In the span of a few days, Canada's curling landscape has shifted dramatically. The country's past women's and men's Olympic teams and last year's women's world champion team have all split.

The Passover season leads to a young Israeli woman asking about the Passover Lamb.

God uses a new believer in North Africa to release legal paperwork for the first missions training centre in the district.

Balboa, Panama :: Crewmembers teach sewing skills to young mothers from a local tribe and donate sewing machines to the community.

STYLE AND SUBSTANCE

HOLIDAYS may be temporarily on hold, but planning magical trips is still possible. Spontaneity shapes thrilling travel escapades, but there's also a case for careful, methodical planning. Often, the preparation – deciding on a route, reading up about a destination – can be just as enjoyable as the trip itself.

Northshore School District teachers, parents, and students practiced remote learning in advance of the district's closure for two weeks.

Over two years, 27 communities have split from their home districts, and the new districts are mostly wealthier, whiter, and more property-rich than the ones left behind.

Rep. Luke Messer, R-Ind., has introduced legislation to allow money in 529 savings plans to be used for home-schooling expenses, a proposal that was stripped out of a late version of the recent tax-code overhaul.

The effects of an ongoing measles outbreak centered in Washington state have spread well beyond the patients who’ve contracted the virus, creating logistical challenges for schools and public health officials.

Pertussis is a poorly controlled vaccine-preventable disease. Verifying outbreaks is challenging owing to nonspecific clinical presentations and imperfect diagnostic tests. Exclusive reliance on highly sensitive polymerase chain reaction has been associated with pseudo-outbreaks.

Contamination of specimens with vaccine derived Bordetella pertussis DNA from pediatric clinic surfaces likely resulted in misdiagnoses. Standard practices, liquid transport medium, and lack of polymerase chain reaction cutoffs for discerning weakly positive (contaminant) DNA are contributory, but modifiable factors. (Read the full article)

Mumps outbreaks continue to occur among unvaccinated and highly vaccinated populations. In highly vaccinated populations, options for outbreak control are limited. No previous study has documented the impact of a third measles-mumps-rubella (MMR) vaccine dose on a mumps outbreak.

Our study assessed the use of a third MMR vaccine dose for mumps outbreak control in a setting with preexisting high 2-dose vaccine coverage. The findings suggest a potential role of MMR vaccine for outbreak control in such limited settings. (Read the full article)

Although amphibians are known Salmonella carriers, aquatic African dwarf frogs are specifically marketed toward children, who are especially vulnerable to Salmonella infections. Both direct animal contact and indirect contact with animal habitats can lead to human Salmonella infections.

This is the first reported outbreak of human Salmonella infections associated with African dwarf frogs, particularly among young children. Parents should be aware of the risk of Salmonella infections from both direct and indirect animal contact. Pediatricians should regularly inquire about animal contact and advise families about risks. (Read the full article)

Coxsackievirus A6 (CVA6) was identified as an important cause of "severe" hand, foot, and mouth disease (HFMD) during the 2011–2012 outbreak in North America. The atypical cutaneous features in this outbreak have not been well documented.

The cutaneous manifestations of CVA6-associated HFMD may be more extensive and variable than classic HFMD. Four distinct morphologies characterize this exanthem: (1) widespread vesiculobullous and erosive lesions, (2) "eczema coxsackium," (3) an eruption similar to Gianotti-Crosti, and (4) purpuric lesions. (Read the full article)

Outbreaks of serogroup B meningococcal disease occur at universities and other organizations. Until October 2014, options for control of serogroup B outbreaks were limited by the absence of a licensed vaccine for serogroup B meningococcal disease in the United States.

We describe a serogroup B outbreak at a university in 2013 and the campaign with investigational serogroup B vaccine held in response. This was the first use of a serogroup B vaccine as an outbreak response in the United States. (Read the full article)

Stevens-Johnson syndrome (SJS) is a rare and severe immunologic phenomenon characterized by rash and mucous membrane disease. SJS may be triggered by medications and, less commonly, by infections such as Mycoplasma pneumoniae (Mp). Outbreaks of SJS are exceedingly rare.

We describe the largest SJS outbreak reported in children, which was also Mp-associated. In the first case-control study of this disease, we identify predictors of Mp-associated SJS versus non–Mp-associated SJS, including fewer skin lesions, pneumonia, and elevated erythrocyte sedimentation rate. (Read the full article)

A studio course for architecture and landscape architecture students in the Stuckeman School prepares students for the collaborative design process they will take part in once they begin careers in their respective fields by blurring the boundaries between the disciplines in the college setting.

Background. CLSI and EUCAST susceptibility breakpoints for voriconazole and C. albicans differ by one dilution (≤0.125 and ≤0.06 mg/l, respectively) whereas the epidemiological cutoff values (ECOFF/ECV) with both methodologies are the same (0.03 mg/L). We therefore determined the pharmacokinetic-pharmacodynamic (PK/PD) breakpoints of voriconazole against C. albicans for both methodologies with an in vitro PK/PD model, which was validated using existing animal PK/PD data.

Methods. Four clinical wild-type and non-wild-type C. albicans isolates (voriconazole MICs 0.008-0.125 mg/l) were tested in an in vitro PK/PD model. For validation purposes, mouse PK were simulated and in vitro PD were compared with in vivo outcome. Human PK were simulated and the exposure-effect relationship fAUC_0-24/MIC was described for EUCAST and CLSI24/48h methods. PK/PD breakpoints were determined using the fAUC_0-24/MIC associated with half-maximal activity (EI₅₀) and Monte Carlo simulation analysis.

Results. The in vitro 24h-PD EI₅₀ of voriconazole against C. albicans were 2.5-5 (1.5-17) fAUC/MIC. However, the 72h-PD were higher, 133 (51-347) fAUC/MIC for EUCAST and 94 (35-252) fAUC/MIC for CLSI. The mean (95% confidence interval) probability of target attainment (PTA) was 100(95-100)%, 97(72-100)%, 83(35-99)%, and 49(8-91)% and 100(97-100)%, 99(85-100)%, 91(52-100)% and 68(17-96)% for EUCAST and CLSI MICs 0.03, 0.06, 0.125, and 0.25 mg/L, respectively. Significantly, >95% PTAs were found for EUCAST/CLSI MICs ≤0.03 mg/ll. For MICs 0.06-0.125 mg/l trough levels 1-4 mg/ll would be required.

Conclusion. A PK/PD breakpoint of C. albicans voriconazole at the ECOFF/ECV of 0.03 mg/L was determined for both EUCAST/CLSI methods, indicating the need for breakpoint harmonization for the reference methodologies.

What separates transformative teachers, schools, and districts from those stuck in the routines of the past? The country's best blended teachers have uncovered these commonalities.

It might sound counterintuitive, but making services harder to use might be the key to making the internet safer and more private.

The WireGuard protocol is intended to be the future of VPNs, promising better speeds and security. We tested NordVPN's implementation, and WireGuard appears set to deliver on its promises.

As students begin gearing up for their spring break travels, the University is reminding travelers to take precautions to stay healthy and avoid illnesses.

'With no incentive to innovate or invest, these conglomerates charge sky-high internet prices to reap profits from consumers,' the Democratic Presidential candidate said in unveiling his 'high-speed internet access for all plan' on Friday.

More than 100 third-placed teams have advanced from group stages in UEFA and FIFA international tournaments over the years, but Portugal have become the first to actually win the trophy.

The impact the Coronavirus outbreak has had on children and young people is to be explored by Holyrood’s Education and Skills Committee as it announces its work in response to the current public health crisis.

The Scottish Parliament’s Justice Committee is backing Scottish Government plans to change the law on deciding parent-child contact in family breakdown cases.

The Alumni Spotlight is a monthly feature in Bridges, highlighting College of Education alumni who are making a difference in the lives of the people around them. This edition features Rob Longwell-Grice, who draws upon personal experience to help students who are also the first in their families to pursue a college degree.

Adil Aouchiche scored a record nine goals in the U17 finals so far: all the facts and figures since 2001/02.

One girl’s dream comes true, as she is now able to go to a village primary school, started by OM.

मल्टीव्हिटॅमीन, आरोग्यवर्धक पेयांचे वाटप

दोन दिवसांत तब्बल १०३ रुग्णांची नोंद

Delaware Governor Jack Markell, Senator Chris Coons and Newark Mayor Polly Sierer were among the officials who joined representatives from Ingerman today to break ground on Alder Creek, Delaware’s newest affordable housing community. Other attendees included State Representative Paul Baumbach, DSHA Director Anas Ben Addi, HUD Regional Administrator Jane Vincent, Newark Housing Authority Executive Director Marene Jordan, Ingerman Development Principal David Holden and Capital One Vice President Thomas Houlihan.

Fans applied for an unprecedented 19.3 million tickets for UEFA EURO 2020 before the 12 July deadline.

A worker uses previous experience with homeless ministry to reach out in Central Asia and introduce his church to people they could serve.

The third Saturday of every month OM Chile organises a free breakfast, during which team members present missions initiatives in Chile and worldwide.

A new study finds one intervention cut early absenteeism by 15 percent by correcting common parent misconceptions about attendance.

A record nine million people visited Delaware in 2016, marking increases in visitors, dollars spent in Delaware and an even greater impact on the state’s economy. Those visitors contributed $3.3 billion to Delaware’s gross domestic product in 2016, according to data released today from the Delaware Tourism Office. “Tourism is a crucial part of Delaware’s […]

The Bombay toasty is a special sandwich sold on the streets of Bombay which is made with lots of fresh vegetables, mint chutney and butter.

China will reform its disease prevention and control system to address weaknesses exposed by the coronavirus outbreak, a senior health official said on Saturday.

As the government says India has been able to prevent community transmission of the coronavirus, there are concerns about at least three different clusters of cases in Delhi, in which the primary...

The coronavirus outbreak exposed "shortcomings" in China's public healthcare system, a top health official admitted Saturday, saying that reforms are underway to improve the country's disease...

Flaminio Squazzoni, J. Gareth Polhill, Bruce Edmonds, Petra Ahrweiler, Patrycja Antosz, Geeske Scholz, Émile Chappin, Melania Borit, Harko Verhagen, Francesca Giardini and Nigel Gilbert: The COVID-19 pandemic is causing a dramatic loss of lives worldwide, challenging the sustainability of our health care systems, threatening economic meltdown, and putting pressure on the mental health of individuals (due to social distancing and lock-down measures). The pandemic is also posing severe challenges to the scientific community, with scholars under pressure to respond to policymakers’ demands for advice despite the absence of adequate, trusted data. Understanding the pandemic requires fine-grained data representing specific local conditions and the social reactions of individuals. While experts have built simulation models to estimate disease trajectories that may be enough to guide decision-makers to formulate policy measures to limit the epidemic, they do not cover the full behavioural and social complexity of societies under pandemic crisis. Modelling that has such a large potential impact upon people’s lives is a great responsibility. This paper calls on the scientific community to improve the transparency, access, and rigour of their models. It also calls on stakeholders to improve the rapidity with which data from trusted sources are released to the community (in a fully responsible manner). Responding to the pandemic is a stress test of our collaborative capacity and the social/economic value of research.

The Delaware Division of Public Health (DPH) is investigating a mumps outbreak among attendees of a February Hispanic dance festival in New Castle County. Officials have confirmed three cases of the mumps, all involving attendees of a social dance (Baile Mejicano or Mexican Dance) that took place at the Chase Center on the Riverfront in Wilmington on Feb.10, 2018. DPH is recommending that anyone who attended the dance, contact their primary care physician to determine if they may have contracted mumps and if they and their family or close contacts need to receive vaccination against mumps.

The Delaware Division of Public Health (DPH) is advising Delawareans of a multistate outbreak of E. coli infections linked to chopped romaine lettuce from the Yuma, Arizona, growing region. The lettuce could be contaminated with Shiga toxin-producing Escherichia coli O157:H7 and could make people sick. To date, there have been no confirmed cases reported in Delaware, but DPH urges consumers to take precautions to prevent illness.

NEW CASTLE (July 23, 2018) – A USDA-funded program designed to help food benefits recipients in Delaware increase their earning power and decrease their dependence on state benefits is expanding its services to eligible participants. Delaware WONDER (Work Opportunity Networks to Develop Employment Readiness), a program administered by the Delaware Department of Health and Social […]

The Division of Public Health (DPH) is investigating an outbreak of pertussis, commonly known as whooping cough, in Kent County. Whooping cough is a highly contagious disease transmitted by coughing or sneezing, or coming in direct contact with respiratory secretions of infected persons. The most common symptom is uncontrollable coughing spells often followed by a characteristic “whoop” sound. The disease can cause severe illness in infants and young children.

The Delaware Division of Public Health (DPH) is advising Delawareans of a multistate outbreak of Listeria infections linked to deli ham. Several companies have recalled ham products that could be contaminated with Listeria monocytogenes bacteria and could make people sick.