An attorney dedicated to upholding religious freedom stated that he is “greatly disturbed” to see what Michigan has become, warning of a “growing hostility” in the state toward the exercise of religion in the public square. 

Javanese Gamelan-New and Traditional: An afternoon of Javanese Gamelan featuring a variety of works for traditional gamelan instruments.Midiyanto, director

Marianne Williamson has written six New York Times best sellers, including The Age Of Miracles and A Return To Love. Known in some circles as Hollywood's favorite self-help guru, we just had to find out what the process for a spiritual author entails. Learn more about your ad choices. Visit podcastchoices.com/adchoices

On December 20 in Sofia, Bulgaria held a charity concert for financial assistance of Eleonora-piano teacher suffered from severe physical abuse with many operational quantity treatments for which she did not have enough money.  The concert was held at the Russian Cultural and Information Centre in Sofia and the main organizer and performer of the works of the piano was Pavlin Stanchev, the author of this site and all of it displayed in musical products.

Queen Elizabeth II died peacefully in Scotland on September 8. The crown passed to her son, Prince Charles, who took the throne name Charles III. His name is translated into Russian as Karl III, which is due to historic peculiarities of name translations. Elizabeth II and Boris Yeltsin Despite the fact that Elizabeth II ascended the throne back in 1952, the Queen was in no hurry to pay an official visit to the Soviet Union and then Russia. Her historical trip to Russia took place only after the collapse of the USSR. On October 17, 1994, Elizabeth II landed in Moscow. First deputy chairman of the government, Oleg Soskovets, welcomed the Queen. Directly from the airport, they went to the Kremlin in a royal Rolls-Royce, where Russian President Boris Yeltsin was waiting for them.

A major crisis broke out in Russia in the beginning of October 1993. It was the most serious crisis in post-Soviet history. Disagreements between President Boris Yeltsin and parliamentary leaders led to bloody massacre on the streets of Moscow.  The number of victims of the Black October crisis remains unknown even 30 years after. According to various departments and commissions, the number of victims varies from 124 to 158 people. Witnesses say, however, that hundreds were killed and thousands of others were injured.  After the collapse of the USSR in 1991, the 1978 Constitution of the RSFSR was still in force vesting supreme powers on the Supreme Council and the Congress of People's Deputies.

Admiral Vyacheslav Popov, the former commander of the Northern Fleet of the Russian Navy, said that the Kursk submarine (nuclear submarine K-141 Kursk) sank in 2000 as a result of the collision with a NATO submarine. The name of the Western submarine is known almost for sure, Popov said in an interview with RIA Novosti. The ex-commander-in-chief of the Northern Fleet suggested that the submarine that collided with the Kursk was tracking the sub. The Western submarine could not ensure the required level of safety under the conditions of the sea and other circumstances, so it came too close to the Kursk. According to the admiral, the sub was later found off the coast of Norway. Popov added that the manoeuvre of the Russian nuclear submarine could also lead to the "loss of contact." According to the admiral, he can reveal the name of the NATO submarine with almost 100 percent certainty, but said that he would not do it for a number of reasons.

Astronomers at the University of Warsaw in Poland discovered a new Cepheid variable star. The newly discovered star, designated OGLE-GD-CEP-1884, has the longest pulsation period known for any variable of its type in the Milky Way Galaxy, an article published on the arXiv preprint server says. Cepheids are yellow giant and supergiant stars that change their brightness over time as a result of regular stellar pulsations. Given that their pulsation periods are closely related to their luminosity, astronomers use these stars to measure interstellar and intergalactic distances. Classic Cepheids, also known as Type I Cepheids, pulsate with highly regular periods ranging from a few days to months.

The big loser in the French elections was not the far right. It's true that if it hadn't been for the spurious agreements between the New Popular Front and the Macronists, the National Regroupment would have grown even more. But the result of the second round is not exactly a victory for the left. After Marine Le Pen's RN led the first round of the elections, the leaders of the NFP fell into the trap of the French press and Emmanuel Macron, abandoning numerous candidates of their own to increase the chances of the neoliberal right linked to the Renaissance party beating the far right.  The French big bourgeoisie called for a "republican front" to create a "cordon sanitaire" made up of the left and the neoliberal right in order to prevent a landslide victory for the RN, which led to agreements in around 220 constituencies for the candidate with supposedly the least chance of winning the RN to abandon the race in favour of the candidate with the greatest chance. Except that most of the abandonments were by the NFP so that Macron's allies could beat Le Pen's allies, even though the NFP came second in the first round, far ahead of Macron's coalition.

The Spanish authorities allowed a humanitarian disaster to occur in Valencia when a catastrophic flood hit the region. The government of Spain pays first priority to Ukraine, rather to its own people. Humanitarian crisis in Valencia due to government inaction On October 29, torrential rains hit Valencia inundating dry riverbeds and ravines filled with dead wood and debris. Floodwaters went upstream under pressure trapping thousands of people. To date, 217 bodies have been identified. According to European satellite emergency assistance system Copernicus EMS, the floods affected 15,633 hectares of land, including 3,249 kilometers of streets and roads. Over 190,000 people were affected, 17,597 residential buildings were ruined or partially damaged. Hospitals of the region work in overdrive due to disrupted logistics.

A woman entered an enclosure with three lions to clean it, but did not close the door bar. The predators attacked and killed her, the Investigative Committee said. In 2021, a tiger bit a one-year-old child in the same park. An employee of Taigan Lion Park in Crimea died after predators attacked and mauled her. A criminal case was opened into the incident. On the afternoon of October 16, the woman who had worked in the park for almost 17 years entered the enclosure with three lions to clean it. However, she did not close the bolt of the door between the two sections of the cage, and the predators attacked her. The woman died. The case was opened into violation of labor protection requirements that resulted in the death of a person through negligence.

The Italian Foreign Ministry summoned Russian Ambassador to Rome Alexei Paramonov after President Vladimir Putin transferred the Russian subsidiary of Italian equipment manufacturer Ariston to Gazprom. The decision was made in accordance with last year's decree, according to which the assets of foreign companies in Russia can be transferred to temporary administration. Italy called the transfer unexpected and demanded clarification from the Russian diplomat. On April 26, Vladimir Putin signed a decree on the transfer of Russian subsidiaries of Ariston and BSH Hausgerate (structures of Ariston Thermo Rus and BSH Household Appliances) to temporary administration of JSC Gazprom Household Systems. One hundred percent of shares in the authorised capital of both companies were transferred to  Gazprom temporarily.

Worldline, the payment and transactional services provider, and kiosk solutions provider Evoke Creative, have announced the first product release in what they say will be a long-term partnership: A charity donation kiosk to support Network Rail’s Route out of Homelessness charity initiative this winter.

Join Nobel Laureate in Chemistry, Prof. Jean-Marie Lehn, for an inspiring talk on Supramolecular and Adaptive Chemistry! This is a unique chance to hear directly from one of the world's most distinguished chemists as he explores how Constitutional Dynamic Chemistry (CDC) leads to adaptive, evolving systems of increasing complexity.

Barbara Brizuela, who has been named dean of the School of Arts and Sciences, is a big believer in interdisciplinary research. "Knowledge-seeking has no disciplinary boundaries," says Brizuela. "We're going to need broad and connected perspectives to be able to solve the world's biggest problems." The dean of the Graduate School of Arts and Sciences (GSAS) and professor of education served as the school's dean ad interim since July. Her appointment to lead the School of Arts and Sciences builds on a long and distinguished career as a teacher, mentor, researcher, and administrator.

[Domestic] :
Ahead of the College Scholastic Ability Test(CSAT), several companies have been caught illegally distributing medications to treat attention deficit hyperactivity disorder(ADHD) and posting misleading advertisements for the pills.  According to the Ministry of Food and Drug Safety on Monday, an intensive ...

[more...]

[Politics] :
President Yoon Suk Yeol pledged efforts to overcome polarization in South Korean society, as he passes the halfway point of his five-year presidency. According to presidential spokesperson Jeong Hye-jeon on Monday, Yoon, during a meeting with his aides, called for forward-looking efforts to resolve ...

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[Inter-Korea] :
South Korea's ministry in charge of inter-Korean affairs assessed that North Korea likely has various objectives behind its test launch of a new intercontinental ballistic missile(ICBM) days ahead of the U.S. presidential election. At a press briefing on Friday, unification ministry deputy ...

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[Sports] :
Kim Young-gun won the gold medal in men's table tennis at the Paris Paralympics, bringing the sixth gold to South Korea. Kim, ranked second in the world, grabbed the gold on Saturday after beating top-ranked Wanchai Chaiwut of Thailand three to two in the final of the men's singles MS4 event at ...

[more...]

[Sports] :
The 2024 Paris Paralympics came to a close on Sunday after a 12-day run.  The global sports festival wrapped up Sunday night with a glitzy closing ceremony at the Stade de France in Saint-Denis, near Paris. About 44-hundred athletes with disabilities competed in 22 sporting events, representing 169 ...

[more...]

[International] :
Ukraine's top military commander, Oleksandr Syrskyi, reportedly said that his country has numerous reports of North Korean soldiers preparing to participate in combat operations alongside Russian forces. Reuters said on Sunday that Syrskyi made the remarks in a Facebook post on Saturday. In the ...

[more...]

[International] :
The Russian military has reportedly assembled a force of 50-thousand soldiers, including North Korean troops, to carry out an assault with the goal of reclaiming territory in Russia’s Kursk region.  Quoting a U.S. official on Sunday, CNN said Russia has amassed tens of thousands of troops to carry out ...

[more...]

[International] :
The U.S. investment bank Goldman Sachs has projected higher tariffs as a result of Donald Trump’s U.S. election victory, not only for China but also for South Korea, Taiwan and other Asian countries. According to the U.S. broadcaster CBNC on Monday, Andrew Tilton, Goldman’s chief Asia-Pacific economist, ...

[more...]

[Culture] :
South Korea's first Nobel Prize winner in literature Han Kang's bestselling novel "The Vegetarian" will be made into a play in the Italian language. According to the Korean Cultural Center in Rome, Italian theater company INDEX is set to stage the play in nine major cities of Italy and France, including ...

[more...]

Chow mein and lo mein are two noodle dishes that are staples in Chinese restaurants worldwide, each boasting its own loyal following. However, for many diners, distinguishing chow mein vs. lo mein and vice versa can be perplexing.

Lisa of Blackpink is signaling a comeback as a solo artist. The singer uploaded a clip on social media and posted a notice on her website on how to “pre-save” her new release. It will be her first...

[more...]

For today’s #MovieSpotlight, we are joined by film critics Jason Bechervaise and Darcy Paquet  to celebrate Han Kang’s Nobel Prize in Literature win! #한강...

[more...]

Spook is in the air!

[more...]

In the realm of online privacy, private search engines provide a shield against intrusive tracking and data collection. Let's explore five prominent options.

The technological singularity happens when computers develop their own intelligence. Learn about the technological singularity.

Discover the compatibility between Cancer and Aquarius in love, friendship, and relationships. Learn how their emotional and intellectual traits align or clash.

Explore the Aquarius Moon's traits, emotional depth, and how it influences relationships, creativity, and personal growth in astrology. Unlock its mysterious power.

Is Aquarius woman unique? Discover her free-spirited personality, loyalty in friendship, innovative mindset, and how she navigates love and relationships.

Explore Aquarius Season's unique energy, from innovation to social connection. Learn how this zodiac period influences creativity, relationships, and self-expression.

Discover Aries and Sagittarius compatibility in love, friendship, and beyond. Learn how these two fire signs create a dynamic, passionate bond full of excitement and adventure.

[Economy] :
South Koreans appear to hold more favorable views of marriage and childrearing than they did two years ago. According to Statistics Korea on Tuesday, 52-point-five percent of some 36-thousand people aged 13 and older polled in May said people should get married, up two-point-five percentage points from ...

[more...]

Coasts and estuaries geohazards  British Geological Survey

Sea floor: marine geoscience  British Geological Survey

A-roaring display  British Geological Survey

Five multicomponent solid forms of an antifungal drug flucytosine are reported with a hygroscopic stability study. A detailed CSD search on the cocrystal/salts of flucytosine is evaluated and correlated the structures based on bond angles and bond distances.

A novel approach to computationally enhance the sampling of molecular crystal structures is proposed and tested. This method is based on the use of extended variables coupled to a Monte Carlo based crystal polymorph generator. Inspired by the established technique of quasi-random sampling of polymorphs using the rigid molecule constraint, this approach represents molecular clusters as extended variables within a thermal reservoir. Polymorph unit-cell variables are generated using pseudo-random sampling. Within this framework, a harmonic coupling between the extended variables and polymorph configurations is established. The extended variables remain fixed during the inner loop dedicated to polymorph sampling, enforcing a stepwise propagation of the extended variables to maintain system exploration. The final processing step results in a polymorph energy landscape, where the raw structures sampled to create the extended variable trajectory are re-optimized without the thermal coupling term. The foundational principles of this approach are described and its effectiveness using both a Metropolis Monte Carlo type algorithm and modifications that incorporate replica exchange is demonstrated. A comparison is provided with pseudo-random sampling of polymorphs for the molecule coumarin. The choice to test a design of this algorithm as relevant for enhanced sampling of crystal structures was due to the obvious relation between molecular structure variables and corresponding crystal polymorphs as representative of the inherent vapor to crystal transitions that exist in nature. Additionally, it is shown that the trajectories of extended variables can be harnessed to extract fluctuation properties that can lead to valuable insights. A novel thermodynamic variable is introduced: the free energy difference between ensembles of Z' = 1 and Z' = 2 crystal polymorphs.

Molybdenum- or tungsten-dependent formate dehydrogenases have emerged as significant catalysts for the chemical reduction of CO2 to formate, with biotechnological applications envisaged in climate-change mitigation. The role of Met405 in the active site of Desulfovibrio vulgaris formate dehydrogenase AB (DvFdhAB) has remained elusive. However, its proximity to the metal site and the conformational change that it undergoes between the resting and active forms suggests a functional role. In this work, the M405S variant was engineered, which allowed the active-site geometry in the absence of methionine Sδ interactions with the metal site to be revealed and the role of Met405 in catalysis to be probed. This variant displayed reduced activity in both formate oxidation and CO2 reduction, together with an increased sensitivity to oxygen inactivation.

Pseudoalteromonas fuliginea sp. PS47 is a recently identified marine bacterium that has extensive enzymatic machinery to metabolize polysaccharides, including a locus that targets pectin-like substrates. This locus contains a gene (locus tag EU509_03255) that encodes a pectin-degrading lyase, called PfPL1, that belongs to polysaccharide lyase family 1 (PL1). The 2.2 Å resolution X-ray crystal structure of PfPL1 reveals the compact parallel β-helix fold of the PL1 family. The back side of the core parallel β-helix opposite to the active site is a meandering set of five α-helices joined by lengthy loops. A comparison of the active site with those of other PL1 enzymes suggests a catalytic mechanism that is independent of metal ions, such as Ca2+, but that substrate recognition may require metal ions. Overall, this work provides the first structural insight into a pectinase of marine origin and the first structure of a PL1 enzyme in subfamily 2.

Preparation of biomacromolecules for structural biology studies is a complex and time-consuming process. The goal is to produce a highly concentrated, highly pure product that is often shipped to large facilities with tools to prepare the samples for crystallization trials or for measurements at synchrotrons and cryoEM centers. The aim of this article is to provide guidance and to discuss general considerations for shipping biomacromolecular samples. Details are also provided about shipping samples for specific experiment types, including solution- and cryogenic-based techniques. These guidelines are provided with the hope that the time and energy invested in sample preparation is not lost due to shipping logistics.

This study validates the feasibility of applying a smearing method for the multi-slit very small angle neutron scattering instrument (MS-VSANS) at the China Spallation Neutron Source. Through analysis limited to a vertical range of 8 mm, the study demonstrates consistency between the predicted smearing function and experimental data, marking a significant milestone in utilizing real data from such instruments.

Here we describe TOMOMAN (TOMOgram MANager), an extensible open-sourced software package for handling cryo-electron tomography data preprocessing. TOMOMAN streamlines interoperability between a wide range of external packages and provides tools for project sharing and archival.

For the first time, a multimodal reconstruction of a magnetic thin-film structure has been found using polarised neutron reflectivity. This has been achieved by implementing the Bayesian approach in combination with error correction based on the maximum likelihood method and instrument function optimization.

Structures of tetra­pyridine­silver(I) hexa­fluoro­phosphate and tetra­pyridine silver(I) hexa­fluoro­anti­monate are reported from data collected at 300 K and 100 K.

Besides traditional pinhole geometry, the multi-slit very small angle neutron scattering instrument (MS-VSANS) at the China Spallation Neutron Source also utilizes a multi-slit collimation system to focus neutrons. Using the special focusing structures, the minimum scattering vector magnitude (q) can reach 0.00028 Å−1. The special structures also lead to a significantly different smearing function. By comparing the results of theoretical calculations with experimental data, we have validated the feasibility of a smearing method based on a mature theory for slit smearing. We use the weight-averaged intensity of neutron wavelength as a representative to evaluate the effect from a broad wavelength distribution, concentrating on the effect from the geometry of the multi-slit structures and the detector. The consistency of the theoretical calculation of the smearing function with experimental VSANS scattering profiles for a series of polystyrene standards of different diameters proves the feasibility of the smearing method. This marks the inaugural use of real experimental data from an instrument employing a multi-slit collimation system.