Kevin lands another magazine cover.

“Wish we were all together.”

New study shows almost no improvement in diversity.

She shared the sentimental letter on Instagram.

Owlet started learning about Beethoven in music class at school just before March break. She ran to meet me at the school gate and this is the conversation we had: OWLET: Mummy, do you know Beethoven? ME: Not personally, but I know his music. OWLET: Why not? ME: Well, honey, he’s dead. OWLET: WHAT. He […]

IBM (NYSE: IBM) and Cúram Software announced today the successful implementation of a number of software solutions for WorkCoverSA to support their business. WorkCover selected IBM Global Business Services to implement the Cúram for Workers' Compensation Solution, a comprehensive and proven claims management solution that manages and automates the complete claim lifecycle from injury to outcome, as part of a comprehensive modernisation of their IT systems.

Eleven members of the Secret Service have tested positive for COVID-19, according a new report. Yahoo News reported Friday it has seen Department of Homeland Security documents which show that 11 individuals currently have the virus and that 23 members of the Secret Service have recovered from the disease. Another 60 employees of the agency…

The post Report: Secret Service Discovers Nearly a Dozen Coronavirus Cases in Its Own Ranks appeared first on The Western Journal.

Grey Bruce provincial police say the OPP canine unit found human remains in Meaford, and one person is under arrest.

Microsoft has introduced a slew of new products, including the Surface Go 2, the Surface Book 3, Surface Headphones 2 and Surface Earbuds. Both the Surface Go 2 and the Surface Book 3 come in consumer and corporate versions. "The two products are very different," noted Rob Enderle, principal analyst at the Enderle Group. "The Go 2 is a high-value product -- the Surface Book 3 high innovation."

At 5,000 years old, the weapon predates the era when humans first started using tin to make bronze

We can expect to see more seasonable temperatures by next weekend, says a meteorologist from Environment Canada.

The issue is significant not only for school employment but also for whether a related federal law would protect students on the same basis.

When she began the biology program at Penn State Schuylkill, senior Dominique Varra thought she wanted to study plants. But after conducting field research studying gray catbirds with Luke Redmond, assistant professor of biology, she has discovered a passion for ornithology. And all of her accomplishments have inspired the next generation of scientists, chiefly her five-year-old daughter Hayden, who hopes to follow in her mother’s footsteps.

Investigations result in discovery and correction of issues impacting consumers The Delaware Department of Insurance’s Market Conduct Examinations resulted in the receipt of nearly $700,000 in fines during 2019 from more than a dozen companies found to violate the Insurance Code or other related regulations. The fines are contributed to the General Fund, providing funding […]

At the end of the second quarter, the Kolkata-based bank's gross NPAs, in absolute terms, stood at Rs 25,665.14 crore, registering over 12% quarter-on-quarter fall.

A report recently released by the U.S. Department of Energy defines and evaluates cost and performance parameters of six battery energy storage technologies (BESS) and four non-BESS storage technologies.

A report recently released by the U.S. Department of Energy defines and evaluates cost and performance parameters of six battery energy storage technologies (BESS) and four non-BESS storage technologies.

Brazil's Real firmed for the first time this week, bouncing from last session's all-time lows, while most other Latin American currencies also strengthened on Friday on signs of easing tensions between the United States and China.

Chinese ride-hailing giant Didi Chuxing’s core business has been profitable, president Jean Liu Qing said for the first time, as ride orders in its domestic market recover from the impact of the coronavirus pandemic.In a rare interview, Liu told the CNBC that Didi’s core business has been profitable, without providing specific figures or explaining how or when the company had measured its profitability. The company has no plans for job cuts or raising capital, Liu said in the interview that…

The United States has reached a settlement to recover more than US$49 million involving Malaysian sovereign wealth fund 1MDB, the US Department of Justice said.The government of former Malaysian prime minister Najib Razak set up the 1MDB fund in 2009 to promote economic development.The US justice department has estimated more than US$4.5 billion was siphoned out of Malaysia by high-level fund officials and their associates between 2009 and 2014 in a scandal that has also embroiled Goldman Sachs…

STUBAI GLACIER, Austria: With its season cut short by the coronavirus pandemic, one of Austria’s most popular glacial ski resorts covered its glacier in protective fabric earlier than usual this year to help preserve it for a still uncertain reopening, foreign media reported.In a normal...

With its season cut short by the coronavirus pandemic, one of Austria's most popular glacial ski resorts covered its glacier in protective fabric earlier than usual this year to help preserve it for a still uncertain reopening.

With its season cut short by the coronavirus pandemic, one of Austria's most popular glacial ski resorts covered its glacier in protective fabric earlier than usual this year to help preserve it for a still uncertain reopening.

ABSTRACT

Marine sponges have been a prolific source of unique bioactive compounds that are presumed to act as a deterrent to predation. Many of these compounds have potential therapeutic applications; however, the lack of efficient and sustainable synthetic routes frequently limits clinical development. Here, we describe a metagenomic investigation of Mycale hentscheli, a chemically gifted marine sponge that possesses multiple distinct chemotypes. We applied shotgun metagenomic sequencing, hybrid assembly of short- and long-read data, and metagenomic binning to obtain a comprehensive picture of the microbiome of five specimens, spanning three chemotypes. Our data revealed multiple producing species, each having relatively modest secondary metabolomes, that contribute collectively to the chemical arsenal of the holobiont. We assembled complete genomes for multiple new genera, including two species that produce the cytotoxic polyketides pateamine and mycalamide, as well as a third high-abundance symbiont harboring a proteusin-type biosynthetic pathway that appears to encode a new polytheonamide-like compound. We also identified an additional 188 biosynthetic gene clusters, including a pathway for biosynthesis of peloruside. These results suggest that multiple species cooperatively contribute to defensive symbiosis in M. hentscheli and reveal that the taxonomic diversity of secondary-metabolite-producing sponge symbionts is larger and richer than previously recognized.

IMPORTANCE Mycale hentscheli is a marine sponge that is rich in bioactive small molecules. Here, we use direct metagenomic sequencing to elucidate highly complete and contiguous genomes for the major symbiotic bacteria of this sponge. We identify complete biosynthetic pathways for the three potent cytotoxic polyketides which have previously been isolated from M. hentscheli. Remarkably, and in contrast to previous studies of marine sponges, we attribute each of these metabolites to a different producing microbe. We also find that the microbiome of M. hentscheli is stably maintained among individuals, even over long periods of time. Collectively, our data suggest a cooperative mode of defensive symbiosis in which multiple symbiotic bacterial species cooperatively contribute to the defensive chemical arsenal of the holobiont.

ABSTRACT

Symbiotic microorganisms can have a profound impact on the host physiology and behavior, and novel relationships between symbionts and their hosts are continually discovered. A colony of social ants consists of various castes that exhibit distinct lifestyles and is, thus, a unique model for investigating how symbionts may be involved in host eusociality. Yet our knowledge of social ant-symbiont dynamics has remained rudimentary. Through 16S rRNA gene deep sequencing of the carpenter ant Camponotus japonicus symbiont community across various castes, we here report caste-dependent diversity of commensal gut microbiota and lineage divergence of "Candidatus Blochmannia," an obligate endosymbiont. While most prevalent gut-associated bacterial populations are found across all castes (Alphaproteobacteria, Gammaproteobacteria, Bacteroidetes, and Cyanobacteria), we also discovered uncultured populations that are found only in males (belonging to Corynebacteriales, Alkanindiges, and Burkholderia). Most of those populations are not detected in laboratory-maintained queens and workers, suggesting that they are facultative gut symbionts introduced via environmental acquisition. Further inspection of "Ca. Blochmannia" endosymbionts reveals that two populations are dominant in all individuals across all castes but that males preferentially contain two different sublineages that are diversified from others. Clearly, each caste has distinct symbiont communities, suggesting an overlooked biological aspect of host-symbiont interaction in social insects.

IMPORTANCE Social animals, such as primates and some insects, have been shown to exchange symbiotic microbes among individuals through sharing diet or habitats, resulting in increased consistency of microbiota among social partners. The ant is a representative of social insects exhibiting various castes within a colony; queens, males, and nonreproductive females (so-called workers) show distinct morphologies, physiologies, and behaviors but tightly interact with each other in the nest. However, how this social context affects their gut microbiota has remained unclear. In this study, we deeply sequenced the gut symbiont community across various castes of the carpenter ant Camponotus japonicus. We report caste-dependent diversity of commensal gut microbial community and lineage divergence of the mutualistic endosymbiont "Candidatus Blochmannia." This report sheds light on the hidden diversity in microbial populations and community structure associated with guts of males in social ants.

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One dog owner has found out the hard way that giving her Pomeranian a haircut at home during the coronavirus lockdown isn't an easy job.

A three-week-old girl has recovered from coronavirus to the delight of her parents.

There is no time like the present to get creative. Photographer Stephanie Girard is normally bustling about on the set of different photoshoots across Los Angeles but with the ongoing...

Boris Johnson watched Dominic Raab take on Sir Keir Starmer at PMQs from Chequers today as he continues his recovery from coronavirus.

- With its season cut short by the coronavirus pandemic, one of Austria's most popular glacial ski resorts covered its glacier in protective fabric earlier than usual this year to help preserve it for a still uncertain reopening.

The 7 Rings singer sang all six parts of the classic ballad

The YouTube star spent the weekend in hospital after having wires removed from his hand

Liverpool legend Sir Kenny Dalglish joined the nation in Thursday's weekly 'Clap for our Carers' to show his appreciation and support for the NHS.

There is no time like the present to get creative. Photographer Stephanie Girard is normally bustling about on the set of different photoshoots across Los Angeles but with the ongoing...

“Wish we were all together.”

She shared the sentimental letter on Instagram.

Douglas Moore, who also has a lung condition, received a round of applause as he was discharged from Kettering General Hospital.

There is no time like the present to get creative. Photographer Stephanie Girard is normally bustling about on the set of different photoshoots across Los Angeles but with the ongoing...

Southern California Best Sellers, May 10, 2020