.com Published On :: Tue, 13 Jan 2015 08:00:00 EST The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions. Full Article
sms Use of synergistic microorganisms and nutrients to produce signals that facilitate the germination and plant root colonization of mycorrhizal fungi in phosphorus rich environments By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A composition of matter comprising: a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi that is placed in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root; and a method for increasing plant yield comprising: placing a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root. Full Article
sms Mechanisms for vaporizing devices By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT The present disclosure generally relates to electronic vaporizing devices comprising a plurality of components, and mechanisms for locking or otherwise securing the components together. Components of the electronic vaporizing devices may include a cartridge (e.g., including a liquid for vaporization) and a battery unit (e.g., including a rechargeable battery), among other possible components. The electronic vaporizing devices may be at least partially disassembled to allow a user to replace, replenish, recharge, and/or repair the device, as needed. Full Article
sms Monitoring and Alert System and Method for Latching Mechanisms By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A monitoring and alert system for retro-fitting to latching mechanisms. A master control unit is located proximate to an operator of the system. It includes a user interface having: an input enabling an operator to arm the system and then allow it to operate with minimal interaction of the operator. It also includes an output alerting the operator as to the status of the system in relation to a plurality of prescribed conditions. One or more slave units having sensing units detecting a latched and unlatched state are attached to a discrete latching mechanism for detecting the latching status thereof. Each slave unit comprises sensing means to detect whether the latching mechanism is in a latched state or an unlatched state. Full Article
sms DEVICES AND METHODS FOR INHIBITING OR PREVENTING COLONIZATION OF FLUID FLOW NETWORKS BY MICROORGANISMS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The invention includes novel devices and methods for inhibiting or preventing colonization of fluid flow networks by bacteria that have upstream surface motility. In certain aspects, the devices and methods of the invention prevent or minimize undesirable bacterial colonization of medical devices and/or treat or prevent bacterial infections. Full Article
sms How to Send and Receive SMS Text Messages on iPad By www.applevis.com Published On :: Fri, 10 May 2019 15:30:17 -0300 In this podcast, Thomas Domville shows us how to send and recieve SMS text messages for iPad in iOS. Full Article iOS iOS & iPadOS Apps New Users Quick Tips Walk-through
sms ‘Wah, wah, wah’: Megan Rapinoe responds to criticisms of celebrations, rebuff of White House By www.seattletimes.com Published On :: Wed, 03 Jul 2019 13:14:59 -0700 Still facing a backlash over saying she wouldn't visit the White House if the United States wins the World Cup, soccer star Megan Rapinoe said Wednesday that she considers herself a proud American. Full Article Reign Soccer Sports World Cup
sms Modest Petrovich Mussorgsky - Pictures, Sarcasms & Visions (feat. piano: Steven Osborne) By www.bbc.co.uk Published On :: Tue, 19 Feb 2013 00:00:00 +0000 This sensitive, dynamic recording is a joy, and may even constitute a revelation. Full Article
sms 'It's not an unknown issue': Remote farmer calls for Telstra to rectify SMS flaw By www.abc.net.au Published On :: Fri, 01 May 2020 13:39:47 +1000 While Australians debate privacy issues around the new COVIDSafe app, those in rural areas are being forced to go to great lengths just to activate the app before even being able to use it. Full Article Health COVID-19 Rural Information and Communication Mobile Phones Wireless Communication
sms Jessica White Explains How Her Squats Give Her Orgasms By feeds.bet.com Published On :: Fri, 18 Mar 2016 13:09:00 EDT She also talks Nick Cannon, and her favorite part of a man. Full Article Jessica White Celebrity Style News
sms Власти Москвы перестанут оформлять пропуска по sms By www.vedomosti.ru Published On :: Fri, 08 May 2020 19:33:09 +0300 Full Article Общество
sms Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm By www.jci.org Published On :: Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting. Full Article
sms Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells By www.jci.org Published On :: Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor. Full Article