Oladito Organic Tortillas are available in three varieties: Organic Traditional Flour, Organic Whole Wheat, and Organic Jalapeño.

Wholly Wholesome's new pie shells and rolled pie dough contains clean-label ingredients that consumers would find in their own kitchens.

The new offering caters to the growing consumer interest in diverse bread options and is the first nationally available roll from Dave’s Killer Bread.

Riverside Natural Foods was able to double its packaging speeds by installing new packaging systems from tna.

Offering a nutritious solution for infant snacks, Little Spoon Puffs encourage self-feeding and fine motor skill development for babies over six months.

Over the past 15 years, Late July Snacks, the 2018 Snack Food & Wholesale Bakery "Snack Producer of the Year", has steadily grown its business to its position today as a leader in organic, non-GMO snacks, most notably its strong level of innovation in the tortilla chip category.

The Essential Baking Co. also now reaches a national audience with its Take & Bake line of artisan sourdough batards and baguettes, which get a notable 190-day ambient shelf life thanks to modified-atmosphere packaging (MAP).

Bakery ingredient supplier Puratos USA has announced a new addition to their sourdough product range with the launch of Sapore Leo Organic.

BENEO has announced the expansion of its chicory root fiber and rice starch ingredient portfolio with two new organic solutions.

Good Health, a member of the Utz Quality Foods family of brands, is launching Good Health Organic with the introduction of Baked Cheese Puffs and Baked Cheese Fries!

D’vash Organics is sweetening the snack aisle with three new products lines available now in select CVS and Whole Foods stores and through Amazon.

The new citrus fibers are in response to the increasing demand for natural, sustainable, and organic food ingredients.

Three-year export initiative unveiled at Bakery @ SIAL America.

Made with just whole-grain rolled oats, it contains 60% more protein than regular oats.

Global Organics Ltd. has solved the twin problems of fluctuating prices and product adulteration with its newly launched Organic Wild Salmiana Agave Syrup. 

Global Organics is proud to recognize its longtime partner, Natíve, for becoming the first Regenerative Organic Certified (ROC) sugar producer. 

Skout Organic is launching its newest snack, Vanilla Macaroon Soft-Baked Cookies, as part of the brand’s limited-time Small Batch line of cookies and bars this month.

The Small Batch Cinnamon Snickerdoodle Kids Bar features just five ingredients.

Skout is collaborating with cookbook author Caroline Chambers and her snack expert kids to launch Caro’s Beast Cookie Kids Bar, Caro Chambers bundle, and a bundle and book.

Coffee trends are prompting beverage-makers to adapt to new consumer demands for the staple American beverage. However, as consumers seek out organic, functional attributes in coffee solutions, experts see more opportunities beyond the traditional coffee category.

Natural and organic retailers anticipate certain consumer trends for the year.

Califia Farms unveiled its Organic Almond Creamers, made with simple ingredients and no gums or oils. 

Mooala, a leading organic plant-based milk brand, announced the launch of its Organic Barista Blend Oatmilk. 

Nixie introduced its new Organic Zero Sugar Soda line with the launch of three varieties: Classic Cola, Root Beer and Ginger Ale.  

Uncle Matt's Organic is adding a new functional juice-based beverage to its portfolio: Uncle Matt's Organic Superfruit Punch.

One of New York's only organic cannabis brands puts soil-to-store ethos at heart of the business

Ian Newbury honored for his commitment of more than four decades to animal welfare and the organic food industry

Chino Valley Ranchers, a pioneer in providing high-quality eggs, is thrilled to announce the expansion of its product offerings with the introduction of Organic Soy Free Corn Free eggs.

Dr. Gregory Allen Sotzing is lauded for his distinguished tenure at the University of Connecticut

Experience the Power of Nature: Discover Superior CBD Wellness Solutions at First Class Organics!

Charleston's Leading Urban Gardener Shares a Transformative Approach to Food, Nature, and Community

By University of British Columbia Many people choose organic thinking it’s better for humans and the planet, but a new UBC study published today in Science Advances finds that might not always be the case. “Organic is often proposed a … Continue reading →

The updated packaging tells the story about Neutral’s work with farmers and explains what it means for its milk to be carbon neutral from “grass to glass.”

Mapping the charge transport in new absorber material combinations points scientists on a different path towards efficient carbon-based solar cells.

Location: Electronic Resource- 

Scientists advance Parkinson’s disease biomarker research one sniff at a time.

National gourmet foods distributor Innovative Food Holdings has bought a Denver-area organic foods company with plans to expand its reach.

How Organic Placement is Affected Some people seem to be hell-bent on believing that it matters. There is no problem with believing it does have a direct effect on organic placement, but the fact of the matter is; it does not. Although you are entitled to believe what you want to believe, but knowing whether […]

You shop local and buy organic when you can, but how can you tell if your farmers market produce is really organic? There have been a few scandals in recent years where farmers market vendors were found to be purchasing and reselling grocery store produce labeled as locally grown. So how can you tell? Here's how to find a great farmers market vendor or food co-op for organic produce.[...]

From droughts to flooding and heat waves, the weather has been tough all across the country recently. Did you know that pests can significantly reduce your garden yield? According to the Connecticut State Agricultural Experiment Station, you could be dealing with several kinds of pests that drastically impact your garden. [...]

Improving organic traffic can sometimes be challenging, but if you apply the correct SEO strategies, the hard work will eventually pay off. Search engine traffic is great because it’s relevant and targeted. For most websites, organic traffic converts much better than traffic from social media or other sources. Another great advantage is that visits from […]

The post 10 Smart Ways To Increase Organic Traffic To A Website appeared first on RSSground.com.

The organic anion transporters (OATs) and organic anion–transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles in handling various endogenous and exogenous compounds of anionic charge. The OATs and OATPs are often implicated in drug therapy by impacting the pharmacokinetics of clinically important drugs and, thereby, drug exposure in the target organs or cells. Various mechanisms (e.g. genetic, environmental, and disease-related factors, drug-drug interactions, and food-drug interactions) can lead to variations in the expression and activity of the anion drug-transporting proteins of OATs and OATPs, possibly impacting the therapeutic outcomes. Previous investigations mainly focused on the regulation at the transcriptional level and drug-drug interactions as competing substrates or inhibitors. Recently, evidence has accumulated that cellular trafficking, post-translational modification, and degradation mechanisms serve as another important layer for the mechanisms underlying the variations in the OATs and OATPs. This review will provide a brief overview of the major OATs and OATPs implicated in drug therapy and summarize recent progress in our understanding of the post-translational modifications, in particular ubiquitination and degradation pathways of the individual OATs and OATPs implicated in drug therapy.

to write organic chemistry lab report

Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are important hepatic transporters. We previously identified OATP1B3 being critically implicated in the disposition of abiraterone. We aimed to further investigate the effects of abiraterone on the activities of OATP1B1 and OATP1B3 utilizing a validated endogenous biomarker coproporphyrin I (CP-I). We used OATP1B-transfected cells to characterize the inhibitory potential of abiraterone against OATP1B-mediated uptake of CP-I. Inhibition constant (K_i) was incorporated into our physiologically based pharmacokinetic (PBPK) modeling to simulate the systemic exposures of CP-I among cancer populations receiving either our model-informed 500 mg or clinically approved 1000 mg abiraterone acetate (AA) dosage. Simulated data were compared with clinical CP-I concentrations determined among our nine metastatic prostate cancer patients receiving 500 mg AA treatment. Abiraterone inhibited OATP1B3-mediated, but not OATP1B1-mediated, uptake of CP-I in vitro, with an estimated K_i of 3.93 μM. Baseline CP-I concentrations were simulated to be 0.81 ± 0.26 ng/ml and determined to be 0.72 ± 0.16 ng/ml among metastatic prostate cancer patients, both of which were higher than those observed for healthy subjects. PBPK simulations revealed an absence of OATP1B3-mediated interaction between abiraterone and CP-I. Our clinical observations confirmed that CP-I concentrations remained comparable to baseline levels up to 12 weeks post 500 mg AA treatment. Using CP-I as an endogenous biomarker, we identified the inhibition of abiraterone on OATP1B3 but not OATP1B1 in vitro, which was predicted and observed to be clinically insignificant. We concluded that the interaction risk between AA and substrates of OATP1Bs is low.

Human organic anion transporting polypeptide (OATP) 1B1 and 1B3 are two highly homologous liver-specific uptake transporters. However, 2’,7’-dichlorofluorescein (DCF) is preferably transported by OATP1B1. In the present study, the molecular mechanisms for the selective transport of DCF by OATP1B1 were investigated by constructing and characterizing an array of OATP1B1/1B3 chimeras and site-directed mutagenesis. Our results show that transmembrane domain (TM) 10 is crucial for the surface expression and function of OATP1B1, in which Q541 and L545 play the most important roles in DCF transport. Replacement of TM10 in OATP1B1 with its OATP1B3 counterpart led to OATP1B1’s complete intracellular retention. Q541 and L545 may interact with DCF directly via hydrogen bonding and hydrophobic interactions. The decrease of DCF uptake by Q541A and L545S was due to their reduced binding affinity for DCF as compared with OATP1B1. In addition, Q541 and L545 are also crucial for the transport of estradiol-17β-glucuronide (E17βG) but not for the transport of estrone-3-sulfate (E3S), indicating different interaction modes between DCF/E17βG and E3S in OATP1B1. Taken together, Q541 and L545 in TM10 are critical for OATP1B1-mediated DCF uptake, but their effect is substrate-dependent.

The organic cation transporter (OCT)-1 mediates hepatic uptake of cationic endogenous compounds and xenobiotics. To date, limited information exists on how Oct1/OCT1 functionally develops with age in rat and human livers and how this would affect the pharmacokinetics of OCT substrates in children or juvenile animals. The functional ontogeny of rOct/hOCT was profiled in suspended rat (2–57 days old) and human hepatocytes (pediatric liver tissue donors: age 2–12 months) by determining uptake clearance of 4-[4-(dimethylamino)styryl]-N-methylpyridinium iodide (ASP+) as a known rOct/hOCT probe substrate. mRNA expression was determined in rat liver tissue corresponding to rat ages used in the functional studies, while hOCT1 mRNA expressions were determined in the same hepatocyte batches as those used for uptake studies. Maturation of rOct/hOCT activity and expression were evaluated by comparing values obtained at the various ages to the adult values. Relative to adult values (at 8 weeks), ASP⁺ uptake clearance in suspended rat hepatocytes aged 0, 1, 2, 3, 4, 5, and 6 weeks reached 26%, 29%, 33%, 37%, 72%, 63%, and 71%, respectively. Hepatic Oct1 mRNA expression was consistent with Oct activity (correlation coefficient of 0.92). In human hepatocytes, OCT1 activity was age dependent and also correlated with mRNA levels (correlation coefficient of 0.88). These data show that Oct1/OCT1 activities and expression mature gradually in rat/human liver, thereby mirroring the expression pattern of organic anion transporting polypeptide in rat. These high-resolution transporter ontogeny profiles will allow for more accurate prediction of the pharmacokinetics of OCT1/Oct1 substrates in pediatric populations and juvenile animals.

Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.

Colombo.25 July 2013. At the request of the Central Environmental Authority (CEA), the International Water Management Institute (IWMI) signed an agreement to collaborate towards Resource Recovery and Reuse in Sri Lanka. IWMI and CEA join hands in targeting two main challenges that Sri Lanka is currently facing: Urban waste management; and the need to increase […]

The post CEA partners with IWMI to turn organic waste into high-quality fertilizer first appeared on International Water Management Institute (IWMI).

Colombo, December 10, 2013. At the request of the Colombo Municipal Council (CMC), the Central Environmental Authority (CEA), in collaboration with the International Water Management Institute (IWMI), organized a stakeholder meeting to discuss improvements that can be made to the management of municipal waste in the City of Colombo. The meeting was held at the […]

The post CEA partners with IWMI to improve Colombo’s municipal waste management and farmers’ access to organic fertilizers first appeared on International Water Management Institute (IWMI).