On 2 April 2019, the European Commission issued a press release regarding its State aid investigation into aspects of the UK controlled foreign company (CFC) rules. This press release explains that certain aspects of the CFC rules under investigatio...

After insisting for weeks it would take no more refugees, Bangladesh relents and rescues hundreds.

Little Richard, whose outrageous showmanship and lightning-fast rhythms intoxicated crowds in the 1950s with hits like “Tutti Frutti” and “Long Tall Sally,” has died. He was 87 years old. Citing the rock ‘n’ roll pioneer’s son, Rolling Stone magazine said Saturday the cause of death was unknown. With a distinctive voice that ranged from robust
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The post Little Richard: Founding father of rock dies at 87 appeared first on Vanguard News.

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An arson case is being investigated after a tavern was torched in Hambanathi, Tongaat, outside Durban, following the discovery of human remains in the nearby Wewe River, KwaZulu-Natal police say. ......

What you need to know UK regulatory guidance has been updated to explain what ‘manifestly unfounded’ and ‘excessive’ means in relation to the individual rights of data subjects under GDPR. This includes but is not limited to ...

Many technology solutions have been crafted,...

They called for larger-scale research on critically-ill patients to ascertain if the drug combo could be a viable treatment for them too

COVID-19 is spread through respiratory droplets or contact and the virus has also been detected in faeces, saliva and urine

[Premium Times] In February, PREMIUM TIMES exclusively spoke with Chris Elias, the President of the Global Development Division of the Bill and Melinda Gates Foundation and Paulin Basinga, the foundation's country director, on the role the foundation played in the eradication of wild polio in Nigeria and a range of other developmental issues.

It is almost ten weeks since the coronavirus emergency erupted here, following confirmation of the first case of Covid-19 in Ireland. Our world has changed in the most unexpected ways.

Little Richard, whose outrageous showmanship and lightning-fast rhythms intoxicated crowds in the 1950s with hits like “Tutti Frutti” and “Long Tall Sally,” has died. He was 87.Citing the rock ‘n’ roll pioneer’s son, Rolling Stone magazine said on Saturday the cause of death was unknown.With a distinctive voice that ranged from robust belting to howling falsetto, Richard transfixed audiences and became an inspiration for artists including The Beatles as he transformed the blues into the…

Prague Daily Monitor

The city of Chur, Switzerland had some excitement on Thursday when a 55 year-old Czech walked into a bank with a pistol, shooting into the ceiling twice, terrifying patrons. The man managed to walk away from the bank with several tens of thousands of Swiss Francs. The suspect was found soon after, sitting in a pub calmly, drinking a beer reported a Swiss daily Tages-Anzeiger.

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Prague Daily Monitor

The Prince of Lichtenstein Foundation has lost its case concerning ownership of 600 hectares of forest close to the city of Říčany, outside of Prague. The Constitutional Court upheld the prior verdict in the case which was not to return the 600 hectares of forest to the foundation. "The Prince of Lichtenstein will in this case use all possible tools and opportunities to get justice in an international court and international institutio," said the foundation's spokesperson.

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In recent months, several Pakistani activists and bloggers living in Europe have claimed to have been targeted for speaking up against human rights violations in Pakistan.

Foundation Services 0.2.1 Binary File

BENGALURU, INDIA –  HARMAN (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today announced that it has launched its global corporate social responsibility initiative, ‘HARMAN Inspired’, in India....

A rigorous randomised trial has put to bed the idea that tapping or flicking a can of beer makes bubbles come to the top and prevents the liquid fizzing out

Google has put the algorithm it used to achieve quantum supremacy to work. It generated verifiably random numbers, which could be used one day in encryption or lotteries

A NASA science balloon picked up two high-energy particles and a new analysis reveals that they can't be explained by the standard model of particle physics

An extinct variety of date palm tree has been grown from ancient seeds preserved in the Judean desert for 2000 years, the oldest seeds ever germinated

The genomes of 2514 new viruses have been identified in DNA recovered from human and animal cells, many of them belonging to wholly new families

A shrimp-like creature found 6 kilometres down in the Pacific Ocean’s deepest trench has been named Eurythenes plasticus after the microplastics found in its gut

The oldest rocks ever found are over four billion years old and we don’t know how they formed – but a massive asteroid bombardment may be responsible

Radar surveys have revealed a crater left when a kilometre-wide asteroid hit Greenland – and the impact could explain a climate mystery

A dead whale found in the Philippines with 40 kilograms of plastic inside its body is the latest example of the problem of plastic pollution

An emotional and intellectual voyage into an underground mythical world imagined by the Sami people reveals truths about our collective future

Preserved microorganisms have been found encased in 3.5-billion-year-old rocks, confirming that single-celled life was thriving early in Earth’s history

While the automotive industry is taking great strides to make a truly autonomous future a reality, there is still a long way to go before fully autonomous vehicles are on our roads. In the meantime, automakers and technology suppliers are developing...

Florian Schneider, co-founder of pioneering German electronic band Kraftwerk, which influenced generations of pop and dance musicians with mesmerising tracks such as "Autobahn", has died of cancer aged 73, longtime bandmate Ralf Huetter said.

A bunch of asteroids near Jupiter and Neptune with orbits perpendicular to the plane of the solar system may have come here from a different star system

Title: No Link Found Between Playing Football in Hot Weather, Concussion Risk
Category: Health News
Created: 4/28/2014 4:36:00 PM
Last Editorial Review: 4/29/2014 12:00:00 AM

Title: Antibodies Found in Nearly All People Infected by New Coronavirus: Study
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Infectious viruses commonly are found in semen, with Zika being one recent notable example. The Chinese researchers noted that 27 different viruses have been detected in human semen.

ABSTRACT

Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 maternal HIV envelope (Env)-specific IgG monoclonal antibodies (MAbs) from seven nontransmitting and transmitting HIV-infected U.S. and Malawian mothers and examined their neutralization activities against nontransmitted autologous circulating viruses and infant-transmitted founder (infant-T/F) viruses. Only a small subset of maternal viruses, 3 of 72 (4%), were weakly neutralized by maternal linear V3 epitope-specific IgG MAbs, whereas 6 out of 6 (100%) infant-T/F viruses were neutralization resistant to these V3-specific IgG MAbs. We also show that maternal-plasma broadly neutralizing antibody (bNAb) responses targeting the V3 glycan supersite in a transmitting woman may have selected for an N332 V3 glycan neutralization-resistant infant-T/F virus. These data have important implications for bNAb-eliciting vaccines and passively administered bNAbs in the setting of MTCT.

IMPORTANCE Efforts to eliminate MTCT of HIV with antiretroviral therapy (ART) have met little success, with >180,000 infant infections each year worldwide. It is therefore likely that additional immunologic strategies that can synergize with ART will be required to eliminate MTCT of HIV. To this end, understanding the role of maternal HIV Env-specific IgG antibodies in the setting of MTCT is crucial. In this study, we found that maternal-plasma broadly neutralizing antibody (bNAb) responses can select for T/F viruses that initiate infection in infants. We propose that clinical trials testing the efficacy of single bNAb specificities should not include HIV-infected pregnant women, as a single bNAb might select for neutralization-resistant infant-T/F viruses.

ABSTRACT

Much of the diversity of prokaryotic genomes is contributed by the tightly controlled recombination activity of transposons (Tns). The Tn3 family is arguably one of the most widespread transposon families. Members carry a large range of passenger genes incorporated into their structures. Family members undergo replicative transposition using a DDE transposase to generate a cointegrate structure which is then resolved by site-specific recombination between specific DNA sequences (res) on each of the two Tn copies in the cointegrate. These sites also carry promoters controlling expression of the recombinase and transposase. We report here that a number of Tn3 members encode a type II toxin-antitoxin (TA) system, typically composed of a stable toxin and a labile antitoxin that binds the toxin and inhibits its lethal activity. This system serves to improve plasmid maintenance in a bacterial population and, until recently, was believed to be associated with bacterial persistence. At least six different TA gene pairs are associated with various Tn3 members. Our data suggest that several independent acquisition events have occurred. In contrast to most Tn3 family passenger genes, which are generally located away from the transposition module, the TA gene pairs abut the res site upstream of the resolvase genes. Although their role when part of Tn3 family transposons is unclear, this finding suggests a potential role for the embedded TA in stabilizing the associated transposon with the possibility that TA expression is coupled to expression of transposase and resolvase during the transposition process itself.

IMPORTANCE Transposable elements (TEs) are important in genetic diversification due to their recombination properties and their ability to promote horizontal gene transfer. Over the last decades, much effort has been made to understand TE transposition mechanisms and their impact on prokaryotic genomes. For example, the Tn3 family is ubiquitous in bacteria, molding their host genomes by the paste-and-copy mechanism. In addition to the transposition module, Tn3 members often carry additional passenger genes (e.g., conferring antibiotic or heavy metal resistance and virulence), and three were previously known to carry a toxin-antitoxin (TA) system often associated with plasmid maintenance; however, the role of TA systems within the Tn3 family is unknown. The genetic context of TA systems in Tn3 members suggests that they may play a regulatory role in ensuring stable invasion of these Tns during transposition.

Objective

Polygenic risk scores (PRSs) are used to quantify the cumulative effects of a number of genetic variants, which may individually have a very small effect on susceptibility to a disease; we used PRSs to better understand the genetic contribution to common epilepsy and its subtypes.

Cowen et al. (1) leverage modern gains in data science to describe impressive cross-cultural similarities in the perception of musical affect and do so in unprecedented detail. Their approach is innovative and fundamentally empirical. As such, it should have important applications for prediction in the field of affective computing, which...

Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians, Inc. (ACP), and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of Clinical Diabetes. The following article describes an initiative of the Cleveland Clinic’s internal medicine residents to improve diabetes care and outcomes within an underserved patient population at an East Cleveland, OH, health center.

This post contains spoilers for Dead to Me Season 2.

Maybe it’s the surreality of, well, everything lately—or maybe it’s just aged like the fine wines all of its characters toss back by the bottle. Whatever the reason, Dead to Me Season 2 hits even better than Season 1—fighting off a sophomore slump with a fresh batch of twists, dramatic ironies, and, most importantly, some more Christina Applegate angsting out to metal. Perhaps this season’s smartest move, however, is a trope pulled straight out of Soapy Dramas 101: Bringing James Marsden back to play his own twin.

Series creator Liz Feldman was sending the usual thank-you notes back and forth with cast and crew after Season 1 wrapped when she received a particularly amusing message from Marsden.

Read more at The Daily Beast.

The TESS space telescope has found its first Earth-sized planet with conditions that might be right for life, orbiting a small star 100 light years away

In our atmosphere, strange dense patches of charged air sometimes bounce radio waves around and disrupt radar – and now they have been spotted on Mars

A team of researchers say they have discovered a protein molecule inside a meteorite, the first extraterrestrial example ever found, but others are sceptical

A tiny meteorite found in Antarctica doesn’t match any asteroid or comet we know of. Instead, it must have come from a mystery parent body that’s full of water

A bunch of asteroids near Jupiter and Neptune with orbits perpendicular to the plane of the solar system may have come here from a different star system

Harrell had been working as an executive producer on a TV miniseries about Uptown Records with BET.

The novel coronavirus has been discovered in the semen of infected male individuals, according to Chinese researchers, potentially raising the prospect that the virus could potentially be sexually transmitted.

The hypothetical Planet 9 has been bandied about for several years, first mentioned in 2014, but researchers have yet to find it. Now, a well-known theoretical physicist believes we could find the mysterious object using "laser-launched spacecraft."