Resolution 94 - (Hammamet, 2016) - Standardization work in the ITU Telecommunication Standardization Sector for cloud-based event data technology

Resolution 95 - (Rev. Geneva, 2022) - ITU Telecommunication Standardization Sector initiatives to raise awareness on best practices and policies related to service quality

Resolution 96 - (Hammamet, 2016) - ITU Telecommunication Standardization Sector studies for combating counterfeit telecommunication/information and communication technology devices

Resolution 97 - (Rev. Geneva, 2022) - Combating mobile telecommunication device theft

Resolution 98 - (Rev. Geneva, 2022) - Enhancing the standardization of Internet of things and smart cities and communities for global development

Resolution 99 - (Geneva, 2022) - Consideration of organizational reform of the ITU Telecommunication Standardization Sector study groups

Resolution 100 - (Geneva, 2022) - A common emergency number for Africa

XSTP-ORS - OID resolution system: Problems, requirements and potential solutions

JSTR-OPTR - Optimizing bit rates and transmission resolution by considering display characteristics and available bandwidth

Object identifier-based resolution framework for IoT grouped services

With uncertainty clouding economic forecasting, employers need to get their priorities straight or face the consequences.

European Parliament resolution on Christians

It’s not breaking news that law school graduates generally have difficulty working with clients, don’t understand the “big picture” of client matters, and aren’t well trained in negotiation. The problem for law students and law schools is exacerbated by the transition to the NextGen bar exam and a movement in various states to use alternative … Continue reading Two Short Articles Proposing Courses Teaching Preparation and Advocacy in Dispute Resolution →

The Journal of Dispute Resolution recently released Issue 2 of Volume 2024.   Here’s a list of the articles in this issue.  Click here to access them.   Take a look. Alternative Dispute Resolution in Agency Administrative Programs by Kristen Blankley, Kathleen Claussen, and Judith Starr Arbitration and the Mandatory Law Problem: A Mixed Mode ADR Approach … Continue reading Latest Articles in Journal of Dispute Resolution →

Partnership aims to transform access to family law dispute resolution for underserved communities The American Arbitration Association and Suffolk University Law School are launching a pioneering Online Dispute Resolution (ODR) Innovation Clinic. This initiative combines Suffolk Law’s expertise in legal technology and clinical education with the AAA’s leadership in alternative dispute resolution innovation, technology, and … Continue reading American Arbitration Association, Suffolk Law and ODR.com Launch Online Dispute Resolution Innovation Clinic →

From my colleague, Rachel Wechsler: The Journal of Dispute Resolution is seeking articles related to labor and employment dispute resolution for its 2024 Writing Competition. The winners will be published in the Winter 2025 Issue of the Journal of Dispute Resolution. Writers should send submissions to umclawjournal@umsystem.edu with the subject line “2024 Writing Competition.” The … Continue reading Journal of Dispute Resolution Writing Competition – September 6 Deadline →

Resolution Life has appointed Moses Ojeisekhoba as President with effect from October 1, 2024. A spokesperson said, “Resolution Life, a global life insurance group focusing on the acquisition and management of portfolios of life insurance policies, announces that it has appointed Moses Ojeisekhoba as President with effect from October 1, 2024 to deliver the next […]

Ilka Wittig
Jul 1, 2007; 6:1215-1225
Research

Amelia C. Peterson
Nov 1, 2012; 11:1475-1488
Technological Innovation and Resources

Alice Santonastaso
Dec 1, 2020; 61:1687-1696
Research Articles

Lipoprotein (a) [Lp(a)] is characterized by an LDL-like composition in terms of lipids and apoB100, and by one copy of a unique glycoprotein, apo(a). The apo(a) structure is mainly based on the repetition of tandem kringle domains with high homology to plasminogen kringles 4 and 5. Among them, kringle IV type 2 (KIV-2) is present in a highly variable number of genetically encoded repeats, whose length is inversely related to Lp(a) plasma concentration and cardiovascular risk. Despite it being the major component of apo(a), the actual function of KIV-2 is still unclear. Here, we describe the first high-resolution crystallographic structure of this domain. It shows a general fold very similar to other KIV domains with high and intermediate affinity for the lysine analog, -aminocaproic acid. Interestingly, KIV-2 presents a lysine binding site (LBS) with a unique shape and charge distribution. KIV-2 affinity for predicted small molecule binders was found to be negligible in surface plasmon resonance experiments; and with the LBS being nonfunctional, we propose to rename it "pseudo-LBS". Further investigation of the protein by computational small-molecule docking allowed us to identify a possible heparin-binding site away from the LBS, which was confirmed by specific reverse charge mutations abolishing heparin binding. This study opens new possibilities to define the pathogenesis of Lp(a)-related diseases and to facilitate the design of specific therapeutic drugs.

Studies of goal setting reveal why it’s so hard to keep resolutions—and how to make ones that actually stick

Further to the Director-General’s speech delivered to the 159^th Session of the FAO Council this morning, Monday 4 June and specifically with reference to the letter from [...]

A recent request to change the wording in a mandatory Indigenous intercultural course for lawyers in British Columbia led to a debate over whether the changes amounted to residential school denialism. 

Gigabyte M27QA ICE monitor has been launched in India. It joins the Taiwanese manufacturer’s extensive lineup of gaming monitors and boasts features such as a 27-inch panel with QHD resolution, a refresh rate of 180Hz, and AMD FreeSync technology for improved visuals. Gigabyte says its monitor carries support for OSD Sidekick software which enables users to tweak various display settings and allows for further customisation through the keyboard and mouse.

In a session led by Chairman Sadiq Sanjrani, the Senate approved a resolution concerning the recent Supreme Court decision on military courts. Senator Dilawar Khan, presenting the resolution, expressed concerns about the court’s interference with Parliament’s legislative authority. The resolution stressed the importance of using military courts, operational since 1967, for actions against terrorists, suggesting ... Read more

The post Senate Passes Resolution Objecting Supreme Court’s Ruling on Military Courts appeared first on Pakistan Tribune.

Caenorhabditis elegans is an important model organism for human health and disease, with foundational contributions to the understanding of gene expression and tissue patterning in animals. An invaluable tool in modern gene expression research is the presence of a high-resolution ribosome structure, though no such structure exists for C. elegans. Here, we present a high-resolution single-particle cryogenic electron microscopy (cryo-EM) reconstruction and molecular model of a C. elegans ribosome, revealing a significantly streamlined animal ribosome. Many facets of ribosome structure are conserved in C. elegans, including overall ribosomal architecture and the mechanism of cycloheximide, whereas other facets, such as expansion segments and eL28, are rapidly evolving. We identify uL5 and uL23 as two instances of tissue-specific ribosomal protein paralog expression conserved in Caenorhabditis, suggesting that C. elegans ribosomes vary across tissues. The C. elegans ribosome structure will provide a basis for future structural, biochemical, and genetic studies of translation in this important animal system.

BACKGROUND AND PURPOSE:

Prediction of aneurysm instability is crucial to guide treatment decisions and to select appropriate patients with unruptured intracranial aneurysms (IAs) for preventive treatment. High-resolution 4D MR flow imaging and 3D quantification of aneurysm morphology could offer insights and new imaging markers for aneurysm instability. In this cross-sectional study, we aim to identify 4D MR flow imaging markers for aneurysm instability by relating hemodynamics in the aneurysm sac to 3D morphologic proxy parameters for aneurysm instability.

BACKGROUND AND PURPOSE:

Incidental findings on brain MRI and variations of the circle of Willis (CoW) are relatively common among the general population. Ethnic differences have been described before, but few studies have explored the prevalence of incidental intracranial cerebrovascular findings and CoW variants in the setting of a single multiethnic cohort. The purpose of this investigation was to describe both incidental cerebrovascular findings and the morphology of the CoW on high-resolution 3T TOF-MRA in a UK tri-ethnic population-based cohort and to present updated prevalence estimates and morphologic reference values.

The diagnosis of maturity-onset diabetes of the young (MODY), a monogenic form of diabetes mellitus caused by a mutation in a single gene, is often uncertain until genetic testing is performed. We report a 13-yr-old Korean boy who was initially diagnosed with type 2 diabetes (T2DM). MODY was suspected because of his nonobese body habitus and family history of multiple affected members. Targeted panel sequencing of all MODY-related genes was performed using the NextSeq 550Dx platform (Illumina). Sanger sequencing was performed using blood samples from the parents, siblings, and other relatives. A frameshift variant in the 3' region of the last exon of PDX1 was detected in the patient and his family members with diabetes. PP1_Moderate criterion was applied and this variant was confirmed to be the genetic cause of diabetes in the family and classified as likely pathogenic. The study highlights the importance of genetic testing for nonobese, early-onset diabetic patients with multiple affected family members. Increased awareness and aggressive genetic testing for MODY are needed.

Here, we highlight the case of a 31-yr-old man who had clinical features of primary hypertrophic osteoarthropathy (PHOAR) and harbored a homozygous variant (c.38C > A, p.Ala13Glu) in the HPGD gene, as indicated by whole-exome sequencing (WES). This variant has been previously classified by our laboratory as a variant of uncertain significance (VUS). However, another patient with the same phenotype and the same homozygous variant in HPGD was subsequently reported. In reassessing the variant, the absence of this variant in the gnomAD population database, supporting computational predictions, observation in homozygosity in two probands, and specificity of the phenotype for HPGD, all provide sufficient evidence to reclassify the HPGD c.38C > A, p.Ala13Glu variant as likely pathogenic.

December 31, 2020 at 11.59 pm – across the world there was a collective sigh of relief that the ‘lost year’ is truly behind us. The end of a year, ...

The post Start 2021 Fresh With These 12 New Year Resolutions appeared first on Star Observer.

Highlights: Around the new year, we end up making a list of new year's resolutions and figuring out how to kee

Air pollution during Diwali is extremely high. The weather, pollution from the crackers and agricultural residue burning, are the reasons for diminishing air quality.

Peoples Conference leader Sajad Lone said that the NC-led coalition regime moved a "weak" resolution in the J&K Assembly and alleged that Wednesday's episode was a fixed match between the ruling party and the opposition.

Accusing Speaker of partisanship, BJP MLAs stage mock Assembly session after some of them were being marshaled out of J&K House

The J&K Legislative Assembly's recent resolution seeking the restoration of special status has ignited a fierce debate between the BJP and Congress.

The Centre has directed the field offices under the office of the Chief Labour Commissioner to speed up the resolution of industrial dispute cases to improve the business climate in the country as this would spur growth.

Sri Sri Ravi Shankar calls for an amicable resolution to the Houston Rath Yatra controversy, emphasising the importance of sentiment in celebrations.

London : Methuen Drama, 2022.

San Francisco : Jossey-Bass Publishers, [2001]

With the new year comes a heap of resolutions. To help you stay on track this time, we ask inspiring personalities from different fields to break down how they tackle challenges