Broad-spectrum antibiotics are frequently used to empirically treat children hospitalized with community-acquired pneumonia despite recent national recommendations to use narrow-spectrum antibiotics.

Narrow-spectrum antibiotics are similar to broad-spectrum antibiotics for the treatment of children hospitalized with community-acquired pneumonia in terms of clinical outcomes and resource utilization. This study provides scientific evidence to support national consensus guidelines. (Read the full article)

Existing data do not demonstrate a need for combination therapy after antimicrobial susceptibility data indicate adequate in vitro activity with β-lactam monotherapy. However, the role of empirical combination therapy for the treatment of Gram-negative bacteremia in children remains unsettled.

We conducted a retrospective, propensity-score matched study demonstrating no improvement in 10-day mortality of children who have Gram-negative bacteremia receiving empirical β-lactam and aminoglycoside combination therapy compared with β-lactam monotherapy, unless the bacteremic episode was attributable to a multidrug-resistant organism. (Read the full article)

Herpes encephalitis outside the neonatal period is typically severe and recognizable to clinicians. Excessive testing for herpes encephalitis is associated with increased medical costs and hospital length of stay, and risks patient harm.

Herpes testing and empirical acyclovir treatment in older and less unwell patients has been increasing in US pediatric hospitals over the past decade, which may reflect a more fundamental problem in current approaches to clinical decision-making. (Read the full article)

The Russia and MFK Dinamo Moskva forward offers you a futsal masterclass.

Chagas disease, caused by the protozoan Trypanosoma cruzi, is one of the main causes of death due to cardiomyopathy and heart failure in Latin American countries. The treatment of Chagas disease is directed at eliminating the parasite, decreasing the probability of cardiomyopathy, and disrupting the disease transmission cycle. Benznidazole (BZ) and nifurtimox (NFX) are recognized as effective drugs for the treatment of Chagas disease by the World Health Organization, but both have high toxicity and limited efficacy, especially in the chronic disease phase. At low doses, aspirin (ASA) has been reported to protect against T. cruzi infection. We evaluated the effectiveness of BZ in combination with ASA at low doses during the acute disease phase and evaluated cardiovascular aspects and cardiac lesions in the chronic phase. ASA treatment prevented the cardiovascular dysfunction (hypertension and tachycardia) and typical cardiac lesions. Moreover, BZ+ASA-treated mice had a smaller cardiac fibrotic area than that in BZ-treated mice. These results were associated with an increase in the number of eosinophils and reticulocytes and level of nitric oxide in the plasma and cardiac tissue of ASA-treated mice relative to respective controls. These effects of ASA and BZ+ASA in chronically infected mice were inhibited by pretreatment with the LXA₄ receptor antagonist, Boc-2, indicating that the protective effects of ASA are mediated by ASA-triggered lipoxin. These results emphasize the importance of exploring new drug combinations for treatments of acute phase of Chagas disease that are beneficial for chronic patients.

C. Michael Cotten
Jan 1, 2009; 123:58-66
ARTICLES

Penn State Harrisburg this spring honored three retiring faculty and staff members.

At its final meeting of the 2019-20 academic year, the Penn State Faculty Senate passed landmark legislation updating its full-time faculty hiring policy for the first time in more than 20 years, as one step in continued efforts to advance the University’s commitment to diversity, equity and inclusion.

French OMer Andre experiences that prayer can change the hearts of authorities regarding victims of human trafficking.

Source: www.youtube.com - Friday, May 08, 2020

Originally announced in February 2015, Apple is giving up on trying to build the new facility.

The second-gen AirPods use a new H1 chip, which allows access to Siri without a button press and extends talk time by an hour. Wireless charging is available if you pay extra for a case.

Workers in Tajikistan long for the people of the country to replace superstition with trust in their Saviour.

A new recording studio aims to bring Central Asian musicians together for collaboration and worship.

For two days, the OM Chile Agape Team share with homeless people about the Holy Spirit and witness miracles.

SD Mishra, DCP (Rohini): Bullets fired in air outside BJP MP Hans Raj Hans' Rohini office. The person has been identified. Further investigation underway. Hans Raj Hans is an Indian singer turned politician. He is a member of Bharatiya Janata Party and a recipient of the civilian honour of Padma

After being on the run for nearly a year, the National Investigation Agency on Saturday arrested Ranjit Singh, a "notorious narco-terrorist", from Sirsa as he was acting as a conduit of Pakistan-based...

Agency: HSS Closing Date: 6/5/2020

“We have no regrets in doing so. It will help us come out of the crisis stronger,” Nilanjan Roy, CFO, said on Monday.

Kerry Cunningham of SiriusDecisions talks about how AI can power the B2B revenue engine

GDPR comes into force on May 25. Here's a timely look at its impact on B2B marketing and sales functions with Julian Archer of SiriusDecisions

The coronavirus pandemic has dealt a massive blow to the hirings trend in the last month with the employment rate slipping by a massive 62% as compared to last year.

India has firmly established itself as a net steel exporter in FY20 with total steel exports at 11.183 MT (31 % growth over last year) exceeding the total steel imports at 7.164 MT by 4.02 MT.

Clown Me In co-founder Sabine Choucair discusses the group’s new online workshop series, each Friday, ‘Happy Half-Hour’

Lisa Nakano of SiriusDecisions describes a framework for understanding customer engagement and maintaining it throughout the customer lifecycle

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A total of 12,000 applicants applied to become astronauts at the National Aeronautics and Space Administration (NASA).

PM Modi also said let us pledge to work towards a cleaner, healthier and a more prosperous planet.

The Delhi Court on Tuesday declined to grant interim stay on the new Netflix series “Hasmukh” which stars Vir Das. The plea, moved by Advocate Ashutosh Dubey, claimed that the fictional series maligned the reputation of advocates, especia

Tips from executives on how to inspire creativity in the workplace

In other words, we can speculate, but frankly, we don’t have much to go by till we know that work can be resumed to some extent.

By Vinay Kumar Dutta During the Covid-19 pandemic, many people may be rethinking how to converge materialism with spiritualism. Why is this thought pervading in their? Are they intimidated, or truly inspired to embrace spiritualism? Humans are materialistic by nature. Greed to acquire and obsession for possession is rooted in their minds. Highly materialistic individuals […]

Amid the carnage of the U.S. employment report for April was one bright spot: superstores led by Walmart Inc, added more than 90,000 jobs.

SOCH - Global Social Change Contest for inspiring short films, videos

Hiring in banking sector is expected to go up to 25% this year

India’s leading IT firm Wipro has said that firing employees can be considered in the coming days, in order to save costs. Employees can be asked to go on unpaid leaves as well. However, the silver lining is that, hiring won’t be stopped. Wipro: Business Hit Due To Coronavirus Wipro declared their 4th quarter earnings, […]

The post Wipro Can Fire Employees, Enforce Unpaid Leaves To Save Costs; Hiring Will Not Stop first appeared on Trak.in . Trak.in Mobile Apps: Android | iOS.

Kyle Larson returned to racing for the first time since he was fired by Chip Ganassi Racing for using a racial slur in an iRacing event last month.

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