TORONTO, canada — A teenager is in critical condition in a British Columbia children's hospital, sick with Canada's first presumptive human case of avian influenza. "This was a healthy teenager prior to this, so no underlying conditions," said provincial health officer Bonnie Henry in a news conference on Tuesday. "It just reminds us that in young people this is a virus that can progress and cause quite severe illness, and the deterioration that I mentioned was quite rapid." British Columbia health officials said on Saturday the province had detected Canada's first human case of H5 bird flu in a teenager. Henry said the province is still identifying the exact strain but assumes the case is H5N1. The World Health Organization says H5N1's risk to humans is low because there is no evidence of human transmission, but the virus has been found in an increasing number of animals, including cattle in the United States. Henry would not disclose the teen's gender or age but said the patient had first developed symptoms on November 2 and was tested on November 8, when admitted to a hospital. Symptoms included conjunctivitis, fever and coughing. As of Tuesday, the teen was hospitalized with acute respiratory distress syndrome, she said. The teen had no farm exposure but had been exposed to dogs, cats and reptiles, Henry said. No infection source had been identified. "That is absolutely an ongoing investigation." More severe illness takes place when the virus binds to receptors deep in the lungs, she said. Public health officials had identified and tested about three dozen contacts and had not found anyone infected with the virus. There has been no evidence that the disease is easily spread between people. But if that were to happen, a pandemic could unfold, scientists have said. Earlier in November, the U.S. Centers for Disease Control and Prevention asked that farm workers exposed to animals with bird flu be tested for the virus even if they did not have symptoms. Bird flu has infected nearly 450 dairy farms in 15 U.S. states since March, and the CDC has identified 46 human cases of bird flu since April. In Canada, British Columbia has identified at least 26 affected premises across the province, Henry said Tuesday, and numerous wild birds have tested positive. Canada has had no cases reported in dairy cattle and no evidence of bird flu in samples of milk.

Former US president Donald Trump's cryptocurrency platform had a faltering sales launch Tuesday, with only a fraction of its digital tokens that went on the market finding a buyer.

[Lesotho Times] Damning revelations have emerged over the "corrupt" recruitment process for 3400 temporary staff at the Ministry of Local Government, Chieftainship, Home Affairs, and Police.

[Dabanga] Airstrikes killed dozens and injured others in Nyala and neighbouring Beleil in South Darfur and Mellit, El Koma, and Kabkabiya in North Darfur on Saturday and Sunday, according to a Radio Dabanga listener. Multiple political actors and groups have condemned the "random" air raids.

Government is scoping the market for potential interest in the design and construction of a new Gozo hospital, a process abandoned when the Steward Health Care concession was terminated

Israeli airstrikes on Gaza and Lebanon kill dozens of people

Afghanistan's Taliban to attend their first UN climate conference

It is ironic that when Paul begins his most thorough systematic presentation of the good news of the gospel, he starts with a statement that is decidedly bad news: “The wrath of God is revealed from heaven against all ungodliness and unrighteousness of men” (Romans 1:18).

High-security card grants access to Queen Camilla and King Charles.Queen Camilla's son, Tom Parker Bowles, has revealed that his mother is likely the "first Queen to have cooked," highlighting her impressive culinary skills. The 49-year-old son of Queen Camilla shared that while his...

Kirsten Dunst’s breakout role in Interview with the Vampire when she was just 11 years old came with an unexpected supporter: Tom Cruise. In a 2021 interview with Netflix, the Oscar-nominated actress, 42, opened up about how the Hollywood superstar seemed to be rooting for her from the...

Skai Jackson shared that her mother is the reason behind her confidence. Skai Jackson is ready to embrace and welcome motherhood.The 22-year-old has announced that she is expecting her first child with her boyfriend, whose identity hasn’t been disclosed yet.In an exclusive interview...

Queen Camilla makes first statement after missing key royal eventQueen Camilla marked her comeback to royal duties after she was forced to miss an important event on the royal calendar on doctor’s advice.A week after palace had cancelled her scheduled engagements, Camilla on Tuesday attended...

Wall Street firms are expected to pay heftier bonuses for this year, the first increase since a bumper year in 2021, according to a report by compensation consultancy Johnson Associates. Payouts will probably rise after financiers benefited from several factors in recent months: a recovery in dealmaking, the Federal Reserve cutting interest rates and equity […]

Foreign Minister Constantinos Kombos met his Azeri counterpart on the sidelines of COP29, the first such contact from the state. Kombos had a bilateral meeting with Azeri Foreign Minister Jeyhun Bayramov, in Baku, Government Spokesman Konstantinos Letymbiotis posted on X. Letymbiotis said the two ministers had discussed issues of mutual interest in a frank exchange […]

to write the first sentence of a research paper

The first generation of stars changed the course of cosmic history. Now, thanks to the James Webb Space Telescope, we have a real chance of spotting them

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

A well in Nebraska is the first in the world to have been drilled in search of naturally occurring geologic hydrogen, but tests to determine how much of the gas it might supply are on hold because of a broken pump

In Iceland, scientists are planning to drill two boreholes to a reservoir of liquid rock. One will give us our first direct measurements of magma – the other could supercharge geothermal power

Long feted by fossil hunters and geologists, if UNESCO recognises the extraordinary rock formation at Madygen in Kyrgyzstan, it will soon be a player on the world stage

This year’s average global temperature is almost certain to exceed 1.5°C above pre-industrial times – a milestone that should spur urgent action, say climate scientists

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Korolevo, a site in Ukraine where early humans made stone tools, has been dated to 1.4 million years ago, suggesting early humans moved from Ukraine into the rest of Europe

The use of cocaine only took off in Europe during the 19th century, after the drug was chemically isolated from coca leaves, but new evidence suggests much earlier use

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

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Background:

Nested within a growing body of evidence of a gender pay gap in medicine are more alarming recent findings from family medicine: a gender pay gap of 16% can be detected at a very early career stage. This article explores qualitative evidence of women’s experiences negotiating for their first job out of residency to ascertain women’s engagement with and approach to the negotiation process.

Purpose Dental professionals are exposed to hazardous noise levels on a daily basis in clinical practice. The purpose of this study was to compare the hearing status of dental hygienists who utilize ultrasonic scalers in the workplace compared to age-matched control participants (non-dental hygienists) who were not exposed to ultrasonic noise.Methods A convenience sample of nineteen dental hygienists (experimental) and nineteen non-dental hygienists (control) was recruited for this study. A matched pairs design was utilized; participants in each group were matched based on age and gender to eliminate confounding variables. The testing procedure consisted of an audiologist performing a series of auditory tests including otoacoustic emissions test, pure-tone audiometry, and tympanometry on the experimental and control groups.Results In the right ear, there were notable differences from 1000 Hz – 10,000 Hz and in the left ear from 6000 Hz – 10,000 Hz, with higher hearing thresholds in the experimental group of dental hygienists. While 56% of the univariate tests conducted on how many days were worked per week showed statistical significance, the regression line slope indicated those that worked more days had better hearing statuses. The variables for years in practice for dental hygienists, how many of those years were full-time employment, and how many years the dental hygienist had used an ultrasonic scaling device, also had many significant univariate tests for the experimental group only. These variables were more likely to serve as proxies representing true noise exposure. The paired t-test between the groups demonstrated statistically significant differences between the experimental and control group at 9000 Hz in both ears.Conclusion While results from this study demonstrated various qualitative differences in hearing status of the control group (non-dental hygienists) and experimental group (dental hygienists), age was found to be the most critical variable. Furthermore, this data demonstrated differences in hearing status based on various frequencies between dental hygienists and age-matched controls that should be further explored with a larger population.

During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions. We found here that knockout of YY1 at the pro-B-cell stage eliminates B lineage commitment. YY1 knockout pro-B cells can generate T lineage cells in vitro using the OP9-DL4 feeder system and in vivo after injection into sublethally irradiated Rag1^–/– mice. These T lineage-like cells lose their B lineage transcript profile and gain a T-cell lineage profile. Single-cell RNA-seq experiments showed that as YY1 knockout pro-B cells transition into T lineage cells in vitro, various cell clusters adopt transcript profiles representing a multiplicity of hematopoietic lineages, indicating unusual lineage plasticity. In addition, YY1 KO pro-B cells in vivo can give rise to other hematopoietic lineages in vivo. Evaluation of RNA-seq, scRNA-seq, ChIP-seq, and scATAC-seq data indicates that YY1 controls numerous chromatin-modifying proteins leading to increased accessibility of alternative lineage genes in YY1 knockout pro-B cells. Given the ubiquitous nature of YY1 and its dual activation and repression functions, YY1 may regulate commitment in multiple cell lineages.

Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.

ABSTRACTToxicological emergencies present a significant health challenge in Nepal. Despite the high burden, the country has inadequate formal toxicology training, medical toxicology expertise, and adequate poison control infrastructure. In recognition of this need, the Nepal Poison Information Center (PIC) was established as a collaborative effort involving local and international partners. Through a comprehensive partnership framework, the Nepal PIC provides 24 hours a day, 7 days a week expert guidance to health care workers, conducts educational webinars, and engages in research. Initial data from the pilot phase indicate successful consultation delivery. Challenges include bureaucratic hurdles and the need for sustainable funding. Despite these challenges, the Nepal PIC demonstrates early feasibility and potential for expansion into a comprehensive toxicology center, contributing to the advancement of clinical toxicology in Nepal. Long-term sustainability relies on governmental support and continued advocacy efforts.