d 1

Apple iPhone 16 and 16 Plus review: The sensible choice (Updated)

The basic iPhones get pretty big updates this year. Should you get them instead of the Pro iPhones? #apple #iphone16 #appleintelligence




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Pre-order the Huawei MatePad 12 X from 18 November and enjoy some specials and freebies!

Unfortunately, the Huawei MatePad 12 X will be available with Wi-Fi only connectivity. #huawei #huaweimatepas12x




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Toronto-based 1Password expands global distribution reach with new TD SYNNEX deal

This is 1Password’s first deal with a major distributor, and they plan to use it to expand their reseller base globally through TD SYNNEX’s broad reach.




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Web Services, Formal Methods, and Behavioral Types 11th International Workshop, WS-FM 2014, Eindhoven, The Netherlands, September 11-12, 2014, and 12th International Workshop, WS-FM/BEAT 2015, Madrid, Spain, September 4-5, 2015, Revised Selected Papers

Location: Electronic Resource- 




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Gatwick Airport strikes ended when workers accepted 10.3% wage increase

Gatwick Airport Strikes Ended When Workers Accepted 10.3% Wage Increase

Creative Media News...




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ANTAD 1st Podcast Episode

In our very first " ANTAD" podcast, Hareth, Krister, Nimer and Warren discuss the history of Android and the events that led to where we are today in Android.

This discussion looks at the weaknesses, strengths and key accessibility issues and when they became available.

Send your questions and inquiries, which would be responded to in the next episode to the following email address:

antadpodcast@gmail.com

Audio File: 




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New collection: Gabriella Exclusive T-Band 10 den

Fine, silky sheer tights that is perfectly transparent and fitting body. Braided with LYCRA® for greater elasticity and durability.

Flat seams. Reinforced toes. With a cotton gusset.

Sizes 2 to 4. See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=GBP101A




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New collection: Intimidea Ice-Land 100 Vita Bassa 100d

Beautifully made Italian ultra-opaque low waist woman tights in comfort microfibre.

Sheer to waist. Matt. Soft waistband with cotton gusset for comfort.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND92015




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New collection: Intimidea Ice-Land 100 Collant

Beautifully Italian made 100den opaque pantyhose in comfort microfibre.

Sheer to waist. Matt. Soft waistband with cotton gusset for comfort. Nero color only. Sizes 1/2, 3, 4 and 5.

See sizechart:
http://www.newlook.com.sg/nd/sizechart5.jpg




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¿Cómo diferenciar los síntomas de la rinitis con los de el covid 19?

¿Cómo diferenciar los síntomas de la rinitis con los de el covid 19?




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La OMS confirma que la inmunidad de las vacunas contra el Covid 19 dura 6 meses




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The Miles Davis Quintet: Miles In France 1963 and 1964: The Bootleg Series Vol. 8


At the very same time Beatlemania was slowly but surely beginning to engulf the globe, Miles Davis was inexorably proceeding toward what was the most adventurous music of his career. Miles In France -The Bootleg Series Vol. 8 captures a group of musicians led by "The Man with the Horn" on the threshold of forming what is referred to as his second great quintet, then actually coalescing into that stellar outfit... [ read more ]




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EVENT: American Classics Kicks Off Its 28th Season With Program Celebrating The Sun on November 8 and 10, 2024

American Classics kicks off its 28th Season, celebrating the SUN (November 8 and 10, 2024), the MOON (February 14 and 16), and the STARS (April 11 and 13, 2025) season with "Here Comes the Sun.” “Sunny” Songs to be performed range from the era of parlor songs with "Wait 'Till the Sun Shines, Nellie," through Irving Berlin and Rodgers and Hammerstein, to Steve Martin with "Sun is Gonna Shine" from "Bright Star" and the Pink hit "Cover Me in Sunshine."...




d 1

One man registered 15,000 businesses in 2022, putting Colorado’s economic growth into question

Colorado residents have formed a record number of new businesses this decade, especially after the state reduced the filing fee for new limited liability companies or LLCs.




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Opinion: Initiatives 50 and 108 are “reckless” efforts to control property taxes

Two reckless initiatives headed for the November ballot, 50 and 108, would gut the resources needed to pay firefighters, recruit and retain volunteers, buy equipment, and respond quickly when you call.





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Retail Sales Decreased 1.5% In July 2024

After adjusting for the retail sales rate of inflation, measured at 3.4% in July, the overall volume of retail sales index decreased 1.5% when compared to July 2023, according to the recently released Retail Sales Index. A Government spokesperson said, “Today, the Ministry of Economy and Labour released the July 2024 Retail Sales Index publication. […]




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Photos/Videos: Beached 17-Ft Minke Whale Dies

[Updated with photos/videos] At sometime before noon today [May 31] a 17-foot whale was discovered on a small beach area in an enclosure in St George’s located in the vicinity of the Meyer Boat Slip. Local boaters spotted the whale at approximately 11.30am and called in the report, although at first they were unsure what […]




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Google может вернуть в Android 15 востребованную функцию кастомизации, которая была в Android 11

Согласно новым утечкам, Google готовится вернуть популярную функцию настройки иконок, которая была доступна в Android 11.




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#346 (revised 1x)

Revision #1


 

 

Dear Query Shark:

 

Lily Carter has hid her singing voice away for years for fear of rejection.

Lily Carter has hidden, not hid.

 

These kinds of mistakes can fell your query before you know it.

If grammar and syntax aren't your forte, it's ok. It's not a sign of bad writing, or low character.

 

Just recognize that it's a stumbling block and make friends with Miss Picklepuss, the copy editor from hell. She'll help you remove these gremlins. It might cost some money, but this is something you do want to invest in.

 

Her best friend (now ex-best friend)

you don't need both of these.

Your reader will intuit that they were once best friends if she's now the ex-best friend.

 

Watch for this kind of over-writing.

 

 

made it clear she should never sing in public if she can help it.

Suggest taking this last part out just to give the sentence more drama.

 

So Lily sings only when she's sure no one else can hear her. Imagine her embarrassment when the new kid in town catches her in the act.

 

Imagine her embarrassment takes us out of the narrative.

You're telling, not showing.

 

Avoid that.

 

She's embarrassed.

 

But embarrassed is such a tepid word for the plot point that's driving the narrative.

Here's a good place to get out the Thesaurus and dig around for more vivid words.

 

mortified

humiliated

(and there are others, take your pick)

 

Already at odds with Jack Sutton after an encounter with him at school, Lily expects nothing but scorn from him.

Again, pare out what you don't need.

This is the meat and tater tots of revising. Early drafts are almost always too long. Pare out everything you don't need.

 

But instead of making fun of her, he compliments her, throwing all her preconceived notions about what a terrible singer she is into question. 

It's NOT a preconceived notion, is it? It's what someone told her (someone with some sort of malevolent agenda it sounds like.)

 

Internal conflicts in a query are huge red flag. It tells me you don't have a handle on the plot, and the full manuscript may not hold together very well. Again, here's where Miss Picklepuss can be of great value.

 

 

Suddenly, the aggravating yet undeniably charming Jack keeps is popping up all over the place. At school, at church, and then there’s the real icing on the cake. It turns out that Jack is the brother of her new best friend.

Do we need to know any of this?

 

This next sentence connects to the previous one more directly.

 

With a musical background himself and a dogged belief that Lily has talent, Jack makes it his mission to get Lily back on the horse. Or the stage, so to speak.

 

Consider:

Jack has a musical background himself, and seems to think Lily has talent.

He makes it his mission to get Lily back on stage.

 

There's a LOT to be said for starting your sentences with the subject, not burying it in a clause.

 

 

 

 

 

As Lily spends more time with Jack and his spirited sister Cat, a self-consciousness Lily didn't even realize she had developed begins to mend.

She didn't realize she was self-conscious about her singing?

Are you serious here? That just doesn't make sense unless Lily is blindingly un-self aware.

She's literally stopped singing outside of the shower.

 

She even gets up the courage to enter the high school talent show thanks to a little prodding from Jack and his agreement to help her prepare for the show. When Jack starts giving her singing lessons, Lily slowly begins believing in herself again.  

 

But Lily has a few obstacles to overcome. Like that pesky stage fright thing. Or the ex-best friend who unexpectedly resurfaces and tries to sabotage Lily’s chances. Or the growing feelings she’s developing for her best friend’s brother. Lily must rely on her friends, her family, and her new-found confidence in order to get ready for talent show day.

 

You've got a lot of stuff going on here, but not very much plot.

What's the problem here?

Lily has been told she shouldn't sing in public.

What problem does that create?

Then Jack comes along and tells her she does have a singing voice.

 

What problem does that solve?

 

TAKE A DEEP BREATH is a young adult novel complete at 60,000 words

You don't need to say it's complete.

That's assumed.

 

And this just doesn't feel YA to me. There's no sense of Lily or Jack learning to navigate in the real world. There's no real romantic element.

 

 

 

that portrays the sarcastic, yet vulnerable Lily along with her lovable family and kindhearted friends.

Sarcastic?

Not in these pages she isn't.

 

 

 

A story of personal growth with a touch of romance, this novel is similar to Maybe This Time by Kasie West or Eyes on Me by Rachel Harris.

 

I am a small town Minnesota gal, where a person can go from wearing a sweatshirt and wool socks one day to a tank top and sandals the next. This is my first novel.

 

Thank you for your time and consideration.

 

 

you've got a lot of concept but not enough story.

You need more plot on the page. The problem Lily faces, and the choices to solve, and what's at stake.

 

It will help if we see those things for Jack too.

 

You've only got 60K here so you've a got a LOT of room to add more depth.

 

 

 

******

Original query

This query is a completely revised one from the one I started with as that one got me a couple of partial requests, but nothing serious. Now, since I've started using this query, I haven't even gotten a nibble. 

In the first  53 words you have two problems that could lead to an immediate pass.

While agents aren't actively looking for reasons to pass if you give them two in short order, that's what's going to happen.

 

My first query was succinct but a bit commercial in my opinion. So I tried to offer a quirkier approach with this one.

 

 


 A bit commercial isn't a bad thing. Agents are looking for things they can sell (ie commercial).


 I did beef up my bio after reading your archives. 

141 words is about 100 too many. See notes below. An extensive bio doesn't make up for problems in the query so lets focus on that.

You also stated in the archives that queries should have at least 2 comps. Is it okay to comp an author instead like I did?  

 No, see notes below

 

 

Dear Query Shark:

People are creatures of habit. They take the same route to school every day, they buy the same brand of soap they always do, and they listen to the same radio station, day in and day out. And they also sit at the same school desk every morning in first period English class.

 

When I read this, I have no idea if you're querying for fiction or non-fiction.

That's a big problem when agents are getting dozens of queries a week.

Big problem = pass.

It's more effective to start with the character's name and what problem she faces

 

At least, that’s what Lily Carter used to do.

 

Consider instead:

People are creatures of habit.

Lily Carter is a creature of habit.

 

They take the same route to school every day, they buy the same brand of soap they always do, and they listen to the same radio station, day in and day out.

 

She takes the same route to school every day, buys the same brand of soap, listens to the same radio station, day in and day you.

 

 

 And they also sit at the same school desk every morning in first period English class.

And sit at the same desk every morning in first period English.

 

 

But when you revise like this the real problem becomes very clear.

You're describing someone who doesn't sound very interesting. In fact, she sounds dull as dishwater.

That's DEATH in a query, particularly in YA.

Death = pass.

 

Now, if there's a reason Lily is so methodical in her daily life, that would give her some depth.

Is this how she feels safe?

Did she read Gustave Flaubert and take his advice to heart: "Be regular and orderly in your life, so that you may be violent and original in your work."

Let's give Lily some context here.

 

 

 Until Jack Sutton just waltzed in and stole it right out from under her. The gentlemanly thing to do would have been to give it back. Instead, he refused to acknowledge her rightful claim of dibs and in the process managed to ruffle her feathers, push her buttons, flip her lid, and get her goat. If you know what I mean.

 

Because he sat in her chair?

Does this seem like a very intense reaction to something that's essentially not important?  It's not like he said her mum wears army boots.

 

So, Jack is the last person on earth that Lily wants witnessing her humiliating attempt at singing.

 

There's no connection here between Jack stealing her seat in English class and witnessing her humiliating attempt at singing.

 

How is it that Jack is in her life at all?

 

 

Lily has been very careful to keep her voice under wraps after receiving rejection at the hands of a close friend.

What was Lily trying to do that a close friend rejected her?

Specifics are much more compelling than generalities.

You don't want to be awash in too much detail, but you need more than you have here.

 

Surprisingly though, Jack challenges her belief of mediocrity. 

What he actually does is challenge her belief that her singing is mediocre.

You need razor sharp, precise sentences in a query.

 

He actually begins to make her question a lot of things. Like the idea that the talent show is out of her league. Maybe, it's not. Maybe, she could even win it.

 

Although there is the small matter of that pesky stage fright thing…

So far, there's nothing interesting about Lily, and she sounds rather like a basket case. This is a HUGE problem in YA that is character driven.

 

As Lily gets closer to Jack and his spirited sister Cat, a self-consciousness Lily didn't even realize she had developed begins to mend. Thanks to a little prodding from her new friends, Lily signs up for the talent show. 

 What does Jack see in Lily that he's investing time and emotional support in her?


But someone from Lily's past is determined to see her fail. 

This is absolutely out of left field. With no context it's like a big ink blot on the page.

Let's give the antagonist some more page time.

 

Lily must rely on her friends, her family, and her new-found confidence in order to overcome the obstacles in her way. 

What obstacles? I thought there was an antagonist trying to thwart her.

 

 

Take a Deep Breath is a young adult novel complete at 60,000 words that portrays the sarcastic, yet vulnerable Lily along with her lovable family and kindhearted friends. A story of personal growth with a touch of romance, this novel will appeal to fans of Kasie West.

You need to use titles, not authors. Those titles need to be recent, no earlier than 2019.

 

Your bio is 141 words. Given a query should be 250-300 you've spent a larger percentage of your word count on your bio and not your book.

 

I am a small town Minnesota gal, where a person can go from wearing a sweatshirt and wool socks one day to a t-shirt and sandals the next. With a penchant for staying in every night with my two cats and a DVD collection to rival a Blockbuster store (are there any of those in existence anymore?) one might be tempted to call me an introvert. If it weren't for my extroverted husband, I just might be. Kudos to him for getting me out of my comfort zone and making friends with the outside world. Who knew I would enjoy things like pickleball and Korean BBQ? (not at the same time, for heaven's sake). This is my first novel and

 

 

 I'm looking to team up with an agent who can help an eager, wide-eyed newcomer navigate the ropes of the literary world.

 

This kind of statement is counter-productive.

Agents see this as code for needy and naive.  Even if you are these things, they're not something you'd put in your bio.  Remember a query is also about the agent assessing if you're someone they want to work with. Someone who clearly will need a lot of hand holding is less likely to get a nod. Just leave this kind of statement out.

 

Thank you for your time and consideration.

 

 

 

This does not have enough edge to be YA.

It sounds middle grade to me.

 

There's no sense of Lily coming to terms with the larger world, or figuring out her place in it.

It's all character development and very light on plot.

 

There's not enough story on the page.

 

 

 

 

 





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Arsenal Women Arsecast 96: Man Utd 1 Arsenal 1

On this episode of the Arsenal Women Arsecast, Tim and Jamie discuss the frustrating 1-1 draw with Manchester United. Tim and Jamie comb over the performance, the encouraging display of Alessia Russo but the irritation at again seeing Arsenal struggle to convert dominance into goals and ask whether there are any green shoots here. They also discuss Arsenal's lack of aerial prowess in defence and whether it can be fixed by any other means than the transfer market. As ever, in part 2 Tim and Jamie take listener questions on the attacking issues, whether the Russo / Stina split works, the relationship between the attackers, the lack of goal celebrations and the new manager search.


Get extra bonus content and help support Arseblog by becoming an Arseblog Member on Patreon: https://www.patreon.com/arseblog



Hosted on Acast. See acast.com/privacy for more information.




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Fauci Received 15 Million Dollars In Taxpayer Funds For Private Security Detail, Report Says

By Eireann Van Natta Dr. Anthony Fauci was granted $15 million in taxpayer-funded security as a private citizen, according to a new report. An agreement between the U.S. Marshals Service (USMS) and the U.S. Department of Health and Human Services (HHS) provided Fauci protection from Jan. 4, 2023 to Sept. 20, 2024, according to FOIA documents […]

The post Fauci Received 15 Million Dollars In Taxpayer Funds For Private Security Detail, Report Says appeared first on Liberty Unyielding.



  • Law and Government

d 1

Lee smashes WBBL record 150 in Hurricanes win

Lizelle Lee sets a new record for the highest individual score in the Women's Big Bash League with 150 not out for Hobart Hurricanes.




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velocityconf: RT @avleen: Ok folks, home stretch! We need 10 more people to record short #OpsSchool videos NEXT WEEK at @velocityconf. We can do it!...

velocityconf: RT @avleen: Ok folks, home stretch! We need 10 more people to record short #OpsSchool videos NEXT WEEK at @velocityconf. We can do it!...




d 1

Humana and 18F-FDG PET/CT: Another Sequel to the Injustice of Being Judged by the Errors of Others




d 1

Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer

Visual Abstract




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Association Between CA 15-3 and 18F-FDG PET/CT Findings in Recurrent Breast Cancer Patients at a Tertiary Referral Hospital in Kenya

The tumor marker cancer antigen 15-3 (CA 15-3) is that most commonly used to monitor metastatic breast cancer during active therapy and surveillance for disease recurrence after treatment. The association of CA 15-3 and 18F-FDG PET/CT findings can be considered complementary, since any significant rise may indicate the presence of disease and imaging is able to map the tumor sites. Although current guidelines do not recommend the routine performance of CA 15-3 in asymptomatic patients being followed up after definitive breast cancer treatment, most oncologists perform serial assessment of the tumor markers as part of routine follow-up of patients. The aim of this study was to evaluate the correlation between CA 15-3 levels and 18F-FDG PET/CT scan findings in patients with recurrent breast cancer. Methods: This was a cross-sectional study with data collected retrospectively. Patients being evaluated for breast cancer recurrence with 18F-FDG PET/CT imaging and CA 15-3 level were included. Evaluation of the association between CA 15-3 levels and 18F-FDG PET/CT scan findings was then done. Results: In total, 154 cases were included in this study; 62 patients had recurrence (positive) on the 18F-FDG PET/CT scans, whereas 92 patients had normal (negative) findings on follow-up 18F-FDG PET/CT scans. There was an association between CA 15-3 levels and the presence or absence of recurrence on 18F-FDG PET/CT scans, with 84.4% (27/32) of patients who had elevated CA 15-3 levels having disease recurrence on 18F-FDG PET/CT and 84.4% (27/32) of patients who had elevated CA 15-3 levels having disease recurrence on 18F-FDG PET/CT as well as a correlation with the burden of metastases. Most patients with disease recurrence on 18F-FDG PET/CT, however, had normal CA 15-3 levels. Conclusion: Higher CA 15-3 levels correlate with breast cancer recurrence on 18F-FDG PET/CT as well as with burden of metastasis. Notably, CA 15-3 levels within the reference range do not exclude breast cancer disease recurrence since more than half of patients with recurrence had normal CA 15-3 levels. 18F-FDG PET/CT should therefore be considered in patients with suspected breast cancer recurrence but normal CA 15-3 levels.




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Webinar: Turkey’s Challenging Post-COVID 19 Outlook

Webinar: Turkey’s Challenging Post-COVID 19 Outlook 7 May 2020 — 1:00PM TO 2:00PM Anonymous (not verified) 17 April 2020

Turkish President Recep Tayyip Erdogan has so far refused to impose a nation-wide lockdown to suppress the spread of coronavirus in the country. In late March, Turkish health officials announced that they expect the virus to peak in three weeks’ time and for Turkey to overcome it quickly. At the same time, Turkey has ruled out turning to the IMF for help in dealing with the crisis despite growing pressures on the Lira and the wider economy. The country’s relations with its traditional allies, the US and Europe, remain thorny.
This event will focus on the likely impact of the epidemic on Turkey’s economy and politics. What are the reasons behind Erdogan’s reluctance to implement a comprehensive lockdown to break the chain of virus transmission? Why is Turkey resolutely opposed to agreeing a funding package with the IMF? What is the macro outlook for 2020 and beyond for the country’s economy? And how may the government’s long-term popularity be affected?




d 1

How One Photographer Recreated 19th Century Portraits With the Descendants of Civil War Heroes

Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA




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Father and Son Discover Rare Trove of 16th- and 17th-Century Silver Coins While Metal Detecting in a Polish Forest

Sławomir and Szymon Milewski were searching for a Roman road when they stumbled upon the cache of coins, which is worth more than $120,000




d 1

An All-Female Crew Sailed 1,000 Miles in a Traditional Voyaging Canoe to Help Save Humpback Whales

The team traveled from New Zealand to Tonga along a humpback highway to collect environmental DNA and raise awareness of the plight of the marine mammals




d 1

This Yellowknife woman biked 1,000 kilometres along WW1's front lines

Stephanie Yuill spent five weeks visiting First World War sites across Europe on a bike she bought from the grocery store. 



  • News/Canada/North

d 1

Why a Minnesota Man Walked Around the World, Traversing 13 Countries and 14,450 Miles in Four Years

Fifty years ago, on October 5, 1974, David Kunst completed the first verified circumnavigation of the globe on foot. Along the way, he met Princess Grace of Monaco, raised money for UNICEF and lost a brother to bandits




d 1

Parents Receive Skull Of Kerala Teen Killed 18 Years Ago

Hands of the couple that received a tiny cardboard box from a Kasargod court trembled with emotions and their eyes welled up.




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OnePlus 12R Android 15-Based OxygenOS 15 Stable Update Rolling Out for Global Users

OnePlus 12R was launched in India in January this year with a Snapdragon 8 Gen 2 chipset paired with up to 16GB of LPDDR5x RAM. It runs on Android 14-based OxygenOS 14 out-of-the-box. Now the stable version of the Android 15-based OxygenOS 15 update with updated features and fixes is rolling out to OnePlus 12R users.




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Android 15 Brings Support for True Adaptive Refresh Rate on Smartphones and Other Devices

Android 15 was released globally in August and since then, original equipment manufacturers (OEMs) such as OnePlus, Oppo and Realme have introduced their iterations of the new operating system (OS) for their smartphones and other devices. The update is said to bring support for true adaptive refresh rate (ARR) which leverages discrete VSync steps to adapt to the frame rate of the on-screen content without changing the current display mode.




d 1

Food Prices Across The World Reached 18-Month High In October 2024

The world prices rose to the highest level in the past 18 months in October, revealed UN.




d 1

Delaware Department of Labor To Hold 10th Employer Conference

Delaware businesses will find topical information about issues affecting their bottom line at the Delaware Department of Labor 10th Employer Conference, May 16, 2013 at Chase Center on the Riverfront.




d 1

Delaware Has Preserved 143,000 Acres of Farmland After 25th Round

Delaware announced its 25th consecutive round of easement selections by the Delaware Agricultural Lands Preservation Foundation. With the preservation of 3,695 acres, Delaware has permanently preserved more than 143,000 acres of farmland for future generations.




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Delaware Advances Toward 1 Million Tree Planting Goal

The Tree for Every Delawarean Initiative (TEDI) is making significant progress toward the goal of planting 1 million trees by 2030. The initiative has awarded funding to seven new projects, which will push the total count beyond 200,000 trees this year.




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48 Individuals and 13 Groups Will Receive Governor’s Outstanding Volunteer Awards in Virtual Ceremony Jan. 17

NEW CASTLE (Dec. 22, 2021) Forty-eight individuals and 13 groups will be honored with the 2021 Governor’s Outstanding Volunteer Award during a virtual ceremony to be held at 7 p.m. Jan. 17, 2022. The recipients will be recognized for significant contributions, engagement and impact in diverse service activities. Throughout the month of December, staff members […]




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Asus ZenBook Pro Duo 15 OLED 10th Gen Core i7-10870H (2021) Review

Read the in depth Review of Asus ZenBook Pro Duo 15 OLED 10th Gen Core i7-10870H (2021) Laptops. Know detailed info about Asus ZenBook Pro Duo 15 OLED 10th Gen Core i7-10870H (2021) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.




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Rapid 15-Minute COVID-19 Test Approved By FDA

Title: Rapid 15-Minute COVID-19 Test Approved By FDA
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM




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Banded Squats: Benefits and 11 Ways to Do Them

Title: Banded Squats: Benefits and 11 Ways to Do Them
Category: Health and Living
Created: 8/8/2022 12:00:00 AM
Last Editorial Review: 8/8/2022 12:00:00 AM




d 1

Association of Free-to-Total PSA Ratio and 18F-DCFPyL Prostate-Specific Membrane Antigen PET/CT Findings in Patients with Biochemical Recurrence After Radical Prostatectomy: A Prospective Single-Center Study

In Canada and across the globe, access to PSMA PET/CT is limited and expensive. For patients with biochemical recurrence (BCR) after treatment for prostate cancer, novel strategies are needed to better stratify patients who may or may not benefit from a PSMA PET scan. The role of the free-to-total prostate-specific antigen (PSA) ratio (FPSAR) in posttreatment prostate cancer, specifically in the PSMA PET/CT era, remains unknown. Our aim in this study was to determine the association of FPSAR in patients referred for 18F-DCFPyL PSMA PET/CT in the BCR setting and assess the correlation between FPSAR and 18F-DCFPyL PSMA PET/CT positivity (local recurrence or distant metastases). Methods: This prospective study included 137 patients who were referred for 18F-DCFPyL PSMA PET/CT and had BCR with a total PSA of less than 1 ng/mL after radical prostatectomy (RP) (including adjuvant or salvage radiotherapy). Blood samples were collected on the day of 18F-DCFPyL PSMA PET/CT. FPSAR was categorized as less than 0.10 or as 0.10 or more. A positive 18F-DCFPyL PSMA PET/CT scan was defined by a PROMISE classification lesion score of 2 or 3, irrespective of the site of increased tracer uptake (e.g., prostate, pelvic nodes, bone, or viscera). Results: Overall, 137 blood samples of patients with BCR after RP were analyzed to calculate FPSAR. The median age at 18F-DCFPyL PSMA PET/CT was 68.6 y (interquartile range, 63.0–72.4 y), and the median PSA at 18F-DCFPyL PSMA PET/CT was 0.3 ng/mL (interquartile range, 0.3–0.6 ng/mL). Eighty-six patients (62.8%) had an FPSAR of less than 0.10, whereas 51 patients (37.2%) had an FPSAR of 0.10 or more. An FPSAR of 0.10 or more was identified as an independent predictor of a positive 18F-DCFPyL PSMA PET/CT scan, with an odds ratio of 6.99 (95% CI, 2.96–16.51; P < 0.001). Conclusion: An FPSAR of 0.10 or more after RP independently correlated with increased odds of a positive 18F-DCFPyL PSMA PET/CT scan among BCR post-RP patients. These findings may offer an inexpensive method by which to triage access to 18F-DCFPyL PSMA PET/CT in jurisdictions where availability is not replete.




d 1

Data | 2021 Monsoon session: LS passed 14 Bills after discussing each less than 10 minutes

The average time spent on discussing a Bill dropped from 213 minutes in 2019 to 85 minutes in 2021




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Top stallion Montjeu dies aged 16

Montjeu, who sired three Epsom Derby winners, dies at the age of 16 following a short illness.




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Tax-News.com: OECD Reports Solid Progress On BEPS Action 5 And 14

The OECD/G20 Inclusive Framework on BEPS has published the outcome of more reviews into territories' preferential tax regimes and on tax dispute resolution through the Mutual Agreement Procedure.




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Tax-News.com: OECD Reports Solid Progress On BEPS Action 5 And 14

The OECD/G20 Inclusive Framework on BEPS has published the outcome of more reviews into territories' preferential tax regimes and on tax dispute resolution through the Mutual Agreement Procedure.