Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population pharmacokinetic meta-analysis was conducted using individual participant data from 10 studies with 6,100 lumefantrine concentrations from 793 nonpregnant adult participants (41% HIV-malaria-coinfected, 36% malaria-infected, 20% HIV-infected, and 3% healthy volunteers). Lumefantrine exposure increased 3.4-fold with coadministration of lopinavir-ritonavir-based antiretroviral therapy (ART), while it decreased by 47% with efavirenz-based ART and by 59% in the patients with rifampin-based antituberculosis treatment. Nevirapine- or dolutegravir-based ART and malaria or HIV infection were not associated with significant effects. Monte Carlo simulations showed that those on concomitant efavirenz or rifampin have 49% and 80% probability of day 7 concentrations <200 ng/ml, respectively, a threshold associated with an increased risk of treatment failure. The risk of achieving subtherapeutic concentrations increases with larger body weight. An extended 5-day and 6-day artemether-lumefantrine regimen is predicted to overcome these drug-drug interactions with efavirenz and rifampin, respectively.

Monoubiquitinated FANCI and FANCD2 constitute the ID complex, which forms a sliding clamp on DNA.

Microsoft has announced many new titles coming to Xbox Game Pass for console and Windows PC in May. The list of games includes DayZ, Final Fantasy IX, and Fractured Minds, Endless Legend and the previously announced Red Dead Redemption 2 for console and Halo 2: Anniversary for Halo: The Master Chief Collection for PC.

Here is the list of games coming soon to Xbox Game Pass for Console:

DayZ (ID@Xbox) – May 7
An unforgiving, authentic, open world game where each one of 60 players on a server follows a single goal: Survive as long as they can, by any means necessary. There are no superficial tips, waypoints, or help given to you. Every decision matters with no saves and no extra lives where mistakes can be lethal. Your choices and decisions will create a gameplay experience that’s completely unique.

Red Dead Redemption 2 – May 7
America, 1899. Arthur Morgan and the Van der Linde gang are outlaws on the run. With federal agents and the best bounty hunters in the nation massing on their heels, the gang must rob, steal, and fight their way across the rugged heartland of America to survive. As deepening internal divisions threaten to tear the gang apart, Arthur must make a choice between his own ideals and loyalty to the gang who raised him. Includes access to Red Dead Online (Xbox Live Gold required).

Final Fantasy IX – May 14
Zidane and the Tantalus Theater Troupe have kidnapped Princess Garnet, the heir of Alexandria. To their surprise, however, the princess herself yearned to escape the castle. Through a series of unusual circumstances, she and her personal guard, Steiner, fall in with Zidane and set out on an incredible journey in this classic entry in the heralded Final Fantasy series.

Fractured Minds (ID@Xbox) – May 19
Fractured Minds is an immersive artistic short game, exploring anxiety and mental health issues. Embark on a journey through the human psyche to experience the everyday challenges associated with these conditions.

Here is the list of games coming soon to Xbox Game Pass for PC:

Endless Legend
Jump in to this 4X strategy game as you lead one of eight unique civilizations, each with their own unique gameplay and story. Food must be grown, industries built, science and magic advanced, and wealth collected. Your planet holds a history of unexplained apocalypse, and the winter you just survived was the worst on record. You have a city, a loyal populace, and a few troops; your power and magic should be sufficient to keep them alive. But beyond that, nothing is certain… Where will you go, what will you find, and how will you react?

Final Fantasy IX
Zidane and the Tantalus Theater Troupe have a plan to kidnap Princess Garnet, the heir of Alexandria. To their surprise, the princess herself beats them to the punch and orchestrates her own escape with their unwitting help, granting her the freedom she yearned for beyond the castle walls. Through a series of unusual circumstances, she and her personal guard, Steiner, fall in with Zidane and his crew, and set out on an incredible journey in this classic Final Fantasy adventure.

Halo Master Chief Collection: Halo 2
Halo 2: Anniversary comes to PC as the next installment in Halo: The Master Chief Collection. Following the destruction of the first Halo ring, Master Chief returns to Earth to prevent the Covenant invasion, leading to a battle with long-hidden secrets that will dramatically alter the course of the Human-Covenant Conflict forever.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443405/xbox-game-pass-adds-dayz-final-fantasy-ix-and-more-in-may/

Sony has released the US PlayStation Store downloads charts for March 2020. Final Fantasy VII Remake topped the PS4 charts, Beat Saber topped the PlayStation VR charts, and Call of Duty: Warzone topped the Free-to-Play Games chart. Fortnite – The Iris Pack topped the DLC and Expansions chart.

Here is the complete list of charts:

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443430/final-fantasy-vii-remake-tops-the-us-playstation-store-downloads-in-april-2020/

Sony has released the Europe PlayStation Store downloads charts for April 2020. Grand Theft Auto V topped the PS4 charts, Blood and Truth topped the PlayStation VR charts, and Call of Duty: Warzone topped the Free-to-Play Games chart. Fortnite – The Iris Pack topped the DLC and Expansions chart.

Final Fantasy VII Remake debuted in fourth on the PS4 charts. Resident Evil 3 debuted in 10th place.

Here is the complete list of charts:

PlayStation 4

1. Grand Theft Auto V (3)
2. EA SPORTS FIFA 20 (2)
3. Call of Duty: Modern Warfare (1)
4. FINAL FANTASY VII REMAKE (New)
5. NBA 2K20 (RE)
6. Call of Duty: Modern Warfare 2 Campaign Remastered (20)
7. EA SPORTS UFC 3 (RE)
8. Minecraft (5)
9. Marvel’s Spider-Man (RE)
10. RESIDENT EVIL 3 (New)
11. MONOPOLY PLUS (RE)
12. Rocket League (11)
13. Assassin’s Creed Odyssey (10)
14. Days Gone (RE)
15. TOM CLANCY’S RAINBOW SIX | SIEGE (RE)
16. Red Dead Redemption 2 (19)
17. The Crew 2 (13)
18. Tom Clancy’s The Division 2 (RE)
19. eFootball PES 2020 (RE)
20. Need for Speed Heat (RE)

PlayStation VR

1. Blood and Truth (5)
2. Beat Saber (1)
3. Creed: Rise to Glory (9)
4. Job Simulator (2)
5. RICK AND MORTY: VIRTUAL RICK-ALITY (RE)
6. ASTRO BOT Rescue Mission (RE)
7. Until Dawn: Rush of Blood (RE)
8. BOXVR (RE)
9. Farpoint (RE)
10. SUPERHOT VR (4)

DLC

1. Fortnite – The Iris Pack (1)
2. Fortnite – Bassassin Challenge Pack (3)
3. GTA Online: Criminal Enterprise Starter Pack (5)
4. Marvel’s Spider-Man: The City That Never Sleeps – Season Pass (RE)
5. Assassin’s Creed Odyssey – Season pass (RE)
6. Fortnite: Save the World – Standard Founder’s Pack (10)
7. The Division 2 – Warlords of New York – Expansion (2)
8. Need for Speed Heat – McLaren F1 Black Market Delivery (6)
9. Modern Warfare – Atlanta FaZe Pack (New)
10. Assassin’s Creed Origins – The Hidden Ones (RE)

Free-to-Play

1. Call of Duty: Warzone (1)
2. Fortnite (2)
3. Apex Legends (3)
4. Brawlhalla (5)
5. DON’T EVEN THINK (New)
6. eFootball PES 2020 LITE (4)
7. Destiny 2 (New)
8. WORLD OF WARSHIPS: LEGENDS (7)
9. DRAGON BALL XENOVERSE 2 Lite Version (6)
10. Paladins (9)

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443431/gtav-tops-the-eu-playstation-store-downloads-in-april-2020-final-fantasy-vii-remake-debuts-in-4th/

New research finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis, but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

Half of the legendary Las Vegas magic duo died on Friday following complications from COVID-19.

At BroadwayCon, the phrase “I’ve never seen ‘Cats’” draws gasps and painted green witches are as common as colonial gear and trios of Schuyler sisters from the hit musical “Hamilton.” BroadwayCon took over part of the Javits Center in New York this past weekend with fans belting word-perfect renditions of show tunes amid a rotating […]

F1 remains hopeful that the season can start in early July with a double header at the Austrian Grand Prix, and that 15-18 of the 22 scheduled races can yet be completed. “It’s going to be very empty," Hamilton said Saturday, evoking the subdued atmosphere of pre-season testing in Spain. “For us it’s going to be like a test day, probably even worse than a test day in a sense," the Mercedes driver said.

Director Josh Trank opens up about the bitterness and resentment he felt towards comic book movies following the critical and commercial failure of his 2015 film Fantastic Four, and praises superhero filmmakers James Gunn and Zack Snyder.

The Italian is reportedly set to leave Stamford Bridge at the end of his contract..

ALEXIS SANCHEZ returns to former club Arsenal tonight - and Manchester United fans are desperate to see him celebrate if he scores at the Emirates..

Liverpool already have one song synonymous with the club but they did attempt to officially do likewise with another. The Reds tried to trademark 'Allez Allez Allez'..

Ariana Grande has reportedly been granted a restraining order against a fan who was found trespassing at her home.

America's Country Airplay chart with the couple's duet, Nobody But You, three months after its initial release.

Remember that time Mrs Carter aka Beyonce aka the reigning...

The post The Beyonce Effect: OnlyFans Sees Massive Traffic Surge After Diva Drops Name appeared first on Man's World India.

There were fans in the stands for baseball in Taiwan on Friday, albeit spaced far apart as a safeguard against the spread of the coronavirus.

George Fant spent most of his college days at Western Kentucky shooting basketballs and grabbing rebounds as a physical power forward with big-time hoop dreams.

There were fans in the stands for baseball in Taiwan on Friday, albeit spaced far apart as a safeguard against the spread of the coronavirus.

Researchers have used a microbiome 'fingerprint' method to report that an individualized mosaic of microbial strains is transmitted to the infant gut microbiome from a mother giving birth through vaginal delivery. They detailed this transmission by analyzing existing metagenomic databases of fecal samples from mother-infant pairs, as well as analyzing mouse dam and pup transmission in a germ-free, or gnotobiotic, mouse model, where the dams were inoculated with human fecal microbes.

The following is a brief roundup of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

War veteran Captain Tom Moore, who has raised £28 million for the NHS by walking lengths of his garden, has been given a Pride of Britain award.

The 89-year-old naturalist and broadcaster is brimming with enthusiasm for his latest TV series, Great Barrier Reef, and the wonder of filming underwater in a submarine. The first of three shows starts on BBC1 on 30 December

The first time I visited the Great Barrier Reef was in 1957 when I was on my way to New Guinea. In those days, television didn’t have a lot of money so, when you got to the other side of the world, you took advantage of it as you never knew when you were going to get back again, and so I took in the Barrier Reef on the way.

It was right at the beginning of the era of underwater swimming. There had been a Viennese pair, Han and Lotte Hass, who had a show underwater called Diving to Adventure. Those of us who had television sets – our jaws dropped! This wonderful girl in this white costume just knocking sharks on the head with the camera. Amazing!

The following is a brief roundup of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus. A new antibody test is highly accurate at determining whether people have been infected with the novel coronavirus, according to a study published on Friday in The Journal of Clinical Microbiology. Researchers at the University of Washington School of Medicine found the test, manufactured by Abbott Laboratories, had a specificity rate of 99.9% and a sensitivity rate of 100%, suggesting little chance of incorrectly diagnosing a healthy person as having been infected and virtually no chance of a false negative readout.

It's a bumper crop of BonusCash at your local Rite-Aid this week, with not 1, 2, 3, but 4 gaming GC's, and 1 of those gives you even more options!

• Nike, GameStop, Netflix ... $5 BonusCash when you buy $25 of these items.*
• Google Play, AMC Theatres, Apple AppStore/iTunes, Fandango, XBOX, Panera Bread, Regal Theatres ... $6 BonusCash when you buy $30 of these items.*

FYI, "GameStop" is a big win, because not only can you purchase (additional) XBOX, PSN, Nintendo, and Steam credit there, but you order the GC credit from their website, and get a redemption code instantly after checkout.
 
For those who are new to the "Rite-Aid wellness+ reward BonusCash" program, you'll receive the $$$ amount when you purchase the minimum amount specified. Gift-cards within the same bullet-point share the same "limit 2 offers per customer", but you can earn rewards on the other bullet-point lines as well. For example, you can purchase $25 each of GameStop & Netflix (or $50 of GameStop) ... and still be able to purchase another $60 mix of Google & Apple & XBOX, and can stagger your 4 GC purchases throughout the week.

Screenshot of 2 separate GC offers (bullet points) included here:

• if you've met the limit of 2 items per BonusCash group with the current transaction, or
• if the transaction you're about to complete exceeds the limit of 2 per week, or
• when your BonusCash rewards will expire.

Luckily the mobile RiteAid app (and website) list your individual accumulation & cashing out on a per transaction basis, so that's a good way to keep tabs on the expiration dates, since you only get 30 days to spend the BonusCash once earned. Good luck!