Huemen, HARMAN’s in-house design agency, brings home 25 iF World Design Awards

Stamford, CT – 12 March, 2020 – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, and its Huemen design team have received 25 iF Design...

Google’s claims of quantum supremacy have some people worried that the internet is now broken. Here's what the development actually means for cybersecurity

A chemical bond between two metal atoms has been filmed breaking and forming for the first time – something scientists say they only dreamed of seeing

A communications network secured by the laws of quantum physics would be unhackable, but building one requires a component called a quantum memory, which is still being developed

Jason Statham’s new film The Meg looks gloriously silly and good luck to it, but it got us thinking about what its giant prehistoric shark was really like and why it died out

EU states should guarantee vouchers for travel cancelled during the coronavirus pandemic and start lifting internal border restrictions in a bid to salvage some of the summer tourism season, the bloc's executive will say next week.

The number of deaths from the coronavirus in Mexico's best-known border city, Tijuana, has soared and the COVID-19 mortality rate is twice the national average, the health ministry says, after medical staff quickly fell ill as the outbreak rampaged through hospital wards.

Music has always been an important part of human culture, dating all the way back to ancient civilizations. Archeologists have unearthed harps in Egypt and primitive trumpets in Rome, as well as Grecian vases and tablets illustrating the presence of...

U.S. deaths from the novel coronavirus topped 60,000 on Wednesday and the outbreak will soon be deadlier than any flu season since 1967, according to a Reuters tally.

Paris and the Netherlands are lending their respective parts of Air France-KLM up to 11 bln euros. The tricky bailout exposes the frailty of the 2004 merger. Ed Cropley reveals how other operators, including Germany’s Lufthansa and Britain’s IAG, could fly into similar problems.

The coronavirus has helped make Big Tech too big to fail. Before the pandemic, political pressure in D.C. and Brussels was mounting on Silicon Valley giants like Facebook. Gina Chon explains how their size has been an asset in a crisis, which will mute arguments to break them up.

North Korea’s portly dictator has dropped out of sight. Concern is rampant: Is he sick with coronavirus? In a coma? Dead? Whatever his condition, Pete Sweeney discusses the country’s succession problem and its implications for the region.

Goldman Sachs shareholders gave lukewarm approval for CEO David Solomon’s $27.5 mln package. It’s similar to what his peers get, and most of it doesn’t come for at least a year. Still, in a time of economic crisis, eight-digit rewards attract extra scrutiny, John Foley suggests.

Shares in Europe’s top banks have plunged as investors fret about a surge in bad debts. Yet most lenders’ capital buffers can absorb a spike three times as bad as the 2009 average. As Liam Proud explains, that makes taxpayer bailouts and widespread equity hikes unlikely.

U.S. billionaire John Malone may merge his Virgin Media broadband outfit with mobile operator O2. A joint venture could see Spain’s Telefonica, O2’s indebted parent, pocketing over 4 billion pounds. Ed Cropley explains how this might mean a lonelier future for rival Vodafone.

Could President Trump refuse to pay back the $1.1 trln the U.S. owes to China? While markets would hate the idea, it’s theoretically possible thanks to broad powers designed for times of emergency. John Foley explains how this dangerous weapon could be used if push came to shove.

Kingsoft Cloud will debut on Nasdaq, testing appetite for Chinese shares a month after the Luckin Coffee scandal. Data demand is booming in China amid Covid-19, and Kingsoft is a strong rival to market leader Alibaba. Robyn Mak explains why New York might like this listing.

U.S. cable firms are in for pain even after the pandemic starts to fade. Sports rights to air football games and other matchups are expected to soar and so will monthly bills. Jennifer Saba explains why non-sports lovers will choose Netflix and Disney+ and ditch their cable.

Like diseases in the past, the pandemic will change intimacy patterns. Covid-19 will make it harder for lovers to swipe right on platforms like $22 bln Match Group’s Tinder with peace of mind. But more engagement, if fewer hookups, may benefit the model, argues Dasha Afanasieva.

* Tourism, travel, hospitality business hit the hardest by COVID

U.S. cable firms are in for pain even after the pandemic starts to fade. Sports rights to air football games and other matchups are expected to soar and so will monthly bills. Jennifer Saba explains why non-sports lovers will choose Netflix and Disney+ and ditch their cable.

Title: Ear Infections: 'Breakthrough' Ear Tube Surgery Tula Approved
Category: Health News
Created: 11/26/2019 12:00:00 AM
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Title: Big Breakfast May Be the Most Slimming Meal of the Day
Category: Health News
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Title: TV Breakups: When a Show Ends, Fans May 'Mourn'
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Since December, when cases of a then-unknown respiratory disease were first reported in Wuhan, China, APHA has working to share information and ensure that public health has the resources it needs to address COVID-19.

During meiotic prophase, concurrent transcription, recombination, and chromosome synapsis place substantial topological strain on chromosomal DNA, but the role of topoisomerases in this context remains poorly defined. Here, we analyzed the roles of topoisomerases I and II (Top1 and Top2) during meiotic prophase in Saccharomyces cerevisiae. We show that both topoisomerases accumulate primarily in promoter-containing intergenic regions of actively transcribing genes, including many meiotic double-strand break (DSB) hotspots. Despite the comparable binding patterns, top1 and top2 mutations have different effects on meiotic recombination. TOP1 disruption delays DSB induction and shortens the window of DSB accumulation by an unknown mechanism. By contrast, temperature-sensitive top2-1 mutants exhibit a marked delay in meiotic chromosome remodeling and elevated DSB signals on synapsed chromosomes. The problems in chromosome remodeling were linked to altered Top2 binding patterns rather than a loss of Top2 catalytic activity, and stemmed from a defect in recruiting the chromosome remodeler Pch2/TRIP13 to synapsed chromosomes. No chromosomal defects were observed in the absence of TOP1. Our results imply independent roles for Top1 and Top2 in modulating meiotic chromosome structure and recombination.

Kelsey L. Jones, Rahmatollah Rajabzadeh, Guncha Ishangulyyeva, Nadir Erbilgin, and Maya L. Evenden

Flight polyphenisms naturally occur as discrete or continuous traits in insects. Discrete flight polyphenisms include winged and wingless morphs, whereas continuous flight polyphenisms can take the form of short- or long-distance fliers. The mountain pine beetle (Dendroctonus ponderosae) exhibits polyphenic variation in flight distance but the consequences of this flight variation on life history strategies of beetles is unknown. This study assessed the effect of flight on two particular aspects of beetle biology: (1) an energetic trade-off between flight distance and host colonisation capacity; and (2) the relationship between flight distance and pheromone production. A 23-h flight treatment was applied to a subset of beetles using computer. After flight treatment, both flown and unflown (control) beetles were given the opportunity to colonise bolts of host trees, and beetles that entered hosts were aerated to collect pheromone. A trade-off occurred between initiation of host colonisation and percent body weight lost during flight, which indicates energy-use during flight affects host acceptance in female mountain pine beetles. Furthermore, production of the aggregation pheromone trans-verbenol by female beetles was influenced by both percent weight lost during flight and flight distance. Male production of exo-brevicomin was affected by beetle condition following flight but not by the energy used during flight. These novel results give new insight into the polyphenic flight behaviour of mountain pine beetles. Flight variation is adaptive by acting to maintain population levels through safe and risky host colonisation strategies. These findings suggest mechanisms that facilitate the extremities of the continuous flight polyphenism spectrum. These opposing mechanisms appear to maintain the high variation in flight exhibited by this species.

Klebsiella species are problematic pathogens in neonatal units and may cause outbreaks, for which the sources of transmission may be challenging to elucidate. We describe the use of whole-genome sequencing (WGS) to investigate environmental sources of transmission during an outbreak of extended-spectrum-β-lactamase (ESBL)-producing Klebsiella michiganensis colonizing neonates. Ceftriaxone-resistant Klebsiella spp. isolated from neonates (or their mothers) and the hospital environment were included. Short-read sequencing (Illumina) and long-read sequencing (MinION; Oxford Nanopore Technologies) were used to confirm species taxonomy, to identify antimicrobial resistance genes, and to determine phylogenetic relationships using single-nucleotide polymorphism profiling. A total of 21 organisms (10 patient-derived isolates and 11 environmental isolates) were sequenced. Standard laboratory methods identified the outbreak strain as an ESBL-producing Klebsiella oxytoca, but taxonomic assignment from WGS data suggested closer identity to Klebsiella michiganensis. Strains isolated from multiple detergent-dispensing bottles were either identical or closely related by single-nucleotide polymorphism comparison. Detergent bottles contaminated by K. michiganensis had been used for washing milk expression equipment. No new cases were identified once the detergent bottles were removed. Environmental reservoirs may be an important source in outbreaks of multidrug-resistant organisms. WGS, in conjunction with traditional epidemiological investigation, can be instrumental in revealing routes of transmission and guiding infection control responses.

The IR Biotyper is a new automated typing system based on Fourier-transform infrared (FT-IR) spectroscopy that gives results within 4 h. We aimed (i) to use the IR Biotyper to retrospectively analyze an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) in a neonatal intensive care unit and to compare results to BOX-PCR and whole-genome sequencing (WGS) results as the gold standard and (ii) to assess how the cutoff values used to define clusters affect the discriminatory power of the IR Biotyper. The sample consisted of 18 isolates from 14 patients. Specimens were analyzed in the IR Biotyper using the default analysis settings, and spectra were analyzed using OPUS 7.5 software. The software contains a feature that automatically proposes a cutoff value to define clusters; the cutoff value defines up to which distance the spectra are considered to be in the same cluster. Based on FT-IR, the outbreak represented 1 dominant clone, 1 secondary clone, and several unrelated clones. FT-IR results, using the cutoff value generated by the accompanying software after 4 replicates, were concordant with WGS for all but 1 isolate. BOX-PCR was underdiscriminatory compared to the other two methods. Using the cutoff value generated after 12 replicates, the results of FT-IR and WGS were completely concordant. The IR Biotyper can achieve the same typeability and discriminatory power as genome-based methods. However, to attain this high performance requires either previous, strain-dependent knowledge about the optimal technical parameters to be used or validation by a second method.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex.

At the end of 2019 and early 2020, an outbreak of pneumonia of unknown etiology emerged in the city of Wuhan in China. The cases were found to be caused by a novel beta coronavirus, which was subsequently named SARS-CoV-2 by the World Health Organization (WHO). The virus has since spread further in China and to other regions of the world, having infected more than 88 K people, and causing close to 3000 deaths as of March 1, 2020. More than 50 million people remain in quarantine at this time. Scientists and clinicians globally are working swiftly to combat COVID-19, the respiratory disease caused by the virus. Notably, diagnostic assays have been developed rapidly in many countries, and have played significant roles in diagnosis, monitoring, surveillance, and infection control. Starting February 29, 2020, the development and performance of molecular testing for SARS-CoV-2 in high complexity Clinical Laboratory Improvement Amendments (CLIA) laboratories prior to emergency use authorization was allowed by the US FDA. Although the epidemic is evolving rapidly, many valuable lessons have been learned and many questions remain to be answered. Here we invited multiple experts across the globe from clinical laboratories, public health laboratories, infection control, and diagnostic industry to share their views on the diagnosis, infection control, and public perception of SARS-CoV-2.

Plazomicin was active against 97.0% of 8,783 Enterobacterales isolates collected in the United States (2016 and 2017), and only 6 isolates carried 16S rRNA methyltransferases conferring resistance to virtually all aminoglycosides. Plazomicin (89.2% to 95.9% susceptible) displayed greater activity than amikacin (72.5% to 78.6%), gentamicin (30.4% to 45.9%), and tobramycin (7.8% to 22.4%) against carbapenem-resistant and extensively drug-resistant isolates. The discrepancies among the susceptibility rates for these agents was greater when applying breakpoints generated using the same stringent contemporary methods applied to determine plazomicin breakpoints.

Get an all day breakfast on a pizza before you go on your killing spree. Only psychopaths will order this, is what I'm saying.