I was hoping to have a few things to write about in this month, but the only thing I finished was this video for SIGBOVIK, right at the beginning:

NaN Gates and Flip FLOPS

There is also the paper which has some merits but I submitted that before actually finishing the project, so I think the video is the definitive version. Either way this one is really aimed at trolling computer scientists, and so may be impenetrable if you don't have the background; sorry about that!

Allergies and various things have got me down recently but it's also getting nice out, which should provide a burst of energy!! This weekend is the Marathon in Pittsburgh, which I intend to run. No costume plans but sometimes I get last minute inspiration / compulsion. Feel free to taunt me with your ideas.

There's no evidence that Bill Gates ever visited Jeffrey Epstein's private island in the Caribbean, contrary to a viral Facebook post claiming he went there numerous times. The "flight records" cited do not show that.

The post False Claim Targets Gates Using Epstein Connection appeared first on FactCheck.org.

1. Das ist dran an Ken Jebsens großer Gates-Verschwörung (t-online.de, Jonas Mueller-Töwe) Ken Jebsen hat auf seinem Youtube-Kanal „KenFM“ einen halbstündigen Monolog veröffentlicht, der innerhalb von wenigen Tagen rund drei Millionen Mal angeklickt wurde. Das Opus heißt „Gates kapert Deutschland“ und gibt damit bereits die Marschrichtung vor. Jonas Mueller-Töwe hat sich die Mühe gemacht, das […]

The probe is part of a broader effort to monitor the influx of donations from other countries to American universities, which also includes investigations at Georgetown and Texas A&M. U.S. colleges are required under federal law to report foreign donations of $250,000 are more.

Plus, candidates line up to replace Susan Brooks. Restaurants give in time of need. Indy finally puts up streetlights. Legislation to help casino fails.

Afghanistan is investigating the alleged torture and drowning of migrants at the Iranian border.

Support from the Bill & Melinda Gates Foundation has enabled Chatham House to develop a global health security track at the Munich Security Conference (MSC).

Coenzyme Q (Qn) is a vital lipid component of the electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant. In the yeast Saccharomyces cerevisiae, coq1–coq9 deletion mutants are respiratory-incompetent, sensitive to lipid peroxidation stress, and unable to synthesize Q6. The yeast coq10 deletion mutant is also respiratory-deficient and sensitive to lipid peroxidation, yet it continues to produce Q6 at an impaired rate. Thus, Coq10 is required for the function of Q6 in respiration and as an antioxidant and is believed to chaperone Q6 from its site of synthesis to the respiratory complexes. In several fungi, Coq10 is encoded as a fusion polypeptide with Coq11, a recently identified protein of unknown function required for efficient Q6 biosynthesis. Because “fused” proteins are often involved in similar biochemical pathways, here we examined the putative functional relationship between Coq10 and Coq11 in yeast. We used plate growth and Seahorse assays and LC-MS/MS analysis to show that COQ11 deletion rescues respiratory deficiency, sensitivity to lipid peroxidation, and decreased Q6 biosynthesis of the coq10Δ mutant. Additionally, immunoblotting indicated that yeast coq11Δ mutants accumulate increased amounts of certain Coq polypeptides and display a stabilized CoQ synthome. These effects suggest that Coq11 modulates Q6 biosynthesis and that its absence increases mitochondrial Q6 content in the coq10Δcoq11Δ double mutant. This augmented mitochondrial Q6 content counteracts the respiratory deficiency and lipid peroxidation sensitivity phenotypes of the coq10Δ mutant. This study further clarifies the intricate connection between Q6 biosynthesis, trafficking, and function in mitochondrial metabolism.

Coenzyme Q (Qn) is a vital lipid component of the electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant. In the yeast Saccharomyces cerevisiae, coq1–coq9 deletion mutants are respiratory-incompetent, sensitive to lipid peroxidation stress, and unable to synthesize Q6. The yeast coq10 deletion mutant is also respiratory-deficient and sensitive to lipid peroxidation, yet it continues to produce Q6 at an impaired rate. Thus, Coq10 is required for the function of Q6 in respiration and as an antioxidant and is believed to chaperone Q6 from its site of synthesis to the respiratory complexes. In several fungi, Coq10 is encoded as a fusion polypeptide with Coq11, a recently identified protein of unknown function required for efficient Q6 biosynthesis. Because “fused” proteins are often involved in similar biochemical pathways, here we examined the putative functional relationship between Coq10 and Coq11 in yeast. We used plate growth and Seahorse assays and LC-MS/MS analysis to show that COQ11 deletion rescues respiratory deficiency, sensitivity to lipid peroxidation, and decreased Q6 biosynthesis of the coq10Δ mutant. Additionally, immunoblotting indicated that yeast coq11Δ mutants accumulate increased amounts of certain Coq polypeptides and display a stabilized CoQ synthome. These effects suggest that Coq11 modulates Q6 biosynthesis and that its absence increases mitochondrial Q6 content in the coq10Δcoq11Δ double mutant. This augmented mitochondrial Q6 content counteracts the respiratory deficiency and lipid peroxidation sensitivity phenotypes of the coq10Δ mutant. This study further clarifies the intricate connection between Q6 biosynthesis, trafficking, and function in mitochondrial metabolism.

Coenzyme Q (Qn) is a vital lipid component of the electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant. In the yeast Saccharomyces cerevisiae, coq1–coq9 deletion mutants are respiratory-incompetent, sensitive to lipid peroxidation stress, and unable to synthesize Q6. The yeast coq10 deletion mutant is also respiratory-deficient and sensitive to lipid peroxidation, yet it continues to produce Q6 at an impaired rate. Thus, Coq10 is required for the function of Q6 in respiration and as an antioxidant and is believed to chaperone Q6 from its site of synthesis to the respiratory complexes. In several fungi, Coq10 is encoded as a fusion polypeptide with Coq11, a recently identified protein of unknown function required for efficient Q6 biosynthesis. Because “fused” proteins are often involved in similar biochemical pathways, here we examined the putative functional relationship between Coq10 and Coq11 in yeast. We used plate growth and Seahorse assays and LC-MS/MS analysis to show that COQ11 deletion rescues respiratory deficiency, sensitivity to lipid peroxidation, and decreased Q6 biosynthesis of the coq10Δ mutant. Additionally, immunoblotting indicated that yeast coq11Δ mutants accumulate increased amounts of certain Coq polypeptides and display a stabilized CoQ synthome. These effects suggest that Coq11 modulates Q6 biosynthesis and that its absence increases mitochondrial Q6 content in the coq10Δcoq11Δ double mutant. This augmented mitochondrial Q6 content counteracts the respiratory deficiency and lipid peroxidation sensitivity phenotypes of the coq10Δ mutant. This study further clarifies the intricate connection between Q6 biosynthesis, trafficking, and function in mitochondrial metabolism.

Previous studies show that 12-week of high-fat diet (HFD) consumption caused not only prediabetes, but also cognitive decline and brain pathologies. Recently, necrostatin-1 (nec-1), a necroptosis inhibitor, showed beneficial effects in brain against stroke. However, the comparative effects of nec-1 and metformin on cognition and brain pathologies in prediabetes have not been investigated. We hypothesized that nec-1 and metformin equally attenuated cognitive decline and brain pathologies in prediabetic rats. Rats (n=32) were fed with either normal diet (ND) or high-fat diet (HFD) for 20 weeks. At week 13, ND-fed rats were given a vehicle (n=8) and HFD-fed rats were randomly assigned into 3 subgroups (n=8/subgroup) with vehicle, nec-1 or metformin for 8 weeks. Metabolic parameters, cognitive function, brain insulin receptor function, synaptic plasticity, dendritic spine density, microglial morphology, brain mitochondrial function, Alzheimer’s protein, and cell death were determined. HFD-fed rats exhibited prediabetes, cognitive decline, and brain pathologies. Nec-1 and metformin equally improved cognitive function, synaptic plasticity, dendritic spine density, microglial morphology, brain mitochondrial function, reduced hyperphosphorylated-tau and necroptosis in HFD-fed rats. Interestingly metformin, but not nec-1, improved brain insulin sensitivity in those rats. In conclusion, necroptosis inhibition directly improved cognition in prediabetic rats without alteration in insulin sensitivity.

Results from a NYU College of Dentistry study suggest how excess fluoride exposure affects the cells forming tooth enamel — possibly explaining how dental fluorosis arises.

Long a country of emigration—13 million Italians went abroad between 1880 and 1915—Italy has also experienced significant inflows of Middle Eastern and sub-Saharan African workers in recent decades. Italy has also been on the frontlines of Europe's refugee crisis. This country profile examines Italy's shifting migration patterns, policy responses over time, and debates.

Sen. John McCain's quest for the Republican presidential nomination was once seen as dead, but like those robots in the "Terminator" movies that reassemble themselves after being blown to smithereens, he came back. Five years ago, Sen. Barack Obama (Ill.) was a virtually unknown African American ...

Philanthropist and Microsoft cofounder Bill Gates offers insights into the COVID-19 pandemic, discussing why testing and self-isolation are essential, which medical advancements show promise and what it will take for the world to endure this crisis. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 24, 2020)

It's part of the foundation's $425 million research and development push, announced last fall.

The foundation wants to help schools in developing countries have access to "better information, evidence, tools, and approaches to improve teaching and learning."

Citing security concerns, the Home Ministry of India puts on hold the proposal sent by Tourism Ministry to provide e-visa facility to the delegates visiting the country for conferences and meetings. According to an  official from Tourism Ministry,…

UK company BAE Systems has been selected as preferred tenderer for the SEA 5000 program to deliver the Australian Government’s nine Future Frigates for the Royal Australian Navy.

Last Friday evening in Surprise, Arizona a storage facility owned by Arizona Public Service (APS) exploded, injuring four firefighters. Reporter for azfamily.com, Maria Hechanova, visited the scene yesterday and reported that the explosion happened while four hazmat firefighters from Peoria were working to extinguish a battery fire at the facility.

Court of appeal overturns High Court judgment in Lloyd v Google LLC [2019] EWCA Civ 1599 Court of Appeal judgment The Court of Appeal has given the go-ahead for a representative claim to be served on Google LLC in the U.S. for alleged data breaches,...

[Premium Times] In February, PREMIUM TIMES exclusively spoke with Chris Elias, the President of the Global Development Division of the Bill and Melinda Gates Foundation and Paulin Basinga, the foundation's country director, on the role the foundation played in the eradication of wild polio in Nigeria and a range of other developmental issues.

This story is published in a content partnership with POLITICO. It was originally reported by Myah Ward on politico.com on May 7, 2020.Melinda Gates on Thursday gave the Trump administration low marks for its handling of the coronavirus pandemic, adding that more money is needed for testing and vaccine development in the United States and across the world.Gates – co-chairman of the Bill & Melinda Gates Foundation, which has donated billions of dollars to health research – gave the…

The Microsoft co-founder said halting funding for the World Health Organisation during a world health crisis was "as dangerous as it sounds".

Although pain is a prevalent nonmotor symptom in Parkinson’s disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms. Considering that the basal ganglia are implicated in pain sensation, and that their synaptic outputs are controlled by the subthalamic nucleus (STN), we hypothesized that...

Neural networks have become the method of choice in surrogate modeling because of their ability to characterize arbitrary, high-dimensional functions in a data-driven fashion. This paper advocates for the training of surrogates that are 1) consistent with the physical manifold, resulting in physically meaningful predictions, and 2) cyclically consistent with...

Deregulation of mitochondrial dynamics leads to the accumulation of oxidative stress and unhealthy mitochondria; consequently, this accumulation contributes to premature aging and alterations in mitochondria linked to metabolic complications. We postulate that restrained mitochondrial ATP synthesis might alleviate age-associated disorders and extend healthspan in mammals. Herein, we prepared a previously...

Bernie Sanders' bid to collect convention delegates hits snag as New York cancels Democratic presidential primary

Read our live updates on coronavirus HERE Coronavirus: The symptoms

Bill Gates has been big on vaccines since before the start of the coronavirus pandemic, but in a new blog posting, the Microsoft co-founder and billionaire philanthropist says the only way to end the pandemic for good is to offer a vaccine to almost all of the planet's 7 billion inhabitants. That's big. "We've never delivered something to every corner of the world before," Gates notes. It's especially big considering that a vaccine hasn't yet been approved for widespread use, and that it may take as long as a year to 18 months to win approval and start distribution. Some… Read More

The co-chair of the Bill & Melinda Gates Foundation cited a lack of national coordination.

The high-end Rockpool Dining Group fronted by Neil Perry is hit by union claims it tampered with digital timesheets as it underpaid workers by up to $10 million, as a former worker enters mediation with the group in the Federal Court.

The Microsoft co-founder said halting funding for the World Health Organisation during a world health crisis was "as dangerous as it sounds".

Police in Malaysia confirm they are investigating a journalist over her reporting on mass raids targeting migrants and refugees amid the COVID-19 pandemic.

A federal grand jury in the Eastern District of Virginia returned an indictment today charging Phillip A. Hamilton, a former member of the Virginia House of Delegates, with allegedly soliciting employees of Old Dominion University for a paid position at the same time he was introducing legislation to fund the position.

Phillip A. Hamilton, a former member of the Virginia House of Delegates, today was convicted by a jury in Richmond, Va., of soliciting employees of Old Dominion University (ODU) for a paid position at the same time he was introducing legislation to fund the position.

Phillip A. Hamilton, a former member of the Virginia House of Delegates, was sentenced today to 114 months in prison after he was previously convicted of soliciting employees of Old Dominion University (ODU) for a paid position in exchange for introducing a budget amendment to fund the position, announced Assistant Attorney General Lanny A. Breuer of the Justice Department’s Criminal Division and U.S. Attorney Neil H. MacBride for the Eastern District of Virginia.