On October 2, 2019, Express.co.uk published an article headlined "Farage picks apart ‘totally dishonest' Boris speech with £1.8 trillion debt warning" that originally claimed Nigel Farage had "laid into the Prime Minister after Boris Johnson had reportedly claimed the Conservative government had ‘wiped out the national debt'" in a speech at the Conservative Party Conference."

AMANDA HOLDEN was live in the BBC studio on Thursday at The One Show with hosts Alex Jones and Gethin Jones talking about what's to come on Britain's Got Talent but also describing just why she is clapping for the NHS during the coronavirus lockdown. However, viewers were left distracted by Amanda's appearance and took to Twitter to comment.

BORIS Johnson will only unveil "limited" changes to coronavirus lockdown rules to come into effect next week, a Cabinet minister said yesterday.

In its first shot at an esports broadcast on cable TV, IndyCar produced viewership numbers in line with latest esports trends.

The governor offered a gentle rebuke to protesters: You're not helping.

Ottawa Fire says a garage three vehicles were destroyed Saturday morning after a fire broke out on Carp Road.

Pulitzer-winning editorial artists aim to find deadline satire in the televised inquiry.

During a somewhat combative episode, Megan McCain asked the president's son about the "pain" his family has caused.

You can easily connect external storage drives to iPad and iPhone, providing easy access to all the files and data on those drives via the Files app. This includes connecting flash drives, USB hard drives, SD cards, and just about any other storage medium to iPhone, iPad Pro, and iPad you can think of, as ... Read More

Technology has come a long way, and cyber protection is the most crucial factor in advancing the future of digital defense. Interestingly enough, cybersecurity was not always an issue in backup and storage; but as technology advances, so do the methods of hackers. Saying this, let’s take a walk down memory lane. The 1900s: Where […]

The post How Backup And Storage Led To Cybercrime appeared first on Dumb Little Man.

While infection rates remain steady across the region, the Simcoe Muskoka District Health Unit is reporting more than half of all 360 cases have now recovered.

Corporate Members Event Nominees Breakfast Briefing Partners and Major Corporates

Event participants

Robert Yates, Head, Centre on Global Health Security, Chatham House
Chair: Professor David R Harper, Senior Consulting Fellow, Centre on Global Health Security, Chatham House; Managing Director, Harper Public Health Consulting Limited
 

Pierre Lairez
J. Amer. Math. Soc. 33 (2019), 487-526.
Abstract, references and article information

M. Wang
Aug 1, 2012; 11:492-500
Technological Innovation and Resources

DL Brasaemle
Nov 1, 1997; 38:2249-2263
Articles

Invitation Only Research Event

Event participants

Richard King, Senior Research Fellow, Energy, Environment and Resources Department, Chatham House
Chair: Duncan Brack, Associate Fellow, Energy, Environment and Resources Department, Chatham House

29 January 2020

Policymakers are in danger of sleepwalking into ineffective carbon dioxide removal solutions in the quest to tackle climate change. This paper warns against overreliance on bioenergy with carbon capture and storage (BECCS). 

Invitation Only Research Event

Event participants

Dr Tedros Adhanom Ghebreyesus, Director-General, World Health Organization 

M. M. Kapustei and P. V. Slyusarchuk
Theor. Probability and Math. Statist. 99 (2020), 101-111.
Abstract, references and article information

The Office of the Communications Authority (OFCA) today announced the launch of the Subsidy Scheme for Encouraging Early Deployment of the fifth-generation mobile technology.

Launched under the second round of the Anti-epidemic Fund, the scheme is open for applications until November 30 on a first come, first served basis.

It encourages various sectors to deploy 5G technology early to foster innovation and smart city applications and to improve the efficiency of their operations and the quality of their services that enhance Hong Kong's competitiveness.

The scheme will subsidise 50% of the actual cost directly relevant to the deployment of 5G technology in an approved project, subject to a cap of $500,000.

About 100 qualified projects will be subsidised.

Click here for more details.

For enquiries, call 2961 6333 or send an email to the OFCA.

(U.S. Army Research Laboratory) A US Army-funded project is identifying how officials at different levels of government can work together to encourage protective behaviors to prevent the spread of COVID-19.

(NOAA Headquarters) While the global average number of tropical cyclones each year has not budged from 86 over the last four decades, climate change has been influencing the locations of where these deadly storms occur, according to new NOAA-led research published in Proceedings of the National Academy of Science.

Dorte B. Bekker-Jensen
Apr 1, 2020; 19:716-729
Technological Innovation and Resources

State-of-the-art proteomics-grade mass spectrometers can measure peptide precursors and their fragments with ppm mass accuracy at sequencing speeds of tens of peptides per second with attomolar sensitivity. Here we describe a compact and robust quadrupole-orbitrap mass spectrometer equipped with a front-end High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Interface. The performance of the Orbitrap Exploris 480 mass spectrometer is evaluated in data-dependent acquisition (DDA) and data-independent acquisition (DIA) modes in combination with FAIMS. We demonstrate that different compensation voltages (CVs) for FAIMS are optimal for DDA and DIA, respectively. Combining DIA with FAIMS using single CVs, the instrument surpasses 2500 peptides identified per minute. This enables quantification of >5000 proteins with short online LC gradients delivered by the Evosep One LC system allowing acquisition of 60 samples per day. The raw sensitivity of the instrument is evaluated by analyzing 5 ng of a HeLa digest from which >1000 proteins were reproducibly identified with 5 min LC gradients using DIA-FAIMS. To demonstrate the versatility of the instrument, we recorded an organ-wide map of proteome expression across 12 rat tissues quantified by tandem mass tags and label-free quantification using DIA with FAIMS to a depth of >10,000 proteins.

Cholesteryl ester transfer protein (CETP) exists as full-length (FL) and exon 9 (E9)-deleted isoforms. The function of E9-deleted CETP is poorly understood. Here, we investigated the role of E9-deleted CETP in regulating the secretion of FL-CETP by cells and explored its possible role in intracellular lipid metabolism. CETP overexpression in cells that naturally express CETP confirmed that E9-deleted CETP is not secreted, and showed that cellular FL- and E9-deleted CETP form an isolatable complex. Coexpression of CETP isoforms lowered cellular levels of both proteins and impaired FL-CETP secretion. These effects were due to reduced synthesis of both isoforms; however, the predominate consequence of FL- and E9-deleted CETP coexpression is impaired FL-CETP synthesis. We reported previously that reducing both CETP isoforms or overexpressing FL-CETP impairs cellular triglyceride (TG) storage. To investigate this further, E9-deleted CETP was expressed in SW872 cells that naturally synthesize CETP and in mouse 3T3-L1 cells that do not. E9-deleted CETP overexpression stimulated SW872 triglyceride synthesis and increased stored TG 2-fold. Expression of E9-deleted CETP in mouse 3T3-L1 cells produced a similar lipid phenotype. In vitro, FL-CETP promotes the transfer of TG from ER-enriched membranes to lipid droplets. E9-deleted CETP also promoted this transfer, although less effectively, and it inhibited the transfer driven by FL-CETP. We conclude that FL- and E9-deleted CETP isoforms interact to mutually decrease their intracellular levels and impair FL-CETP secretion by reducing CETP biosynthesis. E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner.

6 November 2019 , Volume 95, Number 6

Research Event

Event participants

Dr Jon Gibbins, Senior Lecturer in the Department of Mechanical Engineering, Imperial College London
Jim Footner, Senior Climate Change Campaigner, Greenpeace

As Braves manager Brian Snitker evaluates who might serve as his closer, A.J. Minter has made it clear he wants to be the guy who is consistently called upon to handle high-leverage threats that develop in late innings.

The BMJ in partnership with The Harvard Global Health Institute has launched a collection of articles exploring how to achieve effective universal health coverage (UHC). The collection highlights the importance of quality in UHC, potential finance models, how best to incentivise stakeholders, and some of the barriers to true UHC. One of those...

Shane Rea
Nov 1, 1997; 46:1667-1677
Perspectives in Diabetes

Reduced storage of dietary fatty acids (DFAs) in abdominal adipose tissues with enhanced cardiac partitioning has been shown in subjects with type 2 diabetes (T2D) and prediabetes. We measured DFA metabolism and organ partitioning using positron emission tomography with oral and intravenous long-chain fatty acid and glucose tracers during a standard liquid meal in 12 obese subjects with T2D before and 8–12 days after bariatric surgery (sleeve gastrectomy or sleeve gastrectomy and biliopancreatic diversion with duodenal switch). Bariatric surgery reduced cardiac DFA uptake from a median (standard uptake value [SUV]) 1.75 (interquartile range 1.39–2.57) before to 1.09 (1.04–1.53) after surgery (P = 0.01) and systemic DFA spillover from 56.7 mmol before to 24.7 mmol over 6 h after meal intake after surgery (P = 0.01), with a significant increase in intra-abdominal adipose tissue DFA uptake from 0.15 (0.04–0.31] before to 0.49 (0.20–0.59) SUV after surgery (P = 0.008). Hepatic insulin resistance was significantly reduced in close association with increased DFA storage in intra-abdominal adipose tissues (r = –0.79, P = 0.05) and reduced DFA spillover (r = 0.76, P = 0.01). We conclude that bariatric surgery in subjects with T2D rapidly reduces cardiac DFA partitioning and hepatic insulin resistance at least in part through increased intra-abdominal DFA storage and reduced spillover.

Invitation Only Research Event

Event participants

Richard King, Senior Research Fellow, Energy, Environment and Resources Department, Chatham House
Chair: Duncan Brack, Associate Fellow, Energy, Environment and Resources Department, Chatham House

29 January 2020

Policymakers are in danger of sleepwalking into ineffective carbon dioxide removal solutions in the quest to tackle climate change. This paper warns against overreliance on bioenergy with carbon capture and storage (BECCS). 

Animal rescuers in Britain said a fox was rescued from the narrow gap between the external walls of a house and its garage.

Roy W. Beck
Aug 1, 2017; 40:994-999
Perspectives in Care

U.S. retail fuel prices will drop this year and in 2020 from 2018, but in both cases higher than January levels due to mandated lower sulfur in marine fuel.

Here’s my Q&A column from the WSJ this week — and if you have any questions for me, you can tweet them to @danariely with the hashtag #askariely, post a comment on my Ask Ariely Facebook page, or email them to AskAriely@wsj.com. ___________________________________________________ Hi Dan, I have a hard time watching...

Among psychologists who study sports, there is a code word for parents who lose their temper standing on the sidelines of their children's soccer, baseball and football games: THOSE parents -- Tempestuous, Harried, Overwrought, Self-absorbed and Emotional.

When nearly 200 people in India were killed in terrorist attacks late last month, the carnage received saturation media coverage around the globe. When nearly 600 people in Zimbabwe died in a cholera outbreak a week ago, the international response was far more muted.

A recent MPI study reveals that 48 percent of recent immigrants to the United States were college graduates, a sharp increase over earlier periods. How can the United States better leverage this brain gain? This commentary outlines some policies that could allow the United States to more fully utilize the professional and academic credentials that highly skilled immigrants have, for their benefit and that of the U.S. economy.