SUZOHAPP is pleased to announce the appointment of Simon James as its new Executive Vice President of Retail & Transportation.Simon joined SUZOHAPP as Managing Director (MD) of the United Kingdom & Ireland, on September 1, 2018 and has made a very positive impact on our business there in a year's time.

Security and Safety Things GmbH has entered into a partnership with the Johan Cruijff ArenA in Amsterdam to deploy its IoT platform for smart surveillance cameras to enhance overall fan experience, optimize ArenA operations and increase visitor security and privacy.

Leibinger introduced what it describes as the world’s first intelligent coding & marking system – the IQJET – on May 3 in Düsseldorf, the day before the opening of the interpack trade show.

BIXOLON Europe GmbH, a subsidiary of BIXOLON, a global leader in advanced receipt, label and mobile printers, has partnered with G Rigging & Lighting Ltd, an independent event specialist based in the UK.

This issue features a Special Technology Report looking in depth at the latest developments in the world of Printing and Labelling solutions.

Also included is a ‘Cover Story’: Gartner explains that by 2026, 30% of enterprises will automate more than half of their network activities, an increase from under 10% in mid-2023.

The Ukrainian army is suffering huge losses in the Kursk direction of hostilities. Thousands of Ukrainian fighters have gone missing during the incursion into the Russian region. Many already criticise President Zelensky for going on such an "adventure." Ukrainian commanders order their soldiers to take part in "meat-grinding" assaults. Those who refuse are shot for treason. Captured Ukrainians share stories of real genocide in the ranks of the Armed Forces of Ukraine. Ukrainian leaders use common people in uniforms as "consumables", whereas the army of Ukraine has turned into a self-destruction machine under the dictation of the Kyiv authorities. Meanwhile, two Iskander missiles — some call them Korean KN-23 — annihilated another temporary deployment point of the Ukrainian Armed Forces in Sumy where units of the 54th, 61st, 45-1 and 81st brigades of the Ukrainian Armed Forces had arrived from the Kursk direction.

The UK's largest eCommerce and marketing event, eCommerce Expo & Technology for Marketing, will take place on 18-19 September 2024, at ExCeL, London. 

Added August 20, 2006: A 1977 decision of an Indiana superior court ruling against a textbook produced by the Creation Research Society. In some respects this case resembles a young-earth creationist version of the 2005 Kitzmiller case. Introductory material, links, as well as the full text of the judge's memorandum opinion are provided.

British Business-to-Business (B2B) companies take on average 32 days to collect, collate and enrich all the necessary data for a new product launch, significantly impacting UK productivity and go-to-market times, according to research conducted by Akeneo, the Product Experience (PX) Company and leading provider of Product Information Management (PIM) solutions.

Jisp, the retail technology company, has marked the three-year anniversary of its Scan & Save app achieving high performance figures. Jisp reports that, since its launch in 2021, Scan & Save has earned retailers almost £6million while shoppers have saved over £2.2million in that time.

The University of Arkansas at Little Rock has reached an exciting milestone in its Centennial Campaign, raising $203 million toward its overall campaign goal of $250 million by 2027. This represents the largest amount ever raised in a UA Little Rock campaign, exceeding the previous campaign by $100 million.

"Tell me the numbers, I'll take care of the politics." Shashi Nambisan, director of the Transportation Research Center (TRC) at UNLV, recalled a pivotal discussion in the early 1990s with then-County Commissioner Bruce L. Woodbury about the transportation needs of a region on the precipice of substantial growth.

[Sports] :
South Korean golfer An Byeong-hun claimed his first DP World Tour victory in nine years, defeating compatriot Kim Joo-hyung on Sunday in a playoff on home soil.  At Jack Nicklaus Golf Club Korea in Incheon, during the final round of the 2024 Genesis Championship, An secured his second career win on the DP ...

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[Sports] :
South Korean golfer Kim A-lim won the Lotte Championship on Saturday for her second LPGA Tour title. Kim clinched the title at Hoakalei Country Club in Hawaii, closing with a four-under 68 for a two-stroke victory over Nataliya Guseva from Russia. With the first victory in nearly four years since the ...

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[International] :
The operator of Japan’s Fukushima Daiichi nuclear power plant said it retrieved a small amount of melted fuel from one of the reactors for the first time since a major earthquake and tsunami crippled the nuclear facility in 2011. According to Japanese media outlets on Thursday, the Tokyo Electric Power ...

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[Culture] :
The Seoul Metropolitan Government will run a campaign to promote standardized naming of Korean dishes in foreign languages. According to city officials on Thursday, the campaign, in cooperation with the Seoul Tourism Organization and the Korea Food Service Industry Association, is set to continue through ...

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Jinjin of Astro has dropped a single in remembrance of bandmate Moonbin who passed away one year ago.The digital single “Fly”, which features Moonbin’s voice, was co-written by the two members of...

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Actor Yoo Teo has been included in the 2024 version of Gold House's 'The A100' list.The list, announced every May, nominates 100 of the world's most impactful Asian Pacific leaders in American culture...

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EXO’s Suho will release a new solo album this month. The new EP, titled “1 to 3” will drop on May 31, more than two years after his second solo album “Grey Suit” was released in April...

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RM of BTS released his second solo album 'Right Place, Wrong Person' on Friday, his first solo album since 'Indigo' in December 2022.The album carries eleven songs, including the title track...

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Seventeen has become the 1st K-pop group to be appointed UNESCO's Goodwill Ambassador for Youth. It is also the first time UNESCO has designated a youth ambassador. Seventeen has been supporting the...

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The music video for girl group TWICE's 2015 song "Like Ooh-Ahh" has surpassed 500 million views on YouTube. The group's management JYP Entertainment said the video broke the 500 million mark...

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Jimin of BTS is set to release an English version of the single 'Be Mine.' The singer's agency BigHit Music said that the track would be released on Friday. 'Be Mine' is a track listed in...

[more...]

Tzuyu of the girl group TWICE is set to become the third member to launch her solo career. JYP Entertainment dropped the news on Friday via social media, along with an opening trailer.The artist's solo debut...

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Fall is the season of festivals and baseball here in Korea. What are some interesting festivals taking place around the country? What is the deal with the first pitch by celebrities at the baseball...

[more...]

On this week's episode of I Feel You, DJ Hyerim and NVee dive into their fitness routines, sharing the secrets behind staying in shape and the complicated relationships with personal trainers....

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NewJeans’ hit “Super Shy’ has earned a spot in Pitchfork’s list of the best songs of the decade. It was the only K-pop track to be featured on Pitchfork’s list of...

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G-Dragon has helped write a song for Babymonster’s upcoming full-length album which will drop next month. The rookie girl group’s first full-length album “Drip” will drop...

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For today’s #MovieSpotlight, we are joined by film critics Jason Bechervaise and Darcy Paquet  to celebrate Han Kang’s Nobel Prize in Literature win! #한강...

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Start your week off right with NVee and DJ Hyerim in another exciting episode of I Feel You! Today, they’re spilling stories about everything from their school days and being the coolest aunts...

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Spook is in the air!

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We’re thrilled to welcome AMPERS&ONE back to our studio for the second time! Kamden, Brian, Kyrell, and Mackiah join us this week on Good Vibes Only to share their new songs from their...

[more...]

Did you feel the earth move? Mini-earthquake recorded on Shropshire/Staffordshire border  Express & Star

A novel approach to computationally enhance the sampling of molecular crystal structures is proposed and tested. This method is based on the use of extended variables coupled to a Monte Carlo based crystal polymorph generator. Inspired by the established technique of quasi-random sampling of polymorphs using the rigid molecule constraint, this approach represents molecular clusters as extended variables within a thermal reservoir. Polymorph unit-cell variables are generated using pseudo-random sampling. Within this framework, a harmonic coupling between the extended variables and polymorph configurations is established. The extended variables remain fixed during the inner loop dedicated to polymorph sampling, enforcing a stepwise propagation of the extended variables to maintain system exploration. The final processing step results in a polymorph energy landscape, where the raw structures sampled to create the extended variable trajectory are re-optimized without the thermal coupling term. The foundational principles of this approach are described and its effectiveness using both a Metropolis Monte Carlo type algorithm and modifications that incorporate replica exchange is demonstrated. A comparison is provided with pseudo-random sampling of polymorphs for the molecule coumarin. The choice to test a design of this algorithm as relevant for enhanced sampling of crystal structures was due to the obvious relation between molecular structure variables and corresponding crystal polymorphs as representative of the inherent vapor to crystal transitions that exist in nature. Additionally, it is shown that the trajectories of extended variables can be harnessed to extract fluctuation properties that can lead to valuable insights. A novel thermodynamic variable is introduced: the free energy difference between ensembles of Z' = 1 and Z' = 2 crystal polymorphs.

Preparation of biomacromolecules for structural biology studies is a complex and time-consuming process. The goal is to produce a highly concentrated, highly pure product that is often shipped to large facilities with tools to prepare the samples for crystallization trials or for measurements at synchrotrons and cryoEM centers. The aim of this article is to provide guidance and to discuss general considerations for shipping biomacromolecular samples. Details are also provided about shipping samples for specific experiment types, including solution- and cryogenic-based techniques. These guidelines are provided with the hope that the time and energy invested in sample preparation is not lost due to shipping logistics.

Crystallographic fragment screening has become a pivotal technique in structure-based drug design, particularly for bacterial targets with a crucial role in infectious disease mechanisms. The enzyme CdaA, which synthesizes an essential second messenger cyclic di-AMP (c-di-AMP) in many pathogenic bacteria, has emerged as a promising candidate for the development of novel antibiotics. To identify crystals suitable for fragment screening, CdaA enzymes from Streptococcus pneumoniae, Bacillus subtilis and Enterococcus faecium were purified and crystallized. Crystals of B. subtilis CdaA, which diffracted to the highest resolution of 1.1 Å, were used to perform the screening of 96 fragments, yielding data sets with resolutions spanning from 1.08 to 1.87 Å. A total of 24 structural hits across eight different sites were identified. Four fragments bind to regions that are highly conserved among pathogenic bacteria, specifically the active site (three fragments) and the dimerization interface (one fragment). The coordinates of the three active-site fragments were used to perform an in silico drug-repurposing screen using the OpenEye suite and the DrugBank database. This screen identified tenofovir, an approved drug, that is predicted to interact with the ATP-binding region of CdaA. Its inhibitory potential against pathogenic E. faecium CdaA has been confirmed by ITC measurements. These findings not only demonstrate the feasibility of this approach for identifying lead compounds for the design of novel antibacterial agents, but also pave the way for further fragment-based lead-optimization efforts targeting CdaA.

Rotations of small- and wide-angle X-ray scattering samples during acquisition are shown to give a drastic improvement in the reliability of the characterization of anisotropic precipitates in metallic alloys.

This paper describes real-time statistical analysis of liquid jet images for SFX experiments at the European XFEL. This analysis forms one part of the automated jet re-alignment system for SFX experiments at the SPB/SFX instrument of European XFEL.

Nanometric precipitates in metallic alloys often have highly anisotropic shapes. Given the large grain size and non-random texture typical of these alloys, performing small- and wide-angle X-ray scattering (SAXS/WAXS) measurements on such samples for determining their characteristics (typically size and volume fraction) results in highly anisotropic and irreproducible data. Rotations of flat samples during SAXS/WAXS acquisitions are presented here as a solution to these anisotropy issues. Two aluminium alloys containing anisotropic precipitates are used as examples to validate the approach with a −45°/45° angular range. Clear improvements can be seen on the SAXS I(q) fitting and the consistency between the different SAXS/WAXS measurements. This methodology results in more reliable measurements of the precipitate's characteristics, and thus allows for time- and space-resolved measurements with higher accuracy.

Despite the increased brilliance of the new generation synchrotron sources, there is still a challenge with high-resolution scanning of very thick and absorbing samples, such as a whole mouse brain stained with heavy elements, and, extending further, brains of primates. Samples are typically cut into smaller parts, to ensure a sufficient X-ray transmission, and scanned separately. Compared with the standard tomography setup where the sample would be cut into many pillars, the laminographic geometry operates with slab-shaped sections significantly reducing the number of sample parts to be prepared, the cutting damage and data stitching problems. In this work, a laminography pipeline for imaging large samples (>1 cm) at micrometre resolution is presented. The implementation includes a low-cost instrument setup installed at the 2-BM micro-CT beamline of the Advanced Photon Source. Additionally, sample mounting, scanning techniques, data stitching procedures, a fast reconstruction algorithm with low computational complexity, and accelerated reconstruction on multi-GPU systems for processing large-scale datasets are presented. The applicability of the whole laminography pipeline was demonstrated by imaging four sequential slabs throughout an entire mouse brain sample stained with osmium, in total generating approximately 12 TB of raw data for reconstruction.

The demand for powder X-ray diffraction analysis continues to increase in a variety of scientific fields, as the excellent beam quality of high-brightness synchrotron light sources enables the acquisition of high-quality measurement data with high intensity and angular resolution. Synchrotron powder diffraction has enabled the rapid measurement of many samples and various in situ/operando experiments in nonambient sample environments. To meet the demands for even higher throughput measurements using high-energy X-rays at SPring-8, a high-throughput and high-resolution powder diffraction system has been developed. This system is combined with six sets of two-dimensional (2D) CdTe detectors for high-energy X-rays, and various automation systems, including a system for automatic switching among large sample environmental equipment, have been developed in the third experimental hutch of the insertion device beamline BL13XU at SPring-8. In this diffractometer system, high-brilliance and high-energy X-rays ranging from 16 to 72 keV are available. The powder diffraction data measured under ambient and various nonambient conditions can be analysed using Rietveld refinement and the pair distribution function. Using the 2D CdTe detectors with variable sample-to-detector distance, three types of scan modes have been established: standard, single-step and high-resolution. A major feature is the ability to measure a whole powder pattern with millisecond resolution. Equally important, this system can measure powder diffraction data with high Q exceeding 30 Å−1 within several tens of seconds. This capability is expected to contribute significantly to new research avenues using machine learning and artificial intelligence by utilizing the large amount of data obtained from high-throughput measurements.

Aerosol science is of utmost importance for both climate and public health research, and in recent years X-ray techniques have proven effective tools for aerosol-particle characterization. To date, such methods have often involved the study of particles collected onto a substrate, but a high photon flux may cause radiation damage to such deposited particles and volatile components can potentially react with the surrounding environment after sampling. These and many other factors make studies on collected aerosol particles challenging. Therefore, a new aerosol sample-delivery system dedicated to X-ray photoelectron spectroscopy studies of aerosol particles and gas molecules in-flight has been developed at the MAX IV Laboratory. The aerosol particles are brought from atmospheric pressure to vacuum in a continuous flow, ensuring that the sample is constantly renewed, thus avoiding radiation damage, and allowing measurements on the true unsupported aerosol. At the same time, available gas molecules can be used for energy calibration and to study gas-particle partitioning. The design features of the aerosol sample-delivery system and important information on the operation procedures are described in detail here. Furthermore, to demonstrate the experimental range of the aerosol sample-delivery system, results from aerosol particles of different shape, size and composition are presented, including inorganic atmospheric aerosols, secondary organic aerosols and engineered nanoparticles.

Addressing the demand for high stability of beamline instruments at the SHINE facility, a high stability mirror regulating mechanism has been developed for mirror adjustments. Active mass damping was adopted to attenuate pitch angle vibrations of mirrors caused by structural vibrations. An internal absolute velocity feedback was used to reduce the negative impact of spillover effects and to improve performance. The experiment was conducted on a prototype structure of a mirror regulating mechanism, and results showed that the vibration RMS of the pitch angle was effectively attenuated from 47 nrad to 27 nrad above 1 Hz.

CdaA is the most widespread diadenylate cyclase in many bacterial species, including several multidrug-resistant human pathogens. The enzymatic product of CdaA, cyclic di-AMP, is a secondary messenger that is essential for the viability of many bacteria. Its absence in humans makes CdaA a very promising and attractive target for the development of new antibiotics. Here, the structural results are presented of a crystallographic fragment screen against CdaA from Listeria monocytogenes, a saprophytic Gram-positive bacterium and an opportunistic food-borne pathogen that can cause listeriosis in humans and animals. Two of the eight fragment molecules reported here were localized in the highly conserved ATP-binding site. These fragments could serve as potential starting points for the development of antibiotics against several CdaA-dependent bacterial species.

For cryo-electron tomography (cryo-ET) of beam-sensitive biological specimens, a planar sample geometry is typically used. As the sample is tilted, the effective thickness of the sample along the direction of the electron beam increases and the signal-to-noise ratio concomitantly decreases, limiting the transfer of information at high tilt angles. In addition, the tilt range where data can be collected is limited by a combination of various sample-environment constraints, including the limited space in the objective lens pole piece and the possible use of fixed conductive braids to cool the specimen. Consequently, most tilt series are limited to a maximum of ±70°, leading to the presence of a missing wedge in Fourier space. The acquisition of cryo-ET data without a missing wedge, for example using a cylindrical sample geometry, is hence attractive for volumetric analysis of low-symmetry structures such as organelles or vesicles, lysis events, pore formation or filaments for which the missing information cannot be compensated by averaging techniques. Irrespective of the geometry, electron-beam damage to the specimen is an issue and the first images acquired will transfer more high-resolution information than those acquired last. There is also an inherent trade-off between higher sampling in Fourier space and avoiding beam damage to the sample. Finally, the necessity of using a sufficient electron fluence to align the tilt images means that this fluence needs to be fractionated across a small number of images; therefore, the order of data acquisition is also a factor to consider. Here, an n-helix tilt scheme is described and simulated which uses overlapping and interleaved tilt series to maximize the use of a pillar geometry, allowing the entire pillar volume to be reconstructed as a single unit. Three related tilt schemes are also evaluated that extend the continuous and classic dose-symmetric tilt schemes for cryo-ET to pillar samples to enable the collection of isotropic information across all spatial frequencies. A fourfold dose-symmetric scheme is proposed which provides a practical compromise between uniform information transfer and complexity of data acquisition.

The functionality and efficiency of proteins within a biological membrane are highly dependent on both the membrane lipid composition and the physiochemical properties of the solution. Lipid mesophases are directly influenced by changes in temperature, pH, water content or due to individual properties of single lipids such as photoswitchability. In this work, we were able to induce light- and temperature-driven mesophase transitions in a model membrane system containing a mixture of 1,2-dipalmitoyl-phosphatidylcholine phospho­lipids and azo­benzene amphiphiles. We observed reversible and reproducible transitions between the lamellar and Pn3m cubic phase after illuminating the sample for 5 min with light of 365 and 455 nm wavelengths, respectively, to switch between the cis and trans states of the azo­benzene N=N double bond. These light-controlled mesophase transitions were found for mixed complexes with up to 20% content of the photosensitive molecule and at temperatures below the gel-to-liquid crystalline phase transition temperature of 33°C. Our results demonstrate the potential to design bespoke model systems to study the response of membrane lipids and proteins upon changes in mesophase without altering the environment and thus provide a possible basis for drug delivery systems.

A few real case examples are presented on how to report magnetic structures, with precise step-by-step explanations, following the guidelines of the IUCr Commission on Magnetic Structures [Perez-Mato et al. (2024). Acta Cryst. B80, 219–234]. Four examples have been chosen, illustrating different types of single-k magnetic orders, from the basic case to more complex ones, including odd-harmonics, and one multi-k order. In addition to acquainting researchers with the process of communicating commensurate magnetic structures, these examples also aim to clarify important concepts, which are used throughout the guidelines, such as the transformation to a standard setting of a magnetic space group.

We report the synthesis and structures of two transition-metal complexes involving 2-(2-hy­droxy­phen­yl)benzimidazole (2hpbi – a ligand of inter­est for its photoluminescent applications), with cobalt, namely, bis­[μ-2-(1H-1,3-benzo­diazol-2-yl)phenolato]bis­[ethanol(thio­cyanato)­cobalt(II)], [Co2(C13H9N2O)2(NCS)2(C2H6O)2], (1), and manganese, namely, bis­[μ-2-(1H-1,3-benzo­diazol-2-yl)phenolato]bis­{[2-(1H-1,3-benzo­diazol-2-yl)phenolato](thio­cyanato)­mang­an­ese(III)} dihydrate, [Mn2(C13H9N2O)4(NCS)2]·2H2O, (2). These structures are two recent examples of a fruitful collaboration between researchers at the Laboratoire de Chimie de Coordination Organique/Organic Coordination Chemistry Laboratory (LCCO), University of Dakar, Senegal and the National Crystallography Service (NCS), School of Chemistry, University Southampton, UK. This productive partnership was forged through meeting at Pan-African Conferences on Crystallography and quickly grew as the plans for the AfCA (African Crystallographic Association) developed. This article therefore also showcases this productive partnership, in celebration of the IUCr's 75 year anniversary and the recent inclusion of AfCA as a Regional Associate of the IUCr.

In addressing the challenges faced by laboratories and universities with limited (or no) cryo-electron microscopy (cryo-EM) infrastructure, the ESRF, in collaboration with the Grenoble Institute for Structural Biology (IBS), has implemented the cryo-EM Solution-to-Structure (SOS) pipeline. This inclusive process, spanning grid preparation to high-resolution data collection, covers single-particle analysis and cryo-electron tomography (cryo-ET). Accessible through a rolling access route, proposals undergo scientific merit and technical feasibility evaluations. Stringent feasibility criteria demand robust evidence of sample homogeneity. Two distinct entry points are offered: users can either submit purified protein samples for comprehensive processing or initiate the pipeline with already vitrified cryo-EM grids. The SOS pipeline integrates negative stain imaging (exclusive to protein samples) as a first quality step, followed by cryo-EM grid preparation, grid screening and preliminary data collection for single-particle analysis, or only the first two steps for cryo-ET. In both cases, if the screening steps are successfully completed, high-resolution data collection will be carried out using a Titan Krios microscope equipped with a latest-generation direct electron counting detector coupled to an energy filter. The SOS pipeline thus emerges as a comprehensive and efficient solution, further democratizing access to cryo-EM research.

X-ray Laue microdiffraction aims to characterize microstructural and mechanical fields in polycrystalline specimens at the sub-micrometre scale with a strain resolution of ∼10−4. Here, a new and unique Laue microdiffraction setup and alignment procedure is presented, allowing measurements at temperatures as high as 1500 K, with the objective to extend the technique for the study of crystalline phase transitions and associated strain-field evolution that occur at high temperatures. A method is provided to measure the real temperature encountered by the specimen, which can be critical for precise phase-transition studies, as well as a strategy to calibrate the setup geometry to account for the sample and furnace dilation using a standard α-alumina single crystal. A first application to phase transitions in a polycrystalline specimen of pure zirconia is provided as an illustrative example.