Gullermo Alvira en 6AM, sobre ataques con drones a municipio en el Tolima 

Pablo Daza, secretario de Gobierno de Argelia, habló en 6AM sobre cómo está la situación de orden público en Argelia tras la puesta en marcha de Operación Perseo 

Roberto Angulo, secretario de Integración Social de Bogotá, hablo en 6AM sobre cómo va  a actuar el Distrito frente a la instrumentalización de menores en las manifestaciones de indígenas 

Armando Novoa, jefe del equipo negociador del Gobierno nacional con la Segunda Marquetalia de ‘Iván Márquez’, estuvo en 6AM para abordar las especulaciones sobre la muerte del guerrillero disidente.

En 6AM de Caracol Radio estuvo Miguel Silva, Secretario General Alcaldía de Bogotá, quien habló sobre cuáles son las soluciones que plantean para los afectados por la falta de transporte después del partido Millonarios-Pereira y el por qué se dio esta afectación.

President-elect Donald Trump is considering tapping Sen. Marco Rubio (R-FL) as secretary of state, according to the New York Times.

The post Report: President-Elect Donald Trump Considering Marco Rubio as Secretary of State appeared first on Breitbart.

Secretary of State Dr. Shirley Weber walks us through overseeing elections across California. Also, a look at early ballot returns and vote tracking with Political Data. Finally, the California Voter Foundation provides last minute voting tips.

The Denver district attorney has launched an investigation into how a spreadsheet of voting system passwords ended up on the Colorado secretary of state's website earlier this year.

He was fully vaccinated, but fought multiple myeloma.

Pete Hegseth, a 44-year old NATO-skeptic, is perhaps Trump's most surprising pick as he fills out his cabinet ahead of the 20 January inauguration

Victoria Atkins is challenged to name some health trusts meeting their targets to cut waiting lists.

In a surprise move that broke in the early hours of Tuesday morning, President-elect Donald Trump has reportedly picked South Dakota Gov. Kristi Noem as his nominee to head the […]

The post Trump Makes His Pick for Secretary of the Department of Homeland Security Secretary: Report appeared first on The Western Journal.

President-elect Donald Trump is reportedly considering lawyer Alina Habba to be the White House press secretary. Habba often spoke to the media while she was on the legal team representing […]

The post Report Shows New Front-Runner for Trump's Press Secretary Spot: The Media Should Be Terrified appeared first on The Western Journal.

Alzheimer's disease (AD) is characterized by neuronal loss and accumulation of β-amyloid-protein (Aβ) in the brain parenchyma. Sleep impairment is associated with AD and affects about 25–40% of patients in the mild-to-moderate stages of the disease. Sleep deprivation leads to increased Aβ production; however, its mechanism remains largely unknown. We hypothesized that the increase in core body temperature induced by sleep deprivation may promote Aβ production. Here, we report temperature-dependent regulation of Aβ production. We found that an increase in temperature, from 37 °C to 39 °C, significantly increased Aβ production in amyloid precursor protein-overexpressing cells. We also found that high temperature (39 °C) significantly increased the expression levels of heat shock protein 90 (Hsp90) and the C-terminal fragment of presenilin 1 (PS1-CTF) and promoted γ-secretase complex formation. Interestingly, Hsp90 was associated with the components of the premature γ-secretase complex, anterior pharynx-defective-1 (APH-1), and nicastrin (NCT) but was not associated with PS1-CTF or presenilin enhancer-2. Hsp90 knockdown abolished the increased level of Aβ production and the increased formation of the γ-secretase complex at high temperature in culture. Furthermore, with in vivo experiments, we observed increases in the levels of Hsp90, PS1-CTF, NCT, and the γ-secretase complex in the cortex of mice housed at higher room temperature (30 °C) compared with those housed at standard room temperature (23 °C). Our results suggest that high temperature regulates Aβ production by modulating γ-secretase complex formation through the binding of Hsp90 to NCT/APH-1.

In conversation with Julien Harneis, UN Assistant Secretary-General 18 November 2024 — 2:30PM TO 3:30PM Anonymous (not verified) 11 November 2024 Chatham House and Online

In this discussion, Julien Harneis will give critical insights into the UN’s humanitarian response in Yemen and the importance of maintaining independent humanitarian assistance.

According to the United Nations, Yemen has faced the world’s worst humanitarian crisis in the last decade, with over 20 million people in need of assistance. Years of ongoing conflict have devastated infrastructure, displaced millions, and caused widespread food insecurity and health emergencies. Access to essential services remains a daily struggle, and the escalating economic collapse has left vulnerable communities facing critical shortages in food, water, and medical supplies.

However, humanitarian actors are continually facing challenges in delivering aid to Yemen due to security threats and supply chain barriers, highlighting the urgent need for coordinated and sustainable international assistance.

UN Assistant Secretary-General and Humanitarian Coordinator for Yemen, Julien Harneis, will provide an account of the humanitarian mission and evolving strategies in Yemen, the impact of regional conflicts in the delivery of aid and discuss other key questions including:

The peptide hormone ghrelin is produced in cardiomyocytes and acts through the myocardial growth hormone secretagogue receptor (GHSR) to promote cardiomyocyte survival. Administration of ghrelin may have therapeutic effects on post–myocardial infarction (MI) outcomes. Therefore, there is a need to develop molecular imaging probes that can track the dynamics of GHSR in health and disease to better predict the effectiveness of ghrelin-based therapeutics. We designed a high-affinity GHSR ligand labeled with ¹⁸F for imaging by PET and characterized its in vivo properties in a canine model of MI. Methods: We rationally designed and radiolabeled with ¹⁸F a quinazolinone derivative ([¹⁸F]LCE470) with subnanomolar binding affinity to GHSR. We determined the sensitivity and in vivo and ex vivo specificity of [¹⁸F]LCE470 in a canine model of surgically induced MI using PET/MRI, which allowed for anatomic localization of tracer uptake and simultaneous determination of global cardiac function. Uptake of [¹⁸F]LCE470 was determined by time–activity curve and SUV analysis in 3 regions of the left ventricle—area of infarct, territory served by the left circumflex coronary artery, and remote myocardium—over a period of 1.5 y. Changes in cardiac perfusion were tracked by [¹³N]NH₃ PET. Results: The receptor binding affinity of LCE470 was measured at 0.33 nM, the highest known receptor binding affinity for a radiolabeled GHSR ligand. In vivo blocking studies in healthy hounds and ex vivo blocking studies in myocardial tissue showed the specificity of [¹⁸F]LCE470, and sensitivity was demonstrated by a positive correlation between tracer uptake and GHSR abundance. Post-MI changes in [¹⁸F]LCE470 uptake occurred independently of perfusion tracer distributions and changes in global cardiac function. We found that the regional distribution of [¹⁸F]LCE470 within the left ventricle diverged significantly within 1 d after MI and remained that way throughout the 1.5-y duration of the study. Conclusion: [¹⁸F]LCE470 is a high-affinity PET tracer that can detect changes in the regional distribution of myocardial GHSR after MI. In vivo PET molecular imaging of the global dynamics of GHSR may lead to improved GHSR-based therapeutics in the treatment of post-MI remodeling.

Air Force Secretary Frank Kendall said the branch is looking toward confronting China, as well as unity in its ranks, and added that the service needs to retire older aircraft and programs -- and focus on ones that work.

U.S. Defense Secretary Lloyd Austin signed a new security agreement with Georgia Monday, seeking to buttress relations with the Black Sea nation as it continues to face Russian troops in two of its regions.

Billionaire financier John Paulson has declined a likely appointment as U.S Treasury Secretary by President-elect Donald Trump, he announced.

FAO Director-General José Graziano da Silva today praised UN Secretary-General Ban Ki Moon for his support in the fight against hunger at a meeting with FAO member countries, the Committee [...]

Mr Chairman,

I wish to convey, through you, to the Committee on Fisheries, the considered views of the FAO Secretariat on the item on the proposed Fisheries University.  

So far, the [...]

Former President Donald Trump has tapped South Dakota Gov. Kristi Noem to be his Homeland Security secretary.

Fox News host Pete Hegseth is Donald Trump's pick to be defense secretary, the president-elect announced.

Pete Hegseth, a Fox News co-host, author, and US military veteran, has been nominated to lead the world's most powerful military as secretary of defense.

Pete Hegseth, a Fox News co-host, author, and US military veteran, has been nominated to lead the world's most powerful military as secretary of defense.

As we approach November 14th, we join with our Indian neighbors and friends in celebrating Diwali.  It is the celebration of lights with deep cultural significance, celebrating the victory of light over darkness, good over evil, and knowledge over ignorance.  “I especially wish a Happy Diwali to our sister state of Gujarat,” says Secretary Jeff […]

DOVER, Del.— Delaware Secretary of State Jeff Bullock on Wednesday announced the retirement of Paul Weagraff, Director of the Division of Arts, following 24 of years of service to the Department of State. Weagraff will serve through the end of July.  “Paul and I have served together through the bookends of two great challenges to our arts community: […]

Secretary of State Jeffrey Bullock has appointed Matthew Hartigan as Executive Director of the Public Service Commission. Mr. Hartigan has served in roles as the Ombudsman for the Commission and more recently as the Deputy Director since April 26th, 2015. Matt joined the staff over nine years ago. “Matt’s experience and work for more than […]

October is National Italian American Heritage Month, a month dedicated to celebrating the distinguished cultural contributions of Americans with Italian lineage. According to the United States Census Bureau, as of 2019, more than 16 million Americans of Italian descent reside in the United States, making up the seventh largest ethnic group in the country. “Italian […]

This year between November 2nd through 6th, the Delaware Department of State joins Indian Delawareans in celebrating Diwali, the annual festival of lights celebrated by Hindus, Jains, and Sikhs. Diwali, which is celebrated over the course of five days, symbolizes the spiritual “victory of light over darkness, good over evil, and knowledge over ignorance.” “As […]

Dover, Del.—Secretary of State Jeff Bullock has asked Jessica Ball to serve as the next Director of the Delaware Division of the Arts. Ms. Ball most recently served as the Executive Director of the Delaware Arts Alliance and will assume the new role effective November 29th, 2021. “The Division of the Arts plays an integral […]

Dover, Del.—Secretary of State Jeff Bullock announced on Friday that Jordan Schulties, Director of the Division of Small Business, and Tim Slavin, Director of the Division of Historical and Cultural Affairs, will depart from their roles to embark on new journeys at the Delaware Department of Technology and Information (DTI) and Fort Dupont Redevelopment & […]

Secretary of State Jeff Bullock on Monday announced that Suzanne Savery will lead the Delaware Division of Historical and Cultural Affairs as its next director after Tim Slavin’s departure on June 30, 2022. Ms. Savery most recently served as the deputy director of the Delaware Division of Historical and Cultural Affairs and will assume the […]

Dover, Del.—Secretary of State Jeff Bullock on Monday announced that Jessica Welch will lead the Delaware Tourism Office as its next director. Welch most recently served as communications director of the Delaware Division of Small Business. “Jessica brings an immense wealth of knowledge and experience to take on this crucial role in Delaware’s economy,” said […]

Secretary of State Jeff Bullock on Friday announced that Regina Mitchell will lead the Delaware Division of Small Business as its next Director. Mitchell most recently served as the Acting Director of the Division of Small Business. “Regina has the work ethic, experience, and leadership skills to lead the Division through the challenges and opportunities […]

Secretary of State Jeff Bullock on Thursday announced that Andrew (Drew) Slater will depart from his role as Delaware Public Advocate on Friday, February 17, 2023, and will assume a new role as Executive Director of the Sustainable Energy Utility, Inc., also known as Energize Delaware. Ruth Ann Price, who has served as Deputy Public […]

Secretary of State Jeff Bullock announced that Karelin Torres was selected to receive the prestigious 2022 John Lewis Youth Leadership Award. The award, in honor of the late Congressman John Lewis, recognizes a gifted, civic-minded young Delawarean who has demonstrated leadership abilities, has a passion for social justice, and is improving the quality of life in their community.

Delaware Secretary of State Jeff Bullock issued a statement following Senator Tom Carper’s decision to not seek reelection in 2024: Tom Carper has literally bent the arch of Delaware history. Everywhere you look up and down our state, Tom Carper has had an impact. His body of work is unprecedented, and it continues to grow, […]

Delaware Secretary of State Jeff Bullock has placed xylazine, also known as “Tranq”— a non-opioid drug used primarily in veterinary medicine—in Schedule III of the Uniform Controlled Substance Act. Tranq has been used increasingly as an additive in opioid abuse to create a “zombie-like” condition for users. Secretary Bullock’s actions follow a recommendation from the […]

Pursuant to 29 Del.C. §10119(3), Delaware Secretary of State Jeff Bullock has renewed an Emergency Order placing xylazine, also known as “Tranq”, temporarily in Schedule III in the state of Delaware. The Emergency Order took effect June 2, 2023, and was effective 120 days. The public threat posed by xylazine continues. Therefore, the renewal of […]

Secretary of State Jeffrey Bullock has suspended the Delaware certified massage technician license of Robert D. Leech for engaging in inappropriate sexual contact with massage clients. In making this determination, Secretary Bullock considered a complaint filed by the Delaware Department of Justice. The complaint states that Mr. Leech used his position to impose unwelcome sexual […]

Tariah Hyland selected as the 2023 John Lewis Youth Leadership Award recipient Secretary of State Jeff Bullock on Monday announced that Tariah Hyland, a resident of Wilmington, has been selected for the prestigious 2023 John Lewis Youth Leadership Award. The award, in honor of the late Congressman John Lewis, recognizes a gifted, civic-minded young Delawarean […]

Having successfully led the Department of Labor’s efforts to support Delaware workers during one of the most challenging times in the state’s history, Secretary John McMahon announced that he would retire to spend more time with his family.