ios BET+ And Tyler Perry Studios Set Launch Date For 'BRUH' By feeds.bet.com Published On :: Tue, 28 Apr 2020 09:48:00 EDT Perry’s second original series for BET+ Full Article Celebrity News BRUH
ios Background Post and Media Uploading with WordPress for iOS 9.8 By wordpress.com Published On :: Mon, 23 Apr 2018 17:00:54 +0000 Upload images and media in the background with WordPress for iOS 9.8 Full Article Applications Editing Features Photos WordPress for iOS
ios Existing and Emerging Highway Infrastructure Preservation, Maintenance, and Renewal Definitions, Practices, and Scenarios By www.trb.org Published On :: Thu, 23 Apr 2020 13:45:15 GMT The National Cooperative Highway Research Program's NCHRP Web-Only Document 272: Existing and Emerging Highway Infrastructure Preservation, Maintenance, and Renewal Definitions, Practices, and Scenarios provides appendices to NCHRP Report 750, Volume 7: Preservation, Maintenance, andRenewal of Highway Infrastructure . Full Article
ios Amazon Studios Greenlights Season Two of "Upload" from the Emmy Award-Winning Creator Greg Daniels By www.thefutoncritic.com Published On :: Fri, 08 May 2020 10:04:00 GMT Season two will exclusively stream on Amazon Prime Video in more than 200 countries and territories worldwide. Full Article
ios If it feels like the software world is held together by string and a prayer, we don't blame you: Facebook SDK snafu breaks top iOS apps By go.theregister.co.uk Published On :: Fri, 08 May 2020 00:13:07 GMT Update used wrong data type, causing Tinder to Spotify to fall over A change in the Facebook SDK backend managed to crash many popular iOS apps that integrated the code library, used for implementing various Facebook services.… Full Article
ios Вышла iOS 13.5 beta 4 для разработчиков. Что нового By www.iphones.ru Published On :: Wed, 06 May 2020 17:11:25 +0000 Время обновляться. Full Article Новости iOS 13 прошивка
ios It’s not all about muscle: fibroadipogenic progenitors contribute to facioscapulohumeral muscular dystrophy By www.jci.org Published On :: Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat. Full Article
ios Пользователи жалуются на проблемы с iOS 13.2 By www.maccentre.ru Published On :: Fri, 01 Nov 2019 10:33:00 +0300 Вскоре после выхода iOS 13.2 и iPasOS 13.2 пользователи стали замечать, что системы добавили устройствам от компании Apple автономности. Однако очень скоро выяснилось, на какие неприятные шаги пошел п... Full Article
ios M-Industry Transforms Its Mobile Workforce with IBM MobileFirst for iOS By www.ibm.com Published On :: Thu, 07 Sep 2017 12:03:48 GMT IBM today announced that M-Industry, one of the world’s largest private label consumer goods company and subsidiary of Switzerland’s largest retailer and supermarket chain, Migros Group, has launched a new IBM designed mobile offering to transform how product promoters work. Full Article Services and solutions
ios IBM lanza la primera plataforma cognitiva de servicios para transformar las operaciones de negocios By www.ibm.com Published On :: mié, 12 jul 2017 02:19:24 GMT IBM anunció hoy la primera plataforma de servicios basada en IBM Watson y construida en IBM Cloud para aumentar la inteligencia humana y ayudar a mejorar las operaciones de los proveedores de servicios a través de tecnologías cognitivas. Full Article Global Technology Services
ios IBM presenta nuevo servicio de nube que da a los negocios la flexibilidad que requiere su transformación By www.ibm.com Published On :: mié, 08 nov 2017 07:57:08 GMT IBM anuncia el lanzamiento de IBM Cloud Private, una plataforma de software creada para los clientes que requieren la flexibilidad y capacidad de una nube pública en un ambiente privado. IBM Cloud Private transforma los sistemas de TI (Tecnologías de la Información) en un ambiente de nube flexible para crear un puente hasta las nubes públicas y acelerar el desarrollo de aplicativos. Full Article Cloud Computing
ios Apple e IBM lanzan la primera ola de apps para iOS By www.ibm.com Published On :: mié, 10 dic 2014 03:40:51 GMT Apple e IBM lanzaron hoy la primera ola de soluciones IBM MobileFirst para iOS, una nueva clase de apps creadas para los negocios y con soporte para servicios de Cloud, que llevan las capacidades Big Data y Analítica de IBM a los usuarios de iPhone e iPad en las empresas. Full Article Mobile
ios IBM es designada en el reporte MarketScape de IDC como líder mundial en Servicios de Desarrollo de Aplicaciones Móviles y de Consultoría de Pruebas By www.ibm.com Published On :: mar, 07 abr 2015 02:51:27 GMT IBM anunció que fue designada como líder en el prestigiado modelo de evaluación de proveedores “IDC MarketScape: Worldwide Mobile Application Development and Testing Services 2014 Vendor Assessment”. Full Article Mobile
ios Papel San Francisco garantiza la continuidad de operaciones aprovechando Servicios de IBM By www.ibm.com Published On :: vie, 04 jul 2014 08:20:05 GMT Papel San Francisco garantiza la continuidad de operaciones aprovechando Servicios de IBM Full Article Consumer Products
ios Crown apoyará su expansión en México con Servicios de TI y Nube híbrida de IBM By www.ibm.com Published On :: mié, 15 jul 2015 03:34:55 GMT IBM y Crown Holdings, Inc., proveedor global líder en productos de empaques metálicos, anunciaron hoy la firma de un contrato de varios años que incluye servicios de TI y servicios administrados corriendo en la robusta plataforma de cómputo en la nube de clase empresarial de IBM. Full Article Services and solutions
ios Ecodex incrementa servicios de certificación tributaria para empresas con soluciones inteligentes de IBM By www.ibm.com Published On :: jue, 04 dic 2014 04:35:50 GMT La empresa se afianza como líder de Proveedores Autorizados de Certificación (PAC) y logra procesar grandes volúmenes de transacciones de manera sencilla Full Article Software
ios Dona IBM servicios de consultoría a organizaciones mexicanas para proyectos de impacto social By www.ibm.com Published On :: lun, 20 feb 2017 07:59:19 GMT Con la finalidad de apoyar el desarrollo de proyectos de alto impacto en la Ciudad de México, la Asociación Mexiana de Ayuda a Niños con Cáncer (AMANC), Fondo Unido México, Fundación Carlos Slim, el Patronato del Museo Nacional de Antropología e IBM, ponen en marcha el día de hoy el programa de consultoría Corporate Service Corps (CSC), en su edición Ciudad de México. Full Article Corporate
ios Organizaciones beneficiadas e IBM, comparten resultados de servicios de consultoría en proyectos de impacto social By www.ibm.com Published On :: mar, 21 mar 2017 05:07:43 GMT Después de un mes de haber iniciado la consultoria pro-bono de IBM denominada Corporate Service Corps (CSC), el día de hoy se hizo la entrega del resumen ejecutivo de cada uno de los proyectos de las organizaciones receptoras de este apoyo: Asociación Mexiana de Ayuda a Niños con Cáncer (AMANC), Fondo Unido México, Fundación Carlos Slim, el Patronato del Museo Nacional de Antropología. Full Article Corporate
ios Dona IBM Servicios de Consultoría a Organizaciones Queretanas para Proyectos de Impacto Social By www.ibm.com Published On :: mar, 03 oct 2017 08:50:58 GMT IBM, Peace Corps y cuatro instituciones locales dieron inicio el día de hoy al programa de consultoría Corporate Service Corps (CSC), en su edición Cd. de Querétaro; con la finalidad de apoyar el desarrollo de proyectos de alto impacto en esta localidad. IBM y Peace Corps (PC) trabajarán en conjunto con la Secretaría de Desarrollo Social del Estado de Querétaro, el Instituto Queretano de las Mujeres, el Municipio de Querétaro - Delegación Santa Rosa Jáuregui, y la Universidad Politécnica de Santa Rosa Jáuregui (UPSRJ). Full Article Corporate
ios Premian Banorte e IBM apps de estudiantes del Tec de Monterrey que transforman servicios bancarios dirigidos a los jóvenes By www.ibm.com Published On :: mar, 29 sep 2015 04:33:08 GMT Tres proyectos que proponen mejorar la interacción y la experiencia de los jóvenes usuarios con servicios bancarios móviles, fueron reconocidos hoy por Banorte, IBM y el Tec de Monterrey como resultado del Reto Banorte en el marco de la Semana i, que la institución educativa llevó a cabo del 21 al 25 de septiembre en todo el país. Full Article Analytics
ios Apple et IBM annoncent plus de 100 apps MobileFirst pour iOS ! By www.ibm.com Published On :: mer., 16 déc. 2015 04:38:17 GMT Apple et IBM annoncent plus de 100 apps MobileFirst pour iOS ! Full Article Mobile
ios Таск-менеджер Wrike для iOS: отличный помощник в экспресс-работе над задачами By feedproxy.google.com Published On :: Thu, 12 Apr 2018 20:20:00 +0300 Проблема работы на ходу знакома и менеджерам, и исполнителям. Ведь дедлайн страшен любому специалисту и приходит всегда внезапно. Для тех, у кого смартфон под рукой 24/7 (то есть для всех) разработчики известного онлайн-менеджера задач Wrike создали мобильное приложение для iOS и Android. В этом обзоре речь пойдет о продукте для гаджетов Apple. С марта 2018 он «заговорил» на русском языке. Full Article
ios Let Other Studios Race to VOD; Sony Pictures Classics Believes It’s Theaters or Nothing By feedproxy.google.com Published On :: Fri, 27 Mar 2020 19:13:28 +0000 Full Article Film Cinemark Sony Pictures Classics The Burnt Orange Heresy Theaters
ios Studios Would Win in a War Against Theaters, but Isn’t There a Less Painful Victory? By feedproxy.google.com Published On :: Tue, 05 May 2020 16:39:02 +0000 Full Article Film Box Office Coronavirus Hollywood Studios Theaters
ios PM Studios "Stay Safe" Sale - Featuring Switch/PS4, and Limited Run Games. By feedproxy.google.com Published On :: Thu, 23 Apr 2020 21:06:29 +0000 PM Studios online store is back and they made a new sale featuring new reprints, overall deals and restock on rare out-of-print titles from Limited Run Games. https://twitter.com/PMStudiosUSA/status/1253401043414781959 Also all orders over $49.99 will get Cytus Alpha Limited Edition Original Soundtrack CD for free with the Coupon "FREEGIFT". Kinda sick move they did now. https://www.pm-studios.com/store Edit: Price list. Reprints/Pre-Orders: Horizon Chase Turbo (Switch) - $29.99 Ministry of Broadcast (Steelbook Edition) (Switch) - $39.99 Deals: Deemo (Switch) $39.99 - $19.99 Opus Collection (Switch) $39.99 - 19.99 Horizon Chase Turbo (First Print - PS4) $29.99 - $14.99 Hover (Switch) - $29.99 - $24.99 WILL: A Wonderful World Limited Edition (Plush, 120 page Artbook, etc) : $79.99 $69.99 WILL: A Wonderful World - Artbook: $29.99 - $24.99 Limited Run Games products: Mercenaries Series Double Pack (PAX Exclusive): $69.99 Mercenaries Wings Limited Edition (PS4 - LRG) : $59.99 Mercenaries Wings Limited Edition (Switch - LRG): $59.99 Musynx First Print (Vita - LRG): $29.99 Deemo: The Last Recital (Vita - LRG): $29.99 --> Full Article
ios PrideStudios: Jack Andy and Riley Mitchel By feeds.queerclick.com Published On :: Sat, 09 May 2020 04:06:54 +0000 After finding out about their co-worker’s secret on-the-job fuck spot, Riley Mitchel and Jack Andy sneak away the first chance they can get to check it out for themselves. They agree it’s a perfect spot where no one else would think to look for them, and not wanting to be outdone by their co-worker, they... View Article The post PrideStudios: Jack Andy and Riley Mitchel appeared first on QueerClick. Full Article Porn Site Updates Jack Andy PrideStudios Riley Mitchel
ios NextDoorStudios: Dean Hughes By feeds.queerclick.com Published On :: Sat, 09 May 2020 04:16:12 +0000 Mmm take a look. Sexy Dean Hughes is oh so fine to look at. But we all know that casting is about more than looks, so let’s find out. Does Dean have what it takes to blow your load? What do you think, does he pass or fail? See more at NextDoorStudios. The post NextDoorStudios: Dean Hughes appeared first on QueerClick. Full Article Porn Site Updates Dean Hughes NextDoorStudios
ios La EPA y los CDC publican guía para limpiar y desinfectar espacios donde viven, trabajan y juegan los estadounidenses By www.epa.gov Published On :: Wed, 29 Apr 2020 00:00:00 -0400 WASHINGTON (29 de abril de 2020) — Hoy, la Agencia de Protección Ambiental (EPA, por sus siglas en inglés) y los Centros para el Control y la Prevención de Enfermedades (CDC) publicaron una Full Article
ios Trinitarios takedown nabs seven reputed high-ranking gang-bangers By www.nydailynews.com Published On :: Tue, 14 Jan 2020 21:40:47 +0000 The defendants were linked in a 15-page Manhattan court filing with a cornucopia of crimes committed between 2010-19, from murder to robbery, wire fraud to kidnapping, and drug dealing to identity theft. Full Article
ios Judson Studios, oldest family-run stained-glass maker in the U.S., weathers the storm By www.latimes.com Published On :: Fri, 1 May 2020 09:00:48 -0400 Coronavirus stay-at-home orders shut down Judson Studios for the first time in 123 years, just as a new book celebrates its storied stained glass. Full Article
ios Review: The cowboys of Compton, first a curiosity and then a legacy By www.latimes.com Published On :: Tue, 28 Apr 2020 11:00:08 -0400 Walter Thompson-Hernández's "The Compton Cowboys: The New Generation of Cowboys in America's Urban Heartland" tells a grand story in granular detail. Full Article
ios Battered by coronavirus, L.A.'s legendary recording studios prep for a post-shutdown 'resurgence' By www.latimes.com Published On :: Mon, 4 May 2020 06:00:32 -0400 Stars from the Doors to Prince recorded at Sunset Sound. Now, the studio is closed for the first time in 60 years, joining hundreds of others shuttered across L.A. Full Article
ios What's on TV Monday: 'Breeders' on FX; coronavirus; Axios By www.latimes.com Published On :: Sun, 26 Apr 2020 20:00:37 -0400 What's on TV Monday, April 27: Season finale of 'Breeders' on FX; coronavirus; Axios returns; Movies on TV; TV Talk Shows; 'Dispatches From Elsewhere' season finale Full Article
ios Australian Open contingency scenarios revealed amid Rafael Nadal fears for 2020 season By feedproxy.google.com Published On :: Fri, 08 May 2020 11:30:00 +0100 Rafael Nadal expressed his worry this week that there may not be any more tennis in 2020 due to the coronavirus pandemic. Full Article
ios IU President McRobbie gives 5 scenarios for fall 2020 semester By rssfeeds.indystar.com Published On :: Thu, 30 Apr 2020 20:46:20 +0000 While a return to full, in-person classes is unlikely, IU President Michael McRobbie outlined five possibilities for the fall semester. Full Article
ios O culto religioso que levou o coronavírus a cidade de MS By www.bbc.com Published On :: Thu, 07 May 2020 21:57:50 GMT Cerimônia religiosa com mais de 30 pessoas foi organizada para receber dupla vinda de Osasco (SP); dias depois, os dois testaram positivo para covid-19. Full Article
ios Coronavírus: estudo com coquetel de remédios tem bons resultados contra a covid-19, mostra The Lancet By www.bbc.com Published On :: Fri, 08 May 2020 22:30:23 GMT Em estudo clínico randomizado controlado, pessoas que receberam as substâncias interferon beta 1-b, lopinavir-ritonavir e ribavirin tiveram tempo menor para alta e desaparecimento do vírus, na comparação com o grupo controle. Full Article
ios Beta 3 of iOS 13.5, iPadOS 13.5, MacOS Catalina 10.15.5 Released for Testing By feedproxy.google.com Published On :: Thu, 30 Apr 2020 02:18:32 +0000 Apple has released the third beta versions of iOS 13.5, iPadOS 13.5, and MacOS Catalina 10.15.5. Separately, watchOS 6.2.5 beta 3 and tvOS 13.4.5 beta 3 are also available for testing. The third beta versions of iOS 13.5 and iPadOS 13.5 are actually reversioned from iOS 13.4.5 and iPadOS 13.4.5, so if you were testing ... Read More Full Article News beta iOS iOS 13.4.5 iOS 13.5 iPadOS ipados 13.4.5 ipadOS 13.5 macOS 10.15.5 macOS Catalina 10.15.5 tvOS 13.4.5 watchOS 6.2.5
ios Beta 4 of iOS 13.5 & iPadOS 13.5 Released for Testing By feedproxy.google.com Published On :: Thu, 07 May 2020 05:26:23 +0000 Apple has released the fourth beta versions of iOS 13.5 and ipadOS 13.5. Additionally, Apple also released the fourth beta builds for watchOS 6.2.5 and tvOS 13.4.5. As of writing, macOS Catalina 10.5.5 beta 4 is not yet available for testing, but presumably will arrive soon as well. iOS 13.5 beta 4 and ipadOS 13.5 ... Read More Full Article News beta iOS 13.5 ipadOS 13.5 tvOS 13.4.5 watchOS 6.2.5
ios strataconf: A roundup of healthcare tools used in the field from #hdpalooza http://t.co/0d2x3OlaeC including @MedCPU @SVBiosystems @CHRankings & more By twitter.com Published On :: Sun, 09 Jun 2013 15:11:18 +0000 strataconf: A roundup of healthcare tools used in the field from #hdpalooza http://t.co/0d2x3OlaeC including @MedCPU @SVBiosystems @CHRankings & more Full Article
ios Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase [Metabolism] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications. Full Article
ios NAD+ biosynthesis in bacteria is controlled by global carbon/nitrogen levels via PII signaling [Microbiology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 NAD+ is a central metabolite participating in core metabolic redox reactions. The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+. Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln. Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. Here, using affinity chromatography, bioinformatics analyses, NAD synthetase activity, and biolayer interferometry assays, we show that PII and NadEGln physically interact in vitro, that this complex relieves NadEGln negative feedback inhibition by NAD+. This mechanism is conserved in distantly related bacteria. Of note, the PII protein allosteric effector and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII-NadEGln complex within a physiological range. These results indicate an interplay between the levels of ATP, ADP, 2-OG, PII-sensed glutamine, and NAD+, representing a metabolic hub that may balance the levels of core nitrogen and carbon metabolites. Our findings support the notion that PII proteins act as a dissociable regulatory subunit of NadEGln, thereby enabling the control of NAD+ biosynthesis according to the nutritional status of the bacterial cell. Full Article
ios Sir David Attenborough and the BBC Studios Natural History Unit awarded Chatham House Prize 2019 for ocean advocacy By feedproxy.google.com Published On :: Mon, 18 Nov 2019 13:13:54 +0000 19 November 2019 The 2019 Chatham House Prize is awarded to Sir David Attenborough and Julian Hector, head of BBC Studios Natural History Unit, for the galvanizing impact of the Blue Planet II series on tackling ocean plastic pollution. 2019-06-06-DavidAttenboroughB.jpg The Chatham House Prize is awarded to the person, persons or organization who is deemed to have made the most significant contribution to the improvement of international relations in the previous year. The presentation ceremony and panel discussion with the winners will be livestreamed on Wednesday.The Blue Planet II series highlighted the damage caused by discarded plastics to the world’s oceans and marine wildlife. It is estimated that there are more than 150 million tonnes of plastic in the world’s oceans; resulting in the deaths of 1 million birds and 100,000 sea mammals each year. Dr Robin Niblett, director of Chatham House said: ‘Plastic pollution is one of the gravest challenges facing the world’s oceans, and undoubtedly an international issue. Sir David and the BBC Studios Natural History Unit played an instrumental role in helping to put this issue at the forefront of the public agenda. Blue Planet II spurred a passionate global response and generated clear behavioural and policy change.’This year the G20 agreed on an international framework to address marine plastic litter, acknowledging the increasing urgency of the issue and the need for an international solution. This follows action from the UK government, including a plan to ban common plastic items and investment in global research.See full award citationRead more about Chatham House's research work in this areaOther nomineesDr Niblett thanked Chatham House members for voting and acknowledged the outstanding achievements of the 2019 nominees:Abiy Ahmed, prime minister of Ethiopia, nominated for his efforts to transform civic leadership and promote plural politics, free speech and peace in Ethiopia Katrín Jakobsdóttir, prime minister of Iceland, nominated for her commitment to gender equality and women’s financial inclusion in Iceland EventThe Prize was presented to Sir David and Julian Hector by Her Majesty The Queen at Chatham House on Wednesday 20 November.Watch video from the eventFor more information please contactChatham House Press Officepressoffice@chathamhouse.org+44 (0)207 957 5739BBC Studios Natural History Unit Communications ManagerLynn.li@bbc.co.uk+44 (0) 7513 137893About the Chatham House PrizeThe Chatham House Prize is voted for by Chatham House members, following nominations from the institute’s staff. The award is presented on behalf of the institute's patron, Her Majesty the Queen, representing the non-partisan and authoritative character of the Prize.The Chatham House Prize was launched in 2005. Previous recipients of the Prize include the Committee to Protect Journalists, Colombian president Juan Manuel Santos, president of Ghana John Kufuor, Médecins Sans Frontières and Melinda Gates, co-founder of the Bill and Melinda Gates Foundation.Chatham House is a world-leading policy institute based in London. Our mission is to help governments and societies build a sustainably secure, prosperous and just world. We engage governments, the private sector, civil society and our members in open debate and private discussions about the most significant developments in international affairs. Our research and policy ideas involve rigorous analysis of critical global, regional and country-specific challenges and opportunities.About BBC Studios Natural History Unit BBC Studios Natural History Unit produces the world’s most iconic natural history programmes, such as Blue Planet II and Planet Earth II, which have been watched by more than a billion people globally. Ranging from technically challenging live shows and super-landmarks to long-running series and children’s content, The Natural History Unit programmes include Dynasties, Blue Planet Live, Springwatch, Animal Babies: First Year On Earth, Andy’s Dinosaur Adventures as well as the currently on air Seven Worlds, One Planet presented by Sir David Attenborough and third-party commissions for Discovery, Apple, Quibi, National Geographic and BBC America. The Natural History Unit is part of BBC Studios, a subsidiary of the BBC, which develops, produces and distributes bold, British content, making over 2,500 hours of content each year, operating in 22 markets globally and generating revenue of around £1.4bn. In the year to March 2019, it returned £243m to the BBC Group, complementing the BBC’s licence fee and enhancing programmes for UK audiences. Related pages Managing Natural Resources Energy, Environment and Resources Programme Full Article
ios Biosecurity: Preparing for the Aftermath of Global Health Crises By feedproxy.google.com Published On :: Thu, 09 Jan 2020 14:16:59 +0000 9 January 2020 Professor David R Harper CBE Senior Consulting Fellow, Global Health Programme @DavidRossHarper Benjamin Wakefield Research Associate, Global Health Programme @BCWakefield LinkedIn The Ebola outbreak in the Democratic Republic of the Congo is a reminder that the security of samples taken during global health emergencies is a vital part of safeguarding biosecurity. 2020-01-09-DRC.jpg A nurse prepares a vaccine against Ebola in Goma in August 2019. Photo: Getty Images. The world’s second-largest Ebola outbreak is ongoing in the Democratic Republic of the Congo (DRC) and experts from around the world have been parachuted in to support the country’s operation to stamp out the outbreak. The signs are encouraging, but we need to remain cautious.In such emergencies, little thought is usually given to what happens to the body-fluid samples taken during the course of the outbreak after the crisis is over. What gets left behind has considerable implications for global biosecurity.Having unsecured samples poses the obvious risk of accidental exposures to people who might come into contact with them, but what of the risk of malicious use? Bioterrorists would have ready access to materials that have the characteristics essential to their purpose: the potential to cause disease that is transmissible from person to person, the capacity to result in high fatality rates and, importantly, the ability to cause panic and social disruption at the very mention of them.Comparisons can be drawn with the significant international impact of the anthrax attacks in the US in 2001. Not only was there a direct effect in the US with five deaths and a further 17 people infected, but there was a paralysis of public health systems in other countries involved in the testing of countless samples from the so-called ‘white-powder incidents’ that followed.Many laboratory tests were done purely on a precautionary basis to eliminate any possibility of a risk, no matter how remote. However, the UK was also hit when a hoaxer sent envelopes of white powder labelled as anthrax to 15 MPs.The threat of the pathogen alone resulted in widespread fear, the deployment of officers trained in response to chemical, biological, radiological and nuclear incidents and the evacuation of a hospital emergency department.We learned from the 2014–16 West Africa Ebola outbreaks that during the emergency, the future biosecurity implications of the many thousands of samples taken from people were given very little consideration. It is impossible to be sure where they all are and whether they have been secured.It is widely recognized that the systems needed at the time for tracking and monitoring resources, including those necessary for samples, were weak or absent, and this has to be addressed urgently along with other capacity-building initiatives.In Sierra Leone, for example, the remaining biosecurity risk is only being addressed after the fact. To help achieve this, the government of Canada is in the process of providing a secure biobank in the Sierra Leonean capital of Freetown. The aim is to provide the proper means of storage for these hazardous samples and to allow them to remain in-country, with Sierra Leonean ownership.However, it is already more three years since the emergency was declared over by the then director-general of the World Health Organization (WHO), Margaret Chan, and the biobank and its associated laboratory are yet to be fully operational.There are many understandable reasons for this delay, including the critical issue of how best to ensure the sustainability of any new facility. But what is clear is that these solutions take time to implement and must be planned for in advance.The difficulties of responding to an outbreak in a conflict zone have been well documented, and the frequent violence in DRC has undoubtedly caused delays in controlling the outbreak. According to figures from WHO, during 2019 approximately 390 attacks on health facilities in DRC killed 11 and injured 83 healthcare workers and patients.Not only does the conflict inhibit the response, but it could also increase the risk posed by unsecured samples. There are two main potential concerns.First is the risk of accidental release during an attack on a health facility, under which circumstances sample containers may be compromised or destroyed. Second is that the samples may be stolen for malicious use or to sell them to a third-party for malicious use. It is very important in all outbreaks to ensure the necessary measures are in place to secure samples; in conflict-affected areas, this is particularly challenging.The sooner the samples in the DRC are secured, the sooner this risk to global biosecurity is reduced. And preparations for the next emergency must be made without further delay.The following steps need to be taken:Affected countries must ‘own’ the problem, with clear national government commitment to take the required actions.Funding partners must coordinate their actions and work closely with the countries to find the best solutions.If samples are to be kept in-country, secure biobanks must be established to contain them.Sustainable infrastructure must be built for samples to be kept secure into the future.An international agreement should be reached on the best approach to take to prepare for the aftermath of global health emergencies. Full Article
ios NAD+ biosynthesis in bacteria is controlled by global carbon/nitrogen levels via PII signaling [Microbiology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 NAD+ is a central metabolite participating in core metabolic redox reactions. The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+. Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln. Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. Here, using affinity chromatography, bioinformatics analyses, NAD synthetase activity, and biolayer interferometry assays, we show that PII and NadEGln physically interact in vitro, that this complex relieves NadEGln negative feedback inhibition by NAD+. This mechanism is conserved in distantly related bacteria. Of note, the PII protein allosteric effector and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII-NadEGln complex within a physiological range. These results indicate an interplay between the levels of ATP, ADP, 2-OG, PII-sensed glutamine, and NAD+, representing a metabolic hub that may balance the levels of core nitrogen and carbon metabolites. Our findings support the notion that PII proteins act as a dissociable regulatory subunit of NadEGln, thereby enabling the control of NAD+ biosynthesis according to the nutritional status of the bacterial cell. Full Article
ios A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis [Enzymology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Allostery exploits the conformational dynamics of enzymes by triggering a shift in population ensembles toward functionally distinct conformational or dynamic states. Allostery extensively regulates the activities of key enzymes within biosynthetic pathways to meet metabolic demand for their end products. Here, we have examined a critical enzyme, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS), at the gateway to aromatic amino acid biosynthesis in Mycobacterium tuberculosis, which shows extremely complex dynamic allostery: three distinct aromatic amino acids jointly communicate occupancy to the active site via subtle changes in dynamics, enabling exquisite fine-tuning of delivery of these essential metabolites. Furthermore, this allosteric mechanism is co-opted by pathway branchpoint enzyme chorismate mutase upon complex formation. In this study, using statistical coupling analysis, site-directed mutagenesis, isothermal calorimetry, small-angle X-ray scattering, and X-ray crystallography analyses, we have pinpointed a critical node within the complex dynamic communication network responsible for this sophisticated allosteric machinery. Through a facile Gly to Pro substitution, we have altered backbone dynamics, completely severing the allosteric signal yet remarkably, generating a nonallosteric enzyme that retains full catalytic activity. We also identified a second residue of prime importance to the inter-enzyme communication with chorismate mutase. Our results reveal that highly complex dynamic allostery is surprisingly vulnerable and provide further insights into the intimate link between catalysis and allostery. Full Article
ios Thematic Review Series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis By feedproxy.google.com Published On :: 2008-11-01 Chi-Liang Eric YenNov 1, 2008; 49:2283-2301Thematic Reviews Full Article
ios Negative Emissions and Managing Climate Risks Scenarios By feedproxy.google.com Published On :: Thu, 31 Oct 2019 18:15:01 +0000 Research Event 4 July 2019 - 1:30pm to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE This half-day strategic workshop, organized by Chatham House and E3G, brought together key climate experts, policymakers and influential actors, especially in Europe, for a focused and facilitated discussion on the roles, risks and potentials of negative emissions technologies (NETs). An interactive scenario exercise will be conducted, drawing on a climate simulation tool developed by Climate Interactive, to consider the potential roles and risks of different NETs deployments to meet the Paris Agreement targets and to consider the international co-operation required to manage the pathway to net-zero emissions. Participants will explore the political opportunities, discuss different scenarios and risks and identify areas of interventions and collective action.The meeting is part of a series of events being held at Chatham House as part of London Climate Action Week (LCAW). Department/project Energy, Environment and Resources Programme, Bioenergy, Carbon Capture and Storage (BECCS) Full Article
ios Biosecurity: Preparing for the Aftermath of Global Health Crises By feedproxy.google.com Published On :: Thu, 09 Jan 2020 14:16:59 +0000 9 January 2020 Professor David R Harper CBE Senior Consulting Fellow, Global Health Programme @DavidRossHarper Benjamin Wakefield Research Associate, Global Health Programme @BCWakefield LinkedIn The Ebola outbreak in the Democratic Republic of the Congo is a reminder that the security of samples taken during global health emergencies is a vital part of safeguarding biosecurity. 2020-01-09-DRC.jpg A nurse prepares a vaccine against Ebola in Goma in August 2019. Photo: Getty Images. The world’s second-largest Ebola outbreak is ongoing in the Democratic Republic of the Congo (DRC) and experts from around the world have been parachuted in to support the country’s operation to stamp out the outbreak. The signs are encouraging, but we need to remain cautious.In such emergencies, little thought is usually given to what happens to the body-fluid samples taken during the course of the outbreak after the crisis is over. What gets left behind has considerable implications for global biosecurity.Having unsecured samples poses the obvious risk of accidental exposures to people who might come into contact with them, but what of the risk of malicious use? Bioterrorists would have ready access to materials that have the characteristics essential to their purpose: the potential to cause disease that is transmissible from person to person, the capacity to result in high fatality rates and, importantly, the ability to cause panic and social disruption at the very mention of them.Comparisons can be drawn with the significant international impact of the anthrax attacks in the US in 2001. Not only was there a direct effect in the US with five deaths and a further 17 people infected, but there was a paralysis of public health systems in other countries involved in the testing of countless samples from the so-called ‘white-powder incidents’ that followed.Many laboratory tests were done purely on a precautionary basis to eliminate any possibility of a risk, no matter how remote. However, the UK was also hit when a hoaxer sent envelopes of white powder labelled as anthrax to 15 MPs.The threat of the pathogen alone resulted in widespread fear, the deployment of officers trained in response to chemical, biological, radiological and nuclear incidents and the evacuation of a hospital emergency department.We learned from the 2014–16 West Africa Ebola outbreaks that during the emergency, the future biosecurity implications of the many thousands of samples taken from people were given very little consideration. It is impossible to be sure where they all are and whether they have been secured.It is widely recognized that the systems needed at the time for tracking and monitoring resources, including those necessary for samples, were weak or absent, and this has to be addressed urgently along with other capacity-building initiatives.In Sierra Leone, for example, the remaining biosecurity risk is only being addressed after the fact. To help achieve this, the government of Canada is in the process of providing a secure biobank in the Sierra Leonean capital of Freetown. The aim is to provide the proper means of storage for these hazardous samples and to allow them to remain in-country, with Sierra Leonean ownership.However, it is already more three years since the emergency was declared over by the then director-general of the World Health Organization (WHO), Margaret Chan, and the biobank and its associated laboratory are yet to be fully operational.There are many understandable reasons for this delay, including the critical issue of how best to ensure the sustainability of any new facility. But what is clear is that these solutions take time to implement and must be planned for in advance.The difficulties of responding to an outbreak in a conflict zone have been well documented, and the frequent violence in DRC has undoubtedly caused delays in controlling the outbreak. According to figures from WHO, during 2019 approximately 390 attacks on health facilities in DRC killed 11 and injured 83 healthcare workers and patients.Not only does the conflict inhibit the response, but it could also increase the risk posed by unsecured samples. There are two main potential concerns.First is the risk of accidental release during an attack on a health facility, under which circumstances sample containers may be compromised or destroyed. Second is that the samples may be stolen for malicious use or to sell them to a third-party for malicious use. It is very important in all outbreaks to ensure the necessary measures are in place to secure samples; in conflict-affected areas, this is particularly challenging.The sooner the samples in the DRC are secured, the sooner this risk to global biosecurity is reduced. And preparations for the next emergency must be made without further delay.The following steps need to be taken:Affected countries must ‘own’ the problem, with clear national government commitment to take the required actions.Funding partners must coordinate their actions and work closely with the countries to find the best solutions.If samples are to be kept in-country, secure biobanks must be established to contain them.Sustainable infrastructure must be built for samples to be kept secure into the future.An international agreement should be reached on the best approach to take to prepare for the aftermath of global health emergencies. Full Article
ios New Publication: Rules, Procedures and Mechanisms Applicable to Processes under the Cartagena Protocol on Biosafety. By www.cbd.int Published On :: Mon, 16 Jun 2008 00:00:00 GMT New Publication: Rules, Procedures and Mechanisms Applicable to Processes under the Cartagena Protocol on Biosafety. Full Article