never before seen pictures from the war on marriage

Toddlers and Tiaras... Gets more competitive every season.

The service will run between Edinburgh and Cardiff passing through Birmingham New Street

From trekking the foothills of Mont Blanc to snowshoeing in Oulanka National Park, here are some of the best European trails to tread this winter

Extreme weather in Spain is back over Malaga as flights and train travel are disrupted due to wind and rain

Footballers Matt Crossen and Aaron Lucas speak to BBC Sport about representing England at the Cerebral Palsy World Cup in Spain.

Captain Harry Kane is unhappy with the number of players who have withdrawn from the latest England squad, insisting "England comes before club".

Regulators want to give more time to car dealers potentially facing a deluge of mis-selling claims.

1. After Sunita Williams, NASA now worried about her stranded mission partner's losing body mass  Hindustan Times
2. "My Body Has Changed, But....": Sunita Williams On Health Aboard Space Station  NDTV
3. Stranded Sunita Williams dismisses severe weight loss rumours, says she feels ‘healthier than ever’  The Times of India
4. Sunita Williams explains reason behind her changed appearance in space | 'They have routine checks, dedicated surgeons' | Inshorts  Inshorts
5. Inside Sunita Williams' extended mission: What she’s doing in space  India Today

1. 'I have found ways...': Ravichandran Ashwin gives an insight on his mind games with Steve Smith  The Times of India
2. 'I have figured out Steve Smith': R Ashwin tries to get inside Australia star's head ahead of India's series opener  Hindustan Times
3. 'His Time At Delhi Capitals...': R Ashwin Reveals How He Broke Steve Smith's Sound Game Plans  News18
4. BGT 2024-25: Ashwin says over the years he found ways to break Smith's 'sound game plans'  Daijiworld.com
5. I've found ways and means to break it down: Ashwin on Smith's batting  The Hindu

Reading depends on spoken language. This is a simple statement with profound consequences for children whose spoken language differs from the language they are expected to read. For most children, the language skills they bring to school will support learning to read, which is mainly learning to understand their spoken language in a new form: print. However, some children’s language skills differ in important ways from the classroom language variety, and teachers rarely receive sound guidance on how to enhance their literacy instruction to meet these children’s needs.

Filed under: Asia, Thailand

Not only are tourists still coming, but they've been arriving in increasing numbers in recent years, according to government data.

Continue reading Demonstrations in Thailand? No Problem, Travelers Say.

Demonstrations in Thailand? No Problem, Travelers Say. originally appeared on Gadling on Mon, 02 Dec 2013 11:26:00 EST. Please see our terms for use of feeds.

Filed under: Skiing, North America, United States

• 16 Easy Ski Vacation Ideas from U.S. Cities
• 50 Ways to Ski in 50 States

Where to Ski In Every State and 16 Ski Vacations Near Big U.S. Cities originally appeared on Gadling on Thu, 05 Dec 2013 11:29:00 EST. Please see our terms for use of feeds.

Filed under: Europe, Austria, News

No. It's all wrong. Those fake mountains.The captain is a vampire. And there's only one Julie Andrews. Two minutes was enough #SoundofMusic

- Paola (@Paopalinaa) December 6, 2013

Continue reading And the Winner of Sound of Music Live Is...

And the Winner of Sound of Music Live Is... originally appeared on Gadling on Fri, 06 Dec 2013 14:30:00 EST. Please see our terms for use of feeds.

Filed under: Food and Drink, North America, United States

• Regardless of the area's suitability for growing grapes, plop down a vineyard or winery and travelers will come for a taste and buy a sympathy bottle (pro tip: go for the ice wine as it's harder to mess up)
• Ski resorts looking to attract off-season dollars or stale attractions looking to draw media coverage and visitors hook up a zipline

Continue reading Vineyard and Zipline Trends Collide at the Pinot Express

Vineyard and Zipline Trends Collide at the Pinot Express originally appeared on Gadling on Wed, 11 Dec 2013 16:54:00 EST. Please see our terms for use of feeds.

Filed under: Business, Europe, North America, Denmark, Iceland, Belize, United States

Continue reading Top 5 Family Travel Destinations for 2014 (and Possibly Beyond)

Top 5 Family Travel Destinations for 2014 (and Possibly Beyond) originally appeared on Gadling on Thu, 09 Jan 2014 13:09:00 EST. Please see our terms for use of feeds.

Rockies left-hander Kyle Freeland plans to expand his arsenal and attack hitters in every quadrant of the strike zone this season.

Rockies shortstop Trevor Story knows a standout fielding second baseman when he plays alongside one. So Story is a good resource to assess the younger players who are trying to replace three-time Gold Glove Award-winning DJ LeMahieu, who signed a two-year, $24 million contract with the Yankees this winter.

Given a difficult injury history, one of Rockies left-hander Tyler Anderson's biggest accomplishment in 2018 was his wire-to-wire availability.

Donald Trump did not win the 2020 election, but asserting that he did became a prerequisite for Republicans standing for nomination to Congress or the Senate to win their primaries. An entire party became a vehicle for disinformation.1 Trump did win the 2024 presidential election, and key to that victory was building on the success of that lie. If you control enough of the information ecosystem, truth no longer matters.Another telling example: Haitian migrants in Springfield, Ohio, are not eating cats and dogs. US vice president elect, JD Vance, the source of that claim, admitted as much even as he justified it. “If I have to create stories so that the American media actually pays attention to the suffering of the American people, then that’s what I'm going to do,” he said.2Disinformation in politics is nothing new. History is replete with claims that were fabricated to advance political aims. Although...

bmj;387/nov12_10/q2481/FAF1faJulia and Malcolm Donaldsondonaldson20241111.f1Malcolm Donaldson was a distinguished paediatric endocrinologist with a string of research publications to his name—but he was also happy to play second fiddle (almost literally) to his wife Julia, the celebrated author of much loved children’s books, including The Gruffalo and Room on the Broom.Malcolm, a talented musician and performer, accompanied his wife as she toured festivals, schools, and libraries in the UK and around the world. Together they performed the stories, with Malcolm acting characters ranging from an accident prone dragon to a comic cattle thief. His star role, in the words of Julia’s literary agent, was “a particularly suave fox” in The Gruffalo.Malcolm met Julia Shields when they were students at the University of Bristol and they married in 1972. Donaldson went on to work in Brighton, London, and Lyon, France, before moving back to Bristol to be a senior registrar in paediatrics. Six...

At one of my first meetings as an elected council member of the Royal College of Surgeons of England, we approved a report called Access All Ages. It encouraged less ageist thinking and bias among healthcare staff that might lead to them denying older people surgery.1 But sometimes an operation isn’t the best option. Among patients who have surgery, 14% express regret and 15% experience complications, which are at least four times as likely if they’re frail or physically inactive.2 The Centre for Perioperative Care has published information on the importance of exercise before surgery,3 but that alone may not be enough.We need shared decision making,4 including asking patients what matters to them. The public should be primed to ask about BRAN—the benefits, risks, and alternatives to surgery and the likely result from doing nothing.4 A slew of data supports this approach, especially from the POPS initiative (Perioperative Care of...

A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities. By coupling monosynaptic rabies tracing with intersectional genetic targeting in male and female mice, we found that VTA VGluT2+VGaT+ neurons received diverse brainwide inputs. The largest numbers of monosynaptic inputs to VTA VGluT2+VGaT+ neurons were from superior colliculus (SC), lateral hypothalamus (LH), midbrain reticular nucleus, and periaqueductal gray, whereas the densest inputs relative to brain region volume were from the dorsal raphe nucleus, lateral habenula, and VTA. Based on these and prior data, we hypothesized that LH and SC inputs were from glutamatergic neurons. Optical activation of glutamatergic LH neurons activated VTA VGluT2+VGaT+ neurons regardless of stimulation frequency and resulted in flee-like ambulatory behavior. In contrast, optical activation of glutamatergic SC neurons activated VTA VGluT2+VGaT+ neurons for a brief period of time at high frequency and resulted in head rotation and arrested ambulatory behavior (freezing). Stimulation of glutamatergic LH neurons, but not glutamatergic SC neurons, was associated with VTA VGluT2+VGaT+ footshock-induced activity and inhibition of LH glutamatergic neurons disrupted VTA VGluT2+VGaT+ tailshock-induced activity. We interpret these results such that inputs to VTA VGluT2+VGaT+ neurons may integrate diverse signals related to the detection and processing of motivationally salient outcomes.

Goal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus nonfaces recruits different neurocognitive processes. In this study, we simultaneously recorded activity from temporal and frontal nodes of the attention network while macaques performed a goal-directed visual search task. V4 and inferotemporal (IT) visual category-selective units, selected during cue presentation, discriminated fixations on targets and distractors during the search but were differentially engaged by face and house targets. V4 and IT category-selective units also encoded fixation transitions and search dynamics. Compared with distractors, fixations on targets reduced spike–LFP coherence within the temporal cortex. Importantly, target-induced desynchronization between the temporal and prefrontal cortices was only evident for face targets, suggesting that attention to faces differentially engaged the prefrontal cortex. We further revealed bidirectional theta influence between the temporal and prefrontal cortices using Granger causality, which was again disproportionate for faces. Finally, we showed that the search became more efficient with increasing target-induced desynchronization. Together, our results suggest domain specificity for attending to faces and an intricate interplay between visual attention and social processing neural networks.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

Peripheral taste neurons exhibit functional, genetic, and morphological diversity, yet understanding how or if these attributes combine into taste neuron types remains unclear. In this study, we used male and female mice to relate taste bud innervation patterns to the function of a subset of proenkephalin-expressing (Penk+) taste neurons. We found that taste arbors (the portion of the axon within the taste bud) stemming from Penk+ neurons displayed diverse branching patterns and lacked stereotypical endings. The range in complexity observed for individual taste arbors from Penk+ neurons mirrored the entire population, suggesting that taste arbor morphologies are not primarily regulated by the neuron type. Notably, the distinguishing feature of arbors from Penk+ neurons was their propensity to come within 110 nm (in apposition with) different types of taste-transducing cells within the taste bud. This finding is contrary to the expectation of genetically defined taste neuron types that functionally represent a single stimulus. Consistently, further investigation of Penk+ neuron function revealed that they are more likely to respond to innately aversive stimuli—sour, bitter, and high salt concentrations—as compared with the full taste population. Penk+ neurons are less likely to respond to nonaversive stimuli—sucrose, umami, and low salt—compared with the full population. Our data support the presence of a genetically defined neuron type in the geniculate ganglion that is responsive to innately aversive stimuli. This implies that genetic expression might categorize peripheral taste neurons into hedonic groups, rather than simply identifying neurons that respond to a single stimulus.

The prefrontal cortex is critical for decision-making across species, with its activity linked to choosing between options. Drift diffusion models (DDMs) are commonly employed to understand the neural computations underlying this behavior. Studies exploring the specific roles of regions of the rodent prefrontal cortex in controlling the decision process are limited. This study explored the role of the prelimbic cortex (PLC) in decision-making using a two-alternative forced-choice task. Rats first learned to report the location of a lateralized visual stimulus. The brightness of the stimulus indicated its reward value. Then, the rats learned to make choices between pairs of stimuli. Sex differences in learning were observed, with females responding faster and more selectively to high-value stimuli than males. DDM analysis found that males had decreased decision thresholds during initial learning, whereas females maintained a consistently higher drift rate. Pharmacological manipulations revealed that PLC inactivation reduced the decision threshold for all rats, indicating that less information was needed to make a choice in the absence of normal PLC processing. μ-Opioid receptor stimulation of the PLC had the opposite effect, raising the decision threshold and reducing bias in the decision process toward high-value stimuli. These effects were observed without any impact on the rats’ choice preferences. Our findings suggest that PLC has an inhibitory role in the decision process and regulates the amount of evidence that is required to make a choice. That is, PLC activity controls "when," but not "how," to act.

HIV and AIDS can be prevented. It just takes you.

Community leaders in South Africa met with SportsLink to discuss how coaches can impact the fatherless in Randfontein.

Jabulani, a youth from South Africa affected by HIV, receives help and care from the OM team ministering in his community.

A Missions Discipleship Training participant discovers that his sins were dealt with by Jesus on the cross, making him free and forgiven, once and for all.

A young couple who met on the Internet answers God’s call to missions to help others find Christ using their IT and web design skills.

The church in Russia is facing a new threat-HIV/AIDS. OM Russia works in rehab-centres to show God's love and compassion.

A woman from a least-reached group of people accepted Christ during Discipleship Centre student outreach.

After discovering his freedom in Christ and being discipled, former drug addict Ruslan wants to share hope with the least reached.

Although a flash flood inundated most of Metro Manila, Central and North Luzon in the Philippines, recent earthquakes have shaken up the nation even more.

OM Ships’ vessel Logos Hope welcomes her three millionth visitor on board while in Puerto Princesa, Philippines.

A team of three from OM Philippines travel to Leyte Island to assess the situation and connect with local churches.

OM Philippines Field Leader Sally Ababa is concerned about the damage residents of Leyte Island face as clean-up efforts move forward.

On 24 December, OM Philippines-Cebu witnessed the overflowing joy of about 135 families during Christmas parties they hosted in two typhoon-affected areas.

OM Philippines hosts micro-business workshops that offer a future with hope.

An Out of the Comfort Zone team experiences island life as they bring Christ’s love to children and families on Gilutungan and Kinatarcan Island.

A teenage girl's courage and boldness opens door for family´s salvation (Philippines).

Lives are transformed in Mozambique as OM’s Tabitha Project gives local women training in sustainable handiwork skills.

A Turkish believer remains strong in his faith through persecution.