Keeper Tracey Barnes talks about Billie Jean, an Andean bear, and her two new cubs at the Smithsonian's National Zoo.

The post Keeper Tracey Barnes talks about the National Zoo’s Andean bear, Billie Jean, and her two new cubs appeared first on Smithsonian Insider.

The post Belize’s South Water Caye Marine Reserve protects biodiversity of Belizean Barrier Reef appeared first on Smithsonian Insider.

The post Barro Colorado Island: The Smithsonian’s research outpost in the Panama Canal appeared first on Smithsonian Insider.

Dried specimens of nearly 800 flowering plants were acquired by the Botany Department of the Smithsonian’s National Museum of Natural History from the National Botanical Research Institute in Windhoek, Namibia, Africa. The collection includes nearly 160 specimens from the Compositae, or sunflower family.

The post Namibian specimens come to the herbarium of the National Museum of Natural History appeared first on Smithsonian Insider.

Now the Global Plants Initiativeis catapulting biodiversity research to a new level by sharing these historic plant collections in a massive online database of high-resolution scans.

The post Online initiative makes massive database of herbarium specimens accessible worldwide appeared first on Smithsonian Insider.

Fulcaldea stuessyi is a newly discovered member of the Barnadesioideae, a subfamily of the Compositae, or sunflower family of flowering plants. It was found in northeastern […]

The post Fulcaldea stuessyi is newly discovered member of the Barnadesioideae, a subfamily of the Compositae, or sunflower family of flowering plants, appeared first on Smithsonian Insider.

Melinda Peters, museum specialist at the U.S. National Herbarium in the Smithsonian’s National Museum of Natural History, gives an in-depth tour of the U.S. National […]

The post Introduction to the U.S. National Herbarium appeared first on Smithsonian Insider.

Medications to Treat Opioid Addiction Are Effective and Save Lives, But Barriers Prevent Broad Access and Use, Says New Report

Medicine regulatory authorities — including the U.S. Food and Drug Administration (FDA) — should strengthen cooperation with other countries’ regulators to ensure the quality, safety, and efficacy of medicines, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The opioid epidemic in the U.S. is driving a simultaneous epidemic of infectious diseases — including HIV, hepatitis C virus (HCV) and bacterial infections, and sexually transmitted infections — but workforce shortages, stigma, and financial and policy barriers are preventing the integration of opioid use disorder (OUD) and infectious disease services, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Will‘s pick this week is progressbar by Steve Hoelzer. This is a File Exchange contribution that has been around since at least 2005. It has 76 downloads in the past 30 days and a 5 star rating... read more >>

Source: Streetwise Reports   04/22/2020

In an April 19 research note, ROTH Capital Partners analyst Yasmeen Rahimi reported that the Biomedical Advanced Research and Development Authority (BARDA) awarded Moderna Inc. (MRNA:NASDAQ) $483 million in funding, in part for development of its COVID-19 vaccine, mRNA-1273.

Rahimi discussed how Massachusetts-based Moderna will use the funds, which will be provided in tranches to reach certain milestones.

Half of the $483 million award will be used to help cover clinical development costs of mRNA-1273, from trial operations to the filing of a biologics license application.

Currently, the vaccine is in Phase 1 in the clinic. Recently, the biopharma decided to add to the study a cohort of patients aged 51 years and up, which "will be key for demonstrating mRNA-1273's safety and immunogenicity in this vulnerable population," Rahimi noted.

The analyst explained that for mRNA-1273 to advance to Phase 2, the results from Phase 1 must be optimal. The data must demonstrate the vaccine is safe and tolerable. They must show that the vaccine produced a sufficient number of neutralizing antibodies, crucial for stopping viral replication and proving the vaccine's method of action. Phase 1 safety data from the group aged 18–55 years are expected in spring followed by immunogenicity results, likely in mid-July or early August.

Rahimi relayed that as soon as safety data are available, Moderna plans to launch a Phase 2 study of mRNA-1273 rather than wait for the remaining results to become available, according to CEO Stéphane Bancel.

"Pending favorable safety data from Phase 1, we point out that a potential Phase 2 study would enroll hundreds of patients, and that the BARDA funding could potentially allow Moderna to pursue trials in patient populations who are at greater risk, such as patients who have underlying comorbidities, those who are overweight and patients with cancer," commented Rahimi.

Moderna will spend the second half of the $483 million BARDA funding on the engineering and optimization work required to scale up the manufacturing of its messenger RNA (mRNA).

"With the current focus on SARS-CoV-2 and mRNA-1273, Moderna was now able to present BARDA its strategic plans (amount, time and people) of how to be ready for commercial launch," wrote Rahimi. "This preparation was likely helpful in expediting discussions with BARDA and awarding of the grant."

Also regarding mRNA production, Ginkgo Bioworks, a company with expertise in organism biology and genetically engineering bacteria to replace certain industrial applications, is helping Moderna optimize certain parts of the process.

Rahimi, who is closely tracking COVID-19 data, highlighted that April 18 was the first day in five on which the daily death tally, 1,867, was less than that predicted by Dr. Christopher Murray's model, 2,194.

ROTH has a Buy rating on Moderna.

Disclosure:
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5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.

Disclosures from ROTH Capital Partners, Moderna Inc., Company Note, April 19, 2020

Regulation Analyst Certification ("Reg AC"): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and its or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

Within the last twelve months, ROTH has received compensation for investment banking services from Moderna, Inc.

ROTH makes a market in shares of Moderna, Inc. and as such, buys and sells from customers on a principal basis.

Within the last twelve months, ROTH has managed or co-managed a public offering for Moderna, Inc.

ROTH Capital Partners, LLC expects to receive or intends to seek compensation for investment banking or other business relationships with the covered companies mentioned in this report in the next three months.

( Companies Mentioned: MRNA:NASDAQ, )

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

Increasing energy efficiency in Europe is vital to achieving a sustainable economy and tackling climate change. However, new research has shown that lack of capital and concerns about costs of disruption are major barriers to implementing energy efficiency measures in the foundry industry.

Several barriers to upgrading existing social housing with innovative energy systems (IES) have been identified by a study of eight large-scale renovation projects in the Netherlands. These include a lack of trust between stakeholders, opposition from tenants on grounds of increased costs or delays, or poor experience with previous energy projects.

The solar energy market is hampered by multiple barriers to adoption in the EU and worldwide, according to a new review. Researchers from Sweden and Spain found that lack of government commitment as well as various sociotechnical, management and economic barriers prevent photovoltaic technologies from being more readily adopted.

Since the industrial revolution, the ocean has absorbed increased levels of carbon dioxide, leading to the ocean’s pH becoming more acidic. Effects of these pH changes on marine and estuarine biota is the focus of much research effort worldwide and the authors of this study focus on the larval habitat-choice process of a commercially important tropical marine fish species, Lates calcarifer, barramundi.

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

Two of the biggest barriers for organisations refurbishing waste electrical and electronic equipment (WEEE) for re-use are the availability of sufficient quantities of good quality used equipment and a lack of legislation that encourages or enforces re-use. These, and other barriers as well as success factors, were identified in a recent survey of re-use organisations in Africa, Latin America, North America and Europe.

Green walls, designed so they are covered in vegetation, could help cut the amount of noise that enters buildings, a new study has found. In lab. tests, researchers found that a modular green wall system reduced sound levels by 15 decibels (dB). This leads them to believe that it is a promising sound reduction device that could improve quality-of-life for city residents.

New barriers have been developed to prevent invasive American signal crayfish from moving upstream and colonising important European crayfish habitat. The barriers, designed to stop crayfish but allow fish to pass, have been found to be effective where water flow rates are sufficiently high.

If you want to mix drinks for a living, don't expect to have a typical family life.

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A reforestation project has revitalised its surroundings just 80 years after its inception. In the late 1920s, the Saldaña badlands in northern Spain were a barren region, with a thin layer of intensely weathered soil, and only 5% vegetation cover. Now that cover has increased dramatically to 87%, the soil quality is improving, and the water flow in the area has stabilised, bringing greater environmental security to the local community.

Wenz, John, author

There are adequate resources to implement the Marine Strategy Framework Directive (MSFD) in Europe, a recent study concludes. However, more clarity is needed on the roles of different institutions at EU, regional and national levels in implementing the Directive.

NPCI consecutively reported dismal figures for April 2020 for its UPI, IMPS, NETC and Bharat BillPay platforms – as AePS emerges as an outlier.

New barriers have been developed to prevent invasive American signal crayfish from moving upstream and colonising important European crayfish habitat. The barriers, designed to stop crayfish but allow fish to pass, have been found to be effective where water flow rates are sufficiently high.

Genetic identification of species through ‘metabarcoding’ offers a reliable, cost-effective way of producing biodiversity information for policymakers and managers, concludes an international study. The researchers show how the method can be used to help assess the impacts of environmental change and management on biodiversity.

Urban gardeners in Barcelona, Spain, identified 20 ecosystem service benefits, from pollination to environmental learning, in a recent study. Cultural ecosystem services — mainly related to the opportunity for residents to interact with nature — were the most common and highly valued of the ecosystem services identified.

A recent analysis highlights advances in the field of synthetic biology and efforts to develop approaches that will prevent non-natural organisms from interfering with natural organisms and ecosystems. It suggests that synthetic organisms could be developed with inbuilt ‘firewalls’ that prevent genetic interactions with other organisms.

HOBART renters are paying more per week than those in most other Australian capital cities.

An all-singing, all-dancing musical extravaganza is coming to Potters Bar next month.

The post Virtual happy hours take Barossa wines to the world appeared first on The Lead SA.

Following on from a hugely successful first year of touring, live music experience Rock For Heroes is returning next month.

The post $50 million luxury hotel planned at iconic Barossa Valley winery appeared first on The Lead SA.

Brighton and Hove Albion chief executive Paul Barber insists it is not just clubs fighting for Premier League survival who oppose the completion of the season at neutral venues.

Watford legend John Barnes has urged restraint for the return of the Premier League and said footballers should only return to work when the rest of society does.

SPRINGFIELD, Va. – Drivers along the Franconia-Springfield Parkway (Route 289) bridge over Accotink Creek now have better protection from oncoming...

President’s Cup Semi-Final

From Rebecca Martinson's rabid sorority letter to Tom Cruise's manic couch-pouncing, some mortifying moments take on a life of their own.

The ESA hopes to fly a spacecraft close to Phobos, orbit the lower Venusian atmosphere and draw up a map of Mars' hydrous areas in 2013.

Looks like the USDA forgot its 'A' stands for all agriculture and not just beef this week, and Monsanto might have more power than the federal court system. It'

An infographic makes the argument for the USDA to get involved with setting national standards for the snacks allowed to be sold in schools.