live

The world as a ‘live-in lab’

“I think it would be better to expand the boundaries of learning and think of the world as a “live-in lab.”




live

Packed, sealed and delivered

From pickles and photocopies to movie tickets and medicines, a bunch of young men promise to deliver anything anywhere. K. Jeshi finds out more




live

Bhaktha Prahlada: Purana comes alive

The unique appeal of Pouranic verse drama came alive in the staging of ‘Bhaktha Prahlada’.




live

Folic acid-targeted redox responsive polylactic acid-based nanoparticles co-delivering pirarubicin and salinomycin suppress breast cancer tumor growth in vivo

Nanoscale, 2024, 16,20131-20146
DOI: 10.1039/D4NR02365J, Paper
Priya Gupta, Ankushi Bansal, Harshdeep Kaur, Mohd Anees, Neetu Singh, Harpal Singh
Schematic illustration of design, administration, and mechanism of action of Pira/Sal dual-loaded FA-conjugated redox responsive [S-(PLA-b-PEG-CONH)]2 block copolymeric nanoparticles.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Nanoparticle’s shape is the game-changer for blood-brain barrier crossing and delivering through tunneling nanotubes among glioblastoma cells.

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR03174A, Paper
Open Access
Giulia Sierri, Ines Saenz-de-Santa-Maria, Antonio Renda, Marcus Koch, Patrizia Sommi, Umberto Anselmi-Tamburini, Mario Mauri, Alessia D'Aloia, Michela Ceriani, Domenico Salerno, FRANCESCO MANTEGAZZA, Chiara Zurzolo, Francesca Re
Tunneling Nanotubes (TNTs) are thin, dynamic, long membrane protrusions that allow the intercellular exchanges of signal clues, molecules and organelles. The presence of TNTs and their involvement as drug delivery...
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Ultra-efficient delivery of CRISPR/Cas9 using ionic liquid conjugated polymers for genome editing-based tumor therapy

Biomater. Sci., 2024, 12,1716-1725
DOI: 10.1039/D3BM01981K, Paper
Zhongming Huang, Tongren Yang, Jie Yu, Yijian Gao, Yuhua Weng, Yuanyu Huang, Shengliang Li
Through molecular screening, ionic liquid-conjugated polymers (IL-CPs) are developed for highly efficient delivery of CRISPR/Cas9 system, which demonstrated high-performance genome editing-based tumor therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Biomater. Sci., 2024, 12,1662-1692
DOI: 10.1039/D3BM01451G, Review Article
Qiao Li, Yuan Lianghao, Gao Shijie, Wang Zhiyi, Tang Yuanting, Chen Cong, Zhao Chun-Qin, Fu Xianjun
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Copper(II)-based metal–organic framework delivery of calcium ascorbate for enhanced chemodynamic therapy via H2O2 self-supply and glutathione depletion

Biomater. Sci., 2024, 12,1871-1882
DOI: 10.1039/D3BM01922E, Paper
Meng Zhang, Hongjin Xue, Jiaxin Yang, Xin Zhao, Mei Xue, Wei Sun, Jianfeng Qiu, Zhihong Zhu
A Cu/ZIF-8/Vc-Ca/HA nanosystem synchronously releases Fenton catalytic Cu2+ and Vc-Ca to achieve improved chemodynamic therapy via H2O2 self-supply and GSH depletion.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Free drug and ROS-responsive nanoparticle delivery of synergistic doxorubicin and olaparib combinations to triple negative breast cancer models

Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Self-adjuvanted L-arginine-modified dextran-based nanogels for sustained local antigenic protein delivery to antigen-presenting cells and enhanced cellular and humoral immune responses

Biomater. Sci., 2024, 12,1771-1787
DOI: 10.1039/D3BM01150J, Paper
Jin Teng Chung, Mehrnoosh Rafiei, Ying Chau
Antigens are delivered in self-adjuvanted arginine-modified dextran-based nanogels to the dendritic cells in promoting antigen specific cellular immunity.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Exosomes encapsulated in hydrogels for effective central nervous system drug delivery

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01055D, Review Article
Ziba Zakeri, Morteza Heiderzadeh, Azra Kocaarslan, Ecem Metin, Seyed Nasir Hosseini Karimi, Sepideh Saghati, Atay Vural, Göktuğ Akyoldaş, Kemal Baysal, Yusuf Yağcı, Yasemin Gürsoy-Özdemir, Savaş Taşoğlu, Reza Rahbarghazi, Emel Sokullu
The targeted delivery of pharmacologically active molecules, metabolites, and growth factors to the brain parenchyma has become one of the major challenges following the onset of neurodegeneration and pathological conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Clodronate-nintedanib-loaded exosome–liposome hybridization enhances the liver fibrosis therapy by inhibiting Kupffer cell activity

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90028F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keqin Ji, Mingrui Fan, Dong Huang, Lingna Sun, Bingqin Li, Ruoting Xu, Jiajing Zhang, Xuan Shao, Yanzuo Chen
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment

Biomater. Sci., 2024, 12,2007-2018
DOI: 10.1039/D3BM02003G, Review Article
Mark-Jefferson Buer Boyetey, Yonghyun Choi, Hee-Young Lee, Jonghoon Choi
Drugs for Alzheimer's disease (AD) fail to exhibit efficacy in clinical trials for a number of reasons, a major one being blood–brain barrier (BBB) permeability.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy

Biomater. Sci., 2024, 12,2057-2066
DOI: 10.1039/D3BM02071A, Paper
Song Lin, Houjin Jing, Xiaojiao Du, Xianzhu Yang, Jun Wang
A siRNA delivery system was developed using clinically approved mPEG-b-PLGA, cationic lipid and ionizable lipid for siRNA delivery and cancer immunotherapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Beyond Nanoparticle-based Oral Drug Delivery: Transporter-mediated Absorption and Disease Targeting

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4BM00313F, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hana Cho, Kang Moo Huh, Hyun Ji Cho, Bogeon Kim, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Young Jik Kwon, Han Chang Kang
Various strategies in the microscale/nanoscale have been developed to improve oral absorption of therapeutics. Among them, gastrointestinal (GI)-transporter/receptor-mediated nanosized drug delivery systems (NDDSs) have drawn attention due to their many...
The content of this RSS Feed (c) The Royal Society of Chemistry




live

Lipid sulfoxide polymers as potential inhalable drug delivery platforms with differential albumin binding affinity

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D3BM02020G, Paper
Gayathri Ediriweera, Neville Butcher, Ashok Kothapalli, Jiacheng Zhao, Joanne Therese Blanchfield, Christopher N. Subasic, James Lynden Grace, Changkui Fu, Xiao Tan, John F. Quinn, David Ascher, Michael R Whittaker, Andrew Whittaker, Lisa Kaminskas
Inhalable nanomedicines are increasingly being developed to optimise the pharmaceutical treatment of respiratory diseases. Large lipid-based nanosystems at the forefront of the inhalable nanomedicines development pipeline, though, have a number...
The content of this RSS Feed (c) The Royal Society of Chemistry





live

Watch: Women artisans in Lucknow keep Chikankari embroidery alive




live

Dyson Airstrait review: The straightener, now launched in India, promises no heat damage. Does it deliver?

Dyson returns to India with its latest no-heat damage hair styler and dryer, the Airstrait, in Delhi. Does it deliver on its promise?




live

India’s most famous couturier Rohit Bal lived by his heart and died by it

A long-time fashion editor on the designer’s crowd-pulling persona that glossed over the empath he was 




live

Work, live and play

Ramanujan IT City has adopted the Main Street architectural style. Hema Vijay takes a look.




live

Bhanupriya Rao and the inner lives of women

The founder of BehanBox has a perennial source of inspiration




live

Swiggy’s IPO to deliver ₹9,000 crore in employee wealth for 5,000 employees

Nearly 5,000 current and former employees are set to benefit, with around 500 Swiggy employees to enter the ‘crore-pati’ club when the firm makes its stock market debut, according to sources




live

#BlackLivesMatter: Is America on the road to justice?

Will the Black Lives Matter live up to the legacy set forth by Martin Luther King Jr and others?




live

Amazon Great Indian Festival Sale 2024 Live: TWS earphones below ₹5,000 from OnePlus, JBL, Samsung, Jabra, Sony

OnePlus, JBL, Samsung, Jabra, and Sony are just some of the brands offering TWS earphones priced at less than ₹5,000, though their specs can vary greatly




live

CAS verdict on Vinesh deferred again; to be delivered on August 16

The 29-year-old was disqualified from the women's 50kg free-style final for being 100gm overweight at the time of weigh-in on Wednesday last week




live

X block feature update goes live, public posts visible anyway

X indicated that the change was aimed at protecting users who have been blocked.




live

Amazon developing driver eyeglasses to shave seconds off deliveries: Report

The project underscores the online seller's efforts to reduce delivery costs per package and support margins as it fights increased competition from Walmart




live

Innovation is still alive in plastics

Plenty of new polymer technology was on display at the NPE2018 trade show




live

Dow fined $1.7 million over perks for CEO Liveris




live

Modernizing CEPA’s approach to supporting ACS members in their professional lives




live

Meet the exosome, the rising star in drug delivery

Companies are hoping to use the vesicles to package small-molecule, protein, and RNA drugs or even use them as therapies themselves





live

Amazon announces new tools at Alexa Live

Amazon introduces Alexa Ambient Home Dev Kit, multi-assistant voice, and others for developers




live

Stock Market Live Updates 13 November 2024: Gift Nifty signals gap-down opening as market faces earnings and inflation pressures

Sensex, Nifty, Share Prices LIVE: Gift Nifty indicates a likely 100-point gap-down opening for Nifty at 23,870 on Wednesday as global markets remain weak. Analysts cite concerns over an earnings slowdown and persistently high inflation; Jefferies India downgraded full-year earnings for 63% of the 121 large companies it covers due to economic slowing. India’s retail inflation surged to a 14-month high of 6.21% in October, with steep rises in food and metal prices potentially influencing the RBI’s December policy stance. A continued hold on rates seems likely, but analysts at AngelOne note a shallower rate-cut cycle ahead for India, mirroring the US trend. Options data signals resistance around 24,500 due to heavy call writing and support near 23,500, with a bearish put-call ratio drop to 0.52. India VIX rose to 14.60 (+2.40%), suggesting caution; however, lower volatility generally supports bullish sentiment, according to SAMCO’s Dhupesh Dhameja.




live

Swiggy’s stock market debut: Will it deliver listing gains?

With large IPOs like LIC and Hyundai India faltering, Swiggy’s listing today is expected to be muted, as analysts remain cautious amid subdued retail demand and challenging market conditions




live

Kolkata Police starts probe into 'hacking' of live-streaming of Calcutta High Court hearing

During the hearing of Justice Subhasish Samanta at courtroom number 7, an obscene video was allegedly “live-streamed” for nearly one minute before it could be stopped




live

Kolkata tram trundles back to familiar atmosphere of neglect and protests — a sign it is still alive

Friday’s CTUA protest was initially planned to demand restoration of the third surviving route, Ballygunge-Tollygunge, which was shut down temporarily about four months ago due to pipeline work; but by Friday they had more things to protest against as media reports showed bituminisation of not-in-use tram tracks in Alipore.




live

Karun helps Daredevils stay alive

Sunrisers ride on Warner’s half-century to put up 158 which is chased down off the last ball.



  • Indian Premier League

live

IND vs SA, 3rd T20I: Predicted playing XIs, live streaming details, weather and pitch report

India will face South Africa in the third T20I of the series at SuperSport Park today (November 13).




live

Melodies in the making: How Miraj’s sitarmakers keep Indian classical music alive




live

Maharashtra Assembly polls: RR Patil’s daughter enters field to keep his legacy alive in Tasgaon through son




live

Maharashtra Election 2024 Live Updates: ‘It is alleged that Cong using money looted from Karnataka for assembly polls in state,’ says PM Modi at Pune rally




live

India A vs Australia A Live Streaming, 2nd unofficial Test: When and where to watch live telecast?




live

‘It’s been the toughest year of our lives’: Cycling legend Chris Hoy on terminal cancer




live

Australia vs Pakistan 2nd ODI Live Cricket Streaming: When and where to watch AUS vs PAK live?




live

Another day, another Arjun Erigaisi peak: 21-year-old jumps to world no 2 in live ratings




live

IND vs SA 1st T20 Match Date, Live Streaming, Pitch Report, weather, squads, Playing XI prediction




live

Australia vs Pakistan 3rd ODI Live Cricket Streaming: When and where to watch AUS vs PAK live?




live

Afghanistan vs Bangladesh 3rd ODI Live Score Streaming: When and where to watch AFG vs BAN match live