A species of leaf chameleon newly named Brookesia nofy was discovered in a patch of coastal rainforest, a highly threatened habitat in Madagascar

Climate change means extreme heat will become the norm for millions across the world. We joined an experiment in the Saudi Arabian desert designed to find out what that means for our brains and bodies

Olivier Grunewald took this image of the Icelandic volcano's central crater filled with lava, forming a fiery lake of liquid rock

Iceland’s Fagradalsfjall volcano, located on the country’s south-west Reykjanes peninsula, has erupted after weeks of earthquake activity

Global warming means many of the world’s ancient rivers of ice will be gone within decades, threatening ecosystems that rely on their meltwater, a looming crisis that photographer Edward Burtynsky highlights in his work

An off-the-shelf millimetre wave sensor can pick out the tiny vibrations made by a smartphone's speaker, enabling an AI model to transcribe the conversation, even at a distance in a noisy room

Highland and lowland populations in Papua New Guinea have different gene variants derived from Denisovan archaic humans, indicating possible adaptations for lower oxygen levels and higher malaria risk

Title: U.S. to Reopen Borders to Vaccinated Travelers from Canada, Mexico
Category: Health News
Created: 10/13/2021 12:00:00 AM
Last Editorial Review: 10/13/2021 12:00:00 AM

Title: Nasal Spray May Ease Cluster Headaches
Category: Health News
Created: 8/29/2007 12:00:00 AM
Last Editorial Review: 8/29/2007 12:00:00 AM

Title: Acupuncture Might Ease Tension Headaches
Category: Health News
Created: 6/23/2022 12:00:00 AM
Last Editorial Review: 6/23/2022 12:00:00 AM

Title: What Gets Rid of Headaches Quickly?
Category: Diseases and Conditions
Created: 4/12/2016 12:00:00 AM
Last Editorial Review: 7/17/2022 12:00:00 AM

Title: Pandemic Brought More Woes for Kids Prone to Headaches
Category: Health News
Created: 8/9/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Family medicine physicians often see headache as the chief complaint when meeting patients within their practice. The goal is to try different treatment modalities without having to send the patient to a specialist. Headaches affect different individuals during their lifetime. Before any treatment begins, it is best that one rules out possible causes of the headache, for example, drug interactions or structural cerebrum conditions. Nonpharmacological treatment is recommended first before attempting a stepwise approach to cost-effective pharmacological treatment options. Pharmacological treatment options should include preventive and on-demand options. A family physician has all the resources to assist patients with different types of headaches.

BACKGROUD:Lung volume measurements are important for monitoring functional aeration and recruitment and may help guide adjustments in ventilator settings. The expiratory phase of airway pressure release ventilation (APRV) may provide physiologic information about lung volume based on the expiratory flow-time slope, angle, and time to approach a no-flow state (expiratory time [TE]). We hypothesized that expiratory flow would correlate with estimated lung volume (ELV) as measured using a modified nitrogen washout/washin technique in a large-animal lung injury model.METHODS:Eight pigs (35.2 ± 1.0 kg) were mechanically ventilated using an Engström Carescape R860 on the APRV mode. All settings were held constant except the expiratory duration, which was adjusted based on the expiratory flow curve. Abdominal pressure was increased to 15 mm Hg in normal and injured lungs to replicate a combination of pulmonary and extrapulmonary lung injury. ELV was estimated using the Carescape FRC INview tool. The expiratory flow-time slope and TE were measured from the expiratory flow profile.RESULTS:Lung elastance increased with induced lung injury from 29.3 ± 7.3 cm H2O/L to 39.9 ± 15.1cm H2O/L, and chest wall elastance increased with increasing intra-abdominal pressures (IAPs) from 15.3 ± 4.1 cm H2O/L to 25.7 ± 10.0 cm H2O/L in the normal lung and 15.8 ± 6.0 cm H2O/L to 33.0 ± 6.2 cm H2O/L in the injured lung (P = .39). ELV decreased from 1.90 ± 0.83 L in the injured lung to 0.67 ± 0.10 L by increasing IAP to 15 mm Hg. This had a significant correlation with a TE decrease from 2.3 ± 0.8 s to 1.0 ± 0.1 s in the injured group with increasing insufflation pressures (ρ = 0.95) and with the expiratory flow-time slope, which increased from 0.29 ± 0.06 L/s2 to 0.63 ± 0.05 L/s2 (ρ = 0.78).CONCLUSIONS:Changes in ELV over time, and the TE and flow-time slope, could be used to demonstrate evolving lung injury during APRV. Using the slope to infer changes in functional lung volume represents a unique, reproducible, real-time, bedside technique that does not interrupt ventilation and may be used for clinical interpretation.

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.

Bacterial regulatory RNAs (sRNAs) are important players to control gene expression. In Staphylococcus aureus, SprC is an antivirulent trans-acting sRNA known to base-pair with the major autolysin atl mRNA, preventing its translation. Using MS2-affinity purification coupled with RNA sequencing, we looked for its sRNA-RNA interactome and identified 14 novel mRNA targets. In vitro biochemical investigations revealed that SprC binds two of them, czrB and deoD, and uses a single accessible region to regulate its targets, including Atl translation. Unlike Atl regulation, the characterization of the SprC-czrB interaction pinpointed a destabilization of the czrAB cotranscript, leading to a decrease of the mRNA level that impaired CzrB zinc efflux pump expression. On a physiological standpoint, we showed that SprC expression is detrimental to combat against zinc toxicity. In addition, phagocyctosis assays revealed a significant, but moderate, increase of czrB mRNA levels in a sprC-deleted mutant, indicating a functional link between SprC and czrB upon internalization in macrophages, and suggesting a role in resistance to both oxidative and zinc bursts. Altogether, our data uncover a novel pathway in which SprC is implicated, highlighting the multiple strategies used by S. aureus to balance virulence using an RNA regulator.

ABSTRACTIn the Democratic Republic of the Congo (DRC), male engagement, social norms, and social networks mitigate family planning behavior. We discuss the adaptation of the Social Norms Exploration Tool (SNET), which identifies relevant social norms and community members upholding these norms, to inform the development of family planning interventions in the DRC. The SNET provides activity tools and templates to guide users through the following steps: (1) plan and prepare, (2) identify reference groups, (3) explore social norms, (4) analyze results, and (5) apply findings.The SNET approach resulted in discussion of social norms, particularly around birth spacing and gender norms framing the man as the decision-maker. However, despite applying a methodology specifically designed to identify social norms, other factors limiting use of contraceptive methods were identified in the process, including lack of education, rumors, and misconceptions. Adaptations were needed to include the full range of reference groups due to narrow phrasing of primary questions, and some of the participatory methods were overly complicated. Feedback from experienced data collectors suggested that the social norms framework is not intuitive, is difficult to apply correctly, and may require that data collectors have a stronger foundation in the relevant concepts to produce valid and actionable results.Although the SNET provides language for discussing normative factors and techniques to identify reference groups and social norms, modifications to the implementation process are recommended when adapting the tool for research.

It doesn’t matter how long a play is: sometimes 75 minutes can feel like 3 hours if the play is bad, while a three-hour play may first elicit an inner groan, then flow pleasurably by if the writing and performances are in well-oiled tandem.

Kenneth Lonergan’s Hold on to Me Darling (Lucille Lortel Theatre, to Dec. 22) belongs, mostly, to the latter category: it is long, and it feels long, but that’s OK; not gold-standard wow, but far more than pleasant. This is down to Lonergan’s engaging writing and a collection of differently distinctive, carefully drawn performances, led by Adam Driver as a famous country star called Strings (real name Clarence), wondering if he could/should give up all the trappings of fame for a simpler life after his mother’s death.

It is an off-Broadway treat to see Driver, most recently seen on the big screen as the star of Francis Ford Coppola’s polarizing epic Megalopolis, here bestriding—he is so tall, he is really bestriding—the compact Lucille Lortel stage. Theater fans last saw him on Broadway in Burn This, for which he was nominated for the Tony Award for Best Actor in a Play. He is renowned for playing powder-keg personas. With characters like Adam in Girls, Charlie in Marriage Story, and Pale in Burn This, the question, the bubbling menace, was when will Adam Driver go off? Those characters memorably combusted—thrashing, shouting, snarling and occupying spaces that could barely contain them—and Driver made it so that you recoiled from their crackling fury.

Read more at The Daily Beast.

An off-the-shelf millimetre wave sensor can pick out the tiny vibrations made by a smartphone's speaker, enabling an AI model to transcribe the conversation, even at a distance in a noisy room

A biologist at Cape Breton University is hoping a piece of technology used to keep people safe in the pandemic can help protect Nova Scotia's oysters against the effects of warming waters.

Republican Rep. David Valadao has won reelection in California's 22nd Congressional District, defeating Democrat Rudy Salas for the second time.

Kurt “CyberGuy" Knutsson discusses how Axiom Space and luxury designer Prada are collaborating on NASA's Artemis III spacesuit design.

… Trains for 1st Time inside Davis Cup Venue VALENCIA, Spain – World No … the Spanish national team’s Davis Cup quarterfinals against Germany. Nadal, who ….

ROGER FEDERER has explained why he gets injured less than rivals Rafael Nadal and Novak Djokovic..

Adam Peaty roared back at those writing him off after cruising through his 50 metres breaststroke semi-final – but was later accused of being disrespectful towards Commonwealth Games competitors.

Canada’s national anti-money laundering agency has been hit by a cyber attack. The Financial Transactions and Reports Analysis Centre of Canada (FINTRAC) said Tuesday that over the last 24 hours it has been managing a cyber incident. “The incident does not involve the centre’s intelligence or classified systems,” it said in a statement. “As a […]

The government of Canada has announced significant investments to improve connectivity in British Columbia and Alberta over the past two days. That includes combined federal and provincial funding of C$112 million to bring high speed internet access to more than 22,500 households in Alta. and another $37 million for 7,500 households in B.C.. The households, […]

Facing an unprecedented crisis, IT World Canada, a beacon of technology journalism, is on the brink of closure. This poses a critical question: Without IT World Canada, who will narrate Canada’s tech story? After decades of serving the Canadian tech industry, IT World Canada needs help to survive. As of midnight tonight, the company is […]

Wonder Brands Inc. is recalling various brands of bread and buns because of pieces of metal in the products. According to the Canadian Food Inspection Agency (CFIA), the recalled products were distributed in Newfoundland and Labrador, Ontario and Quebec, Canada. The brands listed in the recall include Country Harvest, D’Italiano,... Continue Reading

Human bird flu has hospitalized a Canadian teenager at British Columbia Children’s Hospital. He is the first person in Canada to test positive for the bird flu virus. The B.C. teen likely acquired the virus from exposure to a bird or animal. B.C. Health said the infection is a rare... Continue Reading

Atlantic Canadians say the region has room to grow, but is facing a shrinking labour pool

Canada Post workers might soon be putting down their mailbags and grabbing picket signs

Incumbent Republican David Valadao is projected to emerge victorious in California's 22nd Congressional District. The highly contested race was considered to be a tossup.

A collaboration between a space company and a fashion company yields something elegant.

Industry Minister François-Philippe Champagne said the decision to dissolve TikTok of its Canadian business is meant to address risks perceived to be related to TikTok's Chinese parent company.

‘Idli Kadai,’ Dhanush’s fourth directorial project, has music scored by GV Prakash Kumar

Starring Tamannaah Bhatia, Jimmy Shergill, and Avinash Tiwary, ‘Sikandar Ka Muqaddar’ is directed by Neeraj Pandey

Together, Melinda Watpool and Lucas Bahdi add a heavy dose of Canadian content to the undercard of next Friday's megawatt showdown between Mike Tyson and Jake Paul, which could become the most-viewed boxing event in history.

Pat McLaughlin is stepping down as Hockey Canada's chief operating officer and executive vice-president of strategy, the governing body announced Monday.

​​​​​​​Jocelyne Larocque scored less than 4 minutes into the game, Sarah Nurse added a goal midway through the first period and Canada cruised to a 4-1 win over the United States in Boston on Sunday to take a 2-1 lead in the five-game Rivalry Series.

Canada will be without captain Alphonso Davies for its upcoming CONCACAF Nations League quarterfinal against Suriname. Canada Soccer says the Bayern Munich star has withdrawn as a "precautionary measure due to physical fatigue."

For years, members of Canada's national soccer teams have used drones to spy on their opponents and obtain sensitive information illegally. Radio-Canada's Enquête has found that there was a "culture" of spying at Canada Soccer made possible by the "strong pressure" placed on employees, according to multiple witnesses.

Bev Priestman is out as head coach of the Canadian women's soccer team in the wake of an independent report into the Olympic drone-spying scandal.