With picnics tolerated and even a pub doing takeaway drinks, it seems few in Hackney are obeying the stay-at-home rule

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As the mounted police approached, the group leapt up from their picnic, clearly fearing the worst. They were wrong. Grinning, the officer encouraged them to enjoy the sun and suggested that if the park became too crowded they should consider leaving.

For people sunning themselves in London Fields, Hackney, the incident signified another unheralded shift in the UK’s coronavirus lockdown strategy. “Two days ago, police were confiscating beer from drinkers’ hands,” said media consultant Gavin Jamieson, 34. “Weeks before that, they were turning up in vans and telling people to leave the park.”

Viewers are watching a growing share of video via Internet-based distribution systems. New digital content distribution services are having appreciable impacts on established media industries and network service providers in many OECD countries. This paper argues that convergence should be taken as the rule, rather than the exception. Careful application of best practices can address most policy concerns.

Kings Of Leon, Rudimental and Little Mix headline the Liverpool festival in Sefton Park. Franz Ferdinand, Dizzee Rascal and Anne-Marie provide support. Fri-Sun

Archives, Room Use Only - QC21.L53 1827b

Archives, Room Use Only - Q171.S42 1836

Laura O'Regan, Giancarlo Barone, Rozita Adib, Chang Gok Woo, Hui Jeong Jeong, Emily L. Richardson, Mark W. Richards, Patricia A.J. Muller, Spencer J. Collis, Dean A. Fennell, Jene Choi, Richard Bayliss, and Andrew M. Fry

EML4-ALK is an oncogenic fusion present in ~5% non-small cell lung cancers. However, alternative breakpoints in the EML4 gene lead to distinct variants with different patient outcomes. Here, we show in cell models that EML4-ALK variant 3 (V3), which is linked to accelerated metastatic spread, causes microtubule stabilization, formation of extended cytoplasmic protrusions and increased cell migration. It also recruits the NEK9 and NEK7 kinase to microtubules via the N-terminal EML4 microtubule-binding region. Overexpression of wild-type EML4 as well as constitutive activation of NEK9 also perturb cell morphology and accelerate migration in a microtubule-dependent manner that requires the downstream kinase NEK7 but not ALK activity. Strikingly, elevated NEK9 expression is associated with reduced progression-free survival in EML4-ALK patients. Hence, we propose that EML4-ALK V3 promotes microtubule stabilization through NEK9 and NEK7 leading to increased cell migration. This represents a novel actionable pathway that could drive metastatic disease progression in EML4-ALK lung cancer.

Victor J. F. Kitano, Yoko Ohyama, Chiyomi Hayashida, Junta Ito, Mari Okayasu, Takuya Sato, Toru Ogasawara, Maki Tsujita, Akemi Kakino, Jun Shimada, Tatsuya Sawamura, and Yoshiyuki Hakeda

Osteoporosis is associated with vessel diseases attributed to hyperlipidemia, and bone resorption by multinucleated osteoclasts is related to lipid metabolism. In this study, we generated low-density lipoprotein receptor (LDLR)/lectin-like oxidized LDL receptor-1 (LOX-1) double knockout (dKO) mice. We found that, like LDLR single KO (sKO), LDLR/LOX-1 dKO impaired cell-cell fusion of osteoclast-like cells (OCLs). LDLR/LOX-1 dKO and LDLR sKO preosteoclasts exhibited decreased uptake of LDL. The cell surface cholesterol levels of both LDLR/LOX-1 dKO and LDLR sKO osteoclasts were lower than the levels of wild-type OCLs. Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. Abrogation of the ATP binding cassette G1 (ABCG1) transporter, which transfers PE to the cell surface, caused decreased PE translocation to the cell surface and subsequent cell-cell fusion. The findings of this study indicate the involvement of a novel cascade (LDLR~ABCG1~PE translocation to cell surface~cell-cell fusion) in multinucleation of OCLs.

Along with participation in the International Thermonuclear Experimental Reactor (ITER) project – a large, international burning plasma experiment – the U.S. Department of Energy (DOE) should start a national program of accompanying research and technology to build a compact pilot plant that produces electricity from fusion at the lowest possible capital cost, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Nuclear fusion could one day propel rockets that allow humans to go to Mars and back in 30 days

Fusion energy has proven an elusive goal.

The aurora may hold the secret of a magnetic phenomenon related to the nuclear fusion powering the sun.

Lockheed Martin recently claimed to have designed a fusion reactor that can fit on the back of a truck. If viable, it really could change the world.

An organic pizza franchise is expanding fast with a menu that boasts vegan cheeses, organic meats, and gluten-free brownies.

A lot of people thought white and yellow dandelions were different plants.

Sustainable restaurant aims to prove sustainability can be easy as pie.

Ford announces that its new, faster-charging plug-in hybrid Ford Fusion will get 100+ MPGe. Oh, and it's cute, too.

The 2013 Ford Fusion was named the Green Car Journal’s Green Car of the Year at Los Angeles Auto Show.

A new study suggests confusion can be a powerful learning tool, but only under the right circumstances.

Pro-IV Pledges FREE Treatments For Amputees

Service Fusion is offering cutting edge fleet tracking technology to help companies increase their fleet operation efficiency and improve customer experience.

The new integrated solution opens doors for HVAC and Plumbing contractors to seamlessly provide and manage customer extended warranties

A one-of-a-kind product that delights consumers

The World cannot wait for 30 years to have fusion clean energy, so that PULSOTRON "B" plan is designed to reach ignition in less than 3 years that is by far the fastest way as it was demonstrated by certify ignition in 2013

ADP is the highest level of partner recognition from ForgeRock

February 25 – 27 in Houston - Class Size Limited

Annual listing profiles 10 companies at the forefront of providing cloud communications consulting services and impacting the marketplace

Service Fusion now offers seamless integration with Intuit's award-winning QuickBooks desktop and online software platforms

AP Photo/Alex Brandon

• The federal government on Saturday announced initial plans for distributing a promising coronavirus drug, remdesivir.
• The drug, manufactured by Gilead Sciences, was authorized for emergency use last week, but doctors and hospitals weren't sure how they were going to get it.
• The Department of Health and Human Services now say the drug is first being distributed to health departments in some hard-hit states, and the departments can distribute it to hospitals as they see fit. 
• Eventually, HHS expects the drug to be delivered to all 50 states, terrorities, the Veterans Health Administration and the Indian Health Service. 
• Visit Business Insider's homepage for more stories.

The federal government released its initial distribution plans today for the promising coronavirus drug, remdesivir, which was approved for emergency use last week. 

The drug, donated by manufacturer Gilead Sciences, "will be used to treat hospitalized COVID-19 patients in areas of the country hardest hit by the pandemic," the US Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response (ASPR) said in a press release.

See the rest of the story at Business Insider

NOW WATCH: How the Navy's largest hospital ship can help with the coronavirus

See Also:

• The coronavirus drug remdesivir was OK'd for emergency use a week ago. The plan to get it to patients is still mired in confusion.
• Dispensed: Hospitals are stuck waiting for a promising coronavirus treatment
• 'It's hard to pay off your medical school loans in this kind of a job': Doctors who can protect the world against pandemics are in short supply

Ravi Thiagarajan, MD, MBBS, MPH, discusses his article published in the January Pediatric Critical Care Medicine.

M. Cholette, MD, is the lead author of an article published in the January Pediatric Critical Care Medicine

Margaret Parker, MD, MCCM, speaks with Jacques R. Lacroix, MD.

Margaret Parker, MD, MCCM, speaks with Guillaume Emeriaud, MD, PhD.

Take a marathon for instance; while one runner may have a calculative approach, another might count on his unmatched stamina to run for miles together without stopping - but both could be champions in the same sport, just that their approach is different.

Aussies are finally looking forward to a return to normality after Prime Minister Scott Morrison unveiled a three-step plan to a COVIDSafe Australia yesterday afternoon.

Currently, all treated lumber used in Alaska is imported from the 48 contiguous states and Canada because there are no wood-treating facilities in Alaska. This report explores conventional and alternative wood-treating methods and reviews previous studies and laboratory tests on treated wood. In investigating wood treatment as a possible processing option for Alaska forest products manufacturers, the double-diffusion method of using sodium fluoride followed by a copper sulfate appeared to be the most advantageous approach. This method of treating wood was identified because it can be used to treat freshly cut or green wood. This was an important factor to consider, owing to the limited drying capacity in Alaska. Little information was available as to the chemical retention after treating and its resistance to leaching.

A reaction-diffusion model was developed describing the spread of the COVID-19 virus considering the mean daily movement of susceptible, exposed and asymptomatic individuals. The model was calibrated using data on the confirmed infection and death from France as well as their initial spatial distribution. First, the system of partial differential equations is studied, then the basic reproduction number, R0 is derived. Second, numerical simulations, based on a combination of level-set and finite differences, shown the spatial spread of COVID-19 from March 16 to June 16. Finally, scenarios of unlockdown are compared according to variation of distancing, or partially spatial lockdown.

Deep learning-based models, such as convolutional neural networks, have advanced various segments of computer vision. However, this technology is rarely applied to seismic shot gather noise localization problem. This letter presents an investigation on the effectiveness of a multi-scale feature-fusion-based network for seismic shot-gather noise localization. Herein, we describe the following: (1) the construction of a real-world dataset of seismic noise localization based on 6,500 seismograms; (2) a multi-scale feature-fusion-based detector that uses the MobileNet combined with the Feature Pyramid Net as the backbone; and (3) the Single Shot multi-box detector for box classification/regression. Additionally, we propose the use of the Focal Loss function that improves the detector's prediction accuracy. The proposed detector achieves an AP@0.5 of 78.67\% in our empirical evaluation.

We present a novel numerical scheme to approximate the solution map $smapsto u(s) := mathcal{L}^{-s}f$ to partial differential equations involving fractional elliptic operators. Reinterpreting $mathcal{L}^{-s}$ as interpolation operator allows us to derive an integral representation of $u(s)$ which includes solutions to parametrized reaction-diffusion problems. We propose a reduced basis strategy on top of a finite element method to approximate its integrand. Unlike prior works, we deduce the choice of snapshots for the reduced basis procedure analytically. Avoiding further discretization, the integral is interpreted in a spectral setting to evaluate the surrogate directly. Its computation boils down to a matrix approximation $L$ of the operator whose inverse is projected to a low-dimensional space, where explicit diagonalization is feasible. The universal character of the underlying $s$-independent reduced space allows the approximation of $(u(s))_{sin(0,1)}$ in its entirety. We prove exponential convergence rates and confirm the analysis with a variety of numerical examples.

Further improvements are proposed in the second part of this investigation to avoid inversion of $L$. Instead, we directly project the matrix to the reduced space, where its negative fractional power is evaluated. A numerical comparison with the predecessor highlights its competitive performance.

ON INLANDER.COM NATION: For workers, there's no sign of what "normal is going to look like" in the pandemic economy.…

A system and method for providing more than two levels of classification distinction of a user state are provided. The first and second general states of a user are sensed. The first general state is classified as either a first state or a second state, and the second general state is classified as either a third state or a fourth state. The user state of the user is then classified as one of at least three different classification states.

Disclosed is a splicing method of two second-generation ReBCO high temperature superconductor coated conductors (2G ReBCO HTS CCs), in which, with stabilizing layers removed from the two strands of 2G ReBCO HTS CCs through chemical wet etching or plasma dry etching, surfaces of the two high temperature superconducting layers are brought into direct contact with each other and heated in a splicing furnace in a vacuum for micro-melting portions of the surfaces of the high temperature superconducting layers to permit inter-diffusion of ReBCO atoms such that the surfaces of the two superconducting layers can be spliced to each other and oxygenation annealing for recovery of superconductivity which was lost during splicing.

A centrifuge includes a vacuum pump machine configured of an auxiliary vacuum pump and an oil diffusion pump for exhausting gas inside a rotary chamber to outside, in which a rotor rotates at high speed. In the centrifuge, a thermistor for detecting a temperature of oil and an oil surface inside a boiler of the oil diffusion pump is provided inside the boiler, and power of a heater is adjusted with the temperature detected by the thermistor, so that a degree of vacuum inside the rotary chamber is stably reduced from atmospheric pressure to a high vacuum state. Besides, when the heater does not heat, a current is carried through the thermistor for self-heating, and it is determined from variation in a resistance value whether the oil exists or not at a position at which the thermistor 8 is placed.

A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of: introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3). A perfusion kit includes a perfusion chamber (2) apt to contain a graft (100) to be perfused with a liquid (101) and a transfer chamber (3) apt to contain a liquid (101) to be perfused, the perfusion chamber (2) being connectable in a tight manner with the transfer chamber (3) for allowing a fluid exchange between the two chambers (2, 3) and inhibiting a fluid exchange between the two chambers (2, 3) and the external environment.

The present invention extends to a disinfection cap for disinfecting a male luer end of an infusion therapy device. The disinfection cap can include an internal reservoir containing an antimicrobial or saline solution which is sealed with a flexible septum to prevent the solution from evaporating. The septum can include one or more slits or pierceable seams that allow a male luer end of an infusion therapy device to be inserted through the septum and into the solution. While the male luer is inserted through the septum, the solution contacts both the inner and outer surfaces of the male luer. Because the septum reduces evaporation of the solution and prevents the solution from leaking out of the cap, the solution remains in contact with the male luer for a longer duration then when typical disinfection caps are used thereby increasing the effectiveness of the disinfectant.

A wound dressing including a hydrophilic layer and a hydrophobic layer is described. The hydrophilic layer absorbs exudate from a wound and the hydrophobic layer absorbs the exudate from the hydrophilic layer and traps the exudate. Because the hydrophilic layer is used adjacent to the wound, the exudate is readily absorbed thereby reducing the risk of maceration and infection of the wound tissue by the exudate. The hydrophobic layer receives the absorbed exudate from the hydrophilic layer and traps the exudate through an interaction that in turn prevents lateral diffusion of the exudate through the bandage to healthy portions of the skin. The hydrophilic and hydrophobic layers are fabricated from polymer fibers that can be spun to include components that facilitate wound healing, such as poly(hexamethylene biguanide) and/or hyaluronic acid.

A spinal fixation device includes a housing and a plurality of blades. Each blade includes a body having a central opening configured to rotate on a shaft within the housing. Control openings on opposing sides of the central opening are sized to engage prongs of a rotating tool. At least one cutting extension with a sharp leading edge extends from the body in an orientation about an axis of the shaft. Upon rotation of the blade by the rotating tool about the shaft in a direction in which the at least one cutting extension is oriented, the at least one cutting extension will break an endplate of a vertebra and hook into the vertebra.

The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.