1. The COVIDSafe app – What we know and questions that remain unanswered - Coronavirus (COVID-19) - Australia  Mondaq News Alerts
2. Readers respond to the COVIDSafe app's launch  Sydney Morning Herald
3. COVIDSafe app downloads shoot past five million  Sky News Australia
4. UK contact tracing app source code shared as researchers seek to solve mystery  9to5Mac
5. Lack of honesty on virus app is a problem  9News
6. View Full coverage on Google News

1. 'That's who I am': Life for the Victorians out of work  The Age
2. How some businesses have experienced a boom despite the coronavirus pandemic | ABC News  ABC News (Australia)
3. Wellbeing hit: modelling reveals huge cost of school closures  Sydney Morning Herald
4. Why the best team won't win in a year that will be mental as anything  Sydney Morning Herald
5. Shop owners in virus-free towns plead to reopen  The Age
6. View Full coverage on Google News

"Positive." "But what about the-" "Ssshhh, only dreams now."

NOT WITH THAT ATTITUDE

THAT GUY is between a rock and a hard place

YOU NOTICE THAT but you don't notice the fainting goats for sale

Did last night get away from you? You find the meaning of life in an enlightening grease-soaked bag of fries sometime around 230AM when the bars had finally closed, and your booze-blinded ass somehow made it home? Or did you fail to achieve such lofty goals, and just mindlessly empty whatever bottle was set before you? And now today you're stomaching all the fleeting bliss of last night. Well, sit back, refill that that water glass, prop your feet up, loathe life, and maybe even find yourself laughing at these funny, unintentionally ironic church signs.

You can see more comics over here.

He's still giving the money back though.

He's still giving the money back though.

He's still giving the money back though.

Dr John Wright is intrigued by some singers who became ill long before the UK's first known Covid-19 case.

In 1957 a new strain of flu emerged in East Asia and quickly spread around the world, killing a million people.

Four minutes and 28 seconds. That is how long it took a News24 reporter to find cigarettes – meant to be banned under Level 4 lockdown regulations – which were available for purchase at one of many places in South Africa.

Former captain Paul O'Connell says it will be vital for the British & Irish Lions to pick a leader capable of beating the Springboks at their own game.

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

Millie Small, the first Jamaican vocalist in popular music to make the world stop and look at Jamaica as an emerging musical powerhouse, passed away in London on May 5. She was 72 years old. Speaking to Small by telephone from her home in Shepherd’...

The discovery of an inhibitory memory circuit could lead to novel treatments for conditions such as PTSD

In order to remember, we must forget. Recent research shows that when your brain retrieves newly encoded information, it suppresses older related information so that it does not interfere with the process of recall. Now a team of European researchers has identified a neural pathway that induces forgetting by actively erasing memories. The findings could eventually lead to novel treatments for conditions such as post-traumatic stress disorder (PTSD).

We’ve known since the early 1950s that a brain structure called the hippocampus is critical for memory formation and retrieval, and subsequent work using modern techniques has revealed a great deal of information about the underlying cellular mechanisms. The hippocampus contains neural circuits that loop through three of its sub-regions – the dentate gyrus and the CA3 and CA1 areas – and it’s widely believed that memories form by the strengthening and weakening of synaptic connections within these circuits.

Related: Light switches memories on and off | Mo Costandi

Related: The Homer Simpson effect: forgetting to remember

Why did right-winger Yosemite Sam have problem with the leftist Bugs Bunny?

First, I would love to try Casu marzu and for dessert I am curious about durian. or a drink such as wormwood absinthe.

Would a vaccine for the new coronavirus wind up offering long-lasting immunity? Or will the virus prove to be a shape-shifter, mutating quickly enough that people need annual vaccines like those for seasonal strains of influenza? Researchers are probing for answers in the rush to develop a vaccine for COVID-19.

If you only owned the ground you stood on, how would you make the most out of it? A creative idea becomes a sustainable reality.

Four years after a member of OM Russia befriended her, an Uzbek lady in Novosibirsk came to faith.

Michael (Kenya) participates in a short-term mission trip to Romania and gives an account of God's transforming power at work amongst the Roma people.

The Agency is a first-of-its-kind interactive mission experience that’s set on top of OM’s newly-launched Riverboat.

War, then. Another war. Still another war begun because the last guaranteed-conclusive war produced consequences that made one more shot in the dark inevitable. Intellectual and strategic failure is on a production line.

Ian Bell, the award-winning Herald and Sunday Herald writer and columnist, died last week aged 59. Here are excerpts from 10 of his finest pieces of writing.

God touches lives through OM Czech Republic’s annual summer English camp.

Exciting times ahead as there is at least one 160cc model out there while the majority of the upcoming motorcycles are in the 200-250cc segment.

The Renault Triber is a spacious, budget 7-seater that packs in all the modern day goodies, looks good but the 1.0-litre engine could do with a bit more power.

App Annie’s latest report highlights that Zoom is the most downloaded app on iOS amongst all users. But it has also put focus on privacy and security.

There is nothing further the government can do, Kumar said, adding that there is liquidity, partial credit enhancement and interest rates have moderated. Asked about the progress made in the resolution of stressed NBFC Dewan Housing Finance (DHFL), Kumar said: “That you should ask the company.”

The lockdown has added significant impetus, however, to e-sports or online sports, which are fast becoming a mainstream activity.

Hours after Tesla CEO Elon Musk said that he would pull the car maker’s plant from the Golden State, the company sued Alameda county, accusing officials of “defying” state laws by refusing to allow the facility to reopen.
Read Full Article at RT.com

As trade tensions escalate between Washington and Beijing, India is boosting efforts to lure more than 1,000 US businesses out of China, reportedly offering to ease tax and labor laws, and allowing easier access to land.
Read Full Article at RT.com

The teams are being sent to Gujarat, Tamil Nadu, Uttar Pradesh, Delhi, Rajasthan, Madhya Pradesh, Punjab, West Bengal, Andhra Pradesh and Telangana.

The colour-zoning of India (red, orange and green) and the limited relaxations with several caveats have not helped re-start economic activity.

Sir meri girl friend ki shadi 4 saal pehle hui thi Uske 1 saal k bad hi uske husband ki death car accident me ho gayi.wo uske sasural me uske husband k bade bhai,bade bhai k 2 bachche jise usne bachpan se pala h aur uski saas k sath rehti h.husband k bade bhai ki wife ki b 3 saal pehle bimari se death ho gayi thi.ab problem ye h ki husband k bade bhai ne sare document jaise bachcho k birth certificate, aadhar card, voter id, bank pass book me meri friend ko wife dikha rakha h wo b bina kisi document pr sign kiye.unke beech me shadi b nahi hui h. marriage certificate nahi bana h bt ab agr wo chahe to ye proof kr sakta h ki meri friend uski wife h.hum kaise proof kare ki ye uski wife nahi h.kyonki use aadmi ne iske husband ki death certificate b nahi banbaya, na hi aisa koi proof choda h jisse hum proof kr sake ki ye uski wife nahi h.usne shadi k album, marriage certificate sb ko jala diya h...plz koi solution bataiye...